Pharmacological approaches to functional recovery after spinal injury

Current Drug Targets: CNS and Neurological Disorders

Volumn 4, Issue 2, 2005, Pages 195-210

  Parker, David ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Amines; Metamodulation; Neuropeptide; Paralysis; Plasticity; Spinal lesion

Indexed keywords

1 (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; 1 [5 (3 AZABICYCLO[3.2.2]NON 3 YL) 2,3 DIHYDRO 1 METHYL 2 OXO 1H 1,4 BENZODIAZEPIN 3 YL] 3 (3 METHYLPHENYL)UREA; 2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; 5 CARBAMOYLTRYPTAMINE; 5 HYDROXYTRYPTOPHAN; 5 METHOXY N,N DIMETHYLTRYPTAMINE; 5 METHOXYTRYPTAMINE; ALPHA METHYLSEROTONIN; AMPA RECEPTOR AGONIST; CALCIUM ION; CHOLECYSTOKININ B RECEPTOR ANTAGONIST; CLONIDINE; DEVAZEPIDE; ISOPRENALINE; KAINIC ACID RECEPTOR AGONIST; L 368935; LEVODOPA; METHOXAMINE; MIANSERIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; OXYMETAZOLINE; PEPTIDE YY; PHENYLEPHRINE; QUIPAZINE; SEROTONIN; TIZANIDINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; YOHIMBINE;

BLOOD BRAIN BARRIER; BRADYCARDIA; DRUG MECHANISM; DRUG PENETRATION; EXCITATORY POSTSYNAPTIC POTENTIAL; HUMAN; HYPOTENSION; LOCOMOTION; MOTOR DYSFUNCTION; NERVE CELL NETWORK; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; REVIEW; SIDE EFFECT; SPASTICITY; SPINAL CORD INJURY;

ADRENERGIC AGENTS; ANIMALS; DRUG DESIGN; EXCITATORY AMINO ACID AGENTS; HUMANS; LOCOMOTION; MICE; NEURAL PATHWAYS; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; RECEPTORS, G-PROTEIN-COUPLED; RECOVERY OF FUNCTION; SEROTONIN AGENTS; SPINAL CORD INJURIES;

EID: 18044384808     PISSN: 1568007X     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568007053544192     Document Type: Review

References (163)

1. Dobkin, B.; Havton, L. Annu. Rev. Med., 2004, 55, 255.
2. Eyre, J. A.; Miller, S.; Clowry, G. J.; Conway, E. A.; Watts, C. Brain, 2000, 123, 51.
3. Hochman, S.; McCrea, D. J. Neurophsyiol., 1994, 71, 1452.
4. Hochman, S.; McCrea, D. J. Neurophsyiol., 1994, 71, 1468.
5. Fawcett, J. Spinal Cord, 2002, 40, 615.
6. Ramer, M.; Harper, G.; Bradbury, E. Spinal Cord, 2000, 38, 449.
7. Schwab, M. E. Science, 2002, 295, 1029.
8. Woolf, C. Neuron, 2003, 38, 153.
9. Grillner, S. Science, 1985, 228, 143.
10. Rossignol, S.; Dubuc, R. Curr. Opin. Neurobiol., 1994, 4, 894.
11. Pearson, K.; Ramirez, J.-M. In Neurons, Netwroks, and motor behaviour; Stein, P., Grillner, S., Selverston, A., Stuart, D., Eds.; MIT Press: Cambridge, Mass, 1997.
12. Dietz, V. Clinical Neurophysiology, 2003, 114 , 1379.
13. Marder, E. Ann. Rev. Neurosci., 1998, 21, 25.
14. Marder, E.; Calabrese, R. Physiol. Rev., 1996, 76, 687-717.
15. Hökfelt, T.; Zhang, X.; Wiesenfeld-Hallin, Z. TINS, 1994, 17, 22.
16. Hökfelt, T.; Arvidsson, U.; Cullheim, S.; Millhorn, D.; Nicholas, A.; Pieribone, V.; Seroogy, K.; Ulfhake, B. J. Chem. Neuroanat., 2000, 18, 75.
