-
1
-
-
0036654694
-
A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth
-
Fantin, V. R., Berardi, M. J., Scorrano, L., Korsmeyer, S. J., and Leder, P. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell, 2: 29-42, 2002.
-
(2002)
Cancer Cell
, vol.2
, pp. 29-42
-
-
Fantin, V.R.1
Berardi, M.J.2
Scorrano, L.3
Korsmeyer, S.J.4
Leder, P.5
-
2
-
-
0024148694
-
Mitochondrial membrane potential in living cells
-
Chen, L. B. Mitochondrial membrane potential in living cells. Annu. Rev. Cell Biol., 4: 155-181, 1988.
-
(1988)
Annu. Rev. Cell Biol.
, vol.4
, pp. 155-181
-
-
Chen, L.B.1
-
3
-
-
0035797118
-
Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells
-
Modica-Napolitano, J. S., and Aprille, J. R. Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells. Adv. Drug Delivery Rev., 49: 63-70, 2001.
-
(2001)
Adv. Drug Delivery Rev.
, vol.49
, pp. 63-70
-
-
Modica-Napolitano, J.S.1
Aprille, J.R.2
-
4
-
-
0033568486
-
Mitochondria and cell death: Mechanistic aspects and methodological issues
-
Bernardi, P., Scorrano, L., Colonna, R., Petronilli, V., and Di Lisa, F. Mitochondria and cell death: mechanistic aspects and methodological issues. Eur. J. Biochem., 264: 687-701, 1999.
-
(1999)
Eur. J. Biochem.
, vol.264
, pp. 687-701
-
-
Bernardi, P.1
Scorrano, L.2
Colonna, R.3
Petronilli, V.4
Di Lisa, F.5
-
5
-
-
0036308059
-
Mitochondria, the killer organelles and their weapons
-
Ravagnan, L., Roumier, T., and Kroemer, G. Mitochondria, the killer organelles and their weapons. J. Cell. Physiol., 192: 131-137, 2002.
-
(2002)
J. Cell. Physiol.
, vol.192
, pp. 131-137
-
-
Ravagnan, L.1
Roumier, T.2
Kroemer, G.3
-
6
-
-
0036716281
-
The Bcl2 family: Regulators of the cellular life-or-death switch
-
Cory, S., and Adams, J. M. The Bcl2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer, 2: 647-656, 2002.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 647-656
-
-
Cory, S.1
Adams, J.M.2
-
7
-
-
0033564103
-
Dead or dying: Necrosis versus apoptosis in caspase-deficient human renal cell carcinoma
-
Kolenko, V., Uzzo, R. G., Bukowski, R., Bander, N. H., Novick, A. C., Hsi, E. D., and Finke, J. H. Dead or dying: necrosis versus apoptosis in caspase-deficient human renal cell carcinoma. Cancer Res., 59: 2838-2842, 1999.
-
(1999)
Cancer Res.
, vol.59
, pp. 2838-2842
-
-
Kolenko, V.1
Uzzo, R.G.2
Bukowski, R.3
Bander, N.H.4
Novick, A.C.5
Hsi, E.D.6
Finke, J.H.7
-
8
-
-
0034676455
-
Surfing the p53 network
-
Vogelstein, B., Lane, D., and Levine, A. J. Surfing the p53 network. Nature (Lond.), 408: 307-310, 2000.
-
(2000)
Nature (Lond.)
, vol.408
, pp. 307-310
-
-
Vogelstein, B.1
Lane, D.2
Levine, A.J.3
-
9
-
-
0034608786
-
Mitochondrion as a novel target of anticancer chemotherapy
-
Costantini, P., Jacotot, E., Decaudin, D., and Kroemer, G. Mitochondrion as a novel target of anticancer chemotherapy. J. Natl. Cancer Inst. (Bethesda), 92: 1042-1053, 2000.
-
(2000)
J. Natl. Cancer Inst. (Bethesda)
, vol.92
, pp. 1042-1053
-
-
Costantini, P.1
Jacotot, E.2
Decaudin, D.3
Kroemer, G.4
-
10
-
-
0035956436
-
The channel of death
-
Degterev, A., Boyce, M., and Yuan, J. The channel of death. J. Cell Biol., 155: 695-698, 2001.
