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Volumn 70, Issue 1, 2005, Pages 1-12

Drugs targeting mitochondrial functions to control tumor cell growth

Author keywords

Apoptosis; Cancer chemotherapy; Mitochondria; Permeability transition pore; Respiratory chain

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; 1 (5 CHLORO 2 HYDROXYPHENYL) 5 TRIFLUOROMETHYL 2 BENZIMIDAZOLONE; 1 ETHYL 2 [[3 ETHYL 5 (3 METHYLBENZOTHIAZOLIN 2 YLIDENE) 4 OXOTHIAZOLIDIN 2 YLIDENE]METHYL]PYRIDINIUM CHLORIDE; 17ALPHA ESTRADIOL; 2 AMINO 6 BROMO 4 (1 CYANO 2 ETHOXY 2 OXOETHYL) 4H CHROMENE 3 CARBOXYLIC ACID ETHYL ESTER; 4' CHLORODIAZEPAM; 6 [3 (1 ADAMANTYL) 4 HYDROXYPHENYL] 2 NAPHTHOIC ACID; ANTIHYPERTENSIVE AGENT; ANTINEOPLASTIC AGENT; APOPTOLIDIN; AZELAIC ACID; BENZOTHIAZINE DERIVATIVE; BETULIC ACID; BONGKREKIC ACID; CIPROFLOXACIN; CITRININ; CROMAKALIM; CYCLOSPORIN A; DEQUALINIUM; DIAZOXIDE; DITERCALINIUM; DNA; DNA TOPOISOMERASE INHIBITOR; EMD 57970; EMD 60480; ETHIDIUM; ETOPOSIDE; GOSSYPOL; IMEXON; INTERCALATING AGENT; LEVOSIMENDAN; LONIDAMINE; MALONIC ACID; MINOXIDIL; MITOGUAZONE; MOFAROTENE; MP 6; MQ 18; MYXOTHIAZOL; N METHYL 2 DODECYL 3 METHYLQUINOLINIUM; N METHYL 4 [2 METHYL 3 (4 TERT BUTYLPHENYL)]PROPYLPYRIDINIUM; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; NALIDIXIC ACID; NSC 365400; OLIGOMYCIN; PENTAMIDINE; PICEATANNOL; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PROTEIN BCL 2; PYRIDINIUM DERIVATIVE; QUINOLONE DERIVATIVE; RESVERATROL; ROLLINIASTATIN 1; ROTENONE; TACRINE; TENIPOSIDE; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

EID: 20444429105     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.03.021     Document Type: Note
Times cited : (181)

References (75)
  • 1
    • 0029891049 scopus 로고    scopus 로고
    • Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase
    • A. Rempel, S.P. Mathupala, C.A. Griffin, A.L. Hawkins, and P.L. Pedersen Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase Cancer Res 56 1996 2468 2471
    • (1996) Cancer Res , vol.56 , pp. 2468-2471
    • Rempel, A.1    Mathupala, S.P.2    Griffin, C.A.3    Hawkins, A.L.4    Pedersen, P.L.5
  • 3
    • 0036194529 scopus 로고    scopus 로고
    • Mitochondria as a pharmacological target
    • A. Szewczyk, and L. Wojtczak Mitochondria as a pharmacological target Pharmacol Rev 54 2002 101 127
    • (2002) Pharmacol Rev , vol.54 , pp. 101-127
    • Szewczyk, A.1    Wojtczak, L.2
  • 4
    • 0039250954 scopus 로고    scopus 로고
    • Facile detection of mitochondrial DNA mutations in tumors and bodily fluids
    • M.S. Fliss, H. Usadel, O.L. Caballero, L. Wu, M.R. Buta, and S.M. Eleff Facile detection of mitochondrial DNA mutations in tumors and bodily fluids Science 287 2000 2017 2019
    • (2000) Science , vol.287 , pp. 2017-2019
    • Fliss, M.S.1    Usadel, H.2    Caballero, O.L.3    Wu, L.4    Buta, M.R.5    Eleff, S.M.6
  • 5
    • 0031736203 scopus 로고    scopus 로고
    • Somatic mutations of the mitochondrial genome in human colorectal tumours
    • K. Polyak, Y. Li, H. Zhu, C. Lengauer, J.K. Willson, and S.D. Markowitz Somatic mutations of the mitochondrial genome in human colorectal tumours Nat Genet 20 1998 291 293
    • (1998) Nat Genet , vol.20 , pp. 291-293
    • Polyak, K.1    Li, Y.2    Zhu, H.3    Lengauer, C.4    Willson, J.K.5    Markowitz, S.D.6
  • 6
    • 0035957398 scopus 로고    scopus 로고
    • Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression
    • J. Wang, J.P. Silva, C.M. Gustafsson, P. Rustin, and N.G. Larsson Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression Proc Natl Acad Sci 98 2001 4038 4043
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 4038-4043
    • Wang, J.1    Silva, J.P.2    Gustafsson, C.M.3    Rustin, P.4    Larsson, N.G.5
  • 7
    • 0033581893 scopus 로고    scopus 로고
    • Mitochondrial DNA determines the cellular response to cancer therapeutic agents
