Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells

Journal of Experimental Medicine

Volumn 190, Issue 10, 1999, Pages 1505-1516

  Pende, Daniela ^a   Parolini, Silvia ^b   Pessino, Anna ^c   Sivori, Simona ^c   Augugliaro, Raffaella ^c   Morelli, Luigia ^c   Marcenaro, Emanuela ^c   Accame, Laura ^a   Malaspina, Angela ^a   Biassoni, Roberto ^a   Bottino, Cristina ^a   Moretta, Lorenzo ^a,c   Moretta, Alessandro ^c  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

Natural cytotoxicity; Natural killer cells; Triggering receptor

Indexed keywords

CD3 ANTIGEN; CELL RECEPTOR; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY;

ARTICLE; CELL ACTIVATION; CELLULAR DISTRIBUTION; CROSS LINKING; CYTOTOXICITY; HUMAN; HUMAN CELL; MOLECULAR CLONING; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION;

ANIMALS; ANTIBODIES, MONOCLONAL; CLONING, MOLECULAR; COS CELLS; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; KILLER CELLS, NATURAL; RECEPTORS, IMMUNOLOGIC; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0033571491     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.10.1505     Document Type: Article

References (47)

1. Moretta, A., R. Biassoni, C. Bottino, D. Pende, M. Vitale, A. Poggi, M.C. Mingari, and L. Moretta. 1997. Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes. Imnmnol. Rev. 155:105-117.
2. Lanier, L.L. 1998. NK cell receptors. Annu. Rev. Immunol. 16:359-393.
3. Long, E.O. 1998. Regulation of immune responses through inhibitory receptors. Annu. Rev. Immunol. 17:875-904.
4. Ljunggren, H.-G., and K. Karre. 1990. In search of the missing 'self: MHC molecules and NK cell recognition. Immunol. Today. 11:237-244.
5. Renard, V., A. Cambiaggi, F. Vély, M. Bléry, L. Olcese. S. Olivero, M. Bouchet, and E. Vivier. 1997. Transduction of cytotoxic signals in natural killer cells: a general model of fine tuning between activatory and inhibitory pathways in lymphocytes. Immunol. Rev. 155:205-221.
6. Ciccone, E., D. Pende, M. Vitale, L. Nanni, C. Di Donato, C. Bottino, L. Morelli, O. Viale, A. Amoroso, A. Moretta, and L. Moretta. 1994. Self class I molecules protect normal cells from lysis mediated by autologous natural killer cells. Eur. J. Immunol. 24:1003-1006.
7. + natural killer cells. Role in cell activation and regulation of cytolytic function. J. Exp. Med. 171:695-714.
8. + NK cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition. J. Exp. Med. 172:1589-1598.
9. Wagtmann, N., R. Biassoni, C. Cantoni, S. Verdiani, M. Malnati, M. Vitale, C. Bottino, L. Moretta, A. Moretta, and E.O. Long. 1995. Molecular clones of the p58 NK cell receptor reveal Ig-related molecules with diversity in both the extra- and intracellular domains. Immunity. 2:439-449.
10. Colonna, M., and J. Samaridis. 1995. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science. 268:405-408.
11. Vitale, M., S. Sivon, D. Pende, R. Augugliaro, C. Di Donato, A. Amoroso, M. Malnati, C. Bottino, L. Moretta, and A. Moretta 1996. Physical and functional independency of p70 and p58 NK cell receptors for HLA class I: their role in the definition of different groups of alloreactive NK cell clones. Proc. Natl. Acad. Sci. USA. 93:1453-1457.
12. D'Andrea, A., C. Chang, K. Franz-Bacon, T. McClanahan, J.H. Phillips, and L.L. Lanier. 1995. Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes. J. Immunol. 155:2306-2310.
13. Pende, D., R. Biassoni, C. Cantoni, S. Verdiani, M. Falco, C. Di Donato, L. Accame, C. Bottino, A. Moretta, and L. Moretta. 1996. The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140 kD disulphide-linked dimer. J. Exp. Med. 184:505-518.