-
(2001)
J. Cell Biol.
, vol.155
, pp. 695-698
-
-
Degterev, A.1
Boyce, M.2
Yuan, J.3
-
11
-
-
0036498865
-
Genetic analysis of the mammalian cell death machinery
-
Joza, N., Kroemer, G., and Penninger, J. M. Genetic analysis of the mammalian cell death machinery. Trends Genet., 18: 142-149, 2002.
-
(2002)
Trends Genet.
, vol.18
, pp. 142-149
-
-
Joza, N.1
Kroemer, G.2
Penninger, J.M.3
-
12
-
-
0037459081
-
Mitochondria: Releasing power for life and unleashing the machineries of death
-
Newmeyer, D. D., and Ferguson-Miller, S. Mitochondria: releasing power for life and unleashing the machineries of death. Cell, 112: 481-490, 2003.
-
(2003)
Cell
, vol.112
, pp. 481-490
-
-
Newmeyer, D.D.1
Ferguson-Miller, S.2
-
13
-
-
0035957653
-
Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
-
Wei, M. C., Zong, W. X., Cheng, E. H., Lindsten, T., Panoutsakopoulou, V., Ross, A. J., Roth, K. A., MacGregor, G. R., Thompson, C. B., and Korsmeyer, S. J. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (Wash. DC), 292: 727-730, 2001.
-
(2001)
Science (Wash. DC)
, vol.292
, pp. 727-730
-
-
Wei, M.C.1
Zong, W.X.2
Cheng, E.H.3
Lindsten, T.4
Panoutsakopoulou, V.5
Ross, A.J.6
Roth, K.A.7
MacGregor, G.R.8
Thompson, C.B.9
Korsmeyer, S.J.10
-
14
-
-
0037071388
-
Dysregulation of apoptosis genes in hematopoietic malignancies
-
Kitada, S., Pedersen, I. M., Schimmer, A. D., and Reed, J. C. Dysregulation of apoptosis genes in hematopoietic malignancies. Oncogene, 21: 3459-3474, 2002.
-
(2002)
Oncogene
, vol.21
, pp. 3459-3474
-
-
Kitada, S.1
Pedersen, I.M.2
Schimmer, A.D.3
Reed, J.C.4
-
15
-
-
0032877668
-
Dysregulation of apoptosis in cancer
-
Reed, J. C. Dysregulation of apoptosis in cancer. J. Clin. Oncol., 17: 2941-2953, 1999.
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 2941-2953
-
-
Reed, J.C.1
-
16
-
-
0033179760
-
BCL-2 family members and the mitochondria in apoptosis
-
Gross, A., McDonnell, J. M., and Korsmeyer, S. J. BCL-2 family members and the mitochondria in apoptosis. Genes Dev., 13: 1899-1911, 1999.
-
(1999)
Genes Dev.
, vol.13
, pp. 1899-1911
-
-
Gross, A.1
McDonnell, J.M.2
Korsmeyer, S.J.3
-
17
-
-
0037169358
-
Apoptosis: A link between cancer genetics and chemotherapy
-
Johnstone, R. W., Ruefli, A. A., and Lowe, S. W. Apoptosis: a link between cancer genetics and chemotherapy. Cell, 108: 153-164, 2002.
-
(2002)
Cell
, vol.108
, pp. 153-164
-
-
Johnstone, R.W.1
Ruefli, A.A.2
Lowe, S.W.3
-
18
-
-
0027389763
-
Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line
-
Miyashita, T., and Reed, J. C. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood, 81: 151-157, 1993.
-
(1993)
Blood
, vol.81
, pp. 151-157
-
-
Miyashita, T.1
Reed, J.C.2
-
19
-
-
0036040031
-
The anti-apoptotic genes Bcl-X(L) and Bcl-2 are over-expressed and contribute to chemoresistance of non-proliferating leukaemic CD34+ cells
-
Konopleva, M., Zhao, S., Hu, W., Jiang, S., Snell, V., Weidner, D., Jackson, C. E., Zhang, X., Champlin, R., Estey, E., Reed, J. C., and Andreeff, M. The anti-apoptotic genes Bcl-X(L) and Bcl-2 are over-expressed and contribute to chemoresistance of non-proliferating leukaemic CD34+ cells. Br. J. Haematol., 118: 521-534, 2002.
-
(2002)
Br. J. Haematol.
