Cathepsin B knockout mice are resistant to tumor necrosis factor-α-mediated hepatocyte apoptosis and liver injury: Implications for therapeutic applications

American Journal of Pathology

Volumn 159, Issue 6, 2001, Pages 2045-2054

  Guicciardi, M E ^a   Miyoshi, H ^a   Bronk, S F ^a   Gores, G J ^a  

^a MAYO CLINIC COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (PROPYLCARBAMOYL)OXIRANE 2 CARBONYLISOLEUCYLPROLINE; CA 074 ME; CASPASE 3; CASPASE 9; CATHEPSIN B; CYSTEINE PROTEINASE INHIBITOR; CYTOCHROME C; I KAPPA B; PROLINE DERIVATIVE; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RELEASE; IN VIVO STUDY; KNOCKOUT MOUSE; LIVER CELL; LIVER INJURY; LIVER MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEINASE INHIBITION; REPRESSOR GENE; SIGNAL TRANSDUCTION;

EID: 0035180207     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63056-8     Document Type: Article

References (41)

1. Tumor necrosis factor receptor and Fas signaling mechanisms
2. Mechanisms of hepatic toxicity. I. TNF-induced liver injury
3. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis
4. Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat
5. Induction of tumor necrosis factor alpha production by human hepatocytes in chronic viral hepatitis
6. Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins
7. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
8. Cytokine-mediated hepatic apoptosis
9. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor
10. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death
11. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release
12. Functions of ceramide in coordinating cellular responses to stress
13. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
14. Caspase structure, proteolytic substrates, and function during apoptotic cell death
15. Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis
16. Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
17. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor
18. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration
19. Suppression of TNF-alpha-induced apoptosis by NF-kappaB
20. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
21. The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade
22. Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas
23. NF-kB is activated in cholestasis and function to reduce liver injury
24. In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system
25. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
26. Characterization of caspase processing and activation in HL-60 cell cytosol under cell-free conditions
27. Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes
28. Cystatin A expression reduces bile salt-induced apoptosis in a rat hepatoma cell line
29. Differential suppression by protease inhibitors and cytokines of apoptosis induced by wild-type p53 and cytotoxic agents
30. Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity
31. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
32. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
33. Lysosomal protease pathways to apoptosis: Cleavage of bid, not Pro-caspases, is the most likely route
34. Cathepsin B, cathepsin H, and cathepsin L
35. Lysosomal heterogeneity between and within cells with respect to resistance against oxidative stress
36. Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress
37. Alpha-tocopheryl succinate-induced apoptosis in Jurkat T cells involves caspase-3 activation, and both lysosomal and mitochondrial destabilisation
38. Involvement of caspase-like proteinases in apoptosis of neuronal PC 12 cells and primary cultured microglia induced by 6-hydroxydopamine
39. Cathepsin B-mediated activation of the proinflammatory caspase-11
40. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock
41. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE