Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production

Journal of Biological Chemistry

Volumn 278, Issue 10, 2003, Pages 8516-8525

  Li, Nianyu ^a   Ragheb, Kathy ^a   Lawler, Gretchen ^a   Sturgis, Jennie ^a   Rajwa, Bartek ^a   Melendez, J Andres ^b   Robinson, J Paul ^a  

^a PURDUE UNIVERSITY   (United States)

^b ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; CELLS; DNA; OXYGEN;

APOPTOSIS;

BIOCHEMISTRY;

ACETYLCYSTEINE; ANTIOXIDANT; ASCORBIC ACID; CASPASE 3; CYTOCHROME C; DNA FRAGMENT; GLUTATHIONE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; SUPEROXIDE DISMUTASE; ENZYME INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL STRAIN HL 60; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; ENZYME ACTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RESPIRATORY CHAIN; DRUG ANTAGONISM; ENZYMOLOGY; METABOLISM; MITOCHONDRION;

APOPTOSIS; ENZYME INHIBITORS; HL-60 CELLS; HUMANS; MITOCHONDRIA; NADH DEHYDROGENASE; REACTIVE OXYGEN SPECIES; ROTENONE;

EID: 0037424245     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M210432200     Document Type: Article

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