17. Cullheim, S.; Arvidsson, U. Prog. Neurobiol., 1995 , 104, 21.
18. Brodin, L.; Grillner, S.; Rovainen, C. Brain Res., 1985, 325, 302.
19. Dale, N.; Roberts, A. J. Physiol., 1985, 348 , 527.
20. Currie, S. J. Physiol. (Paris), 1999, 93, 199.
21. Barriere, G.; Mellen, N.; Cazalets, J. Eur. J. Neurosci. , 2004, 19, 1325.
22. Cazalets, J.; Sqalli-Houssaini, Y.; Clarac, F. J. Physiol. , 1992, 455, 187-204.
23. Clarke, K.; Kirby, K. Neuropeptides, 1994, 26 , 71.
24. Kiehn, O.; Kjaerulff, O. J. Neurophysiol., 1996, 75, 1472-1482.
25. Madriaga, M. A.; McPhee, L. C.; Chersa, T.; Christie, K. J.; Whelan, P. J. J. Neurophysiol., 2004.
26. Pearson, S. A.; Mouihate, A.; Pittman, Q. J.; Whelan, P. J. J. Neurosci., 2003, 23, 10154.
27. Fenaux, F.; Corio, M.; Palisses, R.; Viala, D. Exp. Brain Res., 1991, 86, 393.
28. Douglas, J.; Noga, B.; Dai, X.; Jordan, L. J. Neurosci. , 1993, 13, 990.
29. Fedirchuk, B.; Nielsen, J.; Petersen, N.; Hultborn, H. Exp. Brain Res., 1998, 122, 351.
30. Grillner, S.; Manira, A. E.; Tegner, J.; Wadden, T.; Vinay, L.; Barthe, J.-Y. In Dynamic changes in functional connectivity in a lower vertebrate model. John Wiley and Sons Ltd., 1994, pp. 127-147.
31. Harris-Warrick, R.; Johnson, B.; Peck, J.; Kloppenburg, P.; Ayali, A.; Skarbinski, J. Annal. N. Y. Acad. Sci., 1998, 860, 155.
32. Parker, D. Mol. Neurobiol., 2000, 22, 55.
33. Kiehn, O.; Sillar, K.; Kjaerulff, O.; McDearmid, J. J. Neurophysiol., 1999, 82, 741.
34. Sillar, K.; Woolston, A.; Wedderburn, J. Proc. R Soc. Lond. B. Biol. Sci., 1995, 259, 65.
35. McDearmid, J.; Scrymgeour-Wedderburn, J.; Sillar, K. J. Physiol., 1997, 503, 111.
36. McLean, D.; Sillar, K. A J. Comp. Physiol., 2004, 190, 391.
37. Wikstrom, M.; Hill, R.; Hellgren, J.; Grillner, S. Brain Res., 1995, 678, 191.
38. Sqalli-Houssaini, Y.; Cazalets, J.-R. Brain Res., 2000, 852, 100.
39. Barthe, J-Y.; Clarac, F. Exp. Brain Res., 1997, 115, 485.
40. Kupfermann, I. Physiol. Rev., 1991, 71, 683.
41. Katz, P.; Edwards, D. In Beyond Neurotransmission; Katz, P., Ed.; Oxford University Press: New York, 1999; pp. 349-381.
