Principles of rhythmic motor pattern generation

Physiological Reviews

Volumn 76, Issue 3, 1996, Pages 687-717

  Marder, Eve ^a   Calabrese, Ronald L ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL TISSUE; BEHAVIOR; CONTROL SYSTEM; MOTONEURON; MOTOR ACTIVITY; MOTOR COORDINATION; NERVE CELL NETWORK; NERVOUS SYSTEM FUNCTION; NEUROTRANSMITTER RELEASE; NONHUMAN; PATTERN RECOGNITION; PRIORITY JOURNAL; REVIEW; SYNAPTIC TRANSMISSION;

EID: 0029847273     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.1996.76.3.687     Document Type: Review

References (327)

1. ABBOTT, L. F., S. L. HOOPER, AND E. MARDER. Oscillating networks: control of burst duration by electrically coupled neurons. Neural Comput. 3: 487-497, 1991.
2. ADAMS, M. E., AND M. O'SHEA. Peptide cotransmitter at a neuromuscular junction. Science Wash. DC 221: 286-288, 1983.
3. ALFORD, S., AND K. A. SIGVARDT. Excitatory neurotransmitters activate voltage-dependent properties in neurons in spinal motor system of lamprey. J. Neurophysiol. 62: 334-341, 1989.
4. ANGSTADT, J. D., AND R. L. CALABRESE. A hyperpolarization-activated inward current in heart interneurons of the medicinal leech. J. Neurophysiol. 9: 2846-2857, 1989.
5. ANGSTADT, J. D., AND R. L. CALABRESE. Calcium currents and graded synaptic transmission between heart interneurons of the leech. J. Neurosci. 11: 746-759, 1991.
6. ANGSTADT, J. D., AND W. O. FRIESEN. Modulation of swimming behavior in the medicinal leech. I. Effects of serotonin on the electrical properties of swim-gating cell 204. J. Comp. Physiol A Sens. Neural Behav. Physiol. 172: 223-234, 1993.
7. ANGSTADT, J. D., AND W. O. FRIESEN. Modulation of swimming behavior in the medicinal leech. II. Ionic conductances underlying serotonergic modulation of swim-gating cell 204. J. Comp. Physiol. A Sens. Neural Behav. Physiol. 172: 235-248, 1993.
8. ARBAS, E. A., AND R. L. CALABRESE. Ionic conductances underlying the activity of interneurons that control heartbeat in the medicinal leech. J. Neurosci. 7: 3945-3952, 1987.
9. ARBAS, E. A., AND R. L. CALABRESE. Slow oscillations in membrane potential in interneurons that control heartbeat in the medicinal leech. J. Neurosci. 7: 3953-3960, 1987.
10. ARSHAVSKY, Y. I., T. G. BELIAGINA, G. N. ORLOVSKY, Y. PANCHIN, G. A. PAVLOVA, AND L. B. POPOVA. Control of locomotion in marine mollusc Clione limacina. VI. Activity of isolated neuron of pedal ganglia. Exp. Brain Res. 63: 106-112, 1986.
11. ARSHAVSKY, Y. I., I. N. BELOOZEROVA, G. N. ORLOVSKY, Y. PANCHIN, AND G. A. PAVLOVA. Control of locomotion in marine mollusc Clione limacina. I. Efferent activity during actual and fictitious swimming. Exp. Brain Res. 58: 255-262, 1985.
12. ARSHAVSKY, Y. I., I. N. BELOOZEROVA, G. N. ORLOVSKY, Y. PANCHIN, AND G. A. PAVLOVA. Control of locomotion in marine mollusc Clione limacina. I. Rhythmic neurons of pedal ganglia. Exp. Brain Res. 58: 263-272, 1985.
13. ARSHAVSKY, Y. I., I. N. BELOOZEROVA, G. N. ORLOVSKY, Y. PANCHIN, AND G. A. PAVLOVA. Control of locomotion in marine mollusc Clione limacina. III. On the origin of locomotory rhythm. Exp. Brain Res. 58: 273-284, 1985.
14. ARSHAVSKY, Y. I., I. N. BELOOZEROVA, G. N. ORLOVSKY, Y. PANCHIN, AND G. A. PAVLOVA. Control of locomotion in marine mollusc Clione limacina. IV. Role of type 12 interneurons. Exp. Brain Res. 58: 285-293, 1985.
15. ARSHAVSKY, Y. I., G. N. ORLOVSKY, Y. PANCHIN, AND G. A. PAVLOVA. Control of locomotion in marine mollusc Clione limacina. VII. Reexamination of type 12 interneurons. Exp. Brain Res. 78: 398-406, 1989.
16. ARSHAVSKY, Y. I., G. N. ORLOVSKY, Y. V. PANCHIN, A. ROBERTS, AND S. R. SOFFE. Neuronal control of swimming locomotion: analysis of the pteropod mollusc Clione and embryos of the amphibian Xenopus. Trends Neurosci. 16: 227-233, 1993.
17. AYERS, J., AND A. I. SELVERSTON. Monosynaptic entrainment of an endogenous pacemaker network: a cellular mechanism for von Hoist's magnet effect. J. Comp. Physiol. 129: 5-17, 1979.
18. BAL, T., F. NAGY, AND M. MOULINS. The pyloric central pattern generator in crustacea: a set of conditional neuronal oscillators. J. Comp. Physiol. A Sens. Neural Behav. Physiol. 163: 715-727, 1988.
19. BAXTER, D. A., AND J. H. BYRNE. Ionic conductance mechanisms contributing to the electrophysiological properties of neurons. Curr. Opin. Neurobiol. 1: 105-112, 1991.
