Natural killer cell receptor signaling

Current Opinion in Immunology

Volumn 15, Issue 3, 2003, Pages 308-314

  Lanier, Lewis L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CD16 ANTIGEN; CD3 ANTIGEN; CELL SURFACE RECEPTOR; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN KINASE SYK; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE KINASE; TYROSINE; UNCLASSIFIED DRUG;

CYTOPLASM; HUMAN; IMMUNE RESPONSE; NATURAL KILLER CELL; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0037716818     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(03)00039-6     Document Type: Review

References (38)

1. •] provide an excellent overview of NK cell receptors and their biological functions. Only articles published since 2001 have been cited in this article to comply with the limitation on the number of cited references. Earlier citations are incorporated by reference within these recent reviews.
2. •].
3. •].
4. •].
5. Arase H., Suenaga T., Arase N., Kimura Y., Ito K., Shiina R., Ohno H., Saito T. Negative regulation of expression and function of Fc gamma RIII by CD3 zeta in murine NK cells. J. Immunol. 166:2001;21-25.
6. Jevremovic D., Billadeau D.D., Schoon R.A., Dick C.J., Leibson P.J. Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3bp2. J. Immunol. 166:2001;7219-7228.
7. Galandrini R., Tassi I., Morrone S., Lanfrancone L., Pelicci P., Piccoli M., Frati L., Santoni A. The adaptor protein shc is involved in the negative regulation of NK cell-mediated cytotoxicity. Eur. J. Immunol. 31:2001;2016-2025.
8. Ortaldo J.R., Bere E.W., Hodge D., Young H.A. Activating ly-49 NK receptors: central role in cytokine and chemokine production. J. Immunol. 166:2001;4994-4999.
9. Diefenbach A., Tomasello E., Lucas M., Jamieson A.M., Hsia J.K., Vivier E., Raulet D.H. Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat. Immunol. 3:2002;1142-1149 An intriguing observation demonstrating that alternative splicing can generate NKG2D proteins able to pair only with DAP10 or with both DAP10 and DAP12. The latter provides potent stimulation and co-stimulation by the same receptor.
10. Gilfillan S., Ho E.L., Cella M., Yokoyama W.M., Colonna M. NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat. Immunol. 3:2002;1150-1155 The first description of a DAP10-deficient mouse and evidence that after NK cell activation an NKG2D isoform can associate with DAP12.
11. Jamieson A.M., Diefenbach A., McMahon C.W., Xiong N., Carlyle J.R., Raulet D.H. The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity. 17:2002;19-29 This paper describes the distribution of NKG2D on mouse NK cells, activated T cells and activated macrophages, and demonstrates the role of the receptor in effector functions.
12. Sutherland C.L., Chalupny N.J., Schooley K., VandenBos T., Kubin M., Cosman D. UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells. J. Immunol. 168:2002;671-679 The authors provide evidence that soluble NKG2D ligands activate human NK cells and stimulate multiple biochemical pathways.
13. Bottino C., Falco M., Parolini S., Marcenaro E., Augugliaro R., Sivori S., Landi E., Biassoni R., Notarangelo L.D., Moretta L.et al. NTB-a, a novel SH2D1a-associated surface molecule contributing to the inability of natural killer cells to kill Epstein Barr virus-infected B cells in X-linked lymphoproliferative disease. J. Exp. Med. 194:2001;235-246.
14. Veillette A: The SAP family: a new class of adaptor-like molecules that regulates immune cell functions. Sci STKE 2002, 120:PE8.
15. Klem J., Verrett P.C., Kumar V., Schatzle J.D. 2B4 is constitutively associated with linker for the activation of T cells in glycolipid-enriched microdomains: properties required for 2B4 lytic function. J. Immunol. 169:2002;55-62.
16. Chuang S.S., Kumaresan P.R., Mathew P.A. 2B4 (CD244)-mediated activation of cytotoxicity and IFN-γ release in human NK cells involves distinct pathways. J. Immunol. 167:2001;6210-6216.
17. Veillette A, Latour S: Regulation and functions of the SLAM family of immune cell receptors. Curr Opin Immunol 2003, in press.
18. Le Bouteiller P, Barakonyi A, Giustiniani J, Lenfant F, Marie-Cardine A, Aguerre-Girr M, Rabot M, Hilgert I, Mami-Chouaib F, Tabiasco J et al.: Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity. Proc Natl Acad Sci USA 2002.