    • K.K. Singh, J. Russell, B. Sigala, Y. Zhang, J. Williams, and K.F. Keshav Mitochondrial DNA determines the cellular response to cancer therapeutic agents Oncogene 18 1999 6641 6646
    • (1999) Oncogene , vol.18 , pp. 6641-6646
    • Singh, K.K.1    Russell, J.2    Sigala, B.3    Zhang, Y.4    Williams, J.5    Keshav, K.F.6
  • 8
    • 0033862761 scopus 로고    scopus 로고
    • Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity
    • G. Moyle Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity Clin Ther 22 2000 911 936
    • (2000) Clin Ther , vol.22 , pp. 911-936
    • Moyle, G.1
  • 9
    • 0028006997 scopus 로고
    • Effect of anti-HIV 2′-beta-fluoro-2′,3′- dideoxynucleoside analogs on the cellular content of mitochondrial DNA and on lactate production
    • C.H. Tsai, S.L. Doong, D.G. Johns, J.S. Driscoll, and Y.C. Cheng Effect of anti-HIV 2′-beta-fluoro-2′,3′-dideoxynucleoside analogs on the cellular content of mitochondrial DNA and on lactate production Biochem Pharmacol 48 1994 1477 1481
    • (1994) Biochem Pharmacol , vol.48 , pp. 1477-1481
    • Tsai, C.H.1    Doong, S.L.2    Johns, D.G.3    Driscoll, J.S.4    Cheng, Y.C.5
  • 10
    • 0037308546 scopus 로고    scopus 로고
    • Simultaneous targeting of telomeres and telomerase as a cancer therapeutic approach
    • Y. Mo, Y. Gan, S. Song, J. Johnston, X. Xiao, and M.G. Wientjes Simultaneous targeting of telomeres and telomerase as a cancer therapeutic approach Cancer Res 63 2003 579 585
    • (2003) Cancer Res , vol.63 , pp. 579-585
    • Mo, Y.1    Gan, Y.2    Song, S.3    Johnston, J.4    Xiao, X.5    Wientjes, M.G.6
  • 11
    • 0030972845 scopus 로고    scopus 로고
    • 3′-Azido-3′-deoxythmidine uptake into isolated rat liver mitochondria and impairment of ADP/ATP translocator
    • M. Barile, D. Valenti, S. Passarella, and E. Quagliariello 3′-Azido-3′-deoxythmidine uptake into isolated rat liver mitochondria and impairment of ADP/ATP translocator Biochem Pharmacol 53 1997 913 920
    • (1997) Biochem Pharmacol , vol.53 , pp. 913-920
    • Barile, M.1    Valenti, D.2    Passarella, S.3    Quagliariello, E.4
  • 12
    • 0018197495 scopus 로고
    • Reversible tenfold reduction in mitochondria DNA content of human cells treated with ethidium bromide
    • A. Wiseman, and G. Attardi Reversible tenfold reduction in mitochondria DNA content of human cells treated with ethidium bromide Mol Gen Genet 167 1978 51 63
    • (1978) Mol Gen Genet , vol.167 , pp. 51-63
    • Wiseman, A.1    Attardi, G.2
  • 13
    • 0042976304 scopus 로고    scopus 로고
    • Ditercalinium chloride, a pro-anticancer drug, intimately associates with mammalian mitochondrial DNA and inhibits its replication
    • M. Okamaoto, T. Ohsato, K. Nakada, K. Isobe, J.N. Spelbrink, and J. Hayashi Ditercalinium chloride, a pro-anticancer drug, intimately associates with mammalian mitochondrial DNA and inhibits its replication Curr Genet 43 2003 364 370
    • (2003) Curr Genet , vol.43 , pp. 364-370
    • Okamaoto, M.1    Ohsato, T.2    Nakada, K.3    Isobe, K.4    Spelbrink, J.N.5    Hayashi, J.6
  • 14
    • 0023727983 scopus 로고
    • Cytoplasmic accumulation of ditercalinium in rat hepatocytes and induction of mitochondrial damage
    • R. Fellous, D. Coulaud, I. el Abed, B.P. Roques, J.B. Le Pecq, and E. Delain Cytoplasmic accumulation of ditercalinium in rat hepatocytes and induction of mitochondrial damage Cancer Res 48 1988 6542 6549
    • (1988) Cancer Res , vol.48 , pp. 6542-6549
    • Fellous, R.1    Coulaud, D.2    El Abed, I.3    Roques, B.P.4    Le Pecq, J.B.5    Delain, E.6
  • 15
    • 0027405785 scopus 로고
    • 4-Quinolones cause a selective loss of mitochondrial DNA from mouse L1210 leukemia cells
    • J.W. Lawrence, S. Darkin-Rattray, F. Xie, A.H. Neims, and T.C. Rowe 4-Quinolones cause a selective loss of mitochondrial DNA from mouse L1210 leukemia cells J Cell Biochem 51 1993 165 174
    • (1993) J Cell Biochem , vol.51 , pp. 165-174
    • Lawrence, J.W.1    Darkin-Rattray, S.2    Xie, F.3    Neims, A.H.4    Rowe, T.C.5
