Amplification and overexpression of the cyclin D1 and epidermal growth factor receptor genes in non-small-cell lung cancer

Journal of Cancer Research and Clinical Oncology

Volumn 125, Issue 2, 1999, Pages 61-70

  Reissmann, Peter T ^a   Koga, Hironobu ^b   Figlin, Robert A ^c   Holmes, E Carmack ^c   Slamon, Dennis J ^c  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cyclin D1; Epidermal growth factor receptor; Gene amplification; Lung cancer

Indexed keywords

CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR;

ARTICLE; CANCER SURVIVAL; DIAGNOSTIC VALUE; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; NORTHERN BLOTTING; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; SOUTHERN BLOTTING;

ADENOCARCINOMA; AGED; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; CARCINOMA, LARGE CELL; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; COHORT STUDIES; DNA, NEOPLASM; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BCL-1; GENES, ERBB-1; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MIDDLE AGED; RNA, MESSENGER; RNA, NEOPLASM;

EID: 0032928459     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004320050243     Document Type: Article

References (75)

1. Albanese C, Johnson J, Watanabe G, Eklund N, Vu D, Arnold A, Pestell R (1995) Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J Biol Chem 270:23 589-23 597
2. Ali I, Merlo G, Callahan R, Lidereau R (1989) The amplification unit on chromosome 11q13 in aggressive primary human breast tumors entails the bcl-1, int-2 and hst loci. Oncogene 4:89-92
3. Ausubel F, Brent R, Kingston R, Moore D, Seidman J, Smith J, Struhl K (eds) (1989) Current protocols in molecular biology, vol 2. Wiley, New York, pp 10.2.1-10.2.18
4. Bartkova J, Lukas J, Muller H, Lutzhoft D, Strauss M, Bartek J (1994a) Cyclin D1 protein expression and function in human breast cancer. Int J Cancer 57:353-61
5. Bartkova J, Lukas J, Strauss M, Bartek J (1994b) Cell cycle-related variation and tissue-restricted expression of human cyclin D1 protein. J Pathol 172:237-245
6. Berenson J, Yang J, Mickel R (1989) Frequent amplification of the bcl-1 locus in head and neck squamous cell carcinomas. Oncogene 4:1111-1116
7. Berenson J, Koga H, Yang J, Pearl J, Holmes E, Figlin R (1990) Frequent amplification of the bcl-1 locus in poorly differentiated squamous cell carcinoma of the lung. Oncogene 5:1343-1348
8. Berger M, Gullick W, Greefield C, Evans S, Addis B, Waterfield M (1987) Epidermal growth factor receptors in lung tumours. J Pathol 152:297-307
9. Betticher DC, Heighway J, Hasleton PS, Altermatt HJ, Ryder WD, Cerny T, Thatcher N (1996) Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer. Br J Cancer 73:294-300
10. Bigner SH, Wong AJ, Mark J, Muhlbaier LH, Kinzler KW, Vogelstein B, Bigner DD (1987) Relationship between gene amplification and chromosomal deviations in malignant human gliomas. Cancer Genet Cytogenet 29:165-170
11. Bigner SH, Burger PC, Wong AJ, Werner MH, Hamilton SR, Muhlbaier LH, Vogelstein B, Bigner DD (1988) Gene amplification in malignant human gliomas: clinical and histopathologic aspects. J Neuropathol Exp Neurol 47:191-205
12. Caputi M, De Luca L, Papaccio G, D'Aponte A, Cavallotti I, Scala P, Scarano F, Manna M, Gualdiero L, De Luca B (1997) Prognostic role of cyclin D1 in non small cell lung cancer: an immunohistochemical analysis. Eur J Histochem 41:133-138
13. Cerny T, Barnes D, Hasleton P, Barber P, Healy K, Gullick W, Thatcher N (1986) Expression of epidermal growth factor receptor (EGF-R) in human lung tumours. Br J Cancer 54:265-269
14. Damjanov I, Mildner B, Knowles B (1986) Immunohistochemical localization of the epidermal growth factor receptor in normal human tissues. Lab Invest 55:588-592
