Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissues

European Journal of Cancer

Volumn 37, Issue 1, 2001, Pages 114-121

  Torres, J ^a   Navarro, S ^b   Rogla I ^a   Ripoll, F ^a   Lluch, A ^b   Garcia Conde J ^b   Llombart Bosch, A ^b   Cervera, J ^a   Pulido, R ^a  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Cancer; Protein phosphatases; PTEN; Tumour suppressor

Indexed keywords

PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE;

ARTICLE; CARCINOGENESIS; CHROMOSOME 10Q; CONTROLLED STUDY; GENE LOCATION; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NEOPLASM; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE;

EID: 0035146778     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(00)00366-X     Document Type: Article

References (47)

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4. Germline mutations of the PTEN gene in Cowden disease, and inherited breast and thyroid cancer syndrome
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6. Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease
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18. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
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26. Impaired Fas response and autoimmunity in Pten +/- mice
27. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma
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34. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage
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41. Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors
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43. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers
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