Early locomotor training with clonidine in spinal cats

Journal of Neurophysiology

Volumn 79, Issue 1, 1998, Pages 392-409

  Chau, Connie ^a   Barbeau, Hugues ^a,b   Rossignol, Serge ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CLONIDINE;

ADAPTATION; ANIMAL EXPERIMENT; ARTICLE; CAT; CONTROLLED STUDY; ELECTROMYOGRAPHY; INTRAPERITONEAL DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; LOCOMOTION; NONHUMAN; PRIORITY JOURNAL; TRAINING; VELOCITY; WALKING;

EID: 0031915450     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1998.79.1.392     Document Type: Article

References (49)

1. BARBEAU, H. AND BEDARD, P. Denervation supersensitivity to 5-HT in rats following spinal transection and 5,7 dihydroxytryptamine injection. Neuropharmacology 20: 611-616, 1981.
2. BARBEAU, H., CHAU, C., AND ROSSIGNOL, S. Noradrenergic agonists and locomotor training affect locomotor recovery after cord transection in adult cats. Brain Res. Bull. 30: 387-393, 1993.
3. BARBEAU, H., DANNAKAS, M., AND ARSENAULT, B. The effects of locomotor training in spinal cord injured subjects: a preliminary study. Restorative Neurol. Neurosci. 12: 93-96, 1992.
4. BARBEAU, H., JULIEN, C., AND ROSSIGNOL, S. The effects of clonidine and yohimbine on locomotion and cutaneous reflexes in the adult chronic spinal cat. Brain Res. 437: 83-96, 1987.
5. BARBEAU, H. AND ROSSIGNOL, S. Recovery of locomotion after chronic spinalization in the adult cat. Brain Res. 412: 84-95, 1987.
6. BARBEAU, H. AND ROSSIGNOL, S. Initiation and modulation of the locomotor pattern in the adult chronic spinal cat by noradrenergic, serotonergic and dopaminergic drugs. Brain Res. 546: 250-260, 1991.
7. BELANGER, M., DREW, T., PROVENCHER, J., AND ROSSIGNOL, S. A comparison of treadmill locomotion in adult cats before and after spinalization. J. Neurophysiol. 76: 471-491, 1996.
8. CARRIER, L., BRUSTEIN, E., PROVENCHER, J., AND ROSSIGNOL, S. Adaptation of the locomotor pattern to neuro-muscular lesions in normal and chronic spinal cats. Soc. Neurosci. Abstr. 18: 861, 1992.
9. CARRIER, L., BRUSTEIN, E., AND ROSSIGNOL, S. Locomotion of the hindlimbs following a neurectomy of the ankle flexors in intact and spinal cats: a model for study of plasticity. J. Neurophysiol. 77: 1979-1993, 1997.
10. DAVIES, D. S., WING, L.M.H., REID, J. L., NEILL, E., TIPPETT, P., AND DOLLERY, M. B. Pharmacokinetics and concentration-effect relationships of intravenous and oral clonidine. Clin. Pharmacol. Ther. 21: 593-601, 1976.
11. DIETZ, V., COLOMBO, G., AND JENSEN, L. Locomotor activity in spinal man. Lancet 344: 1260-1263, 1994.
12. DIETZ, V., COLOMBO, G., JENSEN, L., AND BAUMGARTNER, L. Locomotor capacity of spinal cord in paraplegic patients. Ann. Neurol. 37: 574-582, 1995.
13. DURKOVIC, R. G. Classical conditioning of the flexion reflex in spinal cat: features of the reflex circuitry. Neurosci. Lett. 39: 155-160, 1983.
14. EDGERTON, V. R., DE GUZMAN, C. P., GREGOR, R. J., ROY, R. R., HODGSON, J. A., AND LOVELY, R. G. Trainability of the spinal cord to generate hindlimb stepping patterns in adult spinalized cats. In: Neurobiological Basis of Human Locomotion, edited by M. Shimamura, S. Grillner, and V. R. Edgerton. Tokyo: Japan Scientific Societies Press, 1991, p. 411-423.
