The impaired NK cell cytolytic function in viremic HIV-1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44)

European Journal of Immunology

Volumn 33, Issue 9, 2003, Pages 2410-2418

  De Maria, Andrea ^a   Fogli, Manuela ^a   Costa, Paola ^a   Murdaca, Giuseppe ^a   Puppo, Francesco ^a   Mavilio, Domenico ^a   Moretta, Alessandro ^a,b   Moretta, Lorenzo ^a,b,c  

^a UNIVERSITY OF GENOA   (Italy)

^b Ctr di Eccellenza Ricerche Biomed   (Italy)

^c G GASLINI INSTITUTE   (Italy)

Author keywords

ART; HIV 1; Natural cytotoxicity receptor; NK cell

Indexed keywords

LYMPHOCYTE MEMBRANE RECEPTOR; PROTEIN P44;

ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CYTOLYSIS; DONOR; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; LYMPHOCYTE CLONE; LYMPHOCYTE FUNCTION; MALE; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; RECEPTOR DENSITY; REGULATORY MECHANISM; T LYMPHOCYTE SUBPOPULATION; TARGET CELL; VIREMIA;

DOWN-REGULATION; HIV INFECTIONS; HIV-1; HUMANS; KILLER CELLS, NATURAL; RECEPTORS, IMMUNOLOGIC;

EID: 0141650530     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324141     Document Type: Article

References (38)