  • 16
    • 0025777674 scopus 로고
    • DNA topoisomerase II from mammalian mitochondria is inhibited by the antitumor drugs, m-AMSA and VM-26
    • J.H. Lin, and F.J. Castora DNA topoisomerase II from mammalian mitochondria is inhibited by the antitumor drugs, m-AMSA and VM-26 Biochem Biophys Res Commun 176 1991 690 697
    • (1991) Biochem Biophys Res Commun , vol.176 , pp. 690-697
    • Lin, J.H.1    Castora, F.J.2
  • 17
    • 0034693227 scopus 로고    scopus 로고
    • Distinct pathways for stimulation of cytochrome c release by etoposide
    • J.D. Robertson, V. Gogvadze, B. Zhivotovsky, and S. Orrenius Distinct pathways for stimulation of cytochrome c release by etoposide J Biol Chem 275 2000 32438 32443
    • (2000) J Biol Chem , vol.275 , pp. 32438-32443
    • Robertson, J.D.1    Gogvadze, V.2    Zhivotovsky, B.3    Orrenius, S.4
  • 18
    • 0043029566 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in primary leukemia cells after chemotherapy: clinical significance and therapeutic implications
    • J.S. Carew, Y. Zhou, M. Albitar, J.D. Carew, M.J. Keating, and P. Huang Mitochondrial DNA mutations in primary leukemia cells after chemotherapy: clinical significance and therapeutic implications Leukemia 17 2003 1437 1447
    • (2003) Leukemia , vol.17 , pp. 1437-1447
    • Carew, J.S.1    Zhou, Y.2    Albitar, M.3    Carew, J.D.4    Keating, M.J.5    Huang, P.6
  • 21
    • 9944244102 scopus 로고    scopus 로고
    • Promises and challenges of targeting Bcl-2 anti-apoptotic proteins for cancer therapy
    • J. O'Neil, M. Manion, P. Schwartz, and D.M. Howkenbery Promises and challenges of targeting Bcl-2 anti-apoptotic proteins for cancer therapy Biochim Biophys Acta 1705 2004 43 51
    • (2004) Biochim Biophys Acta , vol.1705 , pp. 43-51
    • O'Neil, J.1    Manion, M.2    Schwartz, P.3    Howkenbery, D.M.4
  • 22
    • 0033922250 scopus 로고    scopus 로고
    • 1-ATPase/ATP synthase by polyphenolic phytochemicals
    • 1-ATPase/ATP synthase by polyphenolic phytochemicals Br J Pharmacol 130 2000 1115 1123
    • (2000) Br J Pharmacol , vol.130 , pp. 1115-1123
    • Zheng, J.1    Ramirez, V.D.2
  • 23
    • 0031010114 scopus 로고    scopus 로고
    • Probing the ubiquinone reduction site of mitochondrial complex I using novel cationic inhibitors
    • H. Miyoshi, M. Inoue, S. Okamoto, M. Ohshima, K. Sakamoto, and H. Iwamura Probing the ubiquinone reduction site of mitochondrial complex I using novel cationic inhibitors J Biol Chem 272 1997 16176 16183
    • (1997) J Biol Chem , vol.272 , pp. 16176-16183
    • Miyoshi, H.1    Inoue, M.2    Okamoto, S.3    Ohshima, M.4    Sakamoto, K.5    Iwamura, H.6
  • 25
    • 0842305874 scopus 로고    scopus 로고
    • In vitro antitumor SAR of threo/cis/threo/cis/erythro bis-THF acetogenins: correlations with their inhibition of mitochondrial complex I
    • I. Royo, N. DePedro, E. Estornell, D. Cortes, F. Pelaez, and J.R. Tormo In vitro antitumor SAR of threo/cis/threo/cis/erythro bis-THF acetogenins: correlations with their inhibition of mitochondrial complex I Oncol Res 13 2003 521 528
    • (2003) Oncol Res , vol.13 , pp. 521-528
    • Royo, I.1    DePedro, N.2    Estornell, E.3    Cortes, D.4    Pelaez, F.5    Tormo, J.R.6
  • 26
    • 0037424245 scopus 로고    scopus 로고
    • Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production
    • N. Li, K. Ragheb, G. Lawler, J. Sturgis, B. Rajwa, and J.A. Melendez Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production J Biol Chem 278 2003 8516 8525
    • (2003) J Biol Chem , vol.278 , pp. 8516-8525
    • Li, N.1    Ragheb, K.2    Lawler, G.3    Sturgis, J.4    Rajwa, B.5    Melendez, J.A.6
  • 27
    • 0345772125 scopus 로고    scopus 로고
    • Antitumor effects of photodynamic therapy are potentiated by 2-methoxyestradiol. A superoxide dismutase inhibitor
