Mechanisms of H+ and Na+ changes induced by glutamate, kainate, and D- aspartate in rat hippocampal astrocytes

Journal of Neuroscience

Volumn 16, Issue 17, 1996, Pages 5393-5404

  Rose, Christine R ^a   Ransom, Bruce R ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

aspartate; glial cell; glutamate; glutamate transport; intracellular pH; intracellular sodium; ion regulation; ionotropic glutamate receptor; kainate; Na+ HCO3 cotransport

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; GLUTAMIC ACID; KAINIC ACID;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL INTERACTION; CELL MEMBRANE TRANSPORT; CELL PH; GLIA CELL; HIPPOCAMPUS; NERVE CELL MEMBRANE POTENTIAL; NEWBORN; NONHUMAN; NUCLEIC ACID TRANSPORT; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT; SODIUM CELL LEVEL; TRANSPORT KINETICS;

EID: 0029820948     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-17-05393.1996     Document Type: Article

References (61)

1. Amato A, Ballerini L, Attwell D (1994) Intracellular pH changes produced by glutamate uptake in rat hippocampal slices. J Neurophysiol 72:1686-1696.
2. + exchanger. Annu Rev Physiol 47:545-560.
3. Backus KH, Kettenmann H, Schachner M (1989) Pharmacological characterization of the glutamate receptor in cultured astrocytes. J Neurosci Res 22:274-282.
4. + activity in cultured mouse oligodendrocytes. J Neurosci Res 26:455-460.
5. Ballanyi K, Schlue WR, Dorner R (1989) Glutamate and kainate increase intracellular sodium activity in leech neuropile glial cells. Glia 2:51-54.
6. Barbour B, Magnus C, Szatkowski M, Gray PTA, Attwell D (1993) Changes in NAD(P)H fluorescence and membrane current produced by glutamate uptake into salamander Mueller cells. J Physiol (Lond) 466:573-597.
7. Bouvier M, Szatkowski M, Amato A, Attwell D (1992) The glial cell glutamate uptake carrier countertransports pH-changing anions. Nature 360:471-474.
8. Bowman CL, Kimelbcrg HK (1984) Excitatory amino acids directly depolarize rat brain astrocytes in primary culture. Nature 311:656-659.
9. 3. Am J Physiol 255:C844-C856.
10. Boyarski G, Ransom BR, Schlue WR, Davis MBE, Boron WF (1993) Intracellular pH regulation in single cultured astrocytes from rat forebrain. Glia 8:241-248.
11. Brew H, Attwell D (1987) Electrogenic glutamate uptake is a major current carrier in the membrane of axolotl retinal glial cells. Nature 327:707-709.
12. Brookes N, Turner RJ (1993) Extracellular potassium uptake regulates the glutamine content of astrocytes: mediation by intracellular pH. Neurosci Lett 160:73-76.
13. 2+ transients in cultured rat cerebellar astrocytes evoked by glutamate agonists and noradrenaline. Glia 14:153-161.
14. Brune T, Fetzer S, Backus KH, Deitmer JW (1994) Evidence for electrogenic sodium-bicarbonate cotransport in cultured rat cerebellar astrocytes. Pflügers Arch 429:64-71.
15. Chen JCT, Chesler M (1992) Extracellular alkaline shifts in rat hippocampal slice are mediated by NMDA and non-NMDA receptors. J Neurophysiol 68:342-344.
16. Chesler M (1990) The regulation and modulation of pH in the nervous system. Prog Neurobiol 34:401-427.
17. Chesler M, Kraig RP (1989) Intracellular pH transients of mammalian astrocytes. J Neurosci 9:2011-2019.
18. Deitmer JW (1995) pH regulation. In: Neuroglial cells (Kettenmann H, Ransom BR, eds), pp 230-245. New York: Oxford UP.
19. Deitmer JW, Munsch T (1992) Kainate/glutamate-induced changes in intracellular calcium and pH in leech glial cells. NeuroReport 3:693-696.
20. Deitmer JW, Rose CR (1996) pH regulation and proton signalling by glial cells. Prog Neurobiol 48:73-103.
21. Deitmer JW, Schneider HP (1995) Voltage-dependent clamp of intracellular pH of identified leech glial cells. J Physiol (Lond) 485:157-166.
22. Deitmer JW, Schneider HP (1996) Glutamate and aspartate-induced intracellular acidification in the leech giant glial cell. Proceedings of the 24th Goettingen Neurobiology Report, p 555.
23. + pump activity during electrogenic uptake of acidic amino acid transmitters by rat brain synaptosomes. J Neurochem 52:135-139.
24. Erecinska M, Silver JA (1990) Metabolism and role of glutamate in mammalian brain. Prog Neurobiol 35:245-296.
25. Flott B, Seifert W (1991) Characterization of glutamate uptake systems in astrocyte primary cultures from rat brain. Glia 4:293-304.
26. + modulation of NMDA receptor-mediated EPSC's revealed by carbonic anhydrase inhibition in rat hippocampus. J Physiol (Lond) 478:373-378.
27. Grichtchenko II, Chesler M (1994) Depolarization-induced alkalinization of astrocytes in gliotic hippocampal slices. Neuroscience 62:1071-1078.