20. BEKOFF, A., AND J. A. KAUER. Neural control of hatching: role of neck position in turning on hatching leg movements in post-hatching chicks. J. Comp. Physiol. 145: 495-504, 1982.
21. BEKOFF, A., AND J. A. KAUER. Neural control of hatching: fate of the pattern generator for the leg movements of hatching in post-hatching chicks. J. Neurosci. 4: 2659-2666, 1984.
22. BEKOFF, A, M. P. NUSBAUM, A. L. SABICHI, AND M. CLIFFORD. Neural control of hatching and walking motor output patterns in normal and deafferented chicks. J. Neurosci. 7: 2320-2330, 1987.
23. BELANGER, J. H., AND I. ORCHARD. The locust ovipositor opener muscle: proctolinergic central and peripheral neuromodulation in a centrally driven motor system. J. Exp. Biol. 174: 343-362, 1993.
24. BENSON, J. A., AND W. B. ADAMS. Ionic mechanisms of endogenous activity in molluscan burster neurons. In: Neuronal and Cellular Oscillators, edited by J. Jacklet. New York: Dekker, 1989, p 87-120.
25. BERKOWITZ, A., AND P. S. G. STEIN, Activity of descending propriospinal axons in the turtle hindlimb enlargement during two forms of fictive scratching: broad tuning to regions of the body surface. J. Neurosci. 14: 5089-5104, 1994.
26. BERKOWITZ, A., AND P. S. G. STEIN. Activity of descending propriospinal axons in the turtle hindlimb enlargement during two forms of fictive scratching: phase analyses. J. Neurosci. 14: 5105-5119, 1994.
27. BERTRAM, R. A computational study of the effects of serotonin on a molluscan burster neuron. Biol. Cybern. 69: 257-267, 1993.
28. BIDAUT, M. Pharmacological dissection of pyloric network of the lobster stomatogastric ganglion using picrotoxin. J. Neurophysiol. 44: 1089-1101, 1980.
29. BISHOP, C. A., J. J. WINE, F. NAGY, AND M. R. O'SHEA. Physiological consequences of a peptide cotransmitter in a crayfish nerve-muscle preparation. J. Neurosi. 7: 1769-1779, 1987.
30. BOOTHBY, K. M., AND A. ROBERTS. The stopping response of Xenopus laevis embryos: behaviour, development and physiology. J. Comp. Physiol. A Sens. Neural Behav. Physiol. 170: 171-180, 1992.
31. BRAUN, G., AND B. MULLONEY. Coordination in the crayfish swimmeret system: differential excitation causes changes in intersegmental phase. J. Neurophysiol. 73: 880-885, 1995.
32. BREZINA, V., C. G. EVANS, AND K. R. WEISS. Enhancement of Ca current in the accessory radula closer muscle of Aplysia californica by neuromodulators that potentiate its contractions. J. Neurosci. 14: 4393-4411, 1994.
33. BREZINA, V., C. G. EVANS, AND K. R. WEISS. Activation of K current in the acessory radula closer muscle of Aplysia californica by neuromodulators that depress its contractions. J. Neurosci. 14: 4412-4432, 1994.
34. BRODFUEHRER, P. D., AND W. O. FRIESEN. From stimulation to undulation: an identified pathway for the control of swimming activity in the leech. Science Wash. DC 234: 1002-1004, 1986.
35. BRODIN, L. S., S. GRILLNER, AND C. ROVAINEN. NMDA, kainate and quisqualate receptors and the generation of fictive locomotion in the lamprey spinal cord. Brain Res. 325: 302-306, 1984.
36. BUCHANAN, J. T. Identification of interneurons with contralateral caudal axons in the lamprey spinal cord: synaptic interactions and morphology. J. Neurophysiol. 47: 961-975, 1982.
37. BUCHANAN, J. T. Neural network simulations of coupled locomotor oscillators in the lamprey spinal cord. Biol. Cybern. 66: 367-374, 1992.
38. BUCHANAN, J. T., AND S. GRILLNER. Newly identified "glutamate interneurons" and their role in locomotion in the lamprey spinal cord. Science Wash. DC 236: 312-314, 1987.
39. BUCHANAN, J. T., S. GRILLNER, S. CULHEIM, AND M. RISLING. Identification of excitatory interneurons contributing to generation of locomotion in lamprey: structure, pharmacology, and function. J. Neurophysiol. 62: 59-69, 1989.
40. BUCHANAN, J. T., S. KASICKI, AND D. KOMOROSKI. Swim oscillator coupling signals in lamprey spinal cord. Soc. Neurosci. Abstr. 21: 687, 1995.
41. BURROWS, M., AND M. V. SIEGLER. Graded synaptic transmission between local interneurons and motor neurons in the metathoracic ganglion of the locust. J. Physiol. Lond. 285: 231-255, 1978.
42. BUTERA, R. J., J. W. CLARK, C. C. CANAVIER, D. A. BAXTER, AND J. H. BYRNE. Analysis of the effects of modulatory agents on a modeled bursting neuron: dynamic interactions between voltage and calcium dependent systems. J. Computat. Neurosci. 2: 19-44, 1995.
43. BYRNE, J. H. Cellular analysis of associative learning. Physiol. Rev. 67: 329-439, 1987.
44. CALABRESE, R. L. Modulation of muscle and neuromuscular junctions in invertebrates. Semin. Neurosci. 1: 25-34, 1989.
45. CALABRESE, R. L., J. D. ANGSTADT, AND E. A. ARBAS. A neural oscillator based on reciprocal inhibition. In: Perspectives in Neural Systems and Behavior, edited by T. J. Carew and D. B. Kelley. New York: Liss, 1989, p. 33-50.
46. CALABRESE, R. L., AND E. DESHUTTER. Motor pattern generating networks in invertebrates: modeling our way toward understanding. Trends Neurosci. 15: 439-445, 1992.