42. Abraham, W.; Bear, M. TINS, 1996, 19, 126.
43. Parker, D. J. Neurophysiol., 2000, 83, 2497.
44. Nyberg, F.; Greves, P. L.; Terenius, L. Biochimie, 1988, 70, 65.
45. Le Greves, P.; Nyberg, F.; Terenius, L.; Hökfelt, T. Eur. J. Pharmacol., 1985, 115, 309.
46. Schaible, H.-G.; Hope, P.; Lang, C.; Duggan, A. Eur. J. Neurosci., 1992, 4, 750.
47. Mitchell, R.; Fleetwood-Walker, S. Eur. J. Pharmacol., 1981, 76, 119.
48. Agnati, L.; Fuxe, K.; Benfenati. F.; Zini. I.; Hökfelt, T. Acta Physiol. Scand., 1983, 117, 299.
49. Svensson, E.; Grillner, S.; Parker, D. J. Neurosci., 2001, 21, 5984.
50. Turrigiano, G. TINS, 1999, 22, 221.
51. Chen, R.; Cohen, L.; Hallett, M. Neuroscience, 2002 , 111, 761.
52. Li, Y.; Bennett, D. J. J. Neurophysiol., 2003, 90, 857.
53. Mackert, B.; Sappok, T.; Grusser, S.; Flor, H.; Curio, G. Neuroreport, 2003, 14, 409.
54. Picconi, B.; Centonze, D.; Hakansson, K.; Bernardi, G.; Greengard, P.; Fisone, G.; Cenci, M.; Calabresi, P. Nat. Neurosci., 2003, 6, 501.
55. Edgerton, V.; Leon, R.; Harkema, S.; Hodgson, J.; London, N.; Reinkensmeyer, D.; Roy, R.; Talmadge, R.; Tillakaratne, N.; Timoszyk, W.; Tobin, A. J. Physiol., 2001, 533, 15.
56. Grasso, R.; Ivanenko, Y.; Zago, M.; Molinari, M.; Scivoletto, G.; Castellano, V.; Macellari, V.; Lacquaniti, F. Brain, 2004 , 127, 1019.
57. Leblond, H.; L'Esperance, M.; Orsal, D.; Rossignol, S. J. Neurosci., 2003, 23, 11411.
58. Nacimiento, W.; Sappok, T.; Brook, G.; Toth, L.; Schoen, S.; Noth, J.; Kreutzberg, G. Acta Neuropathol., 1995, 90, 552.
59. Tai, Q.; Palazzolo, K.; Mautes, A.; Nacimiento, W.; Kuhtz-Buschbeck, J.; Nacimiento, A.; Goshgarian, H. J. Spinal Cord Med., 1997, 20, 311.
60. Tillakaratne, N.; de Leon, R.; Hoang, T.; Roy, R.; Edgerton, V.; Tobin. A. J. Neurosci., 2002, 22, 3130.
61. Belanger, M.; Drew, T.; Provencher, J.; Rossignol, S. J. Neurophysiol., 1996, 76, 471.
62. Schallert, T.; Bland, S.; Leasure, J.; Tillerson, J.; Gonzales, R.; Williams, L.; Aronowski, J.; Grotta, J. In Cerebral reorganisation of function after brain damage.; Grafman, J., Levin, H., Eds.; Oxford University Press: New York, 2000; pp. 145-167.
63. Tononi, G.; Sporns, O.; Edelman, G. Proc. Natl. Acad. Sci. , 1999, 96, 3257.
64. Rossignol, S.; Giroux, N.; Chau, C.; Marcoux, J.; Brustein, E.; Reader, T. J. Physiol., 2001, 533, 65.
65. MacDonald, E.; Kobilka, B.; Scheinin, M. TIPS, 1997 , 18, 211.
66. Giroux, N.; Reader, T. A.; Rossignol, S. J. Neurophysiol. , 2001, 85, 2516.
67. Giroux, N.; Brustein, E.; Chau, C.; Barbeau, H.; Reader, T.; Rossignol, S. Ann. N.Y. Acad. Sci., 1998, 860, 517.
68. Brustein, E.; Rossignol, S. J. Neurophysiol., 1999 , 81, 1513.
69. Remy-Neris, O.; Barbeau, H.; Daniel, O.; Boiteau, F. Exp. Brain Res., 1999, 129, 433.
70. Filos, K.; Goudas, L.; Patroni, O.; Polyzou, V. Anesthesiology, 1994, 81, 591.
71. Marlier, L.; Teilhac, J.; Cerruti, C.; Privat, A. Brain Res., 1991, 550, 15.
72. Antri, M.; Orsal, D.; Barthe, J.-Y. Eur. J. Neurosci., 2002, 16, 467.
73. Antri, M.; Mouffle, C.; Orsal, D.; Barthe, J. Eur. J. Neurosci., 2003, 18, 1963.
74. McEwen, M.L.; Van Hartesveldt, C.; Stehouwer, D.J. Behav. Neurosci., 1997, 111, 825.
75. Kim, D.; Adipudi, V.; Shibayama, M.; Giszter, S.; Tessler, A.; Murray, M.; Simansky, K. J. J. Neurosci., 1999, 19, 6213.
