Commentary: Regulated equilibrium between opposite signals: A general paradigm for T cell function?

European Journal of Immunology

Volumn 34, Issue 8, 2004, Pages 2084-2088

  Moretta, Alessandro ^a   Bottino, Cristina ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b G GASLINI INSTITUTE   (Italy)

Author keywords

B7 family members; Co signaling receptors; T cell activation

Indexed keywords

B7 ANTIGEN; B7 H1 ANTIGEN; B7 H2 ANTIGEN; B7 H3 ANTIGEN; B7 H4 ANTIGEN; CD28 ANTIGEN; CELL SURFACE PROTEIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INDUCIBLE COSTIMULATOR PROTEIN; PROGRAM DEATH 1 PROTEIN; RECEPTOR PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; LYMPHOCYTE ANTIGEN RECEPTOR;

ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; HUMAN; IMMUNOMODULATION; IMMUNOREGULATION; IMMUNOSTIMULATION; LYMPHOCYTE FUNCTION; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; IMMUNE SYSTEM; IMMUNOLOGY; NOTE;

IMMUNE SYSTEM; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 4344656536     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200425388     Document Type: Article

References (49)

1. Salomon, B. and Bluestone, J. A., Complexities of CD28/B7: CTLA-4 co-stimulatory pathway in autoimmunity and transplantation. Annu. Rev. Immunol. 2001. 19: 225-252
2. Lenschow, D. J., Walunas, T. L. and Bluestone, J. A., CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 1996. 14: 233-258.
3. June, C. H., Bluestone, J. A., Nadler, L. M. and Thompson, C. B., The B7 and CD28 receptor families. Immunol. Today 1994. 15: 321-331.
4. Chen, L., Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat. Rev. Immunol. 2004. 4: 336-347.
5. Tivol, E. A., Borriello, F., Schweitzer, A. N., Lynch, W. P., Bluestone, J. A. and Sharpe, A. H., Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995. 3: 541-547.
6. Waterhouse, P., Penninger, J. M., Timms, E., Wakeham, A., Shahinian, A., Lee, K. P., Thompson, C. B., Griesser, H. and Mak, T. W., Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 1995. 270: 985-988.
7. Mandelbrot, D. A., McAdam, A. J. and Sharpe, A. H., B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen (CTLA-4). J. Exp. Med. 1999. 189: 435-440.
8. Chikuma, S., Imboden, J. B. and Bluestone, J. A., Negative regulation of cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 2003. 197: 129-135.
9. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 2000. 192: 303-310.
10. Ueda, H., Howson, J. M., Esposito, L., Heward, J., Snook, H., Chamberlain, G., Rainbow, D. B., Hunter, K. M., Smith, A. N., Di Genova, G. et al., Association of the T cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003. 423: 506-511.
11. Vijayakrishnan, L., Slavik, J. M., Illes, Z., Greenwald, R. J., Rainbow, D., Greve, B., Peterson, L. B., Hafler, D. A., Freeman, G. J., Sharpe, A. H., Wicker, L. S. and Kuchroo, V. K., An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity 2004. 20: 563-575.
12. Coyle, A. J. and Gutierrez-Ramos, J. C., The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function. Nat. Immunol. 2001. 2: 203-209.
13. Fallarino, F., Grohmann, U., Hwang, K. W., Orabona, C., Vacca, C., Bianchi, R., Belladonna, M. L., Fioretti, M. C., Alegre, M. L., Puccetti, P., Modulation of tryptophan catabolism by regulatory T cells. Nat. Immunol. 2003. 4: 1206-1212.
14. Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I. and Kroczek, R. A., ICOS is an inducible T cell co-stimulator structurally and functionally related to CD28. Nature 1999. 397: 263-266.