47. CALABRESE, R. L., AND E. L. PETERSON. Neural control of heartbeat in the leech, Hirudo medicinalis. In: Neural Origin of Rhythmic Movements, edited by A. Roberts and B. Roberts. Cambridge, UK: Cambridge Univ. Press, 1983, p. 195-221.
48. CANAVIER, C. C., D. A. BAXTER, J. W. CLARK, AND J. H. BYRNE. Nonlinear dynamics in a model neuron provide a novel mechanism for transient synaptic inputs to produce long-term alterations of postsynaptic activity. J. Neurophysiol. 69: 2252-2257, 1993.
49. CANAVIER, C. C., D. A. BAXTER, J. W. CLARK, AND J. H. BYRNE. Multiple modes of activity in a model neuron suggest a novel mechanism for the effects of neuromodulators. J. Neurophysiol. 72:872-882, 1994.
50. CANAVIER, C. C., J. W. CLARK, AND J. H. BYRNE. Simulation of the bursting activity of neuron R15 in Aplysia: role of ionic currents, calcium balance, and modulatory transmitters. J. Neurophysiol. 66: 2107-2124, 1991.
51. CARDI, P., F. NAGY, J. R. CAZALETS, AND M. MOULINS. Multimodal distribution and discontinuous variation in period of interacting oscillators in the crustacean stomatogastric nervous system. J. Comp. Physiol. 167: 23-41, 1990.
52. CHAY, T. R., AND J. KEISER. Minimal model for membrane osculations in the pancreatic β-cell. Biophys. J. 42: 181-189, 1983.
53. CHRISTENSON, J., F. BONGIANNI, S. GRILLNER, AND T. HÖKFELT. Putative GABAergic input to axons of spinal interneurons and primary sensory neurons in the lamprey spinal cord as shown by intracellular Lucifer yellow and GABA immunohistochemistry. Brain Res. 538: 313-318, 1991.
54. CLARAC, F., A. EL MANIRA, AND D. CATTAERT. Presynaptic control as a mechanism of sensory-motor integration. Curr. Opin. Neurol. 2: 764-769, 1992.
55. COHEN, A. H. The structure and function of the intersegmental coordination system in the lamprey spinal cord. J. Comp. Physiol. A Sens. Neural Behav. Physiol. 160: 181-193, 1987.
56. COHEN, A. H., P. J. HOLMES, AND R. H. RAND. The nature of the coupling between segmental oscillators of the lamprey spinal generator for locomotion: a mathematical model. J. Math. Biol. 13: 345-369, 1982.
57. COHEN, A. H., S. ROSSIGNOL, AND S. GRILLNER. Neural Control of Rhythmic Movements in Vertebrates. New York: Wiley, 1988.
58. COHEN, A. H., AND P. WALLÉN. The neuronal correlate of locomotion in fish. "Fictive swimming" induced in an in vitro preparation of the lamprey spinal cord. Exp. Brain Res. 41: 11-18, 1980.
59. COLEMAN, M. J., P. MEYRAND, AND M. P. NUSBAUM. Presynaptic inhibition mediates a switch between two modes of synaptic transmission. Nature Lond. 378: 502-505, 1995.
60. COLEMAN, M. J., AND M. P. NUSBAUM. Functional consequences of compartmentalization of synaptic input. J. Neurosci. 14: 6544-6552, 1994.
61. COLEMAN, M. J., M. P. NUSBAUM, I. COURNIL, AND B. J. CLAIBORNE. Distribution of modulatory inputs to the stomatogastric ganglion of the crab, Cancer borealis. J. Comp. Neurol. 325: 581-594, 1992.
62. CONWAY, B. A., H. HULTBORN, O. KIEHN, AND I. MINTZ. Plateau properties in α-motoneurones induced by intravenous injection of L-dopa and clonidine in the spinal cat. J. Physiol. Lond. 405: 369-384, 1988.
63. 2+-activated potassium currents. J. Exp. Biol. 152:211-241, 1990.
64. CROPPER, E. C., D. PRICE, R. TENENBAUM, I. KUPFERMANN, AND K. R. WEISS. Release of peptide transmitters from a cholinergic motor neuron under physiological conditions. Proc. Natl. Acad. Sci. USA 87: 933-937, 1990.
65. DALE, N. The isolation and identification of spinal neurons that control movement in the Xenopus embryo. Eur. J. Neurosci 3: 1025-1035, 1991.
66. DALE, N., AND A. ROBERTS. Dual-component amino-acid-mediated synaptic potentials: excitatory drive for swimming in Xenopus embryos. J. Physiol. Lond. 363: 35-59, 1985.
67. DALE, N., A. ROBERTS, AND S. R. SOFFE. The anatomy, development, physiology and role of glycinergic neurons in the Xenopus embryo spinal cord. In: Glycine Neurotransmission, edited by O. P. Ottersen and J. Storm-Mathisen. Chichester, UK: Wiley, 1990, p. 329-353.
68. DALE, N. C., AND S. R. SOFFE. Kinematic analysis of amphibian tadpole swimming (Abstract). J. Mar. Biol. Assoc. UK 71: 734, 1991.
69. DANDO, M. R., AND A. I. SELVERSTON. Command fibers from the supra-oesophageal ganglion to the stomatogastric ganglion in Panulirus argus. J. Comp. Physiol. 78: 138-175, 1972.
70. DAVIS, W. J., AND D. KENNEDY. Command interneurons controlling swimmeret movements in the lobster. I. Types of effects on motoneurons. J. Neurophysiol. 35: 1-12, 1972.