15. FORSSBERG, H. AND GRILLNER, S. The locomotion of the acute spinal cat injected with clonidine i.v. Brain Res. 50: 184-186, 1973.
16. FORSSBERG, H. AND SVARTENGREN, G. Hardwired locomotor network in cat revealed by a retained motor pattern to gastrocnemius after muscle transposition. Neurosci. Lett. 41: 283-288, 1983.
17. FUNG, J., STEWART, J. E., AND BARBEAU, H. The combined effects of clonidine and cyproheptadine with interactive training on the modulation of locomotion in spinal cord injured subjects. J. Neurol. Sci. 100: 85-93, 1990.
18. GIROUX, N., ALOYZ, R. S., ROSSIGNOL, S., AND READER, T. A. Serotonin 1a and α1 and α2-noradrenergic receptors in the spinal cord of spinalized cats. Soc. Neurosci. Abstr. 21: 926, 1995.
19. GOLDBERGER, M. E. AND MURRAY, M. Restitution of function and collateral sprouting in the cat spinal cord: the deafferented animal. J. Comp. Neurol. 158: 37-54, 1974.
20. GOLDBERGER, M. E. AND MURRAY, M. Lack of sprouting and its presence after lesions of the cat spinal cord. Brain Res. 241: 227-239, 1982.
21. HAGGENDAL, J. AND DAHLSTROM, A. The time course of noradrenaline decrease in rat spinal cord following transection. Neuropharmacology 12: 349-354, 1973.
22. HODGSON, J. A., ROY, R. R., DE LEON, R., DOBKIN, B., AND EDGERTON, V. R. Can the mammalian lumbar spinal cord learn a motor task? Med. Sci. Sports Exer. 26: 1491-1497, 1994.
23. LI, Y. AND RAISMAN, G. Schwann cells induce sprouting in motor and sensory axons in the adult rat spinal cord. J. Neurosci. 14: 4050-4063, 1994.
24. LIU, C. N. AND CHAMBERS, W. W. Intraspinal sprouting of dorsal root axons. Arch. Neurol. Psychiat. 79: 46-61, 1958.
25. LOVELY, R. G., GREGOR, R. J., ROY, R. R., AND EDGERTON, V. R. Weight-bearing hindlimb stepping in treadmill-exercised adult spinal cat. Brain Res. 514: 206-218, 1990.
26. MURRAY, M. AND GOLDBERGER, M. E. Replacement of synaptic terminals in lamina II and clarke's nucleus after unilateral lumbosacral dorsal rhizotomy in adult cats. J. Neurosci. 6: 3205-3217, 1986.
27. MURRAY, M. AND GOLDBERGER, M. E. Restitution of function and collateral sprouting in the cat spinal cord: the partially hemisected animal. J. Comp. Neurol. 158: 19-36, 1974.
28. PEARSON, K. G. AND ROSSIGNOL, S. Fictive motor patterns in chronic spinal cats. J. Neurophysiol. 66: 1874-1887, 1991.
29. PHILIPPSON, M. L'autonomie et la centralisation dans le système nerveux des animaux. Trav. Lab. Physiol. Inst. Solvay (Bruxelles) 7: 1-208, 1905.
30. ROBINSON, G. A. AND GOLDBERGER, M. E. The development and recovery of motor function in spinal cats. II. Pharmacological enhancement of recovery. Exp. Brain Res. 62: 387-400, 1986.
31. ROSSIGNOL, S. Neural control of Stereotypic limb movements. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Washington, DC: Am. Physiol. Soc., 1996, sect. 12, p. 173-216.
32. ROSSIGNOL, S., BARBEAU, H., AND CHAU, C. Pharmacology of locomotion in chronic spinal cat. In: Alpha and Gamma Motor Systems, edited by A. Taylor, M. H. Gladden, and R. Durbaba. New York: Plenum, 1995, p. 449-455.
