Expression of VEGF, semaphorin SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumours, and cell lines

Journal of Pathology

Volumn 200, Issue 3, 2003, Pages 336-347

  Lantuéjoul, Sylvie ^a   Constantin, Bruno ^c   Drabkin, Harry ^d   Brambilla, Christian ^a   Roche, Joëlle ^b   Brambilla, Elisabeth ^a  

^a INSERM   (France)

^b IBMIG Institut de Biologie Moleculaire et dIngenierie Genetique   (France)

^c UNIVERSITÉ DE POITIERS   (France)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Lung tumours; Neuropilins; Preneoplastic bronchial lesions; Semaphorin (SEMA3F); VEGF

Indexed keywords

NEUROPILIN 1; NEUROPILIN 2; SEMAPHORIN 3A; TUMOR SUPPRESSOR PROTEIN; TYROSINE KINASE RECEPTOR; VASCULOTROPIN;

ADVANCED CANCER; BINDING AFFINITY; BINDING COMPETITION; BRONCHUS INJURY; CANCER GRADING; CANCER GROWTH; CANCER STAGING; CARCINOMA IN SITU; CELL LINE; CELL MIGRATION; CHROMOSOME 3P; CHROMOSOME DELETION; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE ISOLATION; GENE LOCATION; GENE LOSS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INVASIVE CARCINOMA; LUNG CANCER; LUNG DYSPLASIA; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; LUNG TUMOR; NEUROENDOCRINE TUMOR; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR BINDING; REVIEW;

BRONCHIAL NEOPLASMS; ENDOTHELIAL GROWTH FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG NEOPLASMS; LYMPHOKINES; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; NERVE TISSUE PROTEINS; NEUROPILIN-1; NEUROPILIN-2; PRECANCEROUS CONDITIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0038010147     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1367     Document Type: Review

References (48)