14. Dohring, C., D. Scheidegger, J. Samaridis, M. Cella, and M. Colonna. 1996. A human killer inhibitory receptor specific for HLA-A1,2. J. Immunol. 156:3098-3101.
15. Cosman, D., N. Fanger, L. Borges, M. Kubin, W. Chin, L. Peterson, and M.L. Hus. 1997. A novel immunoglobilin superfamily receptor for cellular and viral MHC class I molecules. Immunity. 7:273-282.
16. Samaridis, J., and M. Colonna. 1997. Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. Eur. J. Immunol. 27: 660-665.
17. Sivori, S., M. Vitale, C. Bottino, E. Marcenaro, L. Sanseverino, S. Parolini, L. Moretta, and A. Moretta. 1996. CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles: identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies. Eur. J. Immunol. 26:2487-2492.
18. Braud, V.M., E.Y. Jones, and A.J. McMichael. 1997. The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9. Eur. J. Immunol. 27: 1164-1169.
19. Lee, N., M. Llano, M. Carretero, A. Ishitani, F. Navarro, M. Lopez-Botet, and D. Geraghty. 1998. HLA-E is a major ligand for the natural killer inhibitory receptor CD94/ NKG2A. Proc. Natl. Acad. Sci. USA. 95:5199-5204.
20. Garrido, F., F. Ruiz-Cabello, R. Cabrera, J.J. Pérez-Villar, M. López-Botet, M. Duggan-Keen, and P.L. Stern. 1997. Implications for immunosurveillance of altered HLA-class I phenotypes in human tumours. Immunol. Today. 18:89-95.
21. Pende, D., L. Accame, L. Pareti, A. Mazzocchi, A. Moretta, G. Parmiani, and L. Moretta. 1998. The susceptibility to natural killer cell-mediated lysis of HLA class I-positive melanomas reflects the expression of insufficient amounts of HLA class I alleles. Eur. J. Immunol. 28:2384-2394.
22. Sivori, S., M. Vitale, L. Morelli, L. Sanseverino, R. Augugliaro, C. Bottino, L. Moretta, and A. Moretta. 1997. p46, a novel natural killer cell-specific surface molecule that mediates cell activation. J. Exp. Med. 186:1129-1136.
23. Vitale, M., C. Bottino, S. Sivori, L. Sanseverino, R. Castriconi, R. Marcenaro, R. Augugliaro, L. Moretta, and A. Moretta. 1998. NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells is involved in non-MHC restricted tumor cell lysis. J. Exp. Med. 187:2065-2072.
24. Pessino, A., S. Sivori, C. Bottino, A. Malaspina, L. Morelli, L. Moretta, R. Biassoni, and A. Moretta. 1998. Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. J. Exp. Med. 188:953-960.
25. Cantoni, C., C. Bottino, M. Vitale, A. Pessino, R. Augugliaro, A. Malaspina, S. Parolini, L. Moretta, A. Moretta, and R. Biassoni. 1999. NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily. J. Exp. Med. 189:787-796.
26. Sivori, S., D. Pende, C. Bottino, E. Marcenaro, A. Pessino, R. Biassoni, L. Moretta, and A. Moretta. 1999. NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells. Eur. J. Immunol. 29:1656-1666.
27. Moretta, A. 1985. Frequency and surface phenotype of human T lymphocytes producing interleukin 2. Analysis by limiting dilution and cell cloning. Eur. J. Immunol. 151:148-155.
28. Poggi, A., R. Pardi, N. Pella, L. Morelli, S. Sivori, M. Vitale, V. Revello, A. Moretta, and L. Moretta. 1993. CD45-mediated regulation of LFA1 function in human natural killer cells. Anti-CD45 monoclonal antibodies inhibit the calcium mobilization induced via LFA1 molecules. Eur. J. Immunol. 23:2445-2463.
29. Bordier, C. 1981. Phase separation of integral membrane proteins in Triton X-114 solution. J. Biol. Chem. 256:1604-1607.
