Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity

Journal of Experimental Medicine

Volumn 197, Issue 11, 2003, Pages 1427-1439

  Dunn, Claire ^a   Chalupny, N Jan ^b   Sutherland, Claire L ^b   Dosch, Stephanie ^b   Sivakumar, P V ^b,c   Johnson, David C ^a   Cosman, David ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b AMGEN INC   (United States)

^c ZYMOGENETICS INC   (United States)

Author keywords

HCMV; MIC; NKG2D; UL16; ULBP

Indexed keywords

LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NATURAL KILLER CELL RECEPTOR NKG2D; PROTEIN; PROTEIN MIC; PROTEIN MICB; PROTEIN UL16; PROTEIN ULBP1; PROTEIN ULBP2; RECEPTOR PROTEIN; ULBP PROTEIN; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CELL ACTIVATION; CELL TRANSFORMATION; CONTROLLED STUDY; DOWN REGULATION; EFFECTOR CELL; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IMMUNE EVASION; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; INFECTION; LIGAND BINDING; MOUSE; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; STRESS; TARGET CELL;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CELL LINE; CELL MEMBRANE; CROSS REACTIONS; CYTOMEGALOVIRUS; CYTOTOXICITY, IMMUNOLOGIC; DOWN-REGULATION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; KILLER CELLS, NATURAL; LIGANDS; MEMBRANE GLYCOPROTEINS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, IMMUNOLOGIC; VIRAL PROTEINS;

EID: 0037905745     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20022059     Document Type: Article

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