Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia

Journal of Physiology

Volumn 509, Issue 2, 1998, Pages 507-518

  Coney, A M ^a   Marshall, Janice M ^a  

^a Medical School   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2 CHLORO 6 N CYCLOPENTYLADENOSINE; 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 8 PHENYLTHEOPHYLLINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENOSINE RECEPTOR; 8 SULPHOPHENYLTHEOPHYLLINE; ADENOSINE A2A RECEPTOR; THEOPHYLLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; CONTROLLED STUDY; HYPOXIA; MALE; NONHUMAN; PARIETAL LOBE; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASODILATATION; ANIMAL MODEL; ANIMAL TISSUE; BRAIN HYPOXIA; CORTICAL RED CELL FLUX; CORTICAL VASCULAR CONDUCTANCE; MEAN ARTERIAL PRESSURE; NERVOUS SYSTEM PARAMETERS; PARIETAL CORTEX;

ADENOSINE; ANIMALS; ANOXIA; BLOOD FLOW VELOCITY; BLOOD-BRAIN BARRIER; ERYTHROCYTES; LASER-DOPPLER FLOWMETRY; MALE; PARIETAL LOBE; PHENETHYLAMINES; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P1; THEOPHYLLINE; TRIAZINES; TRIAZOLES; VASODILATION;

EID: 0032101921     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1998.507bn.x     Document Type: Article

References (40)

