Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat

British Journal of Pharmacology

Volumn 133, Issue 6, 2001, Pages 825-832

  Standford, Salome J ^a   Gitlin, Jonathan M ^a   Mitchell, Jane A ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Anandamide; ATP; Cannabinoid; EDHF; Nitric oxide; Rat isolated mesenteric bed

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 9 (TETRAHYDRO 2 FURYL)ADENINE; ADENOSINE TRIPHOSPHATE; ANANDAMIDE; CANNABINOID RECEPTOR ANTAGONIST; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; GUANYLATE CYCLASE INHIBITOR; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; POTASSIUM CHLORIDE; RIMONABANT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG SELECTIVITY; ISOLATED ARTERY; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM; VASODILATATION;

ADENINE; ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; ARACHIDONIC ACIDS; CAPSAICIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GUANYLATE CYCLASE; HISTAMINE; MALE; MESENTERIC ARTERIES; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; OXADIAZOLES; PIPERIDINES; POLYUNSATURATED ALKAMIDES; POTASSIUM CHLORIDE; PYRAZOLES; PYRILAMINE; QUINOXALINES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; STEREOISOMERISM; THEOPHYLLINE; VASODILATION;

EID: 0034881494     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704139     Document Type: Article

References (32)

1. Nitric oxide attenuates the release of endothelium-derived hyperpolarising factor
2. Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction
3. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarising factors
4. Cannabinoid CB1 receptor and endothelium-dependent hyperpolarisation in guinea-pig carotid, rat mesenteric and porcine coronary arteries
5. The endothelial component of cannabinoid-induced relaxation in rabbit mesenteric artery depends on gap junctional communication
6. 2-purinoceptor subtypes on the smooth muscle and endothelium of rabbit coronary artery
7. + is an endothelium-derived hyperpolarising factor in rat arteries
8. Differential reactivity of isolated mast cells from the rat and guinea pig
9. Antatagonism of the cardiovascular effects of adenosine by caffeine or 8-(p-sulfophenyl)theophylline
10. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors
11. Release of calcitonin gene-related peptide (CGRP) from capsaicin sensitive vasodilator nerves in the rat mesenteric bed
12. Histamine receptors in mesenteric circulation of the cat and rat
13. Characterisation of cannabinoid receptors coupled to vasorelaxation by endothelium-derived hyperpolarising factor
14. Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact human platelets. Evidence for the unidirectional control of platelet function by cyclic AMP
15. Nitric oxide-independent relaxations to acetylcholine and A23187 involve different routes of heterocellular communication
16. Calcitonin gene-related peptide acts as a novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat
17. Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists
18. Endothelial P2y receptors induce hyperpolarisation of vascular smooth muscle by release of endothelial-derived hyperpolarising factor
19. Nitric oxide is the mediator of ATP-induced dilatation of the rabbit hepatic arterial vascular bed
20. Characterisation and modulation of EDHF-mediated relaxations in the rat isolated superior mesenteric arterial bed
21. Cardiovascular purinoceptors
22. Vascular endothelial and smooth muscle cells in culture selectively release adenine nucleotides
23. Evidence that anandamide and EDHF act via different mechanisms in rat isolated mesenteric arteries
24. Mechanism of prolonged vasorelaxation to ATP in the rat isolated mesenteric bed
25. 2-purinoceptor subtypes in the isolated perfused mesenteric bed of the rat
26. An endogenous cannabinoid as an endothelium-derived vasorelaxant
27. Comparative pharmacology of endothelium-derived hyperpolarising factor and anandamide in the rat isolated mesentery
28. Contribution of P1- (A2b subtype) and P2-purinoceptors to the control of vascular tone in the rat isolated mesenteric arterial bed
29. ATP-induced vasodilatation in the rat mesenteric bed exhibits two apparent phases
30. The dilator response to sensory nerve stimulation in the mesenteric circulation of the rat is modulated prejunctionally by nitric oxide
31. A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery
32. Purinergic axis in cardiac blood vessels: Agonist mediated release of ATP from cardiac endothelial cells