1-Methyl-4-phenylpyridinium ion (MPP+) selectively inhibits the replication of mitochondrial DNA

European Journal of Biochemistry

Volumn 259, Issue 1-2, 1999, Pages 412-418

  Miyako, Kenichi ^a   Irie, Takashi ^a   Muta, Tsuyoshi ^a   Umeda, Shuyo ^a   Kai, Yoichiro ^a   Fujiwara, Toshiyuki ^b   Takeshige, Koichiro ^a   Kang, Dongchon ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b NONE

Author keywords

1 methyl 4 phenylpyridinium ion (MPP+); Mitochondrial DNA; Replication; Transcription

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; MITOCHONDRIAL DNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ARTICLE; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS INHIBITION; HELA CELL; HUMAN; HUMAN CELL; MITOCHONDRION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; TRANSCRIPTION TERMINATION;

1-METHYL-4-PHENYLPYRIDINIUM; BROMODEOXYURIDINE; DNA REPLICATION; DNA, MITOCHONDRIAL; DOPAMINE AGENTS; HELA CELLS; HUMANS; MITOCHONDRIA; TRANSCRIPTION, GENETIC;

EID: 0033555287     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00056.x     Document Type: Article

References (48)

1. Davis, G.C., Williams, A.C., Markey, S.P., Ebert, M.H., Caine, E.D., Reichert, C.M. & Kopin, I.J. (1979) Chronic Parkinsonism secondary to intravenous injection of meperidine analogues. Psychiatry Res. 1, 249-254.
2. Langston, J.W., Ballard, P., Tetrud, J.W. & Irwin, I. (1983) Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219, 979-980.
3. Burns, R.S., Chiueh, C.C., Markey, S.P., Ebert, M.H., Jacobowitz, D.M. & Kopin, I.J. (1983) A primate model of Parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Nat. Acad. Sci. USA 80, 4546-4550.
4. Chiba, K., Trevor, A. & Castagnoli Jr, N. (1984) Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase. Biochem. Biophys. Res. Commun. 120, 574-578.
5. Singer, T.P. & Ramsay, R.R. (1990) Mechanism of the neurotoxicity of MPTP. An update. FEBS Lett. 274, 1-8.
6. Javitch, J.A., D'Amato, R.J., Strittmatter, S.M. & Snyder, S.H. (1985) Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc. Natl Acad. Sci. USA 82, 2173-2177.
7. Ramsay, R.R., Salach, J.I., Dadgar, J. & Singer, T.P. (1986) Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic Parkinsonism. Biochem. Biophys. Res. Commun. 135, 269-275.
8. Ramsay, R.R. & Singer, T.P. (1986) Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria. J. Biol. Chem. 261, 7585-7587.
9. +. Biochem. Biophys. Res. Commun. 134, 743-748.
10. Nicklas, W.J., Vyas, I. & Heikkila, R.E. (1985) Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenylpyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci. 36, 2503-2508.
11. Mizuno, Y., Sone, N. & Saitoh, T. (1987) Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium ion on activities of the enzymes in the electron transport system in mouse brain. J. Neurochem. 48, 1787-1793.
12. +, the neurotoxic bioactivation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is near the Q-binding site of NADH dehydrogenase. Arch. Biochem. Biophys. 259, 645-649.
13. +) involves binding at the same site as the respiratory inhibitor, rotenone. Biochem. Biophys. Res. Commun. 169, 123-128.
14. +) and of the respiratory chain inhibitor piericidin A are the same. Biochem. J. 273, 481-484.
15. +) and its analogs with the rotenone/piericidin binding site of NADH dehydrogenase. J. Neurochem. 56, 1184-1190.
16. Wallace, D.C. (1992) Diseases of the mitochondrial DNA. Annu. Rev. Biochem. 61, 1175-1212.
17. Arnaudo, E., Dalakas, M., Shanske, S., Moraes, C.T., DiMauro, S. & Schon, E.A. (1991) Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy. Lancet 337, 508-510.
18. Moraes, C.T., Shanske, S., Tritschler, H.J., Aprille, J.R., Andreetta, F., Bonilla, E., Schon, E.A. & DiMauro, S. (1991) mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseases. Am. J. Hum. Genet. 48, 492-501.
19. Poulton, J., Morten, K., Freeman-Emmerson, C., Potter, C., Sewry, C., Dubowitz, V., Kidd, H., Stephenson, J., Whitehouse, W., Hansen, F.J., Parisi, M. & Brown, G. (1994) Deficiency of the human mitochondrial transcription factor h-mtTFA in infantile mitochondrial myopathy is associated with mtDNA depletion. Hum. Mol. Genet. 3, 1763-1769.
20. Larsson, N.G., Oldfors, A., Holme, E. & Clayton, D.A. (1994) Low levels of mitochondrial transcription factor A in mitochondrial DNA depletion. Biochem. Biophys. Res. Commun. 200, 1374-1381.
21. Bodnar, A.G., Cooper, J.M., Leonard, J.V. & Schapira, A.H. (1995) Respiratory-deficient human fibroblasts exhibiting defective mitochondrial DNA replication. Biochem. J. 305, 817-822.
22. Shadel, G.S. & Clayton, D.A. (1997) Mitochondrial DNA maintenance in vertebrates. Annu. Rev. Biochem. 66, 409-435.