19. Barber D.F., Long E.O. Coexpression of CD58 or CD48 with intercellular adhesion molecule 1 on target cells enhances adhesion of resting NK cells. J. Immunol. 170:2003;294-299.
20. Veillette A., Latour S., Davidson D. Negative regulation of immunoreceptor signaling. Annu. Rev. Immunol. 20:2002;669-707.
21. Wang J.W., Howson J.M., Ghansah T., Desponts C., Ninos J.M., May S.L., Nguyen K.H., Toyama-Sorimachi N., Kerr W.G. Influence of SHIP on the NK repertoire and allogeneic bone marrow transplantation. Science. 295:2002;2094-2097.
22. Yusa S., Catina T.L., Campbell K.S. SHP-1- and phosphotyrosine-independent inhibitory signaling by a killer cell Ig-like receptor cytoplasmic domain in human NK Cells. J. Immunol. 168:2002;5047-5057.
23. Faure M., Long E.O. KIR2DL4 (CD158d), an NK cell-activating receptor with inhibitory potential. J. Immunol. 168:2002;6208-6214 The authors describe studies of an unusual dual function KIR that possesses both activating and inhibitory activities.
24. Rajagopalan S., Fu J., Long E.O. Cutting edge: induction of IFN-γ production but not cytotoxicity by the killer cell Ig-like receptor kir2dl4 (cd158d) in resting NK cells. J. Immunol. 167:2001;1877-1881 The authors suggest that the induction of cytotoxicity and cytokine production may be dissociated when NK cells are activated through an unusual KIR.
25. Lou Z., Billadeau D.D., Savoy D.N., Schoon R.A., Leibson P.J. A role for a RhoA/ROCK/LIM-kinase pathway in the regulation of cytotoxic lymphocytes. J. Immunol. 167:2001;5749-5757.
26. Fassett M.S., Davis D.M., Valter M.M., Cohen G.B., Strominger J.L. Signaling at the inhibitory natural killer cell immune synapse regulates lipid raft polarization but not class I MHC clustering. Proc. Natl. Acad. Sci. USA. 98:2001;14547-14552.
27. Vyas Y.M., Mehta K.M., Morgan M., Maniar H., Butros L., Jung S., Burkhardt J.K., Dupont B. Spatial organization of signal transduction molecules in the NK cell immune synapses during MHC class I-regulated noncytolytic and cytolytic interactions. J. Immunol. 167:2001;4358-4367.
28. Vyas Y.M., Maniar H., Dupont B. Cutting edge: differential segregation of the SRC homology 2-containing protein tyrosine phosphatase-1 within the early NK cell immune synapse distinguishes noncytolytic from cytolytic interactions. J. Immunol. 168:2002;3150-3154.
29. Galandrini R., Tassi I., Mattia G., Lenti L., Piccoli M., Frati L., Santoni A. SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells. Blood. 100:2002;4581-4589.
30. Watzl C, Long EO: Natural killer cell inhibitory receptors block actin cytoskeletal-dependent recruitment of 2B4 (CD244) to lipid rafts. J Exp Med 2003, 197 in press.
31. Colucci F., Schweighoffer E., Tomasello E., Turner M., Ortaldo J.R., Vivier E., Tybulewicz V.L., Di Santo J.P. Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases. Nat. Immunol. 3:2002;288-294 Surprising findings that normal numbers of NK cells develop in mice lacking both Syk and ZAP70 and many effector functions are intact.
32. Sjolin H., Tomasello E., Mousavi-Jazi M., Bartolazzi A., Karre K., Vivier E., Cerboni C. Pivotal role of KARAP/DAP12 adaptor molecule in the natural killer cell-mediated resistance to murine cytomegalovirus infection. J. Exp. Med. 195:2002;825-834 A formal demonstration that a DAP12-associated receptor is involved in vivo in immunity to a viral infection.
33. Arase H., Mocarski E.S., Campbell A.E., Hill A.B., Lanier L.L. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science. 296:2002;1323-1326 A demonstration that a DAP12-associated receptor Ly49H recognizing a viral glycoprotein ligand fails to function in DAP12-deficient mice.
34. Lowin-Kropf B., Kunz B., Schneider P., Held W. A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors. Eur. J. Immunol. 32:2002;773-782.
35. •] are demonstrations that Vav-1 is important in NK cell-mediated cytotoxicity against certain tumors.
36. •].
37. Brdicka T., Imrich M., Angelisova P., Brdickova N., Horvath O., Spicka J., Hilgert I., Luskova P., Draber P., Novak P.et al. Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. J. Exp. Med. 196:2002;1617-1626.
38. Jiang K., Zhong B., Gilvary D.L., Corliss B.C., Vivier E., Hong-Geller E., Wei S., Djeu J.Y. Syk regulation of phosphoinositide 3-kinase-dependent NK cell function. J. Immunol. 168:2002;3155-3164 The authors propose a testable biochemical model to explain 'natural cytotoxicity', implicating a Syk-PI3 kinase-Rac 1-PAK1-MeK1/2-ERK1/2 pathway.