, vol.118
, pp. 521-534
-
-
Konopleva, M.1
Zhao, S.2
Hu, W.3
Jiang, S.4
Snell, V.5
Weidner, D.6
Jackson, C.E.7
Zhang, X.8
Champlin, R.9
Estey, E.10
Reed, J.C.11
Andreeff, M.12
-
20
-
-
0032828118
-
BCL-2 and p53 expression in clinically localized prostate cancer predicts response to external beam radiotherapy
-
discussion 16-17
-
Scherr, D. S., Vaughan, E. D., Jr., Wei, J., Chung, M., Felsen, D., Allbright, R., and Knudsen, B. S. BCL-2 and p53 expression in clinically localized prostate cancer predicts response to external beam radiotherapy. J. Urol., 162: 12-16; discussion 16-17, 1999.
-
(1999)
J. Urol.
, vol.162
, pp. 12-16
-
-
Scherr, D.S.1
Vaughan Jr., E.D.2
Wei, J.3
Chung, M.4
Felsen, D.5
Allbright, R.6
Knudsen, B.S.7
-
21
-
-
0032127416
-
The central role of the mitochondrial megachannel in apoptosis: Evidence obtained with intact cells, isolated mitochondria, and purified protein complexes
-
Marzo, I., Brenner, C., and Kroemer, G. The central role of the mitochondrial megachannel in apoptosis: evidence obtained with intact cells, isolated mitochondria, and purified protein complexes. Biomed. Pharmacother., 52: 248-251, 1998.
-
(1998)
Biomed. Pharmacother.
, vol.52
, pp. 248-251
-
-
Marzo, I.1
Brenner, C.2
Kroemer, G.3
-
22
-
-
0027485461
-
Bcl-2 functions in an antioxidant pathway to prevent apoptosis
-
Hockenbery, D. M., Oltvai, Z. N., Yin, X. M., Milliman, C. L., and Korsmeyer, S. J. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell, 75: 241-251, 1993.
-
(1993)
Cell
, vol.75
, pp. 241-251
-
-
Hockenbery, D.M.1
Oltvai, Z.N.2
Yin, X.M.3
Milliman, C.L.4
Korsmeyer, S.J.5
-
23
-
-
0031036872
-
Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
-
Yang, J., Liu, X., Bhalla, K., Kim, C. N., lbrado, A. M., Cai, J., Peng, T. I., Jones, D. P., and Wang, X. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science (Wash. DC), 275: 1129-1132, 1997.
-
(1997)
Science (Wash. DC)
, vol.275
, pp. 1129-1132
-
-
Yang, J.1
Liu, X.2
Bhalla, K.3
Kim, C.N.4
Ibrado, A.M.5
Cai, J.6
Peng, T.I.7
Jones, D.P.8
Wang, X.9
-
24
-
-
0031037897
-
The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
-
Kluck, R. M., Bossy-Wetzel, E., Green, D. R., and Newmeyer, D. D. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science (Wash. DC), 275: 1132-1136, 1997.
-
(1997)
Science (Wash. DC)
, vol.275
, pp. 1132-1136
-
-
Kluck, R.M.1
Bossy-Wetzel, E.2
Green, D.R.3
Newmeyer, D.D.4
-
25
-
-
0032558736
-
The oncogene heregulin induces apoptosis in breast epithelial cells and tumors
-
Weinstein, E. J., Grimm, S., and Leder, P. The oncogene heregulin induces apoptosis in breast epithelial cells and tumors. Oncogene, 17: 2107-2113, 1998.
-
(1998)
Oncogene
, vol.17
, pp. 2107-2113
-
-
Weinstein, E.J.1
Grimm, S.2
Leder, P.3
-
26
-
-
0035910057
-
Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK
-
Thomas, D. A., Scorrano, L., Putcha, G. V., Korsmeyer, S. J., and Ley, T. J. Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK. Proc. Nad. Acad. Sci. USA, 98: 14985-14990, 2001.
-
(2001)
Proc. Nad. Acad. Sci. USA
, vol.98
, pp. 14985-14990
-
-
Thomas, D.A.1
Scorrano, L.2
Putcha, G.V.3
Korsmeyer, S.J.4
Ley, T.J.5
-
27
-
-
0033562145
-
Induction of superoxide dismutase and cytotoxicity by manganese in human breast cancer cells
-
Thongphasuk, J., Oberley, L. W., and Oberley, T. D. Induction of superoxide dismutase and cytotoxicity by manganese in human breast cancer cells. Arch. Biochem. Biophys., 365: 317-327, 1999.
-
(1999)
Arch. Biochem. Biophys.
