P-450 epoxygenase and NO synthase inhibitors reduce cerebral blood flow response to N-methyl-D-aspartate

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 279, Issue 4 48-4, 2000, Pages

  Bhardwaj, Anish ^a   Northington, Frances J ^a   Carhuapoma, Juan R ^a   Falck, John R ^b   Harder, David R ^c   Traystman, Richard J ^a   Koehler, Raymond C ^a,d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Arachidonic acid; Epoxyeicosatrienoic acid; Glia; Miconazole; Microdialysis; Nitric oxide; Rat

Indexed keywords

ARACHIDONIC ACID; CITRULLINE; CYTOCHROME P450; CYTOCHROME P450 INHIBITOR; DIZOCILPINE; EPOXIDE; GLUTAMIC ACID; ICOSATRIENOIC ACID; MICONAZOLE; N METHYL DEXTRO ASPARTIC ACID; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; OXYGENASE;

ARTICLE; BRAIN BLOOD FLOW; CONTROLLED STUDY; ENZYME INHIBITION; GLIA; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR SMOOTH MUSCLE; VASODILATATION;

EID: 0033695239     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2000.279.4.h1616     Document Type: Article

References (54)

1. Inhibition of brain P- 450 arachidonic acid epoxygenase decreases baseline cerebral blood flow
2. Role of P- 450 arachidonic acid expoygenase in the response of cerebral blood flow to glutamate in rats
3. Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes
4. Contribution of 20-HETE to vasodilator actions of nitric oxide in the cerebral microcirculation
5. Metabolism of arachidonic acid to epoxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and prostaglandins in cultured rat hippocampal astrocytes
6. Brain synthesis and cerebrovascular action of epoxygenase metabolites of arachidonic acid
7. Absence of N-methyl-D-aspartate receptors on ovine cerebral microvessels
8. Characterization of ionotropic glutamate receptor-mediated nitric oxide production in vivo in rats
9. Adenosine modulates N-methyl-D-aspartate-stimulated hippocampal nitric oxide production in vivo
10. Characterization of metabotropic glutamate receptor-mediated nitric oxide production in vivo
11. 1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine modulates basal and N-methyl-D-aspartate-evoked nitric oxide production in vivo
12. Nitric oxide mediates glutamatelinked enhancement of cGMP levels in the cerebellum
13. ATP-evoked arachidonic acid mobilization in astrocytes is via a P(2Y)-purinergic receptor
14. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors
15. Cytoskeletal assembly and ATP release regulate astrocytic calcium signaling
16. Coupling of cerebral blood flow to neuronal activation: Role of adenosine and nitric oxide
17. Inhibition of endothelial nitric oxide synthase by cytochrome P-450 reductase inhibitors
18. Quantitative examination of tissue concentration profiles associated with microdialysis
19. Dilation of cerebral arterioles by cytochrome P-450 metabolites of arachidonic acid
20. Nitric oxide mediates vasodilation in response to activation of N-methyl-D-aspartate receptors in brain
21. Cytochrome P-450 2C is an EDHF synthase in coronary arteries
22. 2+ current
23. Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle
24. Functional hyperemia in the brain: Hypothesis for astrocyte-derived vasodilator metabolites
25. Glutamate receptor agonists stimulate diverse calcium responses in different types of cultured rat cortical glial cells
26. Importance of nitric oxide synthase inhibition to the attenuated vascular responses induced by topical L-nitroarginine during vibrissal stimulation
27. Cytochrome P-450 in rat astrocytes in vivo and in vitro: Intracellular localization and induction by phenytoin
28. 2+ stores in HL-60 cells: Evidence that a cytochrome P-450 is not involved
29. Immuno-histochemical localization of cytochrome P-450 in the rat brain
30. Newborn piglet cerebral microvascular responses to epoxyeicosatrienoic acids
31. Mechanisms of hypoxia-induced cerebrovascular dilation in the newborn pig
32. 2+ transport pathways in thymic lymphocytes by econazole, miconazole, and SKF-96365
33. Nitric oxide causes glutamate release from brain synaptosomes
34. Glutamate-induced cerebral vasodilation is mediated by nitric oxide through N-methyl-D-aspartate receptors
35. Role of NO production in NMDA receptor-mediated neurotransmitter release in cerebral cortex
36. Evidence that functional glutamate receptors are not expressed on rat or human cerebromicrovascular endothelial cells
37. In vivo production of nitric oxide correlates with NMDA-induced cerebral hyperemia in newborn sheep
38. Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcircualtion
39. NO synthase inhibition modulates NMDA-induced changes in cerebral blood flow and EEG activity
40. 2+](i) in hippocampal astrocytes in situ
41. Responses of Bergmann glia and granule neurons in situ to N-methyl-D-aspartate, norepinephrine, and high potassium
42. News on glutamate receptors in glial cells
43. Glutamate-evoked release of arachidonic acid from mouse brain astrocytes
44. + channel activity and vascular tone in renal arterioles
45. Age-related changes in the NMDA receptor/nitric oxide/cGMP pathway in the hippocampus and cerebellum of freely moving rats subjected to transcerebral microdialysis
46. The effect of local infusion of adenosine and adenosine analogs on local cerebral blood flow
47. Evidence against the involvement of cytochrome P-450 metabolites in endothelium-dependent hyperpolarization of the rat main mesenteric artery
48. Calcium signaling in glial cells
49. Cytochrome P-450-derived arachidonic acid metabolism in the rat kidney: Characterization of selective inhibitors
50. 2 consumption and blood flow in rat
51. The dual mode of inhibition of calmodulin-dependent nitric-oxide synthase by antifungal imidazole agents
52. N-methyl-D-aspartate releases excitatory amino acids in rat corpus striatum in vivo
53. 2 clearance measurement of blood flow: A review of technique and polarographic principles
54. Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P-450 fatty acid omega-hydroxylase, on renal function in rats