30. Brakenhoff, R.H., M. Gerretsen, E.M.C. Knippels, M. van Dijk, H. van Essen, D.O. Weghuis, R.J. Sinke, G.B. Snow, and G.A.M.S. van Dongen. 1995. The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. J. Cell. Biol. 129:1677-1689.
31. Biassoni, R., S. Ferrini, I. Prigione, A. Moretta, and E.O. Long. 1988. CD3-negative lymphokine-activated cytotoxic cells express the CD3 epsilon-gene. J. Immunol. 140:1685-1689.
32. Maniatis, T., E.F. Fritsch, and J. Sambrook. 1982. Molecular cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
33. Biassoni, R., A. Pessino, C. Bottino, D. Pende, L. Moretta, and A. Moretta. 1999. The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity. Eur. J. Immunol. 29:1014-1020.
34. Lanier, L.L., G. Yu, and J.H. Phillips. 1989. Co-association of CD3ζ with a receptor (CD 16) for IgG Fc on human natural killer cells. Nature. 342:803-805.
35. Vivier, E., N. Rochet J.P. Kochan, D.H. Presky, S.F. Schlossman, and P. Anderson. 1991. Structural similarity between Fc receptors and T cell receptors. Expression of the γ subunit of the Fc∈RI in human T cells, natural killer cells and thymocytes. J. Immunol. 147:4263-4270.
36. Olcese, L., A. Cambiaggi, G. Semenzato, C. Bottino, A. Moretta, and E. Vivier. 1997. Human killer cell activatory receptors for MHC class I molecules are included in a multimeric complex expressed by natural killer cells. J. Immunol. 158:5083-5086.
37. Lanier, L.L., B. Corliss, J. Wu, and J.H. Phillips. 1998. Association of DAP12 with activating CD94/NKG2C NK cell receptors. Immunity. 8:693-701.
38. Nalabolu, S.R., H. Shukla, G. Nallur, S. Parimoo, and S.M. Weissman. 1996. Genes in a 220-kb region spanning the TNF cluster in human MHC. Genomics. 31:215-222.
39. Neville, M.J., and R.D. Campbell. 1999. A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. J. Immunol. 162:4745-4754.
40. Moretta, A., R. Biassoni, C. Bottino, M.C. Mingari, and L. Moretta. 1999. The "natural cytotoxicity receptors" which trigger the NK-mediated cytolysis: elusive no more. Immunol. Today. In press.
41. Mandelboim, O., P. Malik, D.M. Davis, C.H. Jo, J.E. Boyson, and J.L. Strominger. 1999. Human CD16 as a lysis receptor mediating direct natural killer cell cytotoxicity. Proc. Natl. Acad. Sci. USA. 96:5640-5644.
42. Bolhuis, R.L., R.C. Roozemond, and R.J. van de Griend. 1986. Induction and blocking of cytolysis in CD2+, CD3-NK and CD2+, CD3+ cytotoxic T lymphocytes via the CD2 50kD sheep erythrocyte receptor. J. Immunol. 136: 3939-3944.
43. Lanier, L.L., B. Corliss, and J.H. Phillips. 1997. Arousal and inhibition of human NK cells. Immunol. Rev. 155:145-154.
44. Moretta, A., A. Poggi, D. Pende, G. Tripodi, A.M. Orengo, N. Pella, R. Augugliaro, C. Bottino, E. Ciccone, and L. Moretta. 1991. CD69-mediated pathway of lymphocyte activation: anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells, with the exception of cytolytic T lymphocytes expressing TCR α/β. J. Exp. Med. 174:1393-1398.
45. Azuma, M., M. Cayabyab, D. Buck, J.H. Phillips, and L.L. Lanier. 1992. Involvement of CD28 in MHC-unrestricted cytotoxicity mediated by a human NK leukemia cell line. J. Immunol. 149:1115-1123.
46. Mathew, P.A., B.A. Garni-Wagner, K. Land, A. Takashima, E. Stoneman, M. Bennett, and V. Kumar. 1993. Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J. Immunol. 151:5328-5337.
47. Bezouska, K., C. Yuen, J. O'Brien, R.A. Childs, W. Chai, A.M. Lawson, K. Drbal, A. Fiserova, M. Pospisil, and T. Feizi. 1994. Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity. Nature. 372:150-157.