, vol.365
, pp. 317-327
-
-
Thongphasuk, J.1
Oberley, L.W.2
Oberley, T.D.3
-
28
-
-
0030900980
-
Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
-
Leist, M., Single, B., Castoldi, A. F., Kuhnle, S., and Nicotera, P. Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J. Exp. Med., 185: 1481-1486, 1997.
-
(1997)
J. Exp. Med.
, vol.185
, pp. 1481-1486
-
-
Leist, M.1
Single, B.2
Castoldi, A.F.3
Kuhnle, S.4
Nicotera, P.5
-
29
-
-
0028999212
-
On the effects of paraquat on isolated mitochondria: Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide
-
Costantini, P., Petronilli, V., Colonna, R., and Bernardi, P. On the effects of paraquat on isolated mitochondria: evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide. Toxicology, 99: 77-88, 1995.
-
(1995)
Toxicology
, vol.99
, pp. 77-88
-
-
Costantini, P.1
Petronilli, V.2
Colonna, R.3
Bernardi, P.4
-
30
-
-
0031032294
-
Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents
-
Decaudin, D., Geley, S., Hirsch, T., Castedo, M., Marchetti, P., Macho, A., Kofler, R., and Kroemer, G. Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. Cancer Res., 57: 62-67, 1997.
-
(1997)
Cancer Res.
, vol.57
, pp. 62-67
-
-
Decaudin, D.1
Geley, S.2
Hirsch, T.3
Castedo, M.4
Marchetti, P.5
Macho, A.6
Kofler, R.7
Kroemer, G.8
-
31
-
-
0030795866
-
Bcl-2 and Bcl-XL can differentially block chemotherapy-induced cell death
-
Simonian, P. L., Grillot, D. A., and Nunez, G. Bcl-2 and Bcl-XL can differentially block chemotherapy-induced cell death. Blood, 90: 1208-1216, 1997.
-
(1997)
Blood
, vol.90
, pp. 1208-1216
-
-
Simonian, P.L.1
Grillot, D.A.2
Nunez, G.3
-
32
-
-
0030916669
-
The proto-oncogene Bcl-2 and its role in regulating apoptosis
-
Kroemer, G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat. Med., 3: 614-620, 1997.
-
(1997)
Nat. Med.
, vol.3
, pp. 614-620
-
-
Kroemer, G.1
-
33
-
-
0344789509
-
Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells
-
Summerhayes, I. C., Lampidis, T. J., Bernal, S. D., Nadakavukaren, J. J., Nadakavukaren, K. K., Shepherd, E. L., and Chen, L. B. Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells. Proc. Natl. Acad. Sci. USA, 79: 5292-5296, 1982.
-
(1982)
Proc. Natl. Acad. Sci. USA
, vol.79
, pp. 5292-5296
-
-
Summerhayes, I.C.1
Lampidis, T.J.2
Bernal, S.D.3
Nadakavukaren, J.J.4
Nadakavukaren, K.K.5
Shepherd, E.L.6
Chen, L.B.7
-
34
-
-
0034951169
-
Mitochondria, oxygen free radicals, and apoptosis
-
Raha, S., and Robinson, B. H. Mitochondria, oxygen free radicals, and apoptosis. Am. J. Med. Genet., 106: 62-70, 2001.
-
(2001)
Am. J. Med. Genet.
, vol.106
, pp. 62-70
-
-
Raha, S.1
Robinson, B.H.2
-
35
-
-
0033585069
-
Modulation of mitochondrial Ca(2+) homeostasis by Bcl-2
-
Zhu, L., Ling, S., Yu, X. D., Venkatesh, L. K., Subramanian, T., Chinnadurai, G., and Kuo, T. H. Modulation of mitochondrial Ca(2+) homeostasis by Bcl-2. J. Biol. Chem., 274: 33267-33273, 1999.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 33267-33273
-
-
Zhu, L.1
Ling, S.2
Yu, X.D.3
Venkatesh, L.K.4
Subramanian, T.5
Chinnadurai, G.6
Kuo, T.H.7
-
36
-
-
0030915587
-
Intracellular ATP levels determine cell death fate by apoptosis or necrosis
-
Eguchi, Y., Shimizu, S., and Tsujimoto, Y. Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res., 57: 1835-1840, 1997.
-
(1997)
Cancer Res.