    • J. Golab, D. Nowis, M. Skrzycki, H. Czeczot, A. Baranczyk-Kuzma, and G.M. Wilczynski Antitumor effects of photodynamic therapy are potentiated by 2-methoxyestradiol. A superoxide dismutase inhibitor J Biol Chem 278 2003 407 414
    • (2003) J Biol Chem , vol.278 , pp. 407-414
    • Golab, J.1    Nowis, D.2    Skrzycki, M.3    Czeczot, H.4    Baranczyk-Kuzma, A.5    Wilczynski, G.M.6
  • 28
    • 0037926836 scopus 로고    scopus 로고
    • Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents
    • Y. Zhou, E.O. Hileman, W. Plunkett, M.J. Keating, and P. Huang Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents Blood 101 2003 4098 4104
    • (2003) Blood , vol.101 , pp. 4098-4104
    • Zhou, Y.1    Hileman, E.O.2    Plunkett, W.3    Keating, M.J.4    Huang, P.5
  • 29
    • 0029016089 scopus 로고
    • The role of mitochondrial potassium fluxes in controlling the protonmotive force in energized mitochondria
    • A. Czyz, A. Szewczyk, M.J. Nalecz, and L. Wojtczak The role of mitochondrial potassium fluxes in controlling the protonmotive force in energized mitochondria Biochem Biophys Res Commun 210 1995 98 104
    • (1995) Biochem Biophys Res Commun , vol.210 , pp. 98-104
    • Czyz, A.1    Szewczyk, A.2    Nalecz, M.J.3    Wojtczak, L.4
  • 30
    • 0029664623 scopus 로고    scopus 로고
    • The mitochondrial KATP channel as a receptor for potassium channel openers
    • K.D. Garlid, P. Paucek, V. Yarov-Yarovoy, X. Sun, and P.A. Schindler The mitochondrial KATP channel as a receptor for potassium channel openers J Biol Chem 271 1996 8796 8799
    • (1996) J Biol Chem , vol.271 , pp. 8796-8799
    • Garlid, K.D.1    Paucek, P.2    Yarov-Yarovoy, V.3    Sun, X.4    Schindler, P.A.5
  • 31
    • 0028334243 scopus 로고
    • In vitro antitumor activity of cromakalim in human brain tumor cells
    • Y.S. Lee, M.M. Sayeed, and R.D. Wurster In vitro antitumor activity of cromakalim in human brain tumor cells Pharmacology 49 1994 69 74
    • (1994) Pharmacology , vol.49 , pp. 69-74
    • Lee, Y.S.1    Sayeed, M.M.2    Wurster, R.D.3
  • 32
    • 0042530130 scopus 로고    scopus 로고
    • Activity of potassium channel-blockers in breast cancer
    • M. Abdul, A. Santo, and N. Hoosein Activity of potassium channel-blockers in breast cancer Anticancer Res 23 2003 3347 3351
    • (2003) Anticancer Res , vol.23 , pp. 3347-3351
    • Abdul, M.1    Santo, A.2    Hoosein, N.3
  • 33
    • 0030780773 scopus 로고    scopus 로고
    • Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection
    • K.D. Garlid, P. Paucek, V. Yarov-Yarovoy, H.N. Murray, R.B. Darbenzio, and A.J. D'Alonzo Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection Circ Res 81 1997 1072 1082
    • (1997) Circ Res , vol.81 , pp. 1072-1082
    • Garlid, K.D.1    Paucek, P.2    Yarov-Yarovoy, V.3    Murray, H.N.4    Darbenzio, R.B.5    D'Alonzo, A.J.6
  • 34
    • 0037341012 scopus 로고    scopus 로고
    • Activation of mitochondrial ATP-sensitive potassium channels increases cell viability against rotenone-induced cell death
    • K.K. Tai, Z.A. McCrossan, and G.W. Abbott Activation of mitochondrial ATP-sensitive potassium channels increases cell viability against rotenone-induced cell death J Neurochem 84 2003 1193 1200
    • (2003) J Neurochem , vol.84 , pp. 1193-1200
    • Tai, K.K.1    McCrossan, Z.A.2    Abbott, G.W.3
  • 36
    • 3843094875 scopus 로고    scopus 로고
    • Potassium-specific effects of levosimendan on heart mitochondria
    • D.M. Kopustinskiene, P. Pollesello, and N.E. Saris Potassium-specific effects of levosimendan on heart mitochondria Biochem Pharmacol 68 2004 807 812
    • (2004) Biochem Pharmacol , vol.68 , pp. 807-812
    • Kopustinskiene, D.M.1    Pollesello, P.2    Saris, N.E.3
  • 38
    • 0035930930 scopus 로고    scopus 로고
    • Rotenone-induced G2/M cell cycle arrest and apoptosis in a human B lymphoma cell-line PW
    • J.S. Armstrong, B. Hornung, P. Lecane, D.P. Jones, and S.J. Knox Rotenone-induced G2/M cell cycle arrest and apoptosis in a human B lymphoma cell-line PW Biochem Biophys Res Commun 289 2001 973 978
