A(2A)-adenosine receptor reserve for coronary vasodilation

Circulation

Volumn 98, Issue 7, 1998, Pages 711-718

  Shryock, John C ^a   Snowdy, Stephen ^a   Baraldi, Pier Giovanni ^c   Cacciari, Barbara ^c   Spalluto, Giampiero ^c   Monopoli, Angela ^d   Ongini, Ennio ^d   Baker, Stephen P ^b   Belardinelli, Luiz ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF FERRARA   (Italy)

^d San Raffaele Science Park   (Italy)

Author keywords

Adenosine; Circulation; Pharmacology; Receptors; Vasodilation

Indexed keywords

2 CHLORO 6 N CYCLOPENTYLADENOSINE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; ADENOSINE; ADENOSINE A2A RECEPTOR; RECEPTOR RESERVE; 2 CHLORO N(6)CYCLOPENTYLADENOSINE; 2-CHLORO-N(6)CYCLOPENTYLADENOSINE; ADENOSINE RECEPTOR; DRUG DERIVATIVE; FSPTP PYRIMIDINE; PHENETHYLAMINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TRIAZINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CIRCULATION; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DILATATION; DRUG RECEPTOR BINDING; GUINEA PIG; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; FEMALE; HEART; IN VITRO STUDY; KINETICS; MALE; PHYSIOLOGY; SYNTHESIS; VASODILATATION;

ADENOSINE; ANIMALS; CORONARY CIRCULATION; FEMALE; GUINEA PIGS; HEART; KINETICS; MALE; PHENETHYLAMINES; PYRIMIDINES; RECEPTOR, ADENOSINE A2A; RECEPTORS, PURINERGIC P1; TRIAZINES; TRIAZOLES; VASODILATION;

EID: 0032543955     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.98.7.711     Document Type: Article

References (24)

1. Berne RM. Metabolic regulation of blood flow. Circ Res. 1964; 14-15(suppl 1):I-261-I-268.
2. Sollevi A. Cardiovascular effects of adenosine in man: possible clinical implications. Prog Neurobiol. 1986;27:319-349.
3. Olsson RA, Pearson JD. Cardiovascular purinoceptors. Physiol Rev. 1990;70:761-845.
4. Belardinelli L, Shryock JC. Does adenosine function as a retaliatory metabolite in the heart? News Physiol Sci. 1992;7:52-56.
5. Glover DK, Ruiz M, Yang JY, Koplan BA, Allen TR, Smith WH, Watson DD, Barrett RJ, Beller GA. Pharmacological stress thallium scintigraphy with 2-cyclohexylmethylidenehydrazino adenosine (WRC-0470). Circulation. 1996;94:1726-1732.
6. 2A receptor agonist, CGS21680, on blood pressure, cardiac index and arterial conductance in anaesthetized rats. Ear J Pharmacol. 1996;307:163-169.
7. Stepp DW, Van Bibber R, Kroll K, Feigl EO. Quantitative relation between interstitial adenosine concentration and coronary blood flow. Circ Res. 1996;79:601-610.
8. a) receptors. J Pharmacol Exp Ther. 1983;227:316-321.
9. Leung E, Johnston CI, Woodcock EA. An investigation of the receptors involved in the coronary vasodilatory effect of adenosine analogues. Clin Exp Pharmacol Physiol. 1985;12:515-519.
10. 2A adenosine receptor mediates coronary vasodilation. J Pharmacol Exp Ther. 1998;284: 1066-1073.
11. Daly JW, Butts-Lamb P, Padgett W. Subclasses of adenosine receptors in the central nervous system: interaction with caffeine and related methylxanthines. Cell Mol Neurobiol. 1983;3:69-80.
12. Bruns RF, Lu GH, Pugsley TA. Adenosine receptor subtypes: binding studies. In: Gerlach E, Becker BF, eds. Topics and Perspectives in Adenosine Research. Berlin, Germany: Springer-Verlag; 1987:59-73.
13. 2 selective adenosine receptor agonist with preferential hypotensive activity. J Pharmacol Exp Ther. 1989;251:47-55.
14. 2a selective adenosine receptor antagonist. Br J Pharmacol. 1995;115:1096-1102.
15. 3H]SCH58261 to coronary artery membranes. Circ Res. 1996;79:1150-1160.
16. Kenakin T. Pharmacologic Analysis of Drug-Receptor Interaction. 2nd ed. New York, NY: Raven Press; 1993:46-49.
17. Bünger R, Haddy FJ, Querengässer A, Gerlach E. An isolated guinea pig heart preparation with in vivo like features. Pflugers Arch. 1975;353:317-326.
18. Schrader J, Haddy FJ, Gerlach E. Release of adenosine, inosine and hypoxanthine from the isolated guinea pig heart during hypoxia, flow-autoregulation and reactive hyperemia. Pflugers Arch. 1977;369:1-6.
19. Furchgott RF, Bursztyn P. Comparison of dissociation constants and of relative efficacies of selected agonists acting on parasympathetic receptors. Ann N Y Acad Sci. 1967;144:882-899.
20. 1-adenosine receptor reserve for two actions of adenosine on guinea pig atrial myocytes. Mol Pharmacol. 1997;52:683-691.
21. 2a adenosine receptor antagonist. J Pharmacol Exp Ther. 1996;276:398-404.
22. 2A adenosine receptor antagonist, to rat striatal membranes. Br J Pharmacol. 1996;117: 1381-1386.
23. King AD, Milavec-Krizman M, Müller-Schweinitzer E. Characterization of the adenosine receptor in porcine coronary arteries. Br J Pharmacol. 1990;100:483-486.
24. Kroll K, Deussen A, Sweet IR. Comprehensive model of transport and metabolism of adenosine and S-adenosylhomocysteine in the guinea pig heart. Circ Res. 1992;71:590-604.