33. ROSSIGNOL, S., BARBEAU, H., AND JULIEN, C. Locomotion of the adult chronic spinal cat and its modification by monoaminergic agonists and antagonists. In: Development and Plasticity of the Mammalian Spinal Cord, edited by M. Goldberger, A. Gorio, and M. Murray. Padova: Liviana, 1986, p. 323-345.
34. ROSSIGNOL, S., BARBEAU, H., AND PROVENCHER, J. Locomotion in the adult chronic spinal cat. Soc. Neurosci. Abstr. 8: 163, 1982.
35. ROUDET, C., MOUCHET, P., FEUERSTEIN, C., AND SAVASTA, M. Normal distribution of alpha-2-adrenoceptors in the rat spinal cord and its modification after noradrenergic denervation: a quantitative autoradiographic study. J. Neurosci. Res. 39: 319-329, 1994.
36. ROUDET, C., SAVASTA, M., AND FEUERSTEIN, C. Normal distribution of alpha-1-adrenoceptors in the rat spinal cord and its modification after noradrenergic denervation: a quantitative autoradiographic study. J. Neurosci. Res. 34: 44-53, 1993.
37. SHURRAGER, P. S. Walking in spinal kittens and puppies. In: Regeneration in the Central Nervous System, edited by W. F. Windle. Springfield, IL: C. C. Thomas, 1955, p. 208-218.
38. SHURRAGER, P. S. AND DYKMAN, R. A. Walking spinal carnivores. J. Comp. Physiol. Psychol. 44: 252-262, 1951.
39. SMITH, J. L., SMITH, L. A., ZERNICKE, R. F., AND HOY, M. Locomotion in exercised and non-exercised cats cordotomized at two or twelve weeks of age. Exp. Neurol. 76: 393-413, 1982.
40. SPERRY, R. W. The functional results of muscle transposition in the hindlimb of the rat. J. Comp. Neurol. 73: 379-404, 1940.
41. SPERRY, R. W. The effects of crossing nerves to anatogonistic muscles in the hindlimb of the rat. J. Comp. Neurol. 75: 1-19, 1941.
42. VIALA, D., VIALA, G., AND FAYEIN, N. Plasticity of locomotor organization in infant rabbits spinalized shortly after birth. In: Development and Plasticity of the Mammalian Spinal Cord, edited by M. Goldberger, A. Gorio, and M. Murray. Padova: Liviana, 1986, p. 301-310.
43. VISINTIN, M. AND BARBEAU, H. The effects of body weight support on the locomotor pattern of spastic paretic patients. Can. J. Neurol. Sci. 16: 315-325, 1989.
44. WERNIG, A. AND MULLER, S. Laufband locomotion with body weight support improved walking in persons with severe spinal cord injuries. Paraplegia 30: 229-238, 1992.
45. WIELER, M., STEIN, R., AND DAI, R. Multi-center clinical testing of functional electrical stimulation systems to assist walking. Proc. 12th Int. Congr. World Confed. Physical Ther. 1995, 773.
46. WOLPAW, J. R. AND CARP, J. Adaptive plasticity in spinal cord. Adv. Neurol. 59: 163-174, 1993.
47. WOLPAW, J. R., CARP, J. S., AND LEE, C. L. Memory traces in spinal cord produced by H-reflex conditioning: effects of post-tetanic potentiation. Neurosci. Lett. 103: 113-119, 1989.
48. WOLPAW, J. R. AND CHONG, L. L. Memory traces in primate spinal cord produced by operant conditioning of H-reflex. J. Neurophysiol. 61: 563-572, 1989.
49. ZHANG, B., GOLDBERGER, M. E., Wu, L. F., AND MURRAY, M. Plasticity of complex terminals in lamina II in partially deafferented spinal cord: the cat spared root preparation. Exp. Neurol. 132: 186-193, 1995.