76. Gimenez y Ribotta, M.; Orsal, D.; Feraboli-Lohnherr, D.; Privat, A. Ann. N. Y. Acad. Sci., 1998, 860, 393.
77. Liu, Y.; Kim, D.; Himes, B. T.; Chow, S. Y.; Schallert, T.; Murray, M.; Tessler, A.; Fischer, I. J. Neurosci., 1999, 19, 4370.
78. Hashimoto, T.; Fukuda, N. Brain Res., 1991, 539, 263.
79. Salzman, S.; Mendez, A.; Dabney, K.; Daley, J.; Freeman, G.; el-Tantawi, S.; Beckman, A.; Bunnell, W. J. Neurotrauma, 1991 , 8, 45.
80. Puniak, M.; Freeman, G.; Agresta, C.; Newkirk, L. V.; Barone, C.; Salzman, S. J. Neurotrauma, 1991, 8, 193.
81. Saruhashi, Y.; Young, W. Exp. Neurol., 1994, 129, 207.
82. Norman, K.; Pepin, A.; Barbeau, H. Spinal Cord, 1998 , 36, 699.
83. Giroux, N.; Chau, C.; Barbeau, H.; Reader, T. A.; Rossignol, S. J. Neurophysiol., 2003, 90, 1027.
84. Chau, C.; Barbeau, H.; Rossignol, S. J. Neurophysiol., 1998, 79, 392.
85. Chau, C.; Giroux, N.; Barbeau, H.; Jordan, L.; Rossignol, S. J. Neurophysiol., 2002, 88, 3032.
86. Guertin, P. Spinal Cord, 2004, 42, 185.
87. Li, S.; Tator, C. Spinal Cord, 1999, 37, 820.
88. Hökfelt, T.; Broberger, C.; Xu, Z.; Sergeyev, V.; Ubink, R.; Diez, M. Neuropeptides, 2000, 39, 1337.
89. Verhage, M.; McMahon, H.; Ghijsen, W.; Boomsa, F.; Scholten, G.; Wiegant, V.; Nicholls, D. Neuron, 1991, 6, 517.
90. Liu, H.; Brown, J.; Jasmin, L.; Maggio, J.; Vigna, S.; Mantyh, P.; Basbaum, A. Proc. Nat. Acad. Sci. USA, 1994, 91, 1009.