71. DAVIS, W. J., AND D. KENNEDY. Command interneurons controlling swimmeret movements in the lobster. II. Interaction of effects on motoneurons. J. Neurophysiol. 35: 13-19, 1972.
72. DE SHUTTER, E., J. D. ANGSTADT, AND R. L. CALABRESE. A model of graded synaptic transmission for use in dynamic network simulations. J. Neurophysiol. 4: 1225-1235, 1993.
73. DESTEXHE, A., A. BABLOYANTZ, AND T. J. SEJNOWSKI. Ionic mechanisms for intrinsic slow oscillations in thalamic relay neurons. Biophys. J. 65: 1538-1552, 1993.
74. DICAPRIO, R. A. Nonspiking interneurons in the ventilatory central pattern generator of the shore crab, Carcinus maenas. J. Comp. Neurol. 185: 83-106, 1989.
75. DICKINSON, P. S., C. MECSAS, AND E. MARDER. Neuropeptide fusion of two motor pattern generator circuits. Nature Lond. 344: 155-158, 1990.
76. DICKINSON, P. S., AND M. MOULINS. Interactions and combinations between different networks in the stomatogastric nervous system. In: Dynamic Biological Networks: The Stomatogastric Nervous System, edited by R. M. Harris-Warrick, E. Marder, A. I. Selverston, and M. Moulins. Cambridge, MA: MIT Press, 1982, p. 139-160.
77. DICKINSON, P. S., AND F. NAGY. Control of a central pattern generator by an identified modulatory interneurone in crustacea. II. Induction and modification of plateau properties in pyloric neurones. J. Exp. Biol. 105: 59-82, 1983.
78. DICKINSON, P. S., F. NAGY, AND M. MOULINS. Control of central pattern generators by an identified neurone in crustacea: activation of the gastric mill motor pattern by a neurone known to modulate the pyloric network. J. Exp. Biol. 136: 53-87, 1988.
79. DIFRANCESCO, D., AND D. NOBLE. Current I, and its contribution to cardiac pacemaking. In: Neuronal and Cellular Oscillators, edited by J. W. Jacklet. New York: Dekker, 1989, chapt. 2, p. 31-57.
80. DIPRISCO, G. V., R. DUBUC, P. WALLÉN, AND S. GRILLNER. 5-Hydroxytryptamine modulates spike frequency regulation in reticulospinal neurons involved in the control of locomotion in lamprey. Neurosci. Lett. 134: 279-283, 1992.
81. DIPRISCO, G. V., P. WALLÉN, AND S. GRILLNER. Synaptic effects of intraspinal stretch receptor neurons mediating movement-related feedback during locomotion. Brain Res. 530: 161-166, 1990.
82. DUBUC, R., AND S. GRILLNER. The role of spinal cord inputs in modulating the activity of reticulospinal neurons during fictive locomotion in the lamprey. Brain Res. 483: 196-200, 1989.
83. DUNLAP, K., AND G. D. FISCHBACH. Neurotransmitters decrease the calcium conductance activated by depolarization of embryonic chick sensory neurones. J. Physiol. Lond. 317: 519-535, 1981.
84. EATON, R. C., R. DIDOMENICO, AND J. NISSANOV. Role of the Mauthner cell in sensorimotor integration by the brain stem escape network. Brain Behav. Evol. 37: 272-285, 1991.
85. EISEN, J. S., AND E. MARDER. Mechanisms underlying pattern generation in lobster stomatogastric ganglion as determined by selective inactivation of identified neurons. III. Synaptic connections of electrically coupled pyloric neurons. J. Neurophysiol. 48: 1392-1415, 1982.
86. EISEN, J. S., AND E. MARDER. A mechanism for the production of phase shifts in a pattern generator. J. Neurophysiol. 51: 1375-1393, 1984.
87. ELSON, R. C., AND A. I. SELVERSTON. Mechanisms of gastric rhythm generation in the isolated stomatogastric ganglion of spiny lobsters: bursting pacemaker potentials, synaptic interactions and muscarinic modulation. J. Neurophysiol. 68: 890-907, 1992.
88. EPSTEIN, I. R., AND E. MARDER. Multiple modes of a conditional neural oscillator. Biol. Cybern. 63: 25-34, 1990.
89. EVOY, W. H., AND D. KENNEDY. The central nervous organization underlying control of antagonistic muscles in the crayfish. Zoologist 165: 223-238, 1967.
90. FIELDS, H. L., M. M. HEINRICHER, AND P. MASON. Neurotransmitters in nocioceptive modulatory circuits. Annu. Rev. Neurosci. 14: 219-245, 1991.
91. FLAMM, R. E., AND R. M. HARRIS-WARRICK. Aminergic modulation in the lobster stomatogastric ganglion. I. Effects on the motor pattern and activity of neurons within the pyloric circuit. J. Neurophysiol. 55: 847-865, 1986.
92. FLAMM, R. E., AND R. M. HARRIS-WARRICK. Aminergic modulation in the lobster stomatogastric ganglion. II. Target neurons of dopamine, octopamine, and serotonin within the pyloric circuit. J. Neurophysiol. 55: 866-881, 1986.
93. FRIESEN, W. O. Neuronal control of leech swimming movements. In: Cellular and Neuronal Oscillators, edited by J. W. Jacklet. New York: Dekker, 1989, p. 269-316.
94. FRIESEN, W. O. Neuronal control of leech swimming movements. II. Motor neuron feedback to oscillator cells 115 and 28. J. Comp. Physiol. A Sens. Neural Behav. Physiol. 166: 205-215, 1989.
95. FRIESEN, W. O., AND R. A. PEARCE. Mechanisms of intersegmental coordination in leech locomotion. Semin. Neurosci. 5: 41-47, 1993.
