Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis

Annual Review of Immunology

Volumn 19, Issue , 2001, Pages 197-223

  Moretta, A ^a   Bottino, C ^a   Vitale, M ^a   Pende, D ^a   Cantoni, C ^a   Cristina, M ^a   Biassoni, R ^a   Moretta, L ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

2B4; Natural cytotoxicity; NKG2D; X linked lymphoproliferative disease

Indexed keywords

CD48 ANTIGEN; CELL RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NATURAL CYTOTOXICITY RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; CELL FUNCTION; CELL MEDIATED CYTOTOXICITY; CYTOLYSIS; EPITHELIUM TUMOR; EPSTEIN BARR VIRUS; IMMUNE DEFICIENCY; LEUKEMIA CELL LINE; LYMPHOPROLIFERATIVE DISEASE; MOLECULAR CLONING; MOLECULAR DYNAMICS; MOUSE; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR DENSITY; REVIEW; X CHROMOSOME LINKED DISORDER;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; CARRIER PROTEINS; CLONING, MOLECULAR; CYTOTOXICITY, IMMUNOLOGIC; EPSTEIN-BARR VIRUS INFECTIONS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KILLER CELLS, NATURAL; LYMPHOPROLIFERATIVE DISORDERS; MEMBRANE GLYCOPROTEINS; MICE; MULTIGENE FAMILY; NEOPLASMS; NEOPLASMS, EXPERIMENTAL; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

EID: 0035059950     PISSN: 07320582     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.immunol.19.1.197     Document Type: Review

References (127)

1. Receptors for HLA-class I molecules in human natural killer cells
2. NK cell receptors
3. Regulation of immune responses through inhibitory receptors
4. Inhibitory pathways triggered by ITIM-containing receptors
5. Signaling pathways engaged by NK cell receptors: Double concerto for activating receptors, inhibitory receptors and NK cells
6. p40, a novel surface molecule involved in the regulation of the non-MHC restricted cytolytic activity in humans
7. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes
8. Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human natural killer cells
9. Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family which functions as an inhibitory receptor in human natural killer cells
10. + T lymphocyte subsets that express HLA class I-specific inhibitory receptors represent oligoclonally or monoclonally expanded cell populations
11. Regulation of KIR expression in human T lymphocytes. A safety mechanism which may impair protective T cell responses
12. Implications for immunosurveillance of altered HLA-class I phenotypes in human tumours
13. MHC molecules in normal and neoplastic cells
14. Viral strategies of immune evasion
15. Activation and function of natural killer cell responses during viral infections
16. Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10
17. The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
18. In search of the "missing self". MHC molecules and NK cell recognition
19. Major histocompability complex class I-specific receptors on human natural killer and T lymphocytes
20. Allorecognition by NK cells: Nonself or no self?
21. RAG2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
22. RAG-1-deficient mice have no mature B and T lymphocytes
23. Self Class I molecules protect normal cells from lysis mediated by autologous natural killer cells
24. Reconstituted killer-cell-inhibitory receptors for MHC class I molecules control mast cell activation induced via immunoreceptor tyrosine-based activation motifs
25. Natural cytotoxicity receptors that trigger human NK-mediated cytolysis
26. Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein
27. Induction and blocking of cytolysis in CD2+, CD3- NK and CD2+, CD3+ cytotoxic T lymphocytes via CD2 50 kD sheep erythrocyte receptor
28. Arousal and inhibition of human NK cells
29. DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes
30. The human natural cytotoxicity receptors (NCR) that induce HLA class I-independent NK cell triggering
31. p46, a novel natural killer cell-specific surface molecule which mediates cell activation
32. Molecular cloning of NKp46: A novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity
33. Antigen receptor tail clue
34. New nomenclature for the Reth motif
35. Family of disulphidelinked dimers containing the zeta and eta chains of the T-cell receptor and the gamma chain of Fc receptors
36. Co-association of CD3 zeta with a receptor (CD16) for IgG Fc on human natural killer cells
37. Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain
38. Fc receptor biology
39. Fc receptors
40. Interaction between lck and syk family tyrosine kinases in Fc gamma receptor-initiated activation of natural killer cells
41. lck with Fc gamma RIIIA (CD16) in natural killer cells
42. Functional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicity
43. Triggering of human natural killer cells through CD16 induces tyrosine phosphorylation of the p72syk kinase
44. lck protein tyrosine kinase with the Fc gamma RIIIA/CD 16 complex in human natural killer cells
45. Plasticity in the organization and sequences of human KIR/ILT gene families
46. The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity
47. Identification of the rat homologue of the human NKp46 triggering receptor
48. Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice
49. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells
50. A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC
51. NKp44, a novel triggering surface molecule specifically expressed by activated Natural Killer cells is involved in non-MHC restricted tumor cell lysis
52. Phenotypic and functional characterization of recombinant interleukin-2 (rIL-2)-induced killer cells: Analysis at the population and the clonal level
53. Cancer immunotherapy-2 and interleukin-2-activated lymphocytes
54. NKp44, a triggering receptor involved in tumor cell lysis by activated human Natural Killer cells, is a novel member of the immunoglobulin superfamily
55. Human killer cell activatory receptors for MHC class I molecules are included in a multimeric complex expressed by natural killer cells
56. Immunoreceptor DAP12 bearing a tyrosine-based activation motifs is involved in activating NK cells
57. Signaling through human killer cell activating receptors triggers tyrosine phosphorylation of an associated protein complex
58. Association of DAP12 with activating CD94/NKG2C NK cell receptors
59. Turning on natural killer cells
60. Identification and molecular characterization of a natural mutant of the p50.2/KIR2DS activating NK receptor that fails to mediate NK cell triggering
61. NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human natural killer cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells
62. Xenogeneic transplantation
63. Human anti-pig cell-mediated cytotoxicity in vitro involves non-T as well as T cell components
64. Xenogeneic human anti-pig cytotoxicity mediated by activated natural killer cells
65. Early recognition of a discordant xenogeneic organ by human circulating lymphocytes
66. Donor-specific prolongation of rat skin graft survival induced by ratdonor cells and cyclophosphamide under coadministration of monoclonal antibodies against T cell receptor and natural killer cells in mice
67. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells
68. The CD94 and NKG2-A Ctype lectins covalently assamble to form a a NK cell inhibitory receptor for HLA class I molecules
69. Human natural killer cell receptors involved in MHC class I recognition are disulphide-linked heterodimers of CD94 and NKG2 subunits
70. The activating form of CD94 receptor complex. CD94 covalently associates with the Kp39 protein that represents the product of the NKG2-C gene
71. Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes
72. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
73. Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis
74. HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A
75. An activating immunoreceptor complex formed by NKG2D and DAP10
76. KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties
77. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
78. Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium
79. Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB
80. Murine NKG2D and CD94 are clustered within the natural killer complex and are expressed independently in natural killer cells
81. Ligands for the murine NKG2D receptor: Expression by tumor cells and activation of NK cells and macrophages
82. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice
83. The molecular and functional characterization of a dominant minor H antigen, H60
84. Genomic structures and characterization of Rael family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain
85. The human cytomegalovirus (HCMV) glycoprotein, UL16, binds to the MHC class I-related protein, MICB/PERB11, and to two novel, MHC class I-related molecules, ULBP1 and ULBP2
86. Soluble forms of the novel MHC class I-related molecules, ULBP1 and ULBP2, bind to, and functionally activate NK cells
87. A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells
88. Activation of murine epidermal gamma delta T cells through surface 2B4
89. Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells
90. The structure and ligand interactions of CD2: Implications for T-cell function
91. 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48
92. Identification of the 2B4 molecule as a counter-receptor for CD48
93. Novel surface molecules involved in human NK cell activation and triggering of the lytic machinery
94. Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes
95. Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4
96. Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48
97. Activating interactions in human NK cell recognition: The role of 2B4-CD48
98. Human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP
99. 2B4 functions as a co-receptor in human natural killer cell activation
100. X-linked lymphoproliferative disease: 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of NK cells to kill EBV-infected cells
101. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome
102. Host response to EBV infection in X-linked lymphoproliferatire disease results from mutations in an SH2-domain encoding gene
103. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM
104. Analysis of the molecular mechanism involved in 2B4-mediated NK cell activation: Evidence that human 2B4 is physically and functionally associated with the linker for activation of T cells (LAT)
105. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
106. A role for the adaptor protein LAT in human NK cell-mediated cytotoxicity
107. Identification of NKp80 a novel triggering molecule expressed by human natural killer cells
108. Human KLRF1, a novel member of the killer cell lectin-like receptor gene family: Molecular characterization, genomic structure, physical mapping to the NK gene complex and expression analysis
109. + natural killer cells. Role in cell activation and regulation of cytolytic function
110. + NK cells by the expression of clonally distributed functional surface molecules. Correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition
111. P58 molecules as putative receptors for MHC class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities
112. Existence of both inhibitory (p58) and activatory (p50) receptors for HLAC molecules in human natural killer cells
113. A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation
114. The HLA-C specific "activatory" and "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions
115. Role of amino acid position 70 in the binding affinity of p50.1 and p58.1 receptors for CW4 molecules
116. Characterization of an antigen that is recognized on a melanoma showing partial HLA-loss by CTL expressing an inhibitory receptor
117. DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming
118. Nonstochastic coexpression of activation receptors on murine natural killer cells
119. T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and Fc epsilon RI gamma)
120. Homozygous human TAP peptide transporter mutation in HLA class I deficiency
121. Activity and phenotype of natural killer cells in peptide transporter (TAP)-deficient patients (type I bare lymphocyte syndrome)
122. A case of primary immunodeficiency due to a defect of the major histocompatibility gene complex class I processing and presentation pathway
123. Fatal infectious mononucleosis in familial lymphohistiocytosis
124. X-linked lymphoproliferative disease: Twenty five years after discovery
125. X-linked proliferative syndrome
126. A novel receptor involved in T-cell activation