23. Chang, D.D., Hauswirth, W.W. & Clayton, D.A. (1985) Replication priming and transcription initiate from precisely the same site in mouse mitochondrial DNA. EMBO J. 4, 1559-1567.
24. Chang, D.D. & Clayton, D.A. (1985) Priming of human mitochondrial DNA replication occurs at the light-strand promoter. Proc. Natl Acad. Sci. USA 82, 351-355.
25. Xu, B. & Clayton, D.A. (1995) A persistent RNA-DNA hybrid is formed during transcription at a phylogenetically conserved mitochondrial DNA sequence. Mol. Cell. Biol. 15, 580-589.
26. Xu, B. & Clayton, D.A. (1996) RNA-DNA hybrid formation at the human mitochondrial heavy-strand origin ceases at replication start sites: an implication for RNA-DNA hybrids serving as primers. EMBO J. 15, 3135-3143.
27. Lee, D.Y. & Clayton, D.A. (1996) Properties of a primer RNA-DNA hybrid at the mouse mitochondrial DNA leading-strand origin of replication, J. Biol. Chem. 271, 24262-24269.
28. Shadel, G.S. & Clayton, D.A. (1993) Mitochondrial transcription initiation. Variation and conservation. J. Biol. Chem. 268, 16083-16086.
29. +). J. Biol. Chem. 272, 9605-9608.
30. Kang, D., Nishida, J., Iyama, A., Nakabeppu, Y., Furuichi, M., Fujiwara, T., Sekiguchi, M. & Takeshige, K. (1995) Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria. J. Biol. Chem. 270, 14659-14665.
31. +)-related compounds in rat pheochromocytoma PC12 cells. Arch. Biochem. Biophys. 337, 75-80.
32. Kang, D., Miyako, K., Kai, Y., Irie, T. & Takeshige, K. (1997) In vivo determination of replication origins of human mitochondrial DNA by ligation-mediated polymerase chain reaction. J. Biol. Chem. 272, 15275-15279.
33. Shaulsky, G. & Loomis, W.F. (1995) Mitochondrial DNA replication but no nuclear DNA replication during development of Dictyostelium. Proc. Natl Acad. Sci. USA 92, 5660-5663.
34. Gelfand, R. & Attardi, G. (1981) Synthesis and turnover of mitochondrial ribonucleic acid in HeLa cells: the mature ribosomal and messenger ribonucleic acid species are metabolically unstable. Mol. Cell. Biol. 1, 497-511.
35. Cantatore, P., Flagella, Z., Fracasso, F., Lezza, A.M.S., Gadaleta, M.N. & de Montalvo, A. (1987) Synthesis and turnover rates of four rat liver mitochondrial RNA species, FEBS Lett. 213, 144-148.
36. Connor, M.K., Takahashi, M. & Hood, D.A. (1996) Tissue-specific stability of nuclear- and mitochondrially encoded mRNAs. Arch. Biochem. Biophys. 333, 103-108.
37. Laiho, K.U., Shelburne, J.D. & Trump, B.F. (1971) Observations on cell volume, ultrastructure, mitochondrial conformation and vital-dye uptake in Ehrlich ascites tumor cells. Effects of inhibiting energy production and function of the plasma membrane. Am. J. Patrol. 65, 203-230.
38. Sahgal, V., Subramani, V., Hughes, R., Shah, A. & Singh, H. (1979) On the pathogenesis of mitochondrial myopathies. An experimental study. Acta Neuropathol. 46, 177-183.
39. Hayashi, J., Takemitsu, M., Goto, Y. & Nonaka, I. (1994) Human mitochondria and mitochondrial genome function as a single dynamic cellular unit. J. Cell Biol. 125, 43-50.
40. Doda, J.N., Wright, C.T. & Clayton, D.A. (1981) Elongation of displacement-loop strands in human and mouse mitochondrial DNA is arrested near specific template sequences. Proc. Natl Acad. Sci. USA 78, 6116-6120.
41. Lewis, W. & Dalakas, M.C. (1995) Mitochondrial toxicity of antiviral drugs. Nature Med. 1, 417-422.
42. Lewis, W., Levine, E.S., Griniuviene, B., Tankersley, K.O., Colacino, J.M., Sommadossi, J., Watanabe, K.A. & Perrino, F.W. (1996) Fialuridine and its metabolites inhibit DNA polymerase γ at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structual defects in cultured hepatoblasts. Proc. Natl Acad. Sci. USA 93, 3592-3597.
43. King, M.P. (1996) Use of ethidium bromide to manipulate ratio of mutated and wild-type mitochondrial DNA. Methods Enzymol. 264, 339-344.
44. Chang, D.D. & Clayton, D.A. (1989) Mouse RNAase MRP RNA is encoded by a nuclear gene and contains a decamer sequence complementary to a conserved region of mitochondrial RNA substrate. Cell 56, 131-139.
45. Lee, D.Y. & Clayton, D.A. (1997) RNase mitochondrial RNA processing correctly cleaves a novel R loop at the mitochondrial DNA leading-strand origin of replication. Genes Dev. 11, 582-592.
46. Lestienne, P. (1987) Evidence for a direct role of the DNA polymerase gamma in the replication of the human mitochondrial DNA in vitro. Biochem. Biophys. Res. Commun. 146, 1146-1153.
47. Maxam, A.M. & Gilbert, W. (1980) Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol. 65, 499-560.
48. Anderson, S., Bankier, A.T., Barrell, B.G., de Bruijn, M.H., Coulson, A.R., Drouin, J., Eperon, I.C., Nierlich, D.P., Roe, B.A., Sanger, F., Schreier, P.H., Smith, A.J., Staden, R. & Young, I.G. (1981) Sequence and organization of the human mitochondrial genome. Nature 290, 457-465.