96. FRIESEN, W. O., M. POON, AND G. S. STENT. Neuronal control of swimming in the medicinal leech. IV. Identification of a network of oscillatory interneurons. J. Exp. Biol. 75: 25-43, 1978.
97. FRIESEN, W. O., AND G. S. STENT. Generation of a locomotory rhythm by a neural network with recurrent cyclic inhibition. Biol. Cybern. 28: 27-40, 1977.
98. FROST, W. N., AND P. S. KATZ. Identification of Tritonia "ramp" interneuron: DRI neuron relays sensory input to the escape swim CPG and also participates in rhythm generation. Soc. Neurosci. Abstr. 20: 1201, 1994.
99. GETTING, P. A. Comparative analysis of invertebrate central pattern generators. In: Neural Control of Rhythmic Movements in Vertebrates, edited by A. H. Cohen, S. Rossignol, and S. Grillner. New York: Wiley, 1988, chapt. 4, p. 101-127.
100. GETTING, P. A. Emerging principles governing the operation of neural networks. Annu. Rev. Neurosci. 12: 185-204, 1989.
101. GETTING, P. A., AND M. S. DEKIN. Tritonia swimming: a model system for integration within rhythmic motor systems. In: Model Neural Networks and Behavior, edited by A. I. Selverston. New York: Plenum, 1985, chapt. 1, p. 3-20.
102. GETTING, P. A., AND M. S. DEKIN. Mechanisms of pattern generation underlying swimming in Tritonia. IV. Gating of central pattern generator. J. Neurophysiol. 53: 466-480, 1985.
103. GOLOWASCH, J., F. BUCHHOLTZ, I. R. EPSTEIN, AND E. MARDER. Contribution of individual ionic currents to activity of a model stomatogastric ganglion neuron. J. Neurophysiol. 67: 341-349, 1992.
104. GOLOWASCH, J., AND E. MARDER. Ionic currents of the lateral pyloric neuron of the stomatogastric ganglion of the crab. J. Neurophysiol. 67: 318-331, 1992.
105. GRAUBARD, K. Synaptic transmission without action potentials: input-output properties of a nonspiking presynaptic neuron. J. Neurophysiol. 41: 1014-1025, 1978.
106. GRAUBARD, K., J. A. RAPER, AND D. K. HARTLINE. Graded synaptic transmission between identified spiking neurons. J. Neurophysiol. 50: 508-521, 1983.
107. GRAY, C. M. Synchronous oscillations in neuronal systems: mechanisms and functions. J. Computat. Neurosci. 1: 11-38, 1994.
108. GRAY, J. Studies in animal locomotion. I. The movement of fish with special reference to the eel. J. Exp. Biol. 10: 88-103, 1933.
109. GRAY, J. Studies in animal locomotion. IV. The neuromuscular mechanism of swimming in the eel. J. Exp. Biol. 13: 170-180, 1936.
110. GRAY, J. Animal Locomotion. London: Weidenfeld & Nicolson, 1968.
111. GRILLNER, S., J. T. BUCHANAN, AND A. LANSNER. Simulation of the segmental burst generating network for locomotion in lamprey. Neurosci. Lett. 89: 31-35, 1988.
112. GRILLNER, S., J. T. BUCHANAN, P. WALLÉN, AND L. BRODIN. Neural control of locomotion in lower vertebrates: from behavior to ionic mechanisms. In: Neural Control of Rhythmic Movements in Vertebrates, edited by A. H. Cohen, S. Rossignol, and S. Grillner. New York: Wiley, 1988, chapt. 1, p. 1-40.
113. GRILLNER, S., AND M. KONISHI, (Editors). Neural control. Curr. Opin. Neurobiol. 1: 553-555, 1991.
114. GRILLNER, S., T. MATSUSHINA, T. WADDEN, A. EL MANIRA, AND P. WALLÉN. The neurophysiological bases of undulatory locomotion in vertebrates. Semin. Neurosci. 5: 17-27, 1993.
115. GRILLNER, S., A. D. MCCLELLAN, AND C. PERRET. Entrainment of the spinal pattern generators for swimming by mechanosensitive elements in the lamprey spinal cord in vitro. Brain Res. 217: 380-386, 1981.
116. GRILLNER, S., A. D. MCCLELLAN, AND K. A. SIGVARDT. Mechanosensitive neurones in the spinal cord of the lamprey. Brain Res. 235: 169-173, 1982.
117. GRILLNER, S., P. WALLÉN, L. BRODIN, and A. LANSNER. Neuronal network generating locomotor behavior in lamprey: circuitry, transmitters, membrane properties, and simulation. Annu. Rev. Neurosci. 14: 169-169, 1991.
118. GUCKENHEIMER, J., S. GUERON, and R. M. HARRIS-WARRICK. Mapping the dynamics of a bursting neuron. Philos. Trans. R. Soc. Lond. B Biol. Sci. 341: 345-359, 1993.
119. HARRIS-WARRICK, R. M. Chemical modulation of central pattern generators. In: Neural Control of Rhythmic Movements in Vertebrates, edited by A. H. Cohen, S. Rossignol, and S. Grillner. New York: Wiley, 1988, p. 285-331.
120. HARRIS-WARRICK, R. M., L. M. CONIGLIO, N. BARAZANGI, J. GUCKENHEIMER, AND S. GUERON. Dopamine modulation of transient potassium current evokes phase shifts in a central pattern generator network. J. Neurosci. 15: 342-358, 1995.
121. HARRIS-WARRICK, R. M., L. M. CONIGLIO, R. M. LEVINI, S. GUERON, AND J. GUCKENHEIMER. Dopamine modulation of two subthreshold currents produces phase shifts in activity of an identified motoneuron. J. Neurophysiol. 74: 1404-1420, 1995.
