Release of ATP in the ventral medulla during hypoxia in rats: Role in hypoxic ventilatory response

Journal of Neuroscience

Volumn 25, Issue 5, 2005, Pages 1211-1218

  Gourine, Alexander V ^a   Llaudet, Enrique ^b   Dale, Nicholas ^b   Spyer, K Michael ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

ATP; Biosensor; Hypoxia; P2X; Respiration; Ventrolateral medulla

Indexed keywords

ADENOSINE TRIPHOSPHATE; OXYGEN; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID;

AMPEROMETRY; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA NERVE; ARTICLE; BIOSENSOR; BRAIN FUNCTION; BREATHING; BREATHING RATE; CAROTID SINUS NERVE; CONCENTRATION (PARAMETERS); HYPOXIA; LUNG VENTILATION; MALE; MEASUREMENT; MEDULLA OBLONGATA; NONHUMAN; PRIORITY JOURNAL; RAT; VAGUS NERVE;

ADAPTATION, PHYSIOLOGICAL; ADENOSINE TRIPHOSPHATE; ANIMALS; ANOXIA; BIOSENSING TECHNIQUES; MALE; MEDULLA OBLONGATA; PHRENIC NERVE; PYRIDOXAL PHOSPHATE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; RESPIRATORY PHYSIOLOGY; SIGNAL TRANSDUCTION; SYMPATHECTOMY, CHEMICAL;

EID: 13944260787     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3763-04.2005     Document Type: Article

References (32)

1. Bissonnette JM (2000) Mechanisms regulating hypoxic respiratory depression during fetal and postnatal life. Am J Physiol Regul Integr Comp Physiol 278:R1391-R1400.
2. Chau A, Koos BJ (1999) Metabolic and cardiorespiratory responses to hypoxia in fetal sheep: adenosine receptor blockade. Am J Physiol 276:R1805-R1811.
3. Dale N, Pearson T, Frenguelli BG (2000) Direct measurement of adenosine release during hypoxia in the CAl region of the rat hippocampal slice. J Physiol (Lond) 526:143-155.
4. Dale N, Gourine AV, Llaudet E, Bulmer D, Thomas T, Spyer KM (2002) Rapid adenosine release in the nucleus tractus solitarii during defence response in rats: real-time measurement in vivo. J Physiol (Lond) 544:149-160.
5. Daly M (1997) Peripheral arterial chemoreceptors and respiratory- cardiovascular integration. Physiological Society Monograph Number 46. Oxford: Oxford UP.
6. Duffin J, Ezure K, Lipski J (1995) Breathing rhythm generation: focus on the rostral ventrolateral medulla. News Physiol Sci 10:133-140.
7. Feldman JL, Mitchell GS, Nattie EE (2003) Breathing: rhythmicity, plasticity, chemosensitivity. Annu Rev Neurosci 26:239-266.
8. Gonzalez C, Almaraz L, Obeso A, Rigual R (1994) Carotid body chemoreceptors: from natural stimuli to sensory discharges. Physiol Rev 74:829-898.
9. Gourine AV, Llaudet E, Thomas T, Dale N, Spyer KM (2002) Adenosine release in nucleus tractus solitarii does not appear to mediate hypoxia-induced respiratory depression in rats. J Physiol (Lond) 544:161-170.
10. Gourine AV, Atkinson L, Deuchars J, Spyer KM (2003) Purinergic signalling in the medullary mechanisms of respiratory control in the rat: respiratory neurones express the P2X2 receptor subunit. J Physiol (Lond) 552:197-211.
11. 1 receptor. Proc Natl Acad Sci USA 98:9407-9412.
12. 2 receptor subunit of the ATP-gated ion channels in the rat central nervous system. J Comp Neurol 407:11-32.
13. Llaudet E, Bolting NP, Crayston JA, Dale N (2003) A three-enzyme microelectrode sensor for detecting purine release from central nervous system. Biosens Bioelectron 18:43-52.
14. Llaudet E, Droniou M, Dale N (2004) A new biosensor for the measurement of extracellular ATP in the CNS. J Physiol (Lond) 555P:C20.
15. 2 sensitivity in vitro. Respir Physiol Neurobiol 142:27-42.
16. North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82:1013-1067.
17. Paxinos G, Watson CH (1998) The rat brain in stereotaxic coordinates. London: Academic.
18. Prabhakar NR (2000) Oxygen sensing by the carotid body chemoreceptors. J Appl Physiol 88:2287-2295.
19. Richter DW, Spyer KM (2001) Studying rhythmogenesis of breathing: comparison of in vivo and in vitro models. Trends Neurosci 24:464-472.
20. Richter DW, Bischoff A, Anders K, Bellingham M, Windhorst U (1991) Response of the medullary respiratory network of the cat to hypoxia. J Physiol (Lond) 443:231-256.
21. Richter DW, Schmidt-Garcon P, Pierrefische O, Bischoff AM, Lalley PM (1999) Neurotransmitters and neuromodulators controlling the hypoxic respiratory response in anaesthetised cats. J Physiol (Lond) 514:567-578.
22. 2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia. J Neurosci 23:11315-11321.
23. Runold M, Lagercrantz H, Prabhakar NR, Fredholm BB (1989) Roleofadenosine in hypoxic ventilatory depression. J Physiol (Lond) 67:541-546.
24. Schmidt C, Bellingham MC, Richter DW (1995) Adenosinergic modulation of respiratory neurones and hypoxic responses in the anaesthetized cat. J Physiol (Lond) 483:769-781.
25. 2 levels: a role for medullary P2X receptors. J Auton Nerv Syst 81:228-235.
26. Spyer KM, Dale N, Gourine AV (2004) ATP is a key mediator of central and peripheral chemosensory transduction. Exp Physiol 89:53-59.
27. Thomas T, Marshall JM (1994) Interdependence of respiratory and cardiovascular changes induced by systemic hypoxia in the rat: the roles of adenosine. J Physiol (Lond) 480:627-636.
28. 2 chemoreception. J Physiol (Lond) 523:441-447.
29. 2 chemoreception: a mechanism involving P2 purinoceptors localized in the ventrolateral medulla of the anaesthetized rat. J Physiol (Lond) 517:899-905.
30. Thomas T, Ralevic V, Bardini M, Burnstock G, Spyer KM (2001) Evidence for the involvement of purinergic signalling in the control of respiration. Neuroscience 107:481-490.
31. 6 receptor immunoreactivity in the brainstem of the rat and the common marmoset (Callithrix jacchus): association with catecholamine cell groups. J Comp Neurol 427:485-507.
32. 2 receptor subunit immunoreactivity on nitric oxide synthase expressing neurones in the brain stem and hypothalamus of the rat: a fluorescence immunohistochemical study. Neuroscience 121:411-419.