Cigarette smoking and lung cancer: Chemical mechanisms and approaches to prevention

Lancet Oncology

Volumn 3, Issue 8, 2002, Pages 461-469

  Hecht, Stephen S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; AROMATIC AMINE; BETA CAROTENE; CARCINOGEN; CIGARETTE SMOKE; DNA; INOSITOL; ISOTRETINOIN; NITROSAMINE; PHENETHYL ISOTHIOCYANATE; POLYCYCLIC AROMATIC HYDROCARBON; RETINOL PALMITATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CHEMICAL REACTION; CHEMOPROPHYLAXIS; CIGARETTE SMOKING; CRUCIFERA; DETOXIFICATION; DIET THERAPY; DNA ADDUCT; DRUG STRUCTURE; EXPOSURE; GENE MUTATION; GENETIC REGULATION; HUMAN; LUNG CANCER; METABOLISM; NONHUMAN; PATIENT EDUCATION; PRIORITY JOURNAL; RAT; REVIEW; RISK ASSESSMENT; SMOKING CESSATION; TOBACCO; TREATMENT FAILURE; VEGETABLE;

EID: 0036333198     PISSN: 14702045     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1470-2045(02)00815-X     Document Type: Review

References (71)

1. Food, nutrition and the prevention of cancer: A global perspective
2. Cancer statistics, 2002
3. Tobacco use
4. Tobacco or health: A global status report
5. Tobacco smoking
6. Cancers weakly related to smoking
7. Cigarette smoking and colorectal cancer mortality in the cancer prevention study II
8. Tobacco use
9. Cigarette smoking among adults, United States, 1998
10. The less harmful cigarette: A controversial issue. A tribute to Ernst L Wynder
11. Tobacco smoke carcinogens and lung cancer
12. Simultaneous exposure to nicotine and hyperoxia causes tumors in hamsters
13. 2′-hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: Formation of a lung carcinogenic precursor
14. Association between carcinogen-DNA adducts in white blood cells and lung cancer risk in the physicians health study
15. Base excision repair in yeast and mammals
16. Cellular responses to DNA damage
17. Controlling the efficiency of excision repair
18. Repair of O-6-alkylguanine by alkyltransferases
19. Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: A molecular epidemiologic study
20. Progress in understanding the molecular pathogenesis of human lung cancer
21. Molecular damage in the bronchial epithelium of current and former smokers
22. The hallmarks of cancer
23. Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines
24. Tobacco-specific nitrosamines
25. Cigar and pipe smoking and lung cancer risk: A multicenter study from Europe
26. Cigar smoking in men and risk of death from tobacco-related cancers
27. Re: Cigar smoking in men and risk of death from tobacco-related cancers
28. Smoking and lung cancer: Scientific challenges and opportunities
29. Intraindividual and interindividual differences in metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers' urine
30. Quantitation of urinary metabolites of a tobacco-specific lung carcinogen after smoking cessation
31. Quantitation of metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone after cessation of smokeless tobacco use
32. The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a β-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via β-adrenergic receptor-mediated release of arachidonic acid
33. Health effects of exposure to environmental tobacco smoke: The report of the California Environmental Protection Agency
34. A tobacco-specific lung carcinogen in the urine of men exposed to cigarette smoke
35. A metabolite of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the urine of hospital workers exposed to environmental tobacco smoke
36. Metabolites of a tobacco-specific lung carcinogen in the urine of nonsmoking women exposed to environmental tobacco smoke in their homes
37. Metabolites of a tobacco-specific lung carcinogen in the urine of elementary school-aged children
38. Environment and cancer: Who are susceptible?
39. Fifty years of benzo[a]pyrene
40. Polynuclear aromatic compounds: Part 1, chemical, environmental, and experimental data
41. Polynuclear aromatic compounds: Part 3, industrial exposures in aluminum production, coal gasification, coke production, and iron and steel founding
42. Polynuclear aromatic compounds: Part 4, bitumens, coal-tars and derived products, shale-oils and soots
43. DNA adducts in human carcinogenesis: Etiological relevance and structure-activity relationship
44. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hot spots in P53
45. The metabolism and activation of benzo[a]pyrene
46. Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers
47. Human lung microsomal cytochrome P4501A1 (CYP1A1) activities: Impact of smoking status and CYP1A1, aryl hydrocarbon receptor, and glutathione S-transferase M1 genetic polymorphisms
48. Determination of r-7, t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene in human urine by gas chromatography-negative ion chemical ionization-mass spectrometry
49. Relationship of exposure to coke-oven emissions and urinary metabolites of benzo[a]pyrene and pyrene in coke-oven workers
50. Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 study
51. Cancers of the lung and pleura
52. Alpha-tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: Effects of base-line characteristics and study compliance
53. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease
54. Randomized phase III intergroup trial of isotretinoin to prevent second primary tumors in stage I non-small-cell lung cancer
55. Effects of the combination of beta carotene and vitamin A on lung cancer and cardiovascular disease
56. EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer
57. The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
58. Myo-inositol content of common foods: Development of a high myo-inositol diet
59. Inhibition of carcinogenesis by isothiocyanates
60. Dose-response study of myo-inositol as an inhibitor of lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butane
61. Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung
62. Anticarcinogenic activities of organic isothiocyanates: Chemistry and mechanism
63. Effects of benzyl isothiocyanate and phenethyl isothiocyanate on benzyl[a]pyrene metabolism and DNA adduct formation in the A/J mouse
64. Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates
65. Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
66. Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: A prospective study of men in Shanghai, China
67. Dietary intake of isothiocyanates: Evidence of a joint effect with glutathione S-transferase polymorphisms in lung cancer risk
68. Dietary isothiocyanates, glutathione S-transferase -M1, -T1 polymorphisms and lung cancer risk among Chinese women in Singapore
69. Chemopreventive effects of myoinositol and dexamethasone on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary carcinogenesis in female A/J mice
70. Chemoprevention of tobacco smoke-induced lung tumors in A/J strain mice with dietary myo-inositol and dexamethasone