122. HARRIS-WARRICK, R. M., AND R. E. FLAMM. Multiple mechanisms of bursting in a conditional bursting neuron. J. Neurosci. 7: 2113-2128, 1987.
123. HARRIS-WARRICK, R. M., AND E. MARDER. Modulation of neural networks for behavior. Annu. Rev. Neurosci. 14: 39-57, 1991.
124. HARTLINE, D. K. Pattern generation in the lobster (Panulirus) stomatogastric ganglion. II. Pyloric network stimulation. Biol. Cybern. 33: 223-236, 1979.
125. HARTLINE, D. K., AND D. V. GASSIE. Pattern generation in the lobster (Panulirus) stomatogastric ganglion. I. Pyloric neuron kinetics and synaptic interactions. Biol. Cybern. 33: 209-222, 1979.
126. HASHENZADEH-GARGARI, H., AND W. O. FRIESEN. Modulation of swimming activity in the medicinal leech by serotonin and octopamine. Comp. Biochem. Physiol. C Comp. Pharmacol. 94: 295-302, 1989.
127. HAWKINS, R. D., E. R. KANDEL, AND S. A. SIEGELBAUM. Learning to modulate transmitter release: themes and variations in synaptic plasticity. Annu. Rev. Neurosci. 16: 625-665, 1993.
128. HEINZEL, H. G. Gastric mill activity in the lobster. I. Spontaneous modes of chewing. J. Neurophysiol. 59: 528-550, 1988.
129. HEINZEL, H. G. Gastric mill activity in the lobster. II. Proctolin and octopamine initiate and modulate chewing. J. Neurophysiol. 59: 551-565, 1988.
130. HEINZEL, H. G., AND A. I. SELVERSTON. Gastric mill activity in the lobster. III. The effects of proctolin on the isolated central pattern generator. J. Neurophysiol. 59: 566-585, 1988.
131. HEINZEL, H.-G., J. M. WEIMANN, AND E. MARDER. The behavioral repertoire of the gastric mill in the crab, Cancer pagurus: an in vivo endoscopie and electrophysiological examination. J. Neurosci. 13: 1793-1803, 1993.
132. HERMANS, C. O., AND R. A. SATTERLIE. Fast-strike feeding behavior in a pteropod mollusk, Clione limacina Phipps. Biol. Bull. 182: 1-7, 1992.
133. HINDMARSH, J. L., AND R. M. ROSE. A model of neural bursting with three coupled first order differential equations. Proc. R. Soc. Lond. B Biol. Sci. 221: 87-102, 1984.
134. HODGKIN, A. L., AND A. F. HUXLEY. A qualitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. Lond. 117: 500-544, 1952.
135. HOOPER, S. L., AND E. MARDER. Modulation of the lobster pyloric rhythm by the peptide proctolin. J. Neurosci. 7: 2097-2112, 1987.
136. HOOPER, S. L., AND M. MOULINS. Switching of a neuron from one network to another by sensory-induced changes in membrane properties. Science Wash. DC 244: 1587-1589, 1989.
137. HOOPER, S. L., AND M. MOULINS. Cellular and synaptic mechanisms responsible for a long-lasting restructuring of the lobster pyloric network. J. Neurophysiol. 64: 1574-1589, 1990.
138. HOUNSGAARD, J., H. HULTBORN, B. JESPERSEN, AND O. KIEHN. Bistability of α-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan. J. Physiol. Lond. 405: 345-367, 1988.
139. HOUNSGAARD, J., AND O. KIEHN. Serotonin-induced bistability of turtle motoneurones caused by a nifedipine-sensitive calcium plateau potential. J. Physiol. Lond. 414: 265-282, 1989.
140. HOUNSGAARD, J., AND O. KIEHN. Calcium spikes and calcium plateaux evoked by differential polarization in dendrites of turtle motoneurones in vitro. J. Physiol. Lond. 468: 245-259, 1993.
141. 2+-mediated plateau potentials in a subpopulation of interneurons in the ventral horn of the turtle spinal cord. Eur. J. Neurol. 4: 183-188, 1992.
142. HOYLE, G. Muscles and Their Neural Control. New York: Wiley, 1983.
143. HUERTA, P. T., AND J. E. LISMAN. Heightened synaptic plasticity of hippocampal CA1 neurons during a cholinergically induced rhythmic state. Nature Lond. 364: 723-725, 1993.
144. HUGUENARD, J. R., AND D. A. MCCORMICK. Simulation of the currents involved in rhythmic oscillations in thalamic relay neurons. J. Neurophysiol. 68: 1373-1383, 1992.
145. JACKLET, J. W. (Editor). Neuronal and Cellular Oscillators. New York: Dekker, 1989.
146. JAN, Y. N., L. Y. JAN, AND S. W. KUFFLER. A peptide as a possible transmitter in sympathetic ganglia of the frog. Proc. Natl. Acad. Sci. USA 76: 1501-1505, 1979.
147. JOHNSON, B. R., AND R. M. HARRIS-WARRICK. Aminergic modulation of graded synaptic transmission in the lobster stomatogastric ganglion. J. Neurosci. 10: 2066-2076, 1990.
148. JOHNSON, B. R., J. H. PECK, AND R. M. HARRIS-WARRICK. Temperature sensitivity of graded synaptic transmission in the lobster stomatogastric ganglion. J. Exp. Biol. 156: 267-285, 1991.
149. JOHNSON, B. R., J. H. PECK, AND R. M. HARRIS-WARRICK. Differential modulation of chemical and electrical components of mixed synapses in the lobster stomatogastric ganglion. J. Comp. Physiol. A Sens. Neural. Behav. Physiol. 175: 233-249, 1994.