1. BOWTON, D. L., HADDON, W. S., PROUGH, D. S., ADAIR, N., ALFORD, P. T. & STUMP, D. A. (1988). Theophylline effect on the cerebral blood flow response to hypoxemia. Chest 94, 371-375.
2. 3H]-NECA in rat striatal membranes. Molecular Pharmacology 29, 331-346.
3. 2A receptors in vasodilatation induced in skeletal muscle of the rat by systemic hypoxia. Journal of Physiology 494.P, 106P.
4. CONEY, A. & MARSHALL, J. M. (1995a). Effect of systemic hypoxia upon circulation of the cerebral cortex in the anaesthetized rat. Journal of Physiology 483.P, 88P.
5. CONEY, A. & MARSHALL, J. M. (1995b). The role of adenosine in cerebral cortical vasodilatation induced by acute systemic hypoxia in normoxic and chronically hypoxic rats under anaesthesia. Journal of Physiology 487.P, 174-175P.
6. CONEY, A. & MARSHALL, J. M. (1996a). Effect of ZM241385 on the responses to acute systemic hypoxia and adenosine in the cerebral cortex of the anaesthetized rat. Journal of Physiology 494.P, 105-106P.
7. CONEY, A. & MARSHALL, J. M. (1996b). The effect of 8-sulphophenyl-theophylline on the vasodilatation induced in the cerebral cortex of the anaesthetized rat by acute systemic hypoxia and exogenous adenosine. Journal of Physiology 497.P, 80P.
8. DALY, J. W. (1985). Adenosine Receptors. Advances in Cyclic Nucleotide and Protein Phosphorylation Research 19, 29-46.
9. DART, C. & STANDEN, N. B. (1993). Adenosine-activated potassium current in smooth muscle cells isolated from the pig coronary artery. Journal of Physiology 471, 767-786.
10. DEUSSEN, A., MÖSER, G. & SCHRADER, J. (1986). Contribution of coronary endothelial cells to cardiac adenosine production. Pflügers Archiv 406, 608-614.
11. EVONIUK, G., VON BORSTEL, R. W. & WURTMAN, R. J. (1987). Antagonism of the cardiovascular effects of adenosine by caffeine or 8-(p-sulphophenyl)-theophylline. Journal of Pharmacology and Experimental Therapeutics 240, 428-432.
12. 14C]iodoantipyrine method suggests discordance during cerebral blood flow increases. Journal of Cerebral Blood Flow and Metabolism 16, 156-161.
13. HALLER, C. & KUSCHINSKY, W. (1987). Moderate hypoxia: reactivity of pial arteries and local effect of theophylline. Journal of Applied Physiology 63, 2208-2215.
14. HEINERT, G., NYE, P. C. G. & PATERSON, D. J. (1997). Effect of a neuronal nitric oxide synthase blocker on eucapnic, hypoxic and hypercapnic cerebral blood flow in the anaesthetised rat. Journal of Physiology 501.P, 66P.
15. 2 selective adenosine receptor agonist with preferential hypotensive activity. Journal of Pharmacology and Experimental Therapeutics 251, 47-55.
16. KOEHLER, R. C., TRAYSTMAN, R. J. & JONES, M. D. (1986). Influence of reduced oxyhemoglobin affinity on cerebrovascular response to hypoxic hypoxia. American Journal of Physiology 251, H756-763.
17. 2 adenosine receptors: their presence and neuromodulatory role in the central nervous system. General Pharmacology 27, 925-933.
18. LAUDIGNON, N., FARRI, E., BEHARRY, K., REX, J. & ARANDA, J. V. (1990). Influence of adenosine on cerebral blood flow during hypoxic hypoxia in the newborn piglet. Journal of Applied Physiology 68, 1534-1541.
19. 1 adenosine receptors. Naunyn-Schmiedeberg's Archives of Pharmacology 337, 687-689.
20. MCPHEE, A. J. & MAXWELL, G. M. (1987). The effect of theophylline on regional cerebral blood flow responses to hypoxia in newborn piglets. Pediatric Research 21, 573-578.
21. MARSHALL, J. M. & METCALFE, J. D. (1988). Analysis of the cardiovascular changes induced in the rat by graded levels of systemic hypoxia. Journal of Physiology 407, 385-403.
22. MARSHALL, J. M. & METCALFE, J. D. (1990). Effects of systemic hypoxia on the distribution of cardiac output in the rat. Journal of Physiology 426, 335-353.
23. MIAN, R. & MARSHALL, J. M. (1991). The role of adenosine in dilator responses induced in arterioles and venules of rat skeletal muscle by systemic hypoxia. Journal of Physiology 443, 499-511.
24. MIAN, R. & MARSHALL, J. M. (1996). The behaviour of muscle microcirculation in chronically hypoxic rats: the role of adenosine. Journal of Physiology 491, 489-498.
25. MORII, S., NGAI, A. C., Ko, K. & WINN, H. R. (1987). Role of adenosine in regulation of cerebral blood flow: effects of theophylline during normoxia and hypoxia. American Journal of Physiology 253, H165-175.
26. MORII, S., NGAI, A. C. & WINN, H. R. (1986). Reactivity of rat pial arterioles and venules to adenosine and carbon dioxide: with detailed description of the closed cranial window technique in rats. Journal of Cerebral Blood Flow and Metabolism 6, 34-41.
27. NEES, S. & GERLACH, E (1983). Adenosine nucleotide and adenosine metabolism in cultured coronary endothelial cells: formation and release of adenine compounds and possible functional implication. In Regulatory Function of Adenosine, ed. BERNE, R. M., RALL, T. W. & RUBIO, R., pp. 347-360. M. Nijhoff Publishers, Amsterdam.
28. OLSSON, R. A. & PEARSON, J. D. (1990). Cardiovascular purinoceptors. Physiological Reviews 70, 761-845.
29. PARDRIDGE, W. M., YOSHIKAWA, T., KANG, Y.-.S. & MILLER, L. P. (1994). Blood-brain barrier transport and brain metabolism of adenosine and adenosine analogs. Journal of Pharmacology and Experimental Therapeutics 268, 14-18.
30. PONTE, J. & PURVES, M. J. (1974). The role of the carotid body chemo-receptors and carotid sinus baroreceptors in the control of cerebral blood vessels. Journal of Physiology 237, 315-340.
31. 2A selective adenosine receptor antagonist. British Journal of Pharmacology 115, 1096-1102.
32. REID, J. M., DAVIES, A. G., ASHCROFT, F. M. & PATERSON, D. J. (1995) Effect of L-NMMA, cromakalim and glibenclamide on cerebral blood flow in hypercapnia and hypoxia. American Journal of Physiology 269, H916-922.
33. SIMPSON, R. E. & PHILLIS, J. W. (1991). Adenosine deaminase reduces hypoxic and hypercapnic dilatation of rat pial arterioles: evidence for mediation by adenosine. Brain Research 553, 305-308.
34. SKARPHEDINSSON, J. O., HARDING, H. &THORéN, P. (1988). Repeated measurements of cerebral blood flow in rats. Comparisons between the hydrogen clearance method and laser Doppler flowmetry. Acta Physiologica Scandinavica 134, 133-142.
35. SKINNEK, M. R. & MARSHALL, J. M. (1996). Studies on the roles of ATP, adenosine and nitric oxide in mediating muscle vasodilatation induced in the rat by acute systemic hypoxia. Journal of Physiology 495, 553-560.
36. SMELLIE, F. W., DAVIS, C. W., DALY, J. W. & WELLS, J. N. (1979). Alkylxanthine: inhibition of adenosine-elicited accumulation of cyclic AMP in brain slices and of brain phosphodiesterase activity. Life Sciences 24, 2475-2482.
37. +) and nitric oxide synthesis in human fetal endothelial cells. Journal of Physiology 499, 135-140.
38. THOMAS, T. & MARSHALL, J. M. (1994). Interdependence of respiratory and cardiovascular changes induced by systemic hypoxia in the rat: the roles of adenosine. Journal of Physiology 480, 627-636.
39. VAN WYLEN, D. G. L., PARK, T. S., RUBIO, R, & BERNE, R. M. (1989). The effect of local infusion of adenosine and adenosine analogues on local cerebral blood flow. Journal of Cerebral Blood Flow 9, 556-562.
40. WINN, H. R., RUBIO, R. & BERNE, R. M. (1981). Brain adenosine concentration during hypoxia in rats. American Journal of Physiology 241, H235-242.