In Vitro Antitumor SAR of threo/cis/threo/cis/erythro bis-THF Acetogenins: Correlations with Their Inhibition of Mitochondrial Complex I

Oncology Research

Volumn 13, Issue 12, 2002, Pages 521-528

  Royo, Inmaculada ^a,b   DePedro, Nuria ^a   Estornell, Ernesto ^b   Cortes, Diego ^b   Peláez, Fernando ^a   Tormo, José R ^a  

^a Medical affairs Merck sharp and Dohme ltd   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Acetogenins; Cancer; Cytotoxicity; Mitochondrial respiratory chain inhibitors; Tumor cell line growth inhibitors

Indexed keywords

2,35 DIHYDRO 2,35 DIHYDROXYROLLINIASTATIN 1; 2,35 DIHYDROROLLINIASTATIN 1; 36 DEOXO 36 HYDROXYLIMINOISOROLLINIASTATIN 1; 36 DIHYDROISOROLLINIASTATIN 1; 4 DEHYDROXY 4 HYDROXYLIMINOROLLINIASTATIN 1; 4 DEHYDROXY 4 OXOROLLINIASTATIN 1; 4,15,24 TRIMESYLROLLINIASTATIN 1; 4,24 DIDEHYDROXY 4,24 DIHYDROXYLIMINOROLLINIASTATIN 1; 4,24 DIDEHYDROXY 4,24 DIOXOROLLINIASTATIN 1; ACETOGENIN; BIS TETRAHYDROFURANIC ACETOGENIN DERIVATIVE; DACTINOMYCIN; DOXORUBICIN; ISOROLLIMEMBRIN; ISOROLLINIASTATIN 1; MEMBRANACIN; MEMBRAROLLIN; NATURAL PRODUCT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROLLIMEMBRIN; ROLLINIA MEMBRANACEA EXTRACT; ROLLINIASTATIN 1; ROTENONE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; COLON CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; DRUG ACTIVITY; DRUG CLASSIFICATION; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CANCER; LUNG CANCER; MITOCHONDRIAL RESPIRATION; PLANT SEED; PRIORITY JOURNAL; ROLLINIA; ROLLINIA MEMBRANACEA; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TUMOR CELL LINE;

EID: 0842305874     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000003108748045     Document Type: Article

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