Sophoranone, extracted from a traditional Chinese medicine Shan Dou Gen, induces apoptosis in human leukemia U937 cells via formation of reactive oxygen species and opening of mitochondrial permeability transition pores

International Journal of Cancer

Volumn 99, Issue 6, 2002, Pages 879-890

  Kajimoto, Sachiko ^a   Takanashi, Noriko ^a   Kajimoto, Tetsuya ^c   Xu, Man ^a   Cao, Judong ^b   Masuda, Yutaka ^a   Aiuchi, Toshihiro ^a   Nakajo, Shigeo ^a   Ida, Yoshiteru ^a   Nakaya, Kazuyasu ^a  

^a SHOWA UNIVERSITY   (Japan)

^b CAPITAL NORMAL UNIVERSITY   (China)

^c TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

Apoptosis; Cancer; Leukemia; Reactive oxygen species; Sophoranone

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOCHROME C OXIDASE; DAIDZEIN; FLAVONOID; GENISTEIN; METHANOL; NATURAL PRODUCT; PLANT EXTRACT; QUERCETIN; REACTIVE OXYGEN METABOLITE; SOPHORANONE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL GROWTH; CHINESE MEDICINE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; DRUG PURIFICATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MEMBRANE PERMEABILITY; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; PLANT; PRIORITY JOURNAL; RESPIRATORY CHAIN; SOLID TUMOR; SOPHORA SUBPROSTRATA; STOMACH CANCER;

APOPTOSIS; CELL CYCLE; CYTOCHROME C GROUP; DNA, NEOPLASM; DRUGS, CHINESE HERBAL; FLAVONOIDS; HUMANS; LEUKEMIA; MAP KINASE SIGNALING SYSTEM; MEDICINE, CHINESE TRADITIONAL; MITOCHONDRIA; PERMEABILITY; PLANTS, MEDICINAL; REACTIVE OXYGEN SPECIES; SUPEROXIDES; U937 CELLS;

EID: 0037142185     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10414     Document Type: Article

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