    • (2001) Biochem Biophys Res Commun , vol.289 , pp. 973-978
    • Armstrong, J.S.1    Hornung, B.2    Lecane, P.3    Jones, D.P.4    Knox, S.J.5
  • 39
    • 0033103489 scopus 로고    scopus 로고
    • Azelaic acid: potential as a general antitumoural agent
    • A.S. Breathnach Azelaic acid: potential as a general antitumoural agent Med Hypotheses 52 1999 221 226
    • (1999) Med Hypotheses , vol.52 , pp. 221-226
    • Breathnach, A.S.1
  • 40
    • 0037434664 scopus 로고    scopus 로고
    • Inhibition of oxidative phosphorylation underlies the antiproliferative and proapoptotic effects of mofarotene (Ro 40-8757) in Burkitt's lymphoma cells
    • R. Cariati, P. Zancai, E. Righetti, S. Rizzo, A. De Rossi, and M. Boiocchi Inhibition of oxidative phosphorylation underlies the antiproliferative and proapoptotic effects of mofarotene (Ro 40-8757) in Burkitt's lymphoma cells Oncogene 22 2003 906 918
    • (2003) Oncogene , vol.22 , pp. 906-918
    • Cariati, R.1    Zancai, P.2    Righetti, E.3    Rizzo, S.4    De Rossi, A.5    Boiocchi, M.6
  • 41
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis
    • R.M. Kluck, E. Bossy-Wetzel, D.R. Green, and D.D. Newmeyer The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis Science 275 1997 1132 1136
    • (1997) Science , vol.275 , pp. 1132-1136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 42
    • 0032523945 scopus 로고    scopus 로고
    • Modulation of Bcl-2 protein levels by an intracellular anti-Bcl-2 single-chain antibody increases drug-induced cytotoxicity in the breast cancer cell-line MCF-7
    • A. Piche, J. Grim, C. Rancourt, J. Gomez-Navarro, J.C. Reed, and D.T. Curiel Modulation of Bcl-2 protein levels by an intracellular anti-Bcl-2 single-chain antibody increases drug-induced cytotoxicity in the breast cancer cell-line MCF-7 Cancer Res 58 1998 2134 2140
    • (1998) Cancer Res , vol.58 , pp. 2134-2140
    • Piche, A.1    Grim, J.2    Rancourt, C.3    Gomez-Navarro, J.4    Reed, J.C.5    Curiel, D.T.6
  • 43
    • 3042570458 scopus 로고    scopus 로고
    • Oblimersen sodium (Genasense bcl-2 antisense oligonucleotide): a rational therapeutic to enhance apoptosis in therapy of lung cancer
    • R.S. Herbst, and S.R. Frankel Oblimersen sodium (Genasense bcl-2 antisense oligonucleotide): a rational therapeutic to enhance apoptosis in therapy of lung cancer Clin Cancer Res 10 2004 s4245 s4248
    • (2004) Clin Cancer Res , vol.10
    • Herbst, R.S.1    Frankel, S.R.2
  • 44
    • 3543128235 scopus 로고    scopus 로고
    • Lessons learnt from Genasense's failure
    • S. Frantz Lessons learnt from Genasense's failure Nat Rev Drug Discov 3 2004 542 543
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 542-543
    • Frantz, S.1
  • 45
    • 0034691130 scopus 로고    scopus 로고
    • Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
    • J.L. Wang, D. Liu, Z.J. Zhang, S. Shan, X. Han, and S.M. Srinivasula Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells Proc Natl Acad Sci USA 97 2000 7124 7129
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7124-7129
    • Wang, J.L.1    Liu, D.2    Zhang, Z.J.3    Shan, S.4    Han, X.5    Srinivasula, S.M.6
  • 46
    • 0242721548 scopus 로고    scopus 로고
    • Targeting Bcl-2 Bcl-XL with non-peptidic small-molecule antagonists
    • S. Wang, D. Yang, M.E. Lippman, and Targeting Bcl-2 Bcl-XL with non-peptidic small-molecule antagonists Semin Oncol 30 2003 133 142
    • (2003) Semin Oncol , vol.30 , pp. 133-142
    • Wang, S.1    Yang, D.2    Lippman, M.E.3
  • 47
    • 13944262237 scopus 로고    scopus 로고
    • (-)-Gossypol acts directly on the mitochondria to overcome Bcl-2 and Bcl-XL-mediated apoptosis resistance
    • C.L. Oliver, M.B. Miranda, S. Shangary, S. Land, S. Wang, and D.E. Johnson (-)-Gossypol acts directly on the mitochondria to overcome Bcl-2 and Bcl-XL-mediated apoptosis resistance Mol Cancer Ther 4 2005 23 31
    • (2005) Mol Cancer Ther , vol.4 , pp. 23-31
