Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D

Nature Immunology

Volumn 3, Issue 12, 2002, Pages 1142-1149

  Diefenbach, Andreas ^a   Tomasello, Elena ^b   Lucas, Mathias ^b   Jamieson, Amanda A ^a   Hsia, Jennifer K ^a   Vivier, Eric ^b   Raulet, David H ^a  

^a University of California Berkeley   (United States)

^b CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; LYMPHOCYTE RECEPTOR; MEMBRANE PROTEIN; NATURAL KILLER CELL RECEPTOR NKG2D; PROTEIN DAP; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; IMMUNE SYSTEM; LIGAND BINDING; LYMPHOCYTE ACTIVATION; MACROPHAGE; MOUSE; NATURAL KILLER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; HUMANS; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PROTEIN SUBUNITS; RECEPTORS, IMMUNOLOGIC; RNA SPLICING; SIGNAL TRANSDUCTION;

EID: 0036915968     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni858     Document Type: Article

References (43)

1. Olcese, L. et al. Human killer cell activatory receptors for MHC class I molecules are included in a multimeric complex expressed by natural killer cells. J. Immunol. 158, 5083-5086 (1997).
2. Lanier, L. L., Corliss, B. C., Wu, J., Leong, C. & Phillips, J. H. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells. Nature 391, 703-707 (1998).
3. Tomasello, E. et al. Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice. Immunity 13, 355-364 (2000).
4. Bakker, A. B. H. et al. DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming. Immunity 13, 345-353 (2000).
5. Wu, J. et al. An activating immunoreceptor complex formed by NKG2D and DAP10. Science 285, 730-732 (1999).
6. Chang, C. et al. KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties. J. Immunol. 163, 4652-4654 (1999).
7. Wu, J., Cherwinski, H., Spies, T., Phillips, J. H. & Lanier, L. L. DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells. J. Exp. Med. 192, 1059-1067 (2000).
8. Diefenbach, A., Jamieson, A. M., Liu, S. D., Shastri, N. & Raulet, D. H. Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nature Immunol. 1, 119-126 (2000).
9. Jamieson, A. M. et al. The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity 17, 19-29 (2002).
10. Cerwenka, A. et al. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity 12, 721-727 (2000).
11. Bauer, S. et al. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285, 727-729 (1999).
12. Cosman, D. et al. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 14, 123-133 (2001).
13. Groh, V. et al. Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc. Natl. Acad. Sci. USA 93, 12445-12450 (1996).
14. Diefenbach, A. & Raulet, D. H. Strategies for target cell recognition by natural killer cells. Immunol. Rev. 181, 170-184 (2001).
15. . Diefenbach, A., Jensen, E. R., Jamieson, A. M. & Raulet, D. H. Rae 1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 413, 165-171 (2001).
16. Pence, D. et al. Role of NKG2D in tumor cell lysis mediated by human NK cells: cooperation with natural cytotoxicity receptors and capability of recognizing tumors of nonepithelial origin. Eur. J. Immunol. 31, 1076-1086 (2001).
17. Groh, V. et al. Costimulation of CD8aαβ T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nature Immunol. 2, 255-260 (2001).
18. Vance, R. E., Tanamachi, D. M., Hanke, T. & Raulet, D. H. Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells. Eur J. Immunol. 27, 3236-3241 (1997).
19. Ho, E. L. et al. Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independently in natural killer cells. Proc. Natl. Acad. Sci. USA 95, 6320-6325 (1998).
20. Lucas, M. et al. Massive inflammatory syndrome and lymphocytic immunodeficiency in KARAP/DAP12 transgenic mice. Eur. J. Immunol. 32, 2653-2663 (2002).
21. Medzhitov, R. & Janeway, C. A. Jr. Decoding the patterns of self and nonself by the innate immune system. Science 296, 298-300 (2002).