91. Zoli, M.; Jansson, A.; Sykova, E.; Agnati, L.; Fuxe, K. TIPS, 1999, 20, 142.
92. Ribeiro-da-Silva, A.; Hokfelt, T. Neuropeptides, 2000, 34, 256-271.
93. Folkers, K.; Horig, J.; Rampold, G.; Lane, P.; Rosell, S.; Bjorkroth, U. Acta Chem. Scand. B., 1982, 36, 389.
94. Betancur, C.; Azzi, M.; Rostene, W. TIPS, 1997, 18, 372.
95. Parker, D.; Grillner, S. J. Neurosci., 1998, 18, 8095.
96. Svensson, E.; Grillner, S.; Parker, D. J. Neurophysiol. , 2002, 87, 113.
97. Parker, D.; Zhang, W.; Grillner, S. J. Neurosci., 1998, 18, 4800.
98. Vita, G.; Haun, C.; Hawkins. E.; Engel, W.; Neuropeptides , 1990, 46, 68.
99. Basbaum, A. Reg. Anesth. Pain Med., 1999, 24 , 59.
100. Willis, W. D., Jr. Ann. N. Y. Acad. Sci., 2001, 933, 142-156.
101. Routh, V.; Helke, C. Prog. Neurobiol., 1995, 104, 93.
102. Guo, J.; Yoshioka, K.; Hosoki, R.; Otsuka, M. Neuropeptides, 1997, 31, 495.
103. Ireland, S.; Wright, I.; Jordan, C. Neuroscience, 1992, 46, 217.
104. Grillner, S. Nat. Rev. Neurosci., 2003, 4, 573.
105. Kiehn, O.; Butt, S. Prog. Neurobiol., 2003, 70 , 347.
106. Roberts, A. Brain Res. Bull., 2000, 53, 585.
107. Getting, P. Ann. Rev. Neurosci., 1989, 12, 185.
108. Hill, R.; Svensson, E.; Dewael, Y.; Grillner, S. Eur. J. Neurosci., 2003, 18, 2919.
109. Sun, Q.-Q.; Dale, N. J. Neurosci., 1999, 19 , 890.
110. Merrywest, S.; McDearmid, J.; Kjaerulff, O.; Kiehn, O.; Sillar, K. Eur. J. Neurosci., 2003, 17, 1013.
111. Schmidt, B.; Hochman, S.; MacLean, J. Ann. N.Y. Acad. Sci. , 1998, 860, 189.
112. Mayer, M.; Westbrook, G.; Guthrie, A. Nature, 1984 , 309, 197.
113. MacLean, J. N.; Schmidt, B. J. J. Neurophysiol., 2001, 86, 1131.
114. Scrymgeour-Wedderburn, J.; Reith, C.; Sillar, K. Eur. J. Neurosci., 1997, 9, 1473.
115. Malenka, R.; Nicoll, R. Science, 1999, 285, 1870.
116. Cruzalegui, F.; Bading, H. Cell Mol. Life Sci., 2000 , 57, 402.
117. Kiehn, O.; Eken, U. Curr. Opin. Neurobiol., 1998, 8, 746.
118. Jankowska, E.; Hammar, I. Brain Res. Brain Res. Rev., 2002, 40, 19.
119. Rudomin, P.; Schmidt, R. Exp. Brain Res., 1999, 129, 1.
120. Arya, T.; Bajwa, S.; Edgley, S. J. Physiol., 1991 , 444, 117.
121. Aggelopoulos, N.; Burton, M.; Clarke, R.; Edgley S. J. Neurosci., 1996, 16, 723.
122. Hultborn, H.; Malmsten, J. Acta Physiol. Scand., 1983, 119, 423.
123. Hammar, I.; Bannatyne, B.; Maxwell, D.; Edgley, S.; Jankowska, E. Eur. J. Neurosci., 2004, 19, 1305.
124. Hammar, I.; Chojnicka, B.; Jankowska, E. J. Comp. Neurol. , 2002, 443, 298.
125. Chen, D.; Bianchetti, M.; Wiesendanger, M. Neuroscience , 1987, 23, 641.
126. Kehne, J.; Gallager, D.; Davis, M. J. Neurosci., 1985, 5, 1583.
127. Kneussel, M.; Betz, H. J. Physiol. (Lond), 2000, 525, 1.
128. Talmadge, R.; Roy, R.; Edgerton, V. In Society for Neuroscience Abstracts, 1996; Vol. 22; pp. 550/17.
129. Robinson, G.; Goldberger, M. Exp. Brain Res., 1986 , 62, 387. Gomez-Pinilla, F.;
130. Ying, Z.; Roy, R. R.; Molteni, R.; Edgerton, V. R. J. Neurophysiol., 2002, 88, 2187.