    • Oliver, C.L.1    Miranda, M.B.2    Shangary, S.3    Land, S.4    Wang, S.5    Johnson, D.E.6
  • 48
    • 0030064081 scopus 로고    scopus 로고
    • MKT-077 a novel rhodacyanine dye in clinical trials, exhibits anticarcinoma activity in preclinical studies based on selective mitochondrial accumulation
    • K. Koya, Y. Li, H. Wang, T. Ukai, N. Tatsuta, and M. Kawakami MKT-077 a novel rhodacyanine dye in clinical trials, exhibits anticarcinoma activity in preclinical studies based on selective mitochondrial accumulation Cancer Res 56 1996 538 543
    • (1996) Cancer Res , vol.56 , pp. 538-543
    • Koya, K.1    Li, Y.2    Wang, H.3    Ukai, T.4    Tatsuta, N.5    Kawakami, M.6
  • 49
    • 0033956563 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of the mitochondrial-specific rhodacyanine dye analog MKT6077
    • C.D. Britten, E.K. Rowinsky, S.D. Baker, G.R. Weiss, L. Smith, and J. Stephenson A phase I and pharmacokinetic study of the mitochondrial-specific rhodacyanine dye analog MKT6077 Clin Cancer Res 6 2000 42 49
    • (2000) Clin Cancer Res , vol.6 , pp. 42-49
    • Britten, C.D.1    Rowinsky, E.K.2    Baker, S.D.3    Weiss, G.R.4    Smith, L.5    Stephenson, J.6
  • 50
    • 0034671731 scopus 로고    scopus 로고
    • Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function
    • R. Wadhwa, T. Sugihara, A. Yoshida, H. Nomura, R.R. Reddel, and R. Simpson Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function Cancer Res 15/60 2000 6818 6821
    • (2000) Cancer Res , vol.1560 , pp. 6818-6821
    • Wadhwa, R.1    Sugihara, T.2    Yoshida, A.3    Nomura, H.4    Reddel, R.R.5    Simpson, R.6
  • 51
    • 0344653616 scopus 로고    scopus 로고
    • Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases
    • G. Beutner, A. Ruck, B. Riede, and D. Brdiczka Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases Biochim Biophys Acta 1368 1998 7 18
    • (1998) Biochim Biophys Acta , vol.1368 , pp. 7-18
    • Beutner, G.1    Ruck, A.2    Riede, B.3    Brdiczka, D.4
  • 52
    • 0029983059 scopus 로고    scopus 로고
    • Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis
    • N. Zamzami, P. Marchetti, M. Castedo, T. Hirsch, S.A. Susin, and B. Masse Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis FEBS Lett 384 1996 53 57
    • (1996) FEBS Lett , vol.384 , pp. 53-57
    • Zamzami, N.1    Marchetti, P.2    Castedo, M.3    Hirsch, T.4    Susin, S.A.5    Masse, B.6
  • 53
    • 0030826778 scopus 로고    scopus 로고
    • Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury
    • A.P. Halestrap, C.P. Connern, E.J. Griffiths, P.M. Kerr, and Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury Mol Cell Biochem 174 1997 167 172
    • (1997) Mol Cell Biochem , vol.174 , pp. 167-172
    • Halestrap, A.P.1    Connern, C.P.2    Griffiths, E.J.3    Kerr, P.M.4
  • 54
    • 0031111715 scopus 로고    scopus 로고
    • Roles of cytoplasmic Ca2+ and intracellular Ca2+ stores in induction and suppression of apoptosis in S49 cells
    • X. Bian, F.M. Hughes Jr., Y. Huang, J.A. Cidlowski, and J.W. Putney Jr. Roles of cytoplasmic Ca2+ and intracellular Ca2+ stores in induction and suppression of apoptosis in S49 cells Am J Physiol 272 1997 C1241 C1249
    • (1997) Am J Physiol , vol.272
    • Bian, X.1    Hughes Jr., F.M.2    Huang, Y.3    Cidlowski, J.A.4    Putney Jr., J.W.5
  • 55
    • 5344253914 scopus 로고    scopus 로고
    • Mitochondrial permeability transition induced by dinuclear gold(I)-carbene complexes: potential new antimitochondrial antitumour agents
    • P.J. Barnard, M.V. Baker, S.J. Berners-Price, and D.A. Day Mitochondrial permeability transition induced by dinuclear gold(I)-carbene complexes: potential new antimitochondrial antitumour agents J Inorg Biochem 98 2004 1642 1647
    • (2004) J Inorg Biochem , vol.98 , pp. 1642-1647
    • Barnard, P.J.1    Baker, M.V.2    Berners-Price, S.J.3    Day, D.A.4
  • 56
    • 0037142185 scopus 로고    scopus 로고
