GNTB-A, a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease

Journal of Experimental Medicine

Volumn 194, Issue 3, 2001, Pages 235-246

  Bottino, C ^a   Falco, M ^a   Parolini, S ^a   Marcenaro, E ^a   Augugliaro, R ^a   Sivori, S ^a   Landi, E ^a   Biassoni, R ^a   Notarangelo, L D ^a   Moretta, L ^a   Moretta, A ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Coreceptors function; Epstein Barr virus; Natural killer cells; Src homology 2 domain containing protein; X linked lymphoproliferative disease

Indexed keywords

GLYCOPROTEIN; PROTEIN NTB A; UNCLASSIFIED DRUG; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; PRIMER DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CELL FUNCTION; CONTROLLED STUDY; CROSS LINKING; EPSTEIN BARR VIRUS; HUMAN; LYMPHOPROLIFERATIVE DISEASE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; T LYMPHOCYTE; ANIMAL; CHEMISTRY; CYTOTOXICITY; GENETICS; IMMUNOLOGY; IN VITRO STUDY; MALE; MUTATION; NUCLEOTIDE SEQUENCE; SRC HOMOLOGY DOMAIN; VIROLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL; B-LYMPHOCYTES; BASE SEQUENCE; CYTOTOXICITY, IMMUNOLOGIC; DNA PRIMERS; HERPESVIRUS 4, HUMAN; HUMANS; KILLER CELLS, NATURAL; LYMPHOPROLIFERATIVE DISORDERS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MUTATION; RECEPTORS, IMMUNOLOGIC; SRC HOMOLOGY DOMAINS;

EID: 0035817326     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.3.235     Document Type: Article

References (48)

1. Receptors for HLA-class I molecules in human natural killer cells
2. NK cell receptors
3. Regulation of immune responses through inhibitory receptors
4. Activating receptors and co-receptors involved in human natural killer cell-mediated cytolysis
5. Implications for immunosurveillance of altered HLA-class I phenotypes in human tumours
6. p46, a novel natural killer cell-specific surface molecule which mediates cell activation
7. Molecular cloning of NKp46: A novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity
8. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells
9. NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells is involved in non-MHC restricted tumor cell lysis
10. NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily
11. Natural cytotoxicity Receptors that trigger human NK-mediated cytolysis
12. NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human natural killer cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells
13. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells
14. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
15. Role of NKG2D in tumor cell lysis mediated by human NK cells: Cooperation with natural cytotoxicity receptors and capability of recognizing tumors of non epithelial origin
16. An activating immunoreceptor complex formed by NKG2D and DAP10
17. KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties
18. Novel surface molecules involved in human NK cell activation and triggering of the lytic machinery
19. Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes
20. A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells
21. Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48
22. Activating interactions in human NK cell recognition: The role of 2B4-CD48
23. 2B4 functions as a co-receptor in human natural killer cell activation
24. The CD2-subset of the Ig superfamily of cell surface molecule: Receptor-ligand pairs expressed by NK cells and other immune cells
25. Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4
26. Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells
27. Human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP
28. X-linked lymphoproliferative disease: 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of NK cells to kill EBV-infected cells
29. Analysis of the molecular mechanism involved in 2B4-mediated NK cell activation: Evidence that human 2B4 is physically and functionally associated with the linker for activation of T cells (LAT)
30. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM
31. Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity
32. Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome
33. Fatal infectious mononucleosis in familial lymphohistiocytosis
34. X-linked lymphoproliferative disease: Twenty-five years after the discovery
35. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome
36. Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene
37. CD3-negative lymphokine-activated cytotoxic cells express the CD3 epsilon-gene
38. The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity
39. Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human natural killer cells
40. CD84 leukocyte antigen is a new member of the Ig superfamily
41. X-linked lymphoproliferative disease: Progressive immunodeficiency
42. Signaling lymphocytic activation molecule (CDw150) is homophilic but self-associates with very low affinity
43. The structure and ligand interactions of CD2: Implications for T-cell function
44. Down-regulation of Class I HLA antigens and of the Epstein-Barr virus (EBV)-encoded latent membrane protein (LMP) in Burkitt lymphoma lines
45. Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10
46. Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein-Barr virus latent membrane protein-1: Coordinate up-regulation of peptide transporters and HLA-class I antigen expression
47. Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction
48. Signaling pathways engaged by NK cell receptors: Double concerto for activating receptors, inhibitory receptors and NK cells