NO synthase inhibition modulates NMDA-induced changes in cerebral blood flow and EEG activity

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 271, Issue 3 40-3, 1996, Pages

  Pelligrino, Dale A ^a,b   Gay III, Robert L ^a   Baughman, Verna L ^a   Wang, Qiong ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b MICHAEL REESE HOSPITAL   (United States)

Author keywords

excitatory amino acids; laser Doppler flowmetry; N( ) nitro L arginine

Indexed keywords

EXCITATORY AMINO ACID; N METHYL DEXTRO ASPARTIC ACID; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; AUTOREGULATION; BRAIN BLOOD FLOW; ELECTROENCEPHALOGRAM; ENZYME INHIBITION; LASER DOPPLER FLOWMETRY; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; VASODILATATION;

EID: 0029816699     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.271.3.h990     Document Type: Article

References (26)

1. Bagetta, G., M. Iannone, A. M. Scorsa, and G. Nistico. Tacrine-induced seizures and brain damage in LiCl-treated rats can be prevented by N omega-nitro-L-arginine methyl ester. Eur. J. Pharmacol. 213: 301-304, 1992.
2. Buisson, A., N. Lakhmeche, C. Verrecchia, M. Plotkine, and R. G. Boulu. Nitric oxide: an endogenous anticonvulsant substance. Neuroreport 4: 444-446, 1993.
3. Butler, A. R., F. W. Flitney, and D. L. H. Williams. NO, nitrosonium ions, nitroxide ions, nitrosothiols and iron-nitrosyls in biology: a chemist's perspective. Trends Pharmacol. Sci. 16: 18-22, 1995.
4. Craig, C. G., and T. D. White. NMDA-evoked adenosine release from rat cortex does not require the intermediate formation of nitric oxide. Neurosci. Lett. 158: 167-169, 1993.
5. De Sarro, G., E. D. Di Paola, A. De Sarro, and M. J. Vidal. L-arginine potentiates excitatory amino acid-induced seizures elicited in the deep prepiriform cortex. Eur. J. Pharmacol. 230: 151-158, 1993.
6. Devasconcelos, A. P., R. A. Baldwin, and C. G. Wasterlain. Nitric oxide mediates the increase in local cerebral blood flow during focal seizures. Proc. Natl. Acad. Sci. USA 92: 3175-3179, 1995.
7. Fagni, L., M. Olivier, M. Lafoncazal, and J. Bockaert. Involvement of divalent ions in the nitric oxide-induced blockade of N-methyl-D-aspartate receptors in cerebellar granule cells. Mol. Pharmacol. 47: 1239-1247, 1995.
8. Faraci, F. M., and K. R. Breese. Nitric oxide mediates vasodilatation in response to activation of N-methyl-D-aspartate receptors in brain. Circ. Res. 72: 476-480, 1993.
9. Faraci, F. M., K. R. Breese, and D. D. Heistad. Nitric oxide contributes to dilatation of cerebral arterioles during seizures. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H2209-H2212, 1993.
10. - produced by stimulation of the fastigial nucleus in rat. Brain Res. 563: 273-277, 1991.
11. Kamisaki, Y., K. Wada, K. Nakamoto, and T. Itoh. Nitric oxide inhibition of the depolarization-evoked glutamate release from synaptosomes of rat cerebellum. Neurosci. Lett. 194: 5-8, 1995.
12. Lauritzen, M., and A. J. Hansen. The effect of glutamate receptor blockade on anoxic depolarization and cortical spreading depression. J. Cereb. Blood Flow Metab. 12: 223-229, 1992.
13. Li, J., and C. Iadecola, Nitric oxide and adenosine mediate vasodilation during functional activation in cerebellar cortex. Neuropharmacology 33: 1453-1461, 1994.
14. Lipton, S. A., Y. B. Choi, Z. H. Pan, S. Z. Z. Lei, H. S. V. Chen, N. J. Sucher, J. Loscalzo, D. J. Singel, and J. S. Stamler. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature Lond. 364: 626-632, 1993
15. Lonart, G., J. Wang, and K. M. Johnson. Nitric oxide induces neurotransmitter release from hippocampal slices. Eur. J. Pharmacol. 220: 271-272, 1992.
16. Manzoni, O. J., L. Prezeau, P. Marin, S. Deshager, J. Bockaert, and L. Fagni. Nitric oxide-induced blockade of NMDA receptors. Neuron 8: 653-662, 1992.
17. Manzoni, O. J., T. Manabe, and R. A. Nicoll. Release of adenosine by activation of NMDA receptors in the hippocampus. Science Wash. DC. 265: 2098-2101, 1994.
18. Northington, F. J., J. R Tobin, R. C. Koehler, and R. J. Traystman. In vivo production of nitric oxide correlates with NMDA-induced cerebral hyperemia in newborn sheep. Am. J. Physiol. 269 (Heart Circ. Physiol. 38): H215-H221, 1995.
19. Pogun, S., V. Dawson, and M. J. Kuhar. Nitric oxide inhibits H-3-glutamate transport in synaptosomes. Synapse 18: 21-26, 1994.
20. Przegalinski, E., L. Baran, and J. Siwanowicz. The role of nitric oxide in the kainate-induced seizures in mice. Neurosci. Lett. 170: 74-76, 1994.
21. Rondouin, G., J. Bockaert, and M. Lernernatoli. L-nitroarginine, an inhibitor of NO synthase, dramatically worsens limhic epilepsy in rats. Neuroreport 4: 1187-1190, 1993.
22. Rundfeldt, C., R. Koch, A. Richter, M. Mevissen, U. Gerecke, and W. Loscher. Dose-dependent anticonvulsant and proconvulsant effects of nitric oxide synthase inhibitors on seizure threshold in a cortical stimulation model in rats. Eur. J. Pharmacol. 274: 73-81, 1995.
23. Theard, M. A., V. L. Baughman, Q. Wang, D. A. Pelligrino, and R. F. Albrecht. The role of nitric oxide in modulating brain activity and blood flow during seizure. Neuroreport 6: 921-924, 1995.
24. Wang, Q., D. A. Pelligrino, O. B. Paulson, and N. A. Lassen. Comparison of the effects of NG-nitro-L-arginine and indomethacin on the hypercapnic cerebral blood flow increase in rats. Brain Res. 641: 257-264, 1994.
25. Wang, Q., A. Theard, D. A. Pelligrino, V. L. Baughman, W. E. Hoffman, R. F. Albrecht, M. Cwik, O. B. Paulson, and N. A. Lassen. Nitric oxide as an endogenous anticonvulsant but not a mediator of the cerebral hyperemia accompanying bicuculline treatment in rats. Brain Res. 658: 192-198, 1994.
26. Zhang, H., and D. Cook. Cerebral vascular smooth muscle potassium channels and their possible role in the management of vasospasm. Pharmacol. Toxicol. 75: 327-336, 1994.