    • Sophoranone, extracted from a traditional Chinese medicine Shan Dou Gen, induces apoptosis in human leukemia U937 cells via formation of reactive oxygen species and opening of mitochondrial permeability transition pores
    • S. Kajimoto, N. Takanashi, T. Kajimoto, M. Xu, J. Cao, and Y. Masuda Sophoranone, extracted from a traditional Chinese medicine Shan Dou Gen, induces apoptosis in human leukemia U937 cells via formation of reactive oxygen species and opening of mitochondrial permeability transition pores Int J Cancer 99 2002 879 890
    • (2002) Int J Cancer , vol.99 , pp. 879-890
    • Kajimoto, S.1    Takanashi, N.2    Kajimoto, T.3    Xu, M.4    Cao, J.5    Masuda, Y.6
  • 57
    • 0036654694 scopus 로고    scopus 로고
    • A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth
    • V.R. Fantin, M.J. Berardi, L. Scorrano, S. Korsmeyer, and P. Leder A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth Cancer Cell 2 2002 29 42
    • (2002) Cancer Cell , vol.2 , pp. 29-42
    • Fantin, V.R.1    Berardi, M.J.2    Scorrano, L.3    Korsmeyer, S.4    Leder, P.5
  • 58
    • 1642494810 scopus 로고    scopus 로고
    • F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell
    • V.R. Fantin, and P. Leder F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell Cancer Res 64 2004 329 336
    • (2004) Cancer Res , vol.64 , pp. 329-336
    • Fantin, V.R.1    Leder, P.2
  • 59
    • 0033555287 scopus 로고    scopus 로고
    • 1-Methyl-4-phenylpyridinium ion (MPP+) selectively inhibits the replication of mitochondrial DNA
    • K. Miyako, T. Irie, T. Muta, S. Umeda, Y. Kai, and T. Fujiwara 1-Methyl-4-phenylpyridinium ion (MPP+) selectively inhibits the replication of mitochondrial DNA Eur J Biochem 259 1999 412 418
    • (1999) Eur J Biochem , vol.259 , pp. 412-418
    • Miyako, K.1    Irie, T.2    Muta, T.3    Umeda, S.4    Kai, Y.5    Fujiwara, T.6
  • 60
    • 0032545386 scopus 로고    scopus 로고
    • Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid
    • S. Fulda, C. Scaffidi, S.A. Susin, P.H. Krammer, G. Kroemer, and M.E. Peter Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid J Biol Chem 273 1998 33942 33948
    • (1998) J Biol Chem , vol.273 , pp. 33942-33948
    • Fulda, S.1    Scaffidi, C.2    Susin, S.A.3    Krammer, P.H.4    Kroemer, G.5    Peter, M.E.6
  • 61
    • 0033594404 scopus 로고    scopus 로고
    • Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore
    • L. Ravagnan, I. Marzo, P. Costantini, S.A. Susin, N. Zamzami, and P.X. Petit Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore Oncogene 18 1999 2537 2546
    • (1999) Oncogene , vol.18 , pp. 2537-2546
    • Ravagnan, L.1    Marzo, I.2    Costantini, P.3    Susin, S.A.4    Zamzami, N.5    Petit, P.X.6
  • 62
    • 17144448793 scopus 로고    scopus 로고
    • The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus
    • P. Marchetti, N. Zamzami, B. Joseph, S. Schraen-Maschke, C. Mereau-Richard, and P. Costantini The novel retinoid 6-[3-(1-adamantyl)-4- hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus Cancer Res 59 1999 6257 6266
    • (1999) Cancer Res , vol.59 , pp. 6257-6266
    • Marchetti, P.1    Zamzami, N.2    Joseph, B.3    Schraen-Maschke, S.4    Mereau-Richard, C.5    Costantini, P.6
  • 63
    • 0035891212 scopus 로고    scopus 로고
    • Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437
    • A.S. Belzacq, C. El Hamel, H.L. Vieira, I. Cohen, D. Haouzi, and D. Metivier Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437 Oncogene 20 2001 7579 7587
    • (2001) Oncogene , vol.20 , pp. 7579-7587
    • Belzacq, A.S.1    El Hamel, C.2    Vieira, H.L.3    Cohen, I.4    Haouzi, D.5    Metivier, D.6
  • 64
    • 1442327526 scopus 로고    scopus 로고
    • Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide
    • Y. Zheng, Y. Shi, C. Tian, C. Jiang, H. Jin, and J. Chen Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide Oncogene 23 2004 1239 1247
    • (2004) Oncogene , vol.23 , pp. 1239-1247
