Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO)

Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2003, Pages 2246-2249

  Bjerrum, Esben J ^a   Kristensen, Anders S ^a   Pickering, Darryl S ^a   Greenwood, Jeremy R ^a   Nielsen, Birgitte ^a   Liljefors, Tommy ^a   Schousboe, Arne ^a   Bräuner Osborne, Hans ^a   Madsen, Ulf ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 (4 CHLORO 3 HYDROXY 5 ISOXAZOLYL)PROPIONIC ACID; 2 AMINO 4 PHOSPHONOMETHYL 3 HEPTENOIC ACID; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMPA RECEPTOR; CHLOROHOMOIBOTENIC ACID; CYCLOTHIAZIDE; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DESENSITIZATION; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; NEUROTOXICITY;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID AGONISTS; ISOXAZOLES; MICE; MODELS, MOLECULAR; NEURONS; OOCYTES; PROPIONATES; PROPIONIC ACIDS; RADIOLIGAND ASSAY; RATS; RECEPTORS, AMPA; RECEPTORS, METABOTROPIC GLUTAMATE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 0038366553     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020588f     Document Type: Article

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