150. JOHNSON, B. R., J. H. PECK, AND R. M. HARRIS-WARRICK. Distributed amine modulation of graded chemical transmission in the pyloric network of the lobster stomatogastric ganglion. J. Neurophysiol. 74: 437-452, 1995.
151. JOHNSTON, R. M., AND A. BEKOFF. Constrained and flexible features of rhythmical hindlimb movements in chicks: kinematic profiles of walking, swimming and airstepping. J. Exp. Biol. 171: 43-66, 1992.
152. KACZMAREK, L. K., AND I. B. LEVITAN (Editors). Neuromodulation: the Biochemical Control of Neuronal Excitability. New York: Oxford Univ. Press, 1987.
153. KATZ, P. S., AND W. N. FROST. Intrinsic neuromodulation in the Tritonia swim CPG: the serotonergic dorsal swim interneurons act presynaptically to enhance transmitter release from interneuron C2. J. Neurosci. 15: 6035-6045, 1995.
154. KATZ, P. S., AND W. N. FROST. Intrinsic neuromodulation in the Tritonia swim CPG: serotonin mediates both neuromodulation and neurotransmission by the dorsal swim interneurons. J. Neurophysiol. 74: 2281-2294, 1995.
155. KATZ, P. S., P. A. GETTING, AND W. N. FROST. Dynamic neuromodulation of synaptic strength intrinsic to a central pattern generator circuit. Nature Lond. 367: 729-731, 1994.
156. KATZ, P. S., AND R. M. HARRIS-WARRICK. Recruitment of crab gastric mill neurons into the pyloric motor pattern by mechanosensory afferent stimulation. J. Neurophysiol. 65: 1442-1451, 1991.
157. KENNEDY, D., AND W. J. DAVIS. The organization of invertebrate motor systems. In: Handbook of Physiology. The Nervous System. Cellular Biology of Neurons. Bethesda, MD: Am. Physiol. Soc., 1977, sect. 1, vol. I, chapt. 27, p. 1023-1087.
158. KENNEDY, D., W. H. EVOY, B. DANE, AND J. T. HANAWALT. The central nervous organization underlying control of antagonistic muscles in the crayfish. II. Coding of position by command fibres. J. Exp. Zool. 165: 239-248, 1967.
159. KEPLER, T. B., E. MARDER, AND L. F. ABBOTT. The effect of electrical coupling on the frequency of model neuronal oscillators. Science Wash. DC 248: 83-85, 1990.
160. KIEHN, O. Plateau potentials and active integration in the "final common pathway" for motor behaviour. Trends Neurosci. 14: 68-73, 1991.
161. KIEHN, O., AND R. M. HARRIS-WARRICK. Serotonergic stretch receptors induce plateau properties in a crustacean motor neuron by a dual-conductance mechanism. J. Neurophysiol. 68: 485-495, 1992.
162. HEHN, O., AND R. M. HARRIS-WARRICK. Serotonergic modulation of hypeipolarization-activated inward current and a calcium-dependent outward current in a crustacean motor neuron. J. Neurophysiol. 68: 496-508, 1992.
163. KOCH, V. T., V. S. BÄSSLER, AND M. BRUNNER. Non-spiking neurons suppress fluctuations in small networks. Biol. Cybern. 62: 75-81, 1989.
164. KOPELL, N. Toward a theory of modeling central pattern generators. In: Neural Control of Rhythmic Movements in Vertebrates, edited by A. H. Cohen, S. Rossignol, and S. Grillner. New York: Wiley, 1988, chapt. 10, p. 369-413.
165. KOPELL, N., AND G. B. ERMENTROUT. Symmetry and phase coupling in chains of weakly coupled oscillators. Commun. Pure Appl. Math. 39: 623-660, 1986.
166. KOPELL, N., AND G. B. ERMENTROUT. Coupled oscillators and the design of central pattern generators. Math. Biosci. 90: 87-109, 1988.
167. KRISTAN, W. B., JR., AND R. L. CALABRESE. Rhythmic swimming activity in neurons of the isolated nerve cord of the leech. J. Exp. Biol. 65: 643-668, 1976.
168. KRISTAN, W. B., JR., G. S. STENT, AND C. A. ORT. Neuronal control of swimming in the medicinal leech. I. Dynamics of the swimming rhythm. J. Comp. Physiol. 94: 97-119, 1974.
169. KRISTAN, W. B., JR., G. S. STENT, AND C. A. ORT. Neuronal control of swimming in the medicinal leech. III. Impulse patterns of the motor neurons. J. Comp. Physiol. 94: 155-176, 1974.
170. KUPFERMANN, I. Functional studies of cotransmission. Physiol. Rev. 71: 683-732, 1991.
171. KUPFERMANN, I., AND K. R. WEISS. The command neuron concept. Behav. Brain Sci. 1: 3-39, 1978.
172. LAURENT, G., AND H. DAVIDOWITZ. Encoding of olfactory information with oscillating neural assemblies. Science Wash. DC 265: 1872-1875, 1994.
173. LAURENT, G., AND M. NARAGHI. Odorant-induced oscillations in the mushroom bodies of the locust. J. Neurosci. 14: 2993-3004, 1994.
174. LEMASSON, G., E. MARDER, AND L. F. ABBOTT. Activity-dependent regulation of conductances in model neurons. Science Wash. DC 259: 1915-1917, 1993.
175. LERESCHE, N., S. LIGHTOWLER, I. SOLTESZ, D. JASSIK-GERSCHENFELD, AND V. CRUNELLI. Low frequency oscillatory activities intrinsic to rat and cat thalamocortical cells. J. Physiol. Lond. 441: 155-174, 1991.
176. LINGLE, C. The modulatory action of dopamine on crustacean foregut neuromuscular preparations. J. Exp. Biol. 94: 285-299, 1981.
