Reduced expression of α-catenin, β-catenin, and γ-catenin is associated with high cell proliferative activity and poor differentiation in non-small cell lung cancer

Journal of Clinical Pathology

Volumn 54, Issue 5, 2001, Pages 391-395

  Pirinen, R T ^a   Hirvikoski, P ^b   Johansson, R T ^a   Hollmen S ^c   Kosma, V M ^a  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c SATAKUNTA CENTRAL HOSPITAL   (Finland)

Author keywords

Catenin; Differentiation; Lung cancer; Proliferation

Indexed keywords

ALPHA CATENIN; BETA CATENIN; PLAKOGLOBIN;

ADULT; ARTICLE; CANCER SURVIVAL; CELL DIFFERENTIATION; CELL PROLIFERATION; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARGE CELL CARCINOMA; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION;

AGED; ALPHA CATENIN; BETA CATENIN; CADHERINS; CARCINOMA, NON-SMALL-CELL LUNG; CELL DIFFERENTIATION; CELL DIVISION; CYTOSKELETAL PROTEINS; DESMOPLAKINS; FEMALE; FOLLOW-UP STUDIES; GAMMA CATENIN; HUMANS; IMMUNOENZYME TECHNIQUES; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; PROGNOSIS; SURVIVAL RATE; TRANS-ACTIVATORS; TUMOR MARKERS, BIOLOGICAL;

EID: 0034996556     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.54.5.391     Document Type: Article

References (35)