28. Hochachka PW, Mommsen TP (1983) Protons and anaerobiosis. Science 219:1391-1397.
29. + currents in glial cells of mouse hippocampal slices. Pflügers Arch 426:310-319.
30. A receptor-mediated IPSPs of rat neocortical neurones. J Physiol (Lond) 464:273-289.
31. Kettenmann H, Schachner M (1985) Pharmacological properties of gamma-aminobutyric acid-, glutamate-, and aspartate-induced depolarizations in cultured astrocytes. J Neurosci 5:3295-3301.
32. + in primary astrocyte cultures. J Neurosci 9:1141-1149.
33. Kraig RP, Chesler M (1990) Astrocytic acidosis in hyperglycemic and complete ischemia. J Cereb Blood Flow Metab 10:104-114.
34. 3-containing media. Exp Brain Res 95:371-380.
35. Muller T, Moller T, Berger T, Schnitzer J, Kettenmann H (1992) Calcium entry through kainate receptors and resulting potassium-channel blockade in Bergmann glial cells. Science 256:1563-1566.
36. Munsch T, Nett W, Deitmer JW (1994) Fura-2 signals evoked by kainate in leech glial cells in the presence of different divalent cations. Glia 11:345-353.
37. Newman EA (1996) Acid efflux from retinal glial cells generated by sodium bicarbonate cotransport. J Neurosci 16:159-168.
38. O'Connor ER, Sontheimer H, Ransom BR (1994) Rat hippocampal astrocytes exhibit electrogenic sodium-bicarbonate co-transport. J Neurophysiol 72:2580-2589.
39. Paalasmaa P, Voipio J, Kaila K (1994) Extracellular alkaline transients mediated by glutamate receptors in the rat hippocampal slice are not due to a proton conductance. J Neurophysiol 72:2031-2033.
40. + pump in hippocampal astrocytes. Glia 9:280-291.
41. Pappas CA, Ransom BR (1994) Depolarization-induced alkalinization (DIA) in rat hippocampal astrocytes. J Neurophysiol 72:2816-2826.
42. Pellerin L, Magistretti PJ (1994) Glutamate uptake into astrocytes stimulate aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci USA 91:10625-10629.
43. i. Glia 13:101-112.
44. Ransom BR (1992) Glial modulation of neural excitability mediated by extracellular pH: a hypothesis. Prog Brain Res 94:37-46.
45. Ransom BR, Goldring S (1973) Ionic determinants of membrane potential of cells presumed to be glia in cerebral cortex of cat. J Neurophysiol 36:855-868.
46. Ransom BR, Barker JL, Nelson PG (1975) Two mechanisms for post-stimulus-hyperpolarizations in cultured mammalian neurones. Nature 256:424-425.
47. Rose CR, Deitmer JW (1994) Evidence that glial cells modulate extracellular pH transients induced by neuronal activity in the leech central nervous system. J Physiol (Lond) 481:1-5.
48. Rose CR, Deitmer JW (1995) Stimulus-induced changes in extra- and intracellular pH in the leech central nervous system. II. Mechanisms and maintenance of pH homeostasis. J Neurophysiol 73:132-140.
49. Rose CR, Ransom BR (1996) Intracellular sodium homeostasis in rat hippocampal astrocytes. J Physiol (Lond) 419:291-305.
50. Schoepp DD, Conn PJ (1993) Metabotropic glutamate receptors in brain functions and pathology. Trends Pharmacol Sci 14:13-20.
51. 3-exchange. J Physiol (Lond) 475:59-67.
52. Schwiening CJ, Kennedy HJ, Thomas RC (1993) Calcium-hydrogen exchange by the plasma membrane Ca-ATPase of voltage-clamped snail neurons. Proc R Soc Lond [Biol] 283:285-289.
53. Shrode LD, Putnam RW (1994) Intracellular pH regulation in primary rat astrocytes and C6 glioma cells. Glia 12:196-210.
54. Sonnewald W, Westergaard N, Petersen S, Unsgard G, Schousboe A (1993) Metabolism of [U-C-13] glutamate in astrocytes studies by C-13 NMR spectroscopy: incorporation of more label into lactate than into glutamine demonstrates the importance of the tricarboxylic acid cycle. J Neurochem 61:1179-1182.
55. + channels in cultured astrocytes. Glia 1:328-336.
56. +-current expression in rat hippocampal astrocytes in vitro: alterations during development. J Neurophysiol 65:3-19.
57. Steinhauser C, Jabs R, Kettenmann H (1994) Properties of GABA and glutamate responses in identified glial cells of the mouse hippocampal slice. Hippocampus 4:16-39.
58. Taira T, Smirnov S, Voipio J, Kaila K (1993) Intrinsic proton modulation of excitatory transmission in rat hippocampal slices. NeuroReport 4:93-96.
59. Thomas RC (1976) The effect of carbon dioxide on the intracellular buffering power of snail neurones. J Physiol (Lond) 255:715-735.
60. Thompson SM, Prince DA (1986) Activation of electrogenic sodium pump in hippocampal CA1 neurons following glutamate-induced depolarization. J Neurophysiol 56:507-522.
61. von Blankenfeld G, Kettenmann H (1991) Glutamate and GABA receptors in vertebrate glial cells. Mol Neurobiol 5:31-43.