    • Zheng, Y.1    Shi, Y.2    Tian, C.3    Jiang, C.4    Jin, H.5    Chen, J.6
  • 65
    • 0141509869 scopus 로고    scopus 로고
    • Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism
    • H. Pelicano, L. Feng, Y. Zhou, J.S. Carew, E.O. Hileman, and W. Plunkett Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism J Biol Chem 278 2003 37832 37839
    • (2003) J Biol Chem , vol.278 , pp. 37832-37839
    • Pelicano, H.1    Feng, L.2    Zhou, Y.3    Carew, J.S.4    Hileman, E.O.5    Plunkett, W.6
  • 66
    • 0010740572 scopus 로고    scopus 로고
    • 3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins
    • 3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins Blood 88 1996 1052 1061
    • (1996) Blood , vol.88 , pp. 1052-1061
    • Chen, G.Q.1    Zhu, J.2    Shi, X.G.3    Ni, J.H.4    Zhong, H.J.5    Si, G.Y.6
  • 67
    • 0037368877 scopus 로고    scopus 로고
    • Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors
    • S. Di Cosimo, G. Ferretti, P. Papaldo, P. Carlini, A. Fabi, and F. Cognetti Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors Drugs Today 39 2003 157 174
    • (2003) Drugs Today , vol.39 , pp. 157-174
    • Di Cosimo, S.1    Ferretti, G.2    Papaldo, P.3    Carlini, P.4    Fabi, A.5    Cognetti, F.6
  • 69
    • 0036494315 scopus 로고    scopus 로고
    • Peripheral benzodiazepine receptor ligands reverse apoptosis resistance of cancer cells in vitro and in vivo
    • D. Decaudin, M. Castedo, F. Nemati, A. Beurdeley-Thomas, G. De Pinieux, and A. Caron Peripheral benzodiazepine receptor ligands reverse apoptosis resistance of cancer cells in vitro and in vivo Cancer Res 62 2002 1388 1393
    • (2002) Cancer Res , vol.62 , pp. 1388-1393
    • Decaudin, D.1    Castedo, M.2    Nemati, F.3    Beurdeley-Thomas, A.4    De Pinieux, G.5    Caron, A.6
  • 70
    • 2542451902 scopus 로고    scopus 로고
    • The peripheral benzodiazepine receptor ligand PK11195 overcomes different resistance mechanisms to sensitize AML cells to gemtuzumab ozogamicin
    • R.B. Walter, B.W. Raden, M.R. Cronk, I.D. Bernstein, F.R. Appelbaum, and D.E. Banker The peripheral benzodiazepine receptor ligand PK11195 overcomes different resistance mechanisms to sensitize AML cells to gemtuzumab ozogamicin Blood 103 2004 4276 4284
    • (2004) Blood , vol.103 , pp. 4276-4284
    • Walter, R.B.1    Raden, B.W.2    Cronk, M.R.3    Bernstein, I.D.4    Appelbaum, F.R.5    Banker, D.E.6
  • 71
    • 4644224402 scopus 로고    scopus 로고
    • Peripheral benzodiazepine receptor and its clinical targeting
    • D. Decaudin Peripheral benzodiazepine receptor and its clinical targeting Anti-Cancer Drugs 15 2004 737 745
    • (2004) Anti-Cancer Drugs , vol.15 , pp. 737-745
    • Decaudin, D.1
  • 72
    • 0346100660 scopus 로고    scopus 로고
    • Chemical basis for the biological activity of imexon and related cyanoaziridines
    • B.S. Iyengar, R.T. Dorr, and W.A. Remers Chemical basis for the biological activity of imexon and related cyanoaziridines J Med Chem 47 2004 218 223
    • (2004) J Med Chem , vol.47 , pp. 218-223
    • Iyengar, B.S.1    Dorr, R.T.2    Remers, W.A.3
  • 74
    • 0034937266 scopus 로고    scopus 로고
    • Mitochondria as targets for established and novel anti-cancer agents
    • J.M. Grad, E. Cepero, and L.H. Boise Mitochondria as targets for established and novel anti-cancer agents Drug Resist Updat 4 2001 85 91
    • (2001) Drug Resist Updat , vol.4 , pp. 85-91
    • Grad, J.M.1    Cepero, E.2    Boise, L.H.3
  • 75
    • 0032904412 scopus 로고    scopus 로고
    • An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses and cell death in neurodegeneration
    • D.S. Cassarino, and J.P. Bennett Jr. An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses and cell death in neurodegeneration Brain Res 1 1999 20 25
    • (1999) Brain Res , vol.1 , pp. 20-25
    • Cassarino, D.S.1    Bennett Jr., J.P.2


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