1. Rosenberg, Z. F. and Fauci, A. S., Immunopathogenesis of HIV infection. FASEB J. 1991. 5: 2382-2390.
2. Brenner, B. G., Gryllis, C., Gornitsky, M. and Wainberg, M. A., Changes in natural immunity during the course of HIV-1 infection. Clin. Exp. Immunol. 1993. 93: 142-148.
3. Ratcliffe, L. T., Lukey, P. T., MacKenzie, C. R. and Ress, S. R., Reduced NK activity correlates with active disease in HIV-patients with multidrug-resistant pulmonary tuberculosis. Clin. Exp. Immunol. 1994. 97: 373-379.
4. Ullum, H., Cozzi Lepri, A., Aladdin, H., Katzenstein, T., Victor, J., Phillips, A. N., Gerstoft, J., Skinhoj, P. and Klarlund Pedersen, B., Natural immunity and HIV disease progression. AIDS 1999. 13: 557-563.
5. - subset. AIDS Res. Hum. Retroviruses 1990. 6: 1451-1457.
6. Sirianni, M. C., Vincenzi, L., Topino, S., Giovannetti, A., Mazzetta, F., Libi, F., Scaramuzzi, D., Andreoni, M., Pinter, E., Baccarini, S., Rezza, G., Monini, P. and Ensoli, B., NK cell activity controls human herpesvirus 8 latent infection and is restored upon highly active antiretroviral therapy in AIDS patients with regressing Kaposi's sarcoma. Eur. J. Immunol. 2002. 32: 2711-2720.
7. - cells with low lytic activity. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1995. 10: 331-340.
8. Cai, Q., Huang, X. L., Rappocciolo, G. and Rinaldo, C. R. Jr., Natural killer cell responses in homosexual men with early HIV infection. J. Acquir. Immune Defic. Syndr. 1990. 3: 669-676.
9. Sirianni, M. C., Mezzaroma, I., Aiuti, F. and Moretta, A., Analysis of the cytolytic activity mediated by natural killer cells from acquired immunodeficiency syndrome patients in response to phytohemagglutinin or anti-CD16 monoclonal antibody. Eur. J. Immunol. 1994. 24: 1874-1878.
10. Scott-Algara, D., Vuillier, F., Cayota, A. and Dighiero, G., Natural killer (NK) cell activity during HIV infection: a decrease in NK activity is observed at the clonal level and is not restored after in vitro long-term culture of NK cells. Clin. Exp. Immunol. 1992. 90: 181-187.
11. Bonavida, B., Katz, J. and Gottlieb, M., Mechanism of defective NK cell activity in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. I. Defective trigger on NK cells for NKCF production by target cells, and partial restoration by IL 2. J. Immunol. 1986. 137: 1157-1163.
12. Katz, J. D., Mitsuyasu, R., Gottlieb, M. S., Lebow, L. T. and Bonavida, B., Mechanism of defective NK cell activity in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. II. Normal antibody-dependent cellular cytotoxicity (ADCC) mediated by effector cells defective in natural killer (NK) cytotoxicity. J. Immunol. 1987. 139: 55-60.
13. Oliva, A., Kinter, A. L., Vaccarezza, M., Rubbert, A., Catanzaro, A., Moir, S., Monaco, J., Ehler, L., Mizell, S., Jackson, R., Li, Y., Romano, J. W. and Fauci, A. S., Natural killer cells from human immunodeficiency virus (HIV)-infected individuals are an important source of CC-chemokines and suppress HIV-1 entry and replication in vitro. J. Clin. Invest. 1998. 102: 223-231.
14. Ahmad, R., Sindhu, S. T., Tran, P., Toma, E., Morisset, R., Menezes, J. and Ahmad, A., Modulation of expression of the MHC class I-binding natural killer cell receptors, and NK activity in relation to viral load in HIV-infected/AIDS patients. J. Med. Virol. 2001. 65: 431-440.
15. Ullum, H., Gotzsche, P. C., Victor, J., Dickmeiss, E., Skinhoj, P. and Pedersen, B. K., Defective natural immunity: an early manifestation of human immunodeficiency virus infection. J. Exp. Med. 1995. 182: 789-799.
16. Valentin, A., Rosati, M., Patenaude, D. J., Hatzakis, A., Kostrikis, L. G., Lazanas, M., Wyvill, K. M., Yarchoan, R. and Pavlakis, G. N., Persistent HIV-1 infection of natural killer cells in patients receiving highly active antiretroviral therapy. Proc. Natl. Acad. Sci. U S A 2002. 99: 7015-7020.
17. Scott-Algara, D., Vuillier, F., Cayota, A., Rame, V., Guetard, D., Moncany, M. L., Marasescu, M., Dauguet, C. and Dighiero, G., In vitro non-productive infection of purified natural killer cells by the BRU isolate of the human immunodeficiency virus type 1. J. Gen. Virol. 1993. 74: 725-731.
18. Moretta, L., Biassoni, R., Bottino, C., Mingari, M. C. and Moretta, A., Human NK-cell receptors. Immunol. Today 2000. 21: 420-422.
19. Moretta, A., Bottino, C., Vitale, M., Pende, D., Biassoni, R., Mingari, M. C. and Moretta, L., Receptors for HLA class I molecules in human natural killer cells. Annu. Rev. Immunol. 1996. 14: 619-648.