, vol.57
, pp. 1835-1840
-
-
Eguchi, Y.1
Shimizu, S.2
Tsujimoto, Y.3
-
37
-
-
0033043803
-
Bcl-2 alters the balance between apoptosis and necrosis, but does not prevent cell death induced by oxidized low density lipoproteins
-
Meilhac, O., Escargueil-Blanc, I., Thiers, J. C., Salvayre, R., and Negre-Salvayre, A. Bcl-2 alters the balance between apoptosis and necrosis, but does not prevent cell death induced by oxidized low density lipoproteins. FASEB J., 13: 485-494, 1999.
-
(1999)
FASEB J.
, vol.13
, pp. 485-494
-
-
Meilhac, O.1
Escargueil-Blanc, I.2
Thiers, J.C.3
Salvayre, R.4
Negre-Salvayre, A.5
-
38
-
-
0031918742
-
The mitochondrial death/life regulator in apoptosis and necrosis
-
Kroemer, G., Dallaporta, B., and Resche-Rigon, M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu. Rev. Physiol., 60: 619-642, 1998.
-
(1998)
Annu. Rev. Physiol.
, vol.60
, pp. 619-642
-
-
Kroemer, G.1
Dallaporta, B.2
Resche-Rigon, M.3
-
39
-
-
0032404536
-
The central executioners of apoptosis: Caspases or mitochondria?
-
Green, D., and Kroemer, G. The central executioners of apoptosis: caspases or mitochondria?. Trends Cell Biol., 8: 267-271, 1998.
-
(1998)
Trends Cell Biol.
, vol.8
, pp. 267-271
-
-
Green, D.1
Kroemer, G.2
-
40
-
-
0036561908
-
Modelling the molecular circuitry of cancer
-
Hahn, W. C., and Weinberg, R. A. Modelling the molecular circuitry of cancer. Nat. Rev. Cancer, 2: 331-341, 2002.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 331-341
-
-
Hahn, W.C.1
Weinberg, R.A.2
-
41
-
-
0033047268
-
Apoptosis versus necrosis: Which should be the aim of cancer therapy?
-
Kiaris, H., and Schally, A. V. Apoptosis versus necrosis: which should be the aim of cancer therapy?. Proc. Soc. Exp. Biol. Med., 221: 87-88, 1999.
-
(1999)
Proc. Soc. Exp. Biol. Med.
, vol.221
, pp. 87-88
-
-
Kiaris, H.1
Schally, A.V.2
-
42
-
-
0028846648
-
Radiation-induced apoptosis: Relevance to radiotherapy
-
Dewey, W. C., Ling, C. C., and Meyn, R. E. Radiation-induced apoptosis: relevance to radiotherapy. Int. J. Radiat. Oncol. Biol. Phys., 33: 781-796, 1995.
-
(1995)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.33
, pp. 781-796
-
-
Dewey, W.C.1
Ling, C.C.2
Meyn, R.E.3
-
43
-
-
0036889436
-
Comparison of anthracycline-induced death of human leukemia cells: Programmed cell death versus necrosis
-
Dartsch, D. C., Schaefer, A., Boldt, S., Kolch, W., and Marquardt, H. Comparison of anthracycline-induced death of human leukemia cells: programmed cell death versus necrosis. Apoptosis, 7: 537-548, 2002.
-
(2002)
Apoptosis
, vol.7
, pp. 537-548
-
-
Dartsch, D.C.1
Schaefer, A.2
Boldt, S.3
Kolch, W.4
Marquardt, H.5
-
44
-
-
0033566932
-
Cutting edge: Differential effect of apoptotic versus necrotic tumor cells on macrophage antitumor activities
-
Reiter, I., Krammer, B., and Schwamberger, G. Cutting edge: differential effect of apoptotic versus necrotic tumor cells on macrophage antitumor activities. J. Immunol., 163: 1730-1732, 1999.
-
(1999)
J. Immunol.
, vol.163
, pp. 1730-1732
-
-
Reiter, I.1
Krammer, B.2
Schwamberger, G.3
-
45
-
-
0037330831
-
Necrosis: A specific form of programmed cell death?
-
Proskuryakov, S. Y., Konoplyannikov, A. G., and Gabai, V. L. Necrosis: a specific form of programmed cell death? Exp. Cell Res., 283: 1-16, 2003.
-
(2003)
Exp. Cell Res.
, vol.283
, pp. 1-16
-
-
Proskuryakov, S.Y.1
Konoplyannikov, A.G.2
Gabai, V.L.3
|