22. Gilfillan, S., Ho, E. L., Cella, M., Yokoyama, W. M. & Colonnal, M. NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat. Immunol.; published online II November 2002 (doi: 10.1038/ni857).
23. Brooks, C. G., Urdal, D. L. & Henney, C. S. Lymphokine-driven "differentiation" of cytotoxic T-cell clones into cells with NK-like specificity: correlations with display of membrane macromolecules. Immunol. Rev. 72, 43-72 (1983).
24. Mingari, M. C., Moretta. A. & Moretta, L. Regulation of KIR expression in human T cells: a safety mechanism that may impair protective T-cell responses. Immunol. Today 19, 153-157 (1998).
25. Uhrberg, M. et al. The repertoire of killer cell Ig-like receptor and CD94:NKG2A receptors in T cells: clones sharing identical αβ TCR rearrangement express highly diverse killer cell Ig-like receptor patterns. J. Immunol. 166, 3923-3932 (2001).
26. Glas, R. et al. Recruitment and activation of natural killer (NK) cells in vivo determined by the target cell phenotype:An adaptive component of NK cell-mediated responses. J. Exp. Med. 191, 129-138 (2000).
27. Cosson, P., Lankford, S. P., Bonifacino, J. S. & Klausner, R. D. Membrane protein association by potential intramembrane charge pairs. Nature 351, 414-416 (1991).
28. Klausner, R. D., Lippincott-Schwartz, J. & Bonifacino, J. S. The T cell antigen receptor: insights into organelle biology. Annu. Rev. Cell Biol. 6, 403-431 (1990).
29. Houchins, J. P., Yabe, T, McSherry, C. & Bach, F. H. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J. Exp. Med. 173, 1017-1020 (1991).
30. Wilson, M. J., Haude, A. & Trowsdale, J. The mouse Dap10 gene. Immunogenetics 53, 347-350 (2001).
31. Howard, F. D., Rodewald, H. R., Kinet J. P. & Reinherz, E. L. CD3ζ subunit can substitute for the gamma subunit of FcE receptor type I in assembly and functional expression of the high- affinity IgE receptor: evidence for interreceptor complementation. Proc. Natl. Acad. Sci. USA 87, 7015-7019 (1990).
32. Orloff, D. G., Ra, C. S., Frank, S. J., Klausner, R. D. & Kinet, J. P. Family of disulphide-linked dimers containing the ζ and E chains of the T-cell receptor and the γ chain of Fc receptors. Nature 347, 189-191 (1990).
33. Vivier, E. et al. Tyrosine phosphorylation of the FcγRIII(CD 16): ζ complex in human natural killer cells. Induction by antibody-dependent cytotoxicity but not by natural killing. J. Immunol. 146, 206-210 (1991).
34. Hayes, S. M. & Love, P. E. Distint structure and signaling potential of the γδ TCR complex. Immunity 16, 827-838 (2002).
35. Tatusova, T. A. & Madden, T. L. BLAST 2 sequences, a new tool for comparing protein and nucleotide sequences. FEMS Microbiol. Lett. 174, 247-250 (1999).
36. Portnoy, D.A., Jacks, P. S. & Hinrichs, D. J. Role of hemolysin for the intracellular growth of Listeria monocytogenes. J. Exp. Med. 167, 1459-1471 (1988).
37. Diefenbach, A. et al. Type I interferon (IFNα/β) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite. Immunity 8, 77-87 (1998).
38. Hanke, T. et al. Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11, 67-77 (1999).
39. Diefenbach, A., Schindler, H., Röllinghoff, M., Yokoyama, W. M. & Bogdan, C. Requirement for type 2 NO synthase for IL-12 signaling in innate immunity. Science 284, 951-955 (1999).
40. Liao, N., Bix, M., Zijlstra, M., Jaenisch, R. & Raulet, D. MHC class I deficiency: susceptibility to natural killer (NK) cells and impaired NK activity. Science 253, 199-202 (1991).
41. Koo, G. C. & Peppard, J. R. Establishment of monoclonal anti-NK-I. I antibody. Hybridoma 3, 301-303 (1984).
42. Coles, M. C., McMahon, C. W, Takizawa, H. & Raulet, D. H. Memory CD8T lymphocytes express inhibitory MHC-specific Ly49 receptors. Eur. J. Immunol. 30, 236-244 (2000).
43. Murali-Krishna, K. et al. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8, 177-187 (1998).