15. Yoshinaga, S. K., Whoriskey, J. S., Khare, S. D., Sarmiento, U., Guo, J., Horan, T., Shih, G., Zhang, M., Coccia, M. A., Kohno, T., Tafuri-Bladt, A., Brankow, D., Campbell, P., Chang, D., Chiu, L., Dai, T., Duncan, G., Elliott, G. S., Hui, A., McCabe, S. M., Scully, S., Shahinian, A., Shaklee, C. L., Van, G. and Mak, T. W., T cell co-stimulation through B7RP-1 and ICOS. Nature 1999. 402: 827-832.
16. Ling, V., Wu, P. W., Finnerty, H. F., Bean, K. M., Spaulding, V., Fouser, L. A., Leonard, J. P., Hunter, S. E., Zollner, R., Thomas, J. L., Miyashiro, J. S., Jacobs, K. A. and Collins, M., Identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. J. Immunol. 2000. 164: 1653-1657.
17. Wang, S., Zhu, G., Chapoval, A. I., Dong, H., Tamada, K., Ni, J. and Chen, L., Costimulation of Tcells by B7-H2, a B7-like molecule that binds ICOS. Blood 2001. 96: 2808-2813.
18. Carreno, B.-M. and Collins, M., BTLA: a new inhibitory receptor with a B7-like ligand. Trends Immunol. 2003. 24: 524-527.
19. Ishida, Y., Agata, Y., Shibahara, K. and Honjo, T., Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992. 11: 3887-3895
20. Dong, H., Zhu, G., Tamada, K. and Chen, L., B7-H1, a third member of the B7 family, co-stimulates T cell proliferation and interleukin-10 secretion. Nat. Med. 1999. 5: 1365-1369.
21. Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L. J., Malenkovich, N., Okazaki, T., Byrne, M. C., Horton, H. F., Fouser, L., Carter, L., Ling, V., Bowman, M. R., Carreno, B. M., Collins, M., Wood, C. R. and Honjo, T., Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 2000. 192: 1027-1034.
22. Tseng, S. Y., Otsuji, M., Gorski, K., Huang, X., Slansky, J. E., Pai, S. I., Shalabi, A., Shin, T., Pardoll, D. M. and Tsuchiya, H., B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 2001. 193: 839-846.
23. Okazaki, T., Honjo, T., Sharpe, A. H. and Freeman, G. J., PD-L2 is a second ligand for PD-I and inhibits T cell activation. Nat. Immunol. 2001. 2: 261-268.
24. Nishimura, H., Nose, M., Hiai, H., Minato, N. and Honjo, T., Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999. 11: 141-151.
25. Okazaki, T., Maeda, A., Nishimura, H., Kurosaki, T. and Honjo, T., PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Proc. Natl. Acad. Sci. USA 2001. 98: 13866-13871.
26. Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., Lennon, V. A., Celis, E. and Chen, L., Tumor-associated B7-H1 promotes T cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 2002. 8: 793-800.
27. Wang, S., Bajorath, J., Flies, D. B., Dong, H., Honjo, T., and Chen, L., Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple most co-stimulatory function from PD-1 interaction. J. Exp. Med. 2003. 197: 1083-1091.
28. Liu, X., Gao, J. X., Wen, J., Yin, L., Li, O., Zuo, T., Gajewski, T. F., Fu, J. X., Zheng, P. and Yang, L., B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism. J. Exp. Med. 2003. 197: 1721-1730.
29. + T cells independent of the PD-1 receptor. J. Exp. Med. 2003. 198: 31-38.
30. + T lymphocytes. Immunity 2004. 20: 327-336
31. Dong, H., Strome, S. E., Matteson, E. L., Moder, K. G., Flies, D. B., Zhu, G., Tamura, H., Driscoll, C. L. and Chen, L., Co-stimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis. J. Clin. Invest. 2003. 111: 363-370.
32. Colonna, M., TREMs in the immune system and beyond. 2003. Nat. Rev. Immunol. 3: 445-453.
33. Watanabe, N., Gavrieli, M., Sedy, J. R., Yang, J., Fallarino, F., Loftin, S. K., Hurchla, M. A., Zimmerman, N., Sim, J., Zang, X., Murphy, T. L., Russell, J. H., Allison, J. P. and Murphy K. M., BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat. Immunol. 2003. 4: 670-679.