1. Pötter E, Bergwitz C, Brabant G. The cadherin-catenin system: implications for growth and differentiation of endocrine tissues. Endocr Rev 1999;20:207-39.
2. Jankowski JA, Bruton R, Shepherd N, et al. Cadherin and catenin biology represent a global mechanism for epithelial cancer progression. Mol Pathol 1997;50:289-90.
3. Shiozaki H, Oka H, Inoue M, et al. E-cadherin mediated adhesion system in cancer cells. Cancer 1996;77:1605-13.
4. Aaltomaa S, Lipponen P, Ala-Opas M, et al. Alpha-catenin expression has prognostic value in local and locally advanced prostate cancer. Br J Cancer 1999;80:477-82.
5. Anttila M, Kosma VM, Ji H, et al. Clinical significance of alpha-catenin, collagen IV, and Ki-67 expression in epithelial ovarian cancer. J Clin Oncol 1998;16:2591-600.
6. Raftopoulos I, Davaris P, Karatzas G, et al. Level of alpha-catenin expression in colorectal cancer correlates with invasiveness, metastatic potential, and survival. J Surg Oncol 1998;68:92-9.
7. Hashizume R, Koizumi H, Ihara A, et al. Expression of beta-catenin in normal breast tissue and breast carcinoma: a comparative study with epithelial cadherin and alpha-catenin. Histopathology 1996;29:139-46.
8. Andrews NA, Jones AS, Helliwell TR, et al. Expression of the E-cadherin-catenin cell adhesion complex in primary squamous cell carcinomas of the head and neck and their nodal metastases. Br J Cancer 1997;75:1474-80.
9. Dillon DA, D'Aquila T, Reynolds AB, et al. The expression of p120ctn protein in breast cancer is independent of alpha- and beta-catenin and E-cadherin. Am J Pathol 1998;152:75-82.
10. Bullions LC, Levine AJ. The role of beta-catenin in cell adhesion, signal transduction, and cancer. Curr Opin Oncol 1998;10:81-7.
11. Brabletz T, Jung A, Hermann K, et al. Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front. Pathol Res Pract 1998;194:701-4.
12. Kimura Y, Shiozaki H, Doki Y, et al. Cytoplasmic beta-catenin in esophageal cancers. Int J Cancer 1999;84:174-8.
13. Nollet F, Berx G, van Roy F. The role of the E-cadherin/catenin adhesion complex in the development and progression of cancer. Mol Cell Biol Res Commun 1999;2:77-85.
14. Syrigos KN, Harrington K, Waxman J, et al. Altered gamma-catenin expression correlates with poor survival in patients with bladder cancer. J Urol 1998;160:1889-93.
15. Franceschi S, Bidoli E. The epidemiology of lung cancer. Ann Oncol 1999;10:3-6.
16. Patz EF. Imaging lung cancer. Semin Oncol 1999;26:21-6.
17. Pantel K, Passlick B, Vogt J, et al. Reduced expression of plakoglobin indicates an unfavorable prognosis in subset of patients with non-small cell lung cancer. J Clin Oncol 1998;16:1407-13.
18. Retera JM, Leers MP, Sulzer MA, et al. The expression of beta-catenin in non-small-cell lung cancer: a clinicopathological study. J Clin Pathol 1998;51:891-4.
19. Smythe WR, Williams JPWMJ, Johnson KR, et al. Cadherin and catenin expression in normal human bronchial epithelium and non-small cell lung cancer. Lung Cancer 1999;24:157-68.
20. UICC, In: Sobin LH, Wittekind C, eds, TNM classification of malignant tumours, 5th ed. New York: Wiley-Liss, 1997.
21. Travis WD, Colby TV, Corrin B, et al. Histological typing of lung and pleural tumours, Berlin: Springer-Verlag, 1999.
22. Nakanishi Y, Ochiai A, Akimoto S, et al. Expression of E-cadherin, alpha-catenin, beta-catenin and plakoglobin in esophageal carcinomas and its prognostic significance: immunohistochemical analysis of 96 lesions. Oncology 1997;54:158-65.
23. Hirvikoski P, Kumpulainen E, Virtanierni J, et al. p53 expression and cell proliferation as prognostic factors in laryngeal squamous cell carcinoma. J Clin Oncol 1997;15:3111-20.
24. Pirinen R, Hirvikoski P, Böhm J, et al. Reduced expression of CD44v3 variant isoform is associated with unfavorable outcome in non-small cell lung cancer. Hum Pathol 2000;9:1088-95.
25. Bagutti C, Speight PM, Watt FM. Comparison of integrin, cadherin, and catenin expression in squamous cell carcinomas of the oral cavity. J Pathol 1998;186:8-16.
26. Shiozaki H, Iihara K, Oka H, et al. Immunohistochemical detection of alpha-catenin expression in human cancers. Am J Pathol 1994;144:667-74.
27. Hirvikoski P, Kumpulainen EJ, Virtaniemi JA, et al. Cytoplasmic accumulation of alpha-catenin is associated with aggressive features in laryngeal squamous-cell carcinoma. Int J Cancer 1998;79:546-50.
28. Krishnadath KK, Tilanus HW, van Blankenstein M, et al. Reduced expression of the cadherin-catenin complex in oesophageal adenocarcinoma correlates with poor prognosis. J Pathol 1997;182:331-8.
29. Shimazui T, Schalken JA, Giroldi LA, et al. Prognostic value of cadherin-associated molecules (alpha-, beta-, and gamma-catenins and p120cas) in bladder tumors. Cancer Res 1996;56:4154-8.
30. Sulzer MA, Leers MPG, van Noord AA, et al. Reduced E-cadherin expression is associated with increased lymph node metastases and unfavorable prognosis in non-small cell lung cancer. Am J Respir Crit Care Med 1998;157:1319-23.
31. Ashida K, Terada T, Kitamura Y, et al. Expression of E-cadherin, alpha-catenin, beta-catenin, and CD44 (standard and variant isoforms) in human cholangiocarcinoma: an immunohistochemical study. Hepatology 1998;27:974-82.
32. Nhieu JT, Renard CA, Wei Y, et al. Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation. Am J Pathol 1999;155:703-7.
33. Pukkila MJ, Virtaniemi JA, Kumpulainen EJ, et al. Nuclear β-catenin expression is related to unfavourable outcome in oropharangeal and hypopharyngeal squamous cell carcinoma. J Clin Pathol 2001;54:42-7.
34. Gunther K, Brabletz T, Kraus C, et al. Predictive value of nuclear beta-catenin expression for the occurrence of distant metastases in rectal cancer. Dis Colon Rectum 1998;41:1256-61.
35. Gunji N, Oda T, Todoroki T, et al. Pancreatic carcinoma: correlation between E-cadherin and alpha-catenin expression status and liver metastasis. Cancer 1998;82:1649-56.