NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells

European Journal of Immunology

Volumn 29, Issue 5, 1999, Pages 1656-1666

  Sivori, Simona ^a   Pende, Daniela ^b   Bottino, Cristina ^b   Marcenaro, Emanuela ^a   Pessino, Anna ^a,b   Biassoni, Roberto ^b   Moretta, Lorenzo ^a,b   Moretta, Alessandro ^a,c  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c Sezione di Istologia   (Italy)

Author keywords

Activating receptor; Natural cytotoxicity; NK cell

Indexed keywords

HLA ANTIGEN CLASS 1; LYMPHOCYTE RECEPTOR; MONOCLONAL ANTIBODY;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; HUMAN; HUMAN CELL; LYMPHOCYTE CLONE; NATURAL KILLER CELL; PHENOTYPE; PRIORITY JOURNAL; TUMOR CELL; XENOGRAFT;

CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; KILLER CELLS, NATURAL; RECEPTORS, IMMUNOLOGIC;

EID: 0032945045     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199905)29:05<1656::AID-IMMU1656>3.0.CO;2-1     Document Type: Article

References (21)

1. Moretta, A., Biassoni, R., Bottino, C., Pende, D., Vitale, M., Poggi, A., Mingari, M. C. and Moretta, L., Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes. Immunol. Rev. 1997. 155: 105-117.
2. Lanier, L. L., NK cell receptors. Annu. Rev. Immunol. 1998. 16: 359-393.
3. Garrido, F., Ruiz-Cabello, F., Cabrera, T., Pérez-Villar, J. J., Lòpez-Botet, M., Duggan-Keen, M. and Stern, P. L., Implications for immunosurveillance of altered HLA class I phenotypes in human tumours, Immunol. Today 1997. 18: 89-95.
4. Trinchieri, G., Biology of natural killer cells. Adv. Immunol. 1989. 47: 187-376.
5. Ljunggren, H.-G. and Kärre, K., In search of the "missing self". MHC molecules and NK cell recognition. Immunol. Today 1990. 11: 237-244.
6. Moretta, A., Bottino, C., Vitale, M., Pende, D., Biassoni, R., Mingari, M. C. and Moretta, L., Receptors for HLA-class I-molecules in human natural killer cells. Annu. Rev. Immunol. 1996. 14: 619-648.
7. Ciccone, E., Pende, D., Vitale, M., Nanni, L., Di Donato, C., Bottino, C., Morelli, L., Viale, O., Amoroso, A., Moretta, A. and Moretta, L., Self Class I molecules protect normal cells from lysis mediated by autologous natural killer Cells. Eur. J. Immunol. 1994. 24: 1003-1006.
8. Hoglund, P., Sundback, J., Olsson-Alheim, M. Y., Johansson, M., Salcedo, M., Ohlén, C., Ljunggren, H. G., Sentman, C. L. and Kärre, K., Host MHC class I gene control of NK cell specificity in the mouse, Immunol. Rev. 1997. 155: 11-28.
9. Sivori, S., Vitale, M., Morelli, L., Sanseverino, L., Augugliaro, R., Bottino, C., Moretta, L. and Moretta, A., p46, a novel natural killer cell-specific surface molecule which mediates cell activation. J. Exp. Med. 1997. 186: 1129-1136.
10. Pessino, A., Sivori, S., Bottino, C., Malaspina, A., Morelli, L., Moretta, L., Biassoni, R. and Moretta, A., Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. J. Exp. Med. 1998. 188: 953-960.
11. Vitale, M., Bottino, C., Sivori, S., Sanseverino, L., Castriconi, R., Marcenaro, R., Augugliaro, R., Moretta, L. and Moretta, A., NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells is involved in non-MHC restricted tumor cell lysis. J. Exp. Med. 1998. 187: 2065-2072.
12. Moretta, A., Bottino, C., Millo, R. and Biassoni, R., HLA-specific and non HLA-specific human NK receptors. Curr. Top. Microbiol. Immunol. 1999, in press.
13. Biassoni, R., Pessino, A., Bottino, C., Pende, D., Moretta, L. and Moretta, A., The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity. Eur. J. Immunol. 1999. 29: 1014-1020.
14. Vitale, M., Sivori, S., Pende, D., Moretta, L. and Moretta, A., Coexpression of two functionally indipendent p58 inhibitory receptors in human NK cell clones results in the inability to kill normal allogeneic target cells. Proc. Natl. Acad. Sci. USA 1995. 95: 3536-3540.
15. + NK cells by the expression of clonally distributed functional surface molecules. Correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition. J. Exp. Med. 1990. 172: 1589-1598.
16. Sivori, S., Vitale, M., Bottino, C., Marcenaro, E., Sanseverino, L., Parolini, S., Moretta, L. and Moretta, A., CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles: identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies. Eur. J. Immunol. 1996. 26: 2487-2492.
17. Ikeda, H., Lethé, B., Lehmann, F., Van Baren, N., Baurain, J. E., De Smet, C., Chambost, H., Vitale, M., Moretta, A., Boon, T. and Coulie, P. G., Characterization of an antigen that is recognized on a melanoma showing partial HLA-loss by CTL expressing an inhibitory receptor. Immunity 1997. 6: 199-208.
18. Pende, D., Accame, L., Pareti, L., Mazzocchi, A., Moretta, A., Parmiani, G. and Moretta, L., The susceptibility to natural killer cell-mediated lysis of HLA class I-positive melanomas reflects the expression of insufficient amounts of HLA class I alleles. Eur. J. Immunol. 1998. 28: 2384-2394.
19. Moretta, A., Vitale, M., Sivori, S., Bottino, C., Morelli, L., Augugliaro, R., Barbaresi, M., Pende, D., Ciccone, E., Lopez-Botet, M. and Moretta, L., Human NK receptors for HLA-class I molecules. Evidence that the KP43 (CD94) molecule functions as receptor for HLA-B alleles. J. Exp. Med. 1994. 180: 545-555.
20. Chelly, J., Kaplan, J.-C., Maire, P., Gautron, S. and Kahn, A., Transcription of the dystrophin gene in human muscle and non muscle tissues. Nature 1998. 333: 858-860.
21. Pessino, A., Sparatore, B., Patrone, M., Passalacqua, M., Melloni, E. and Pontremoli, S., Differential expression of protein kinase C isoform genes in three murine erythroleukemia cell variants: implication for chemical induced differentiation. Biochem. Biophys. Res. Commun. 1994. 204: 461-467.