15. Eisbruch A, Blick M, Lee J, Sacks P, Gutterman J (1987) Analysis of the epidermal growth factor receptor gene in fresh human head and neck tumors. Cancer Res 47:3603-3605
16. Filmus J, Pollak M, Cairncross J, Buick R (1985) Amplified, overexpressed and rearranged epidermal growth factor receptor gene in a human astrocytoma cell line. Biochem Biophys Res Commun 131:207-215
17. Fontanini G, Vignati S, Bigini D, Mussi A, Lucchi H, Angeletti CA, Pingitore R, Pepe S, Basolo F, Bevilacqua G (1995) Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype. Euro J Cancer 31A:178-183
18. Fujino S, Enokibori T, Tezuka N, Asada Y, Inoue S, Kato H, Mori A (1996) A comparison of epidermal growth factor receptor levels and other prognostic parameters in non-small cell lung cancer. Eur J Cancer 32A:2070-2074
19. Fuller GN, Bigner SH (1992) Amplified cellular oncogenes in neoplasms of the human central nervous system. Mutat Res 276:299-306
20. Gansauge S, Gansauge F, Ramadani M, Stobbe H, Rau B, Harada N, Beger, HG (1997) Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis. Cancer Res 57:1634-1637
21. Gill G, Bertics P, Santon J (1987) Epidermal growth factor and its receptor. Mol Cell Endocrinol 51:169-186
22. Gillett C, Fantl V, Smith R, Fisher C, Bartek J, Dickson C, Barnes D, Petes G (1994) Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining Cancer Res 54:1812-1817
23. Gorgoulis V, Giatromanolaki A, Karameris A, Tsatsanis C, Aninos D, Ozanne B, Veslemes MJJ Trigidou R, Papastamatiou H, et al. (1993) Epidermal growth factor receptor expression in squamous cell lung carcinomas: an immunohistochemical and gene analysis in formalin-fixed, paraffin-embedded material Virchows Arch [A] 423:295-302
24. Hendler FJ, Ozanne BW (1984) Human squamous cell lung cancers express increased epidermal growth factor receptors. J Clin Invest 74:647-652
25. Holmes EC (1994) Historic background of the Lung Cancer Study Group. Chest 106:280S-282S
26. Ishikawa T, Furihata M, Ohtsuki Y, Murakami H, Inoue A, Ogoshi S (1998) Cyclin D1 overexpression related to retinoblastoma protein expression as a prognostic marker in human oesophageal squamous cell carcinoma. Br J Cancer 77:92-97
27. Jares P, Fernandez P, Campo E, Nadal A, Bosch F, Aiza G, Nayach I, Traserra J, Cardesa A (1994) PRAD-1/cyclin D1 gene amplification correlates with messenger RNA overexpression and tumor progression in human laryngeal carcinomas. Cancer Res 54:4813-4817
28. Jares P, Campo E, Pinyol M, Bosch F, Miquel R, Fernandez PL, Sanchez BM, Soler F, Perez LA, Nayach I, Mallofre C, Piris MA, Montserrat E, Cardesa A (1996) Expression of retinoblastoma gene product (pRb) in mantle cell lymphomas. Correlation with cyclin D1 (PRAD1/CCND1) mRNA levels and proliferative activity. Am J Pathol 148:1591-1600
29. Jiang W, Kahn S, Tomita N, Zhang Y, Lu S, Weinstein I (1992) Amplification and expression of the human cyclin D gene in esophageal cancer. Cancer Res 52:2980-2983
30. Jiang W, Zhang Y, Kahn S, Hollstein M, Santella R, Lu S, Harris C, Montesano R, Weinstein I (1993) Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc Natl Acad Sci USA 90:9026-9030
31. Kallakury BV, Sheehan CE, Ambros R A, Fisher H A, Kaufman R P Jr, Ross J S (1997) The prognostic significance of p34cdc2 and cyclin D1 protein expression in prostate adenocarcinoma Cancer 80:753-763
32. Kwa H B, Michalides R J, Dijkman J H, Mooi W J (1996) The prognostic value of NCAM, p53 and cyclin D1 in resected non-small cell lung cancer. Lung Cancer 14:207-217
33. Kyomoto R, Kumazawa H, Toda Y, Sakaida N, Okamura A, Iwanaga M, Shintaku M, Yamashita T, Hiai H, Fukumoto M (1997) Cyclin-D1-gene amplification is a more potent prognostic factor than its protein over-expression in human head-and-neck squamous-cell carcinoma. Int J Cancer 74:576-581
34. Leonard J, Kearsley J, Chenevix-Trench G, Hayward N (1991) Analysis of gene amplification in head-and-neck squamous-cell carcinoma. Int J Cancer 48:511-515
35. Libermann T A, Nusbaum H R, Razon N, Kris R, Lax I, Soreq H, Whittle N, Waterfield M D, Ullrich A, Schlessinger J (1985) Amplification enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature 313:144-147
36. Lidereau R, Callahan R, Dickson C, Peters G, Escot C, Ali I (1988) Amplification of the int-2 gene in primary human breast tumors. Oncogene Res 2:285-291
37. Liscia D, Merlo G, Garrett C, French D, Mariani-Costantini R, Callahan R (1989) Expression of int-2 mRNA in human tumors amplified at the int-2 locus. Oncogene 4:1219-1224
38. Liu C, Tsao M S (1993) In vitro and in vivo expressions of transforming growth factor-alpha and tyrosine kinase receptors in human non-small-cell lung carcinomas. Am J Pathol 142:1155-1162
39. Liu J-J, Chao J-R, Jiang M-C, Ng S-Y, Yen J, Yang-Yen H-F (1995) Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells. Mol Cell Biol 15:3654-3663
40. Lu S, Hsieh L, Luo F, Weinstein I (1988) Amplification of the EGF receptor and c-myc genes in human esophageal cancers. Int J Cancer 42:502-505
41. Marchetti A, Doglioni C, Barbareschi M, Buttitta F, Pellegrini S, Gaeta P, La Rocca R, Merlo G, Chella A, Angeletti CA, Dalla Palma P, Bevilacqua G (1998) Cyclin D1 and retinoblastoma susceptibility gene alterations in non-small cell lung cancer. Int J Cancer 75:187-192
42. Mate JL, Ariza A, Aracil C, Lopez D, Isamat M, Perez-Piteira J, Navas-Palacios JJ (1996) Cyclin D1 overexpression in non-small cell lung carcinoma: correlation with Ki67 labelling index and poor cytoplasmic differentiation. J Pathol 180:395-399
43. McIntosh GG, Anderson JJ, Milton I, Steward M, Parr AH, Thomas MD, Henry JA, Angus B, Lennard T W, Horne CH (1995) Determination of the prognostic value of cyclin D1 overexpression in breast cancer. Oncogene 11:885-891
44. Meredith SD, Levine PA, Burns JA, Gaffey MJ, Boyd JC, Weiss LM, Erickson NL, Williams, ME (1995) Chromosome 11q13 amplification in head and neck squamous cell carcinoma. Association with poor prognosis. Arch Otolaryngol Head Neck Surg 121:790-794
45. Merlino G, Xu Y, Ishii S, Clark A, Semba K, Toyoshima K, Yamamoto T, Pastan I (1984) Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. Science 224:417-419
46. Merritt W, Weissler M, Turk B, Gilmer T (1990) Oncogene amplification in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 116:1394-1398
47. Michalides RJ, Veelen NM van, Kristel PM, Hart AA, Loftus BM, Hilgers FJ, Balm AJ (1997) Overexpression of cyclin D1 indicates a poor prognosis in squamous cell carcinoma of the head and neck. Arch of Otolaryngol Head Neck Surg 123:497-502
48. Minna J, Pass H, Glatstein E, Ihde D (1989) Cancer of the lung. In: DeVita V, Hallman S, Rosenberg S (eds) Cancer: principle and practice of oncology. Lippincott, Philadelphia, pp 591-705
49. Motokura T, Bloom T, Kim H, Juppner H, Ruderman J, Kronenberg H, Arnold A (1991) A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature 350:512-515
50. Mountain C (1986) A new international staging system for lung cancer. Chest 89:225s-233s
51. Nishida N, Fukuda Y, Komeda T, Kita R, Sando T, Furukawa M, Amenomori M, Shibagaki I, Nakao K, Ikenaga M, et al. (1994) Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma. Cancer Res 54:3107-3110
52. Parker S, Tong T, Bolden S, Wingo P (1997) Cancer statistics, 1997. CA 47:5-27
53. Pastorino U, Andreola S, Tagliabue E, Pezzella F, Incarbone M, Sozzi G, Buyse M, Menard S, Pierotti M, Rilke F (1997) Immunocytochemical markers in stage I lung cancer: relevance to prognosis. J Clin Oncol 15:2858-2865
54. Pfeiffer P, Clausen PP, Andersen K, Rose C (1996) Lack of prognostic significance of epidermal growth factor receptor and the oncoprotein p185HER-2 in patients with systemically untreated non-small-cell lung cancer: an immunohistochemical study on cryosections. Br J Cancer 74:86-91
