Ditercalinium chloride, a pro-anticancer drug, intimately associates with mammalian mitochondrial DNA and inhibits its replication

Current Genetics

Volumn 43, Issue 5, 2003, Pages 364-370

  Okamaoto, Mayumi ^a   Ohsato, Takashi ^a   Nakada, Kazuto ^b   Isobe, Kotoyo ^c   Spelbrink, Johannes N ^d   Hayashi, Jun Ichi ^b   Hamasaki, Naotaka ^a   Kang, Dongchon ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c DAIICHI SANKYO CO   (Japan)

^d TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

Ditercalinium chloride; DNA; Mitochondria; Mitochondrial DNA

Indexed keywords

ANTINEOPLASTIC AGENT; DITERCALINIUM; DNA DIRECTED DNA POLYMERASE GAMMA; ETHIDIUM BROMIDE; HELICASE; MITOCHONDRIAL DNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA REPLICATION; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG DNA INTERACTION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; FLUORESCENCE MICROSCOPY; HELA CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOUTHERN BLOTTING;

ANIMALS; BLOTTING, SOUTHERN; CARBAZOLES; CELLS, CULTURED; DNA HELICASES; DNA PRIMASE; DNA REPLICATION; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; ETHIDIUM; HELA CELLS; HUMANS; MICE; MICROSCOPY, FLUORESCENCE; MITOCHONDRIAL PROTEINS;

ANIMALIA; MAMMALIA;

EID: 0042976304     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00294-003-0393-4     Document Type: Article

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