1. Souhami R. Lung cancer. Br Med J 1992; 304: 1298-1301.
2. Gazdar A. The molecular and cellular basis of human lung cancer. Anticancer Res 1994; 13: 561-568.
3. Travis WD, Colby TV, Corrin B, Shimosato Y, Brambilla E, in collaboration with Sobin LH and pathologists from 14 countries. International Histological Classification of Tumors: World Health Organization (3rd edn). Springer: Berlin, 1999.
4. Vogelstein B, Kinzler KW. The multistep nature of cancer. Trends Genet 1993; 9: 138-141.
5. Auerbach O, Hammond EC, Garfinkel I. Changes in bronchial epithelium in relation to cigarette smoking 1955-1060 vs 1970-1977. N Engl J Med 1979; 300: 381-386.
6. Brambilla E, Gazzeri S, Lantuejoul S, et al. p53 mutant immunophenotype and deregulation of p53 transcription pathway (Bcl2, Bax, and Waf1) in precursor bronchial lesions of lung cancer. Clin Cancer Res 1998; 4: 1609-1618.
7. Lonardo F, Rush V, Langenfeld J, Dmitrovsky E, Klimstra DS. Overexpression of cyclins D1 and E is frequent in bronchial preneoplasia and precedes squamous cell carcinoma development. Cancer Res 1999; 15: 2470-2476.
8. Brambilla E, Gazzeri S, Moro D, Lantuejoul S, Veyrenc S, Brambilla C. Alterations of Rb pathway (Rb-p16INK4-cyclin D1) in preinvasive bronchial lesions. Clin Cancer Res 1999; 5: 243-250.
9. Siemeister G, Martigny-Baron G, Marme D. The pivotal role of VEGF in tumor angiogenesis: molecular facts and therapeutic opportunities. Cancer Metastasis 1998; 17: 241-248.
10. Kim KJ, Li B, Winer J, et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993; 362: 841-844.
11. Fontanini G, Calcinai A, Boldrini L, et al. Modulation of neoangiogenesis in bronchial preneoplastic lesions. Oncol Rep 1999; 6: 813-817.
12. Keith RL, Miller YE, Gemmill RM, et al. Angiogenic squamous dysplasia in bronchi of individuals at high risk for lung cancer. Clin Cancer Res 2000; 6: 1616-1625.
13. Kolodkin AL, Levengood D, Rowe E, Tai Y, Giger R, Ginty D. Neuropilin is a semaphorin III receptor. Cell 1997; 90: 753-762.
14. He Z, Tessier-Lavigne M. Neuropilin is a receptor for the axonal chemorepellent semaphorin III. Cell 1997; 90: 739-751.
15. Unified nomenclature for the semaphorins/collapsins: Semaphorin Nomenclature Committee. Cell 1999; 97: 551-552.
16. Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 1998; 92: 735-745.
17. Miao HQ, Lee P, Lin H, Soker S, Klagsbrun M. Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression. FASEB J 2000; 14: 2532-2539.
18. Decaussin M, Sartelet H, Robert C, et al. Expression of vascular endothelial growth factor (VEGF) and its two receptors (VEGF-R1-FIt1 and VEGF-R2-Flk1/KDR) in non small cell lung carcinomas (NSCLCs): correlation with angiogenesis and survival. J Pathol 1999; 188: 369-377.
19. Tian X, Song S, Wu J, Meng L, Dong Z, Shou C. Vascular endothelial growth factor: acting as an autocrine growth factor for human gastric adenocarcinoma cell MGC803. Biochem Biophys Res Commun 2001; 286: 505-512.
20. Chen H, Chedotal A, He Z, Goodman CS, Tessier-Lavigne M. Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins SemaE and SemaIV but not SemaIII. Neuron 1997; 19: 547-559.
21. Handa A, Tokunaga T, Tsuchida T, et al. Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma. Int J Oncol 2000; 17: 291-295.
22. Lacal PM, Faila CM, Pagani E, et al. Human melanoma cells secrete and respond to placenta growth factor and vascular endothelial growth factor. J Invest Dermatol 2000; 115: 1000-1007.
23. Kagoshima M, Ito T, Kitamura H, Goshima Y. Diverse gene expression and function of semaphorins in developing lung: positive and negative regulatory roles of semaphorins in lung branching and morphogenesis. Genes Cells 2001; 6: 559-571.
24. Christensen CR, Klingelhofer J, Tarabykina S, Hulgaard EF, Kramerov D, Lukanidin E. Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines. Cancer Res 1998; 58: 1238-1244.
25. Brambilla E, Constantin B, Drabkin H, Roche J. Semaphorin SEMA3F localization in malignant human lung and cell lines: a suggested role in cell adhesion and migration. Am J Pathol 2000; 156: 939-950.
26. Sekido Y, Bader S, Latif F, et al. Human semaphorins A (V) and (IV) reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns. Proc Natl Acad Sci USA 1996; 93: 4120-4125.
27. Roche J, Boldog F, Robinson M, et al. Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin. Oncogene 1996; 12: 1289-1297.
28. Chen H, He Z, Bagri A, Tessier-Lavigne M. Semaphorin-neuropilin interactions underlying sympathetic axon to class III semaphorins. Neuron 1998; 21: 1283-1290.
29. Takahashi T, Fournier A, Nakamura F, et al. Plexin-neuropilin-1 complexes from functional semaphorin-3A receptors. Cell 1999; 99: 59-69.
30. Miao, HQ, Soker S, Feiner L, Alonso JL, Raper JA, Klagsbrun M. Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165. J Cell Biol 1999; 146: 233-242.
31. Giger RJ, Urquart ER, Gillespie SKH, Levengood DV, Ginty DD, Kolodkin AL. Neuropilin-2 is a receptor for semaphorin TV: insight into the structural basis of receptor function and specificity. Neuron 1998; 21: 1079-1092.
32. Bagnard D, Vaillant C, Khuth ST, et al. Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor. J Neurosci 2001; 21: 3332-3341.
33. Hirsch E, Hu L-J, Prigent A, et al. Distribution of semaphorin IV in adult human brain. Brain Res 1999; 823: 67-79.
34. Dobbs SP, Hewette PW, Johnson IR, Carmichael J, Murray JC. Angiogenesis is associated with vascular endothelial growth factor expression in cervical intraepithelial neoplasia. Br J Cancer 1997; 76: 1410-1415.
35. Herold-Mende C, Steiner HH, Andl T, et al. Expression and functional significance of vascular endothelial growth factor receptors in human tumor cells. Lab Invest 1999; 79: 1573.
36. Denhart BC, Guidi AJ, Tognazzi K, Dvorak HF, Brown LF. Vascular permeability factor/vascular endothelial growth factor and its receptors in oral and laryngeal squamous cell carcinoma and dysplasia. Lab Invest 1997; 6: 659-664.
37. Heeschen C, Jang JJ, Weis M, et al. Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nat Med 2001; 7: 833-839.
38. Bachelder R, Crago A, Chung J, et al. Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. Cancer Res 2001; 61: 5736-5740.
39. Byzova TV, Goldman CK, Pampori N, et al. A mechanism for modulation of cellular responses to VEGF: activation of the integrins. Mol Cell 2000; 6: 851-860.
40. Price DJ, Miralem T, Jiang S, Steinberg R, Avraham H. Role of vascular endothelial growth factor in the stimulation of cellular invasion and signaling of breast cancer cells. Cell Growth Diff 2001; 12: 129-135.
41. Barr LF, Campbell SE, Diette GB, et al. C-Myc suppresses the tumorigenicity of lung cancer cells and down regulates vascular endothelial growth factor expression. Cancer Res 2000; 60: 143-149.
42. Wistuba II, Behrens C, Virmani AK, et al. High resolution chromosome 3p allelotyping of human cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints. Cancer Res 2000; 60: 1949-1960.
43. Shi JY, Yang SC, Hong TM, et al. Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells. J Natl Cancer Inst 2001; 93: 1392-1400.
44. Latil A, Bieche I, Pesche S, et al. VEGF overexpression in clinically localized prostate tumors and neuropilin-1 overexpression in metastatic forms. Int J Cancer 2000; 89: 167-172.
45. Ding H, Wu X, Roncari L, et al. Expression and regulation of neuropilin-1 in human astrocytomas. Int J Cancer 2000; 88: 584-592.
46. Oh H, Takagi H, Otani A, et al. Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF- induced angiogenesis. Proc Natl Acad Sci USA 2002; 99: 383-388.
47. Tomizawa Y, Sekido Y, Kondo M, et al. Inhibition of lung cancer cell growth and induction of apoptosis following re-expression of 3p21.1 candidate tumor suppressor gene SEMA3B. Proc Natl Acad Sci USA 2001; 98: 13954-13959.
48. Xiang R, Davalos AR, Hensel CH, Zhou XJ, Tse C, Naylor SL. Semaphorin 3F gene from human 3p21.3 suppresses tumor formation in nude mice. Cancer Res 2002; 62: 2637-2643.