55. Real F, Rettig W, Chesa P, Melamed M, Old L, Mendelsohn J (1986) Expression of epidermal growth factor receptor in human cultured cells and tissues: relationship to cell lineage and stage of differentiation Cancer Res 46:4726-4731
56. Reissmann P, Koga H, Takahashi R, Figlin R, Holmes E, Piantadosi S, Cordon-Cardo C, Slamon D (1993) Inactivation of the retinoblastoma susceptibility gene in non-small-cell lung cancer Oncogene 8:1913-1919
57. Ro J, North S, Gallick G, Hortobagyi G, Gutterman J, Blick M (1988) Amplified and overexpressed epidermal growth factor receptor gene in uncultured primary human breast carcinoma. Cancer Res 48:161-164
58. Rosenwald IB, Kaspar R, Rousseau D, Gehrke L, Leboulch P, Chen JJ, Schmidt EV, Sonenberg N, London IM (1995) Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and pos-transcriptional levels. J Biol Chem 270:21176-21180
59. Rusch V, Baselga J, Cordon-Cardo C, Orazem J, Zaman M, Hoda S, McIntosh J, Kurie J, Dmitrovsky E (1993) Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung. Cancer Res 53:2379-2385
60. Rusch V, Klimstra D, Linkov I, Dmitrovsky E (1995) Aberrant expression of p53 or the epidermal growth factor receptor is frequent in early bronchial neoplasia and coexpression precedes squamous cell carcinoma development. Cancer Res 55:1365-1372
61. Sainsbury J, Farndon J, Needham G, Malcolm A, Harris A (1987) Epidermal-growth-factor receptor status as predictor of early recurrence of and death from breast cancer. Lancet 1:1398-1402
62. Schauer IE, Siriwardana S, Langan TA, Sclafani, RA (1994) Cyclin D1 overexpression vs. retinoblastoma inactivation: Implications for growth control evasion in non-small cell and small cell lung cancer. Proc Natl Acad Sci USA 91:7827-7831
63. Schuuring E, Verhoeven E, Mooi W, Michalides R (1992a) Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas. Oncogene 7:355-361
64. Schuuring E, Verhoeven E, Tinteren H van, Peterse JL, Nunnink B, Thunnissen FB, Devilee P, Cornelisse CJ, Vijver MJ van de, Mooi WJ, et al (1992b) Amplification of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer. Cancer Res 52:5229-5234
65. Shapiro GI, Edwards CD, Kobzik L, Godleski J, Richards W, Sugarbaker DJ, Rollins BJ (1995) Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines. Cancer Res 55:505-509
66. Sherr C (1993) Mammalian G1 cyclins. Cell 73:1059-1065
67. Sherr C (1996) Cancer cell cycles. Science 274:1672-1677
68. Shiraishi M, Noguchi M, Shimosato Y, Sekiya T (1989) Amplification of protooncogenes in surgical specimens of human lung carcinomas. Cancer Res 49:6474-6479
69. Somers K, Cartwright S, Schechter G (1990) Amplification of the int-2 gene in human head and neck squamous cell carcinomas. Oncogene 5:915-920
70. Veale D, Ashcroft T, Marsh C, Gibson G, Harris A (1987) Epidermal growth factor receptors in non-small cell lung cancer. Br J Cancer 55:513-516
71. Veale D, Kerr N, Gibson G, Kelly P, Harris A (1993) The relationship of quantitative epidermal growth factor receptor expression in non-small cell lung cancer to long term survival. Br J Cancer 68:162-165
72. Wong AJ, Bigner SH, Bigner DD, Kinzler KW, Hamilton SR, Vogelstein B (1987) Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci USA 84:6899-6903
73. Xu HJ, Hu SX, Cagle PT, Moore GE, Benedict WF (1991) Absence of retinoblastoma protein expression in primary non-small cell lung carcinomas. Cancer Res 51:2735-2739
74. Yasui W, Sumiyoshi H, Hata J, Kameda T, Ochiai A, Ito H, Tahara E (1988) Expression of epidermal growth factor receptor in human gastric and colonic carcinomas. Cancer Res 48:137-141
75. Zhou P, Jiang W, Weghorst C, Weinstein I (1996) Overexpression of cyclin D1 enhances gene amplification. Cancer Res 56:36-39