20. Moretta, A., Bottino, C., Vitale, M., Pende, D., Cantoni, C., Mingari, M. C., Biassoni, R. and Moretta, L., Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 2001. 19: 197-223.
21. Biron, C. A., Nguyen, K. B. and Pien, G. C., Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 1999. 17: 189-220.
22. Sivori, S., Pende, D., Bottino, C., Marcenaro, E., Pessino, A., Biassoni, R., Moretta, L. and Moretta, A., NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells. Eur. J. Immunol. 1999. 29: 1656-1666.
23. Pende, D., Parolini, S., Pessino, A., Sivori, S., Augugliaro, R., Morelli, L., Marcenaro, E., Accame, L., Malaspina, A., Biassoni, R., Bottino, C., Moretta, L. and Moretta, A., Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. J. Exp. Med. 1999. 190: 1505-1516.
24. De Maria, A., Biassoni, R., Fogli, M., Rizzi, M., Cantoni, C., Costa, P., Conte, R., Mavilio, D., Ensoli, B., Cafaro, A., Moretta, A. and Moretta, L., Identification, molecular cloning and functional characterization of NKp46 and NKp30 natural cytotoxicity receptors in Macaca fascicularis NK cells. Eur. J. Immunol. 2001. 31: 3546-3556.
25. Costello, R. T., Sivori, S., Marcenaro, E., Lafage-Pochitaloff, A., Mozziconacci, M.-J., Reviron, D., Gastaut, J.-A., Pende, D., Olive, D. and Moretta, A., Defective expression and function of natural killer-triggering receptors in patients with acute myeloid leukemia. Blood 2002. 99: 3661-3667.
26. Ruggeri, L., Capanni, M., Urbani, E., Perruccio, K., Shlomchik, W. D., Tosti, A., Posati, S., Rogaia, D., Frassoni, F., Aversa, F., Martelli, M. F. and Velardi, A., Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 2002. 295: 2097-2100.
27. Asai, O., Longo, D. L. and Tian, Z.G., Suppression of graft-versus-host-disease and amplification of graft-versus-tumor effects by activated natural killer cells after allogeneic bone marrow transplantation. J. Clin. Invest. 1998. 101: 1835-1842.
28. Velardi, A., Ruggeri, L., Moretta, A. and Moretta, L., NK cells: a lesson from mismatched hematopoietic transplantation. Trends Immunol. 2002. 23: 438-444.
29. Nicastri, E., Ercoli, L., Sarmati, L., d'Ettorre, G., Iudicone, P., Massetti, P., Vullo, V. and Andreoni, M., Human immunodeficiency virus-1 specific natural cellular immunity in HIV seronegative subjects with multiple sexual exposures to virus. J. Med. Virol. 2001. 64: 232-237.
30. Ironson, G., Balbin, E., Solomon, G., Fahey, J., Klimas, N., Schneiderman, N. and Fletcher, M. A., Relative preservation of natural killer cell cytotoxicity and number in healthy AIDS patients with low CD4 cell counts. AIDS 2001. 15: 2065-2073.
31. Kottilil, S., Chun, T. W., Moir, S., Liu, S., McLaughlin, M., Hallahan, C. W., Maldarelli, F., Corey, L. and Fauci, S., Innate immunity in human immunodeficiency virus infection: effect of viremia on natural killer cell function, J. Imm. Dis. 2003. 187: 1038-1045.
32. Moore, R. D. and Chaisson, R. E., Natural history of opportunistic disease in an HIV-infected urban clinical cohort. Ann. Intern. Med. 1996. 124: 633-642.
33. Sivori, S., Parolini, S., Falco, M., Marcenaro, E., Biassoni, R., Bottino, C., Moretta, L. and Moretta, A., 2B4 functions as a coreceptor in human NK cell activation. Eur. J. Immunol. 2000. 30: 787-793.
34. Castriconi, R., Cantoni, C., Della Chiesa, M., Vitale, M., Marcenaro, E., Conte, R., Biassoni, R., Bottino, C., Moretta, L. and Moretta, A., Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells. Proc. Natl. Acad. Sci. U S A. 2003. 100: 4120-4125.
35. Poli, G., Kinter, A. L., Justement, J. S., Bressler, P., Kehrl, J. H. and Fauci, A. S., Transforming growth factor beta suppresses human immunodeficiency virus expression and replication in infected cells of the monocyte/macrophage lineage. J. Exp. Med. 1991. 173: 589-597.
36. Reinhold, D., Wrenger, S., Kahne, T. and Ansorge, S., HIV-1 Tat: immunosuppression via TGF-beta1 induction. Immunol. Today 1999. 20: 384-385.
37. Hu, R., Oyaizu, N., Than, S., Kalyanaraman, V. S., Wang, X. P. and Pahwa, S., HIV-1 gp160 induces transforming growth factor-beta production in human PBMC. Clin. Immunol. Immunopathol. 1996. 80: 283-289.
38. Gibellini, D., Zauli, G., Re, M. C., Milani, D., Furlini, G., Caramelli, E., Capitani, S. and La Placa, M., Recombinant human immunodeficiency virus type-1 (HIV-1) Tat protein sequentially up-regulates IL-6 and TGF-beta 1 mRNA expression and protein synthesis in peripheral blood monocytes. Br. J. Haematol. 1994. 88: 261-267.