131. Ying, Z.; Roy, R.; Edgerton, V.; Gomez-Pinilla, F. Brain Res., 2003, 987, 93.
132. Jakeman, L.; Wei, P.; Guan, Z.; Stokes, B. Exp. Neurol. , 1998, 154, 170.
133. Giroux, N.; Rossignol, S.; Reader, T. J. Comp. Neurol., 1999, 406, 402.
134. Howe, J.; Yaksh, T.; Go, V. Neuroscience, 1987, 21, 385.
135. Roudet, C.; Mouchet, P.; Feuerstein, C.; Savasta, M. J. Comp. Neurol., 1994, 39, 319-329.
136. Wikberg, J.; Hajos, M. Neurosci. Lett., 1987, 76, 63.
137. Li, Y.; Harvey, P. J.; Li, X.; Bennett, D. J. J. Neurophysiol., 2004, 91, 2236.
138. Bareyre, F.; Schwab, M. TINS, 2003, 25, 555.
139. Borodinsky, L.; Root, C.; Cronin, J.; Sann, S.; Gu, X.; Spitzer, N. Nature, 2004, 429, 523.
140. Severini, C.; Improta, G.; Falconieri-Erspamer, G.; Salvadori, S.; Erspamer, V. Pharmacol. Rev., 2002, 54, 285.
141. Hahm, S.; Chen, Y.; Vinson, C.; Eiden, L. Mol. Pharmacol. , 2003, 64, 1503.
142. MacArthur, L.; Eiden, L. Peptides, 1996, 17 , 721.
143. Grabowski, P.; Black, D. Prog. Neurobiol., 2001, 65, 289.
144. Lipsky, R.; Goldman, D. Ann. N.Y. Acad. Sci., 2003 , 1003, 22.
145. Cherubini, E.; Conti, F. TINS, 2001, 24, 155.
146. Mayer, M.; Armstrong, N. Ann. Rev. Physiol., 2004 , 66, 161.
147. Dev, K.; Henley, J. Mol. Neurobiol., 1998, 17 , 33.
148. Nishimune, A.; Isaac, J.; Molnar, E.; Noel, J.; Nash, S.; Tagaya, M.; Collingridge, G.; Nakanishi, S.; Henley, J. Neuron, 1998, 21, 87.
149. Lomeli, H.; Mosbacher, J.; Melcher, T.; Hoger, T.; Geiger, J.; Kuner, T.; Monyer, H.; Higuchi, M.; Bach, A.; Seeburg, P. Science , 1994, 266, 1709.
150. Partin, K.; Patneau, D.; Mayer, M. Mol. Pharmacol., 1994, 46, 129.
151. Huettner, J. Prog. Neurobiol., 2003, 70, 387.
152. Moldrich, R.; Cheung, N.; Pascoe, C.; Beart, P. Eur. J. Pharmacol., 1999, 378, R1.
153. Bjerrum, E.; Kristensen, A.; Pickering, D.; Greenwood, J.; Nielsen, B.; Liljefors, T.; Schousboe, A.; Brauner-Osborne, H.; Madsen, U. J. Med. Chem., 2003, 46, 2246.
154. Sekiguchi, M.; Fleck, M.; Mayer, M.; Takeo, J.; Chiba, Y.; Yamashita, S.; Wada, K. J. Neurosci., 1997, 17, 5760.
155. More, J.; Troop, H.; Jane, D. Br. J. Pharmacol., 2002, 137, 1125.
156. Kilpatrick, G.; Dautzenberg, F.; Martin, G.; Eglen, R. TIPS, 1999, 20, 294.
157. Minneman, K. P. Mol. Interv., 2001, 1, 108.
158. Dracheva, S.; Elhakem, S.; Marcus, S.; Siever, L.; McGurk, S.; Haroutunian, V. J. Neurochem., 2003, 87, 1402.
159. Bockaert, J.; Marin, P.; A; Fagni, L. FEBS letters, 2003, 546, 65.
160. Evans, P.; Robb, S.; Reale, T. C. V.; Hannan, F.; Swales, L.; Hall, L.; Midgley, J. Prog. Brain Res., 1995, 106, 259.
161. Berg, K.; Cropper, J.; Niswender, C.; Sanders-Bush, E.; Emeson, R.; Clarke, W. Br. J. Pharmacol., 2001, 134, 386.
162. Selverston, A. Behav. Brain Sciences, 1980, 3 , 535.
163. Bailey, P.L.; Lu, J.K.; Pace, N.L.; Orr, J.A.; White, J.L; Hamber, E.A.; Slawson, M.H.; Crouch, D.J.; Rollins, D.E. N. Engl. J. Med., 2000, 343, 1228.