34. Carreno, B.-M. and Collins, M., BTLA: a new inhibitory receptor with a B7-like ligand. Trends Immunol. 2003. 24: 524-527.
35. Sica, G.-L., Choi, I.-H., Zhu, G., Tamada, K., Wang, S.-D., Tamura, H., Chapoval, A.-I., Flies, D.-B., Bajorath, J. and Chen, L., B7-H4, a molecule ofthe B7 family, negatively regulates T cell immunity. Immunity 2003. 18: 849-861.
36. Prasad, D.-V., Richards, S., Mai, X-M. and Dong, C., B7S1, a novel B7 family member that negatively regulates T cell activation. Immunity 2003. 18: 863-873.
37. Zang, X., Loke, P., Kim, J., Murphy, K., Waitz, R. and Allison, J.-P., B7x: a widely expressed B7 family member that inhibits T cell activation. Proc. Natl. Acad. Sci. USA 2003. 100: 10388-10392.
38. Choi, I.-H., Zhu, G., Sica, G. L., Strome, S. E., Cheville, J. C., Lau, J. S., Zhu, Y., Flies, D. B., Tamada, K. and Chen, L., Genomic organization and expression analysis of B7-H4: an immune inhibitory molecule of the B7 family. J. Immunol. 2003. 171: 4650-4654.
39. Chapoval, A.-I., Ni, J., Lau, J.-S., Wilcox, R.-A., Flies, D.-B., Liu, D., Dong, H., Sica, G. L., Zhu, G., Tamada, K. and Chen, L., B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat. Immunol. 2001. 2: 269-274.
40. Sun, M., Richards, S., Prasad, D.-V., Mai, X-M., Rudensky, A. and Dong, C., Characterization of mouse and human B7-H3 genes. J. Immunol. 2002. 168: 6294-6297.
41. Steinberger, P., Majidic, O., Derdak, S.-V., Pfistershammer, K., Kirchberger, S., Klauser, C., Zlabinger, G., Pickl, W.-F., Stockl, J. and Knapp, W., Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains. J. Immunol. 2004. 172: 2352-2359.
42. Suh, W.-K., Gajewska, B.-U., Okada, H., Gronski, M.-A., Bertram, E.-M., Dawicki, W., Duncan, G.-S., Bukczynski, J., Plyte, S., Elia, A., Wakeham, A., Itie, A., Chung, S., Da Costa, J., Arya, S., Horan, T., Campbell, P., Gaida, K., Ohashi, P.-S., Watts, T.-H., Yoshinaga, S.-K., Bray, M.-R., Jordana, M. and Mak, T.-W., The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat. Immunol. 2003. 4: 899-906.
43. Compte, E., Pontarotti, P., Collette, Y., Lopez, M. and Olive, D., Characterization of BT3 molecules belonging to the B7 family expressed on immune cells. Eur. J. Immunol. 2004. 34: (this issue).
44. Rhodes, D. A., Stammers, M., Malcherek, G., Beck, S. and Trowsdale, J., The cluster of BTN genes in the extended major histocompatibility complex. Genomics 2001. 71: 351-362.
45. Ruddy, D. A., Kronmal, G. S., Lee, V. K., Mintier, G. A., Quintana, L., Domingo, R., Jr., Meyer, N. C., Irrinki, A., McClelland, E. E., Fullan, A., Mapa, F. A., Moore, T., Thomas, W., Loeb, D. B., Harmon, C., Tsuchihashi, Z., Wolff, R. K., Schatzman, R. C. and Feder, J. N., A 1.1-Mb transcript map of the hereditary hemochromatosis locus. Genome Res. 1997. 7: 441-456.
46. Henry, J., Mather, I. H., McDermott, M. F. and Pontarotti, P., B30.2-like domain proteins: update and new insights into a rapidly expanding family of proteins. Mol. Biol. Evol. 1998. 15: 1696-1705.
47. Ishii, T., Aoki, N., Noda, A., Adachi, T., Nakamura, R. and Matsuda, T., Carboxy-terminal cytoplasmic domain of mouse butyrophilin specifically associates with a 150-kDa protein of mammary epithelial cells and milk fat globule membrane. Biochim. Biophys. Acta 1995. 1245: 285-292.
48. Moretta, A., Bottino, C., Vitale, M., Pende, D., Cantoni, C., Mingari, M. C., Biassoni, R. and Moretta, L., Activating receptors and co-receptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 2001. 19: 197-223.
49. Moretta, A., Bottino, C., Mingari, M. C., Biassoni R. and Moretta, L., What is a natural killer cell? Nat. Immunol. 2002. 3: 6-8.