177. LISMAN, J. E., AND M. A P. IDIART. Storage of 7±2 short-term memories in oscillatory subcycles. Science Wash. DC 267: 1512-1515, 1995.
178. LLINÁS, R. R. The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. Science Wash. DC 242: 1654-1664, 1988.
179. LOFARO, T., N. KOPELL, E. MARDER, AND S. L. HOOPER. Subharmonic coordination in networks of neurons with slow conductances. Neural Comp. 6: 69-84, 1994.
180. MA, P. M., B. S. BELTZ, AND E. A. KRAVITZ. Serotonin-containing neurons in lobsters: their role as gain-setters in postural control mechanisms. J. Neurophysiol. 68: 36-54, 1992.
181. MARDER, E. Neurotransmitters and neuromodulators. In: The Crustacean Stomatogastric System, edited by A. I. Selverston and M. Moulins. Berlin: Springer-Verlag, 1987, p. 263-300.
182. MARDER, E. Plateaus in time. Curr. Biol. 1: 326-327, 1991.
183. MARDER, E. Modulating membrane properties of neurons: role in information processing. In: Exploring Brain Functions: Models in Neuroscience, edited by T. A. Poggio and D. A. Glaser. Chichester, UK: Wiley, 1993, p. 27-42.
184. MARDER, E., AND J. S. EISEN. Transmitter identification of pyloric neurons: electrically coupled neurons use different neurotransmitters. J. Neurophysiol. 51: 1345-1361, 1984.
185. MARDER, E., AND J. S. EISEN. Electrically coupled pacemaker neurons respond differently to the same physiological inputs and neurotransmitters. J. Neurophysiol. 51: 1362-1374, 1984.
186. MARDER, E., AND S. L. HOOPER. Neurotransmitter modulation of the Stomatogastric ganglion of decapod crustaceans. In: Model Neural Networks and Behavior, edited by A. I. Selverston. New York: Plenum, 1985, p. 319-337.
187. MARDER, E., AND P. MEYRAND. Chemical modulation of an oscillatory neural circuit. In: Neuronal and Cellular Oscillators, edited by J. Jacklet. New York:
188. MARDER, E., P. SKIEBE, AND A. E. CHRISTIE. Multiple modes of network modulation. Dtsch. Zool. Ges. 87: 177-184, 1994.
189. MARDER, E., AND J. M. WEIMANN. Modulatory control of multiple task processing in the Stomatogastric nervous system. In: Neurobiology of Motor Programme Selection: New Approaches to Mechanisms of Behavioral Choice, edited by J. Kien, C. McCrohan, and W. Winlow. Oxford, UK: Pergamon, 1992, p. 3-19.
190. MARDER, E., J. M. WEIMANN, T. B. KEPLER, AND L. F. ABBOTT. Computational implications of a serotonin-sensitive region of axonal membrane on a dual function motor neuron. In: Neural Systems: Analysis and Modeling, edited by F. H. Eeckman. Boston: Kluwer, 1992, p. 377-390.
191. MATSUSHIMA, T., AND S. GRILLNER. Neural mechanisms of intersegmental coordination in lamprey: local excitability changes modify the phase coupling along the spinal cord. J. Neurophysiol. 67: 373-388, 1992.
192. MATSUSHIMA, T., AND S. GRILLNER. Local serotonergic modulation of calcium-dependent potassium channels controls intersegmental coordination in the lamprey spinal cord. J. Neurophysiol. 67: 1683-1690, 1992.
193. MAYNARD, D. M. Simpler networks. Ann. NY Acad. Sci. 193: 59-72, 1972.
194. MAYNARD, D. M., AND K. D. WALTON. Effects of maintained depolarization of presynaptic neurons on inhibitory transmission in lobster neuropil. J. Comp. Physiol. 97: 215-243, 1975.
195. MCCLELLAN, A. D., G. D. BROWN, AND P. A. GETTING. Modulation of swimming in Tritonia: excitatory and inhibitory effects of serotonin. J. Comp. Physiol. A Sens. Neural. Behav. Physiol. 174: 257-266, 1994.
196. MCCLELLAN, A., AND S. GRILLNER. Activation of "fictive swimming" by electrical microstimulation of brainstem locomotor regions in an in vitro preparation of the lamprey central nervous system. Brain Res. 300: 357-361, 1984.
197. MCCLELLAN, A. D., AND K. A. SIGVARDT. Features of entrapment of spinal pattern generators for locomotor activity in the lamprey spinal cord. J. Neurosci. 8: 133-145, 1988.
198. MCCORMICK, D. A., AND H.-C. PAPE. Properties of a hyperpolarization-activated cation current and its role in rhythmic oscillation in thalamic relay neurones. J. Physiol. Lond. 431: 291-318, 1990.
199. MCCORMICK, D. A., AND H.-C. PAPE. Noradrenergic and serotonergic modulation of a hyperpolarization-activated cation current in thalamic relay neurones. J. Physiol. Lond. 431: 319-342, 1990.
200. MEYRAND, P., AND E. MARDER. Matching neural and muscle oscillators: control by FMRFamide-like peptides. J. Neurosci. 11. 1150-1161, 1991.
201. MEYRAND, P., J. SIMMERS, AND M. MOULINS. Construction of a pattern generating circuit with neurons of different networks. Nature Lond. 351: 60-63, 1991.
202. MEYRAND, P., J. SIMMERS, AND M. MOULINS. Dynamic construction of a neural network from multiple pattern generators in the lobster stomatogastric nervous system. J. Neurosci. 14: 630-644, 1994.
203. MEYRAND, P., J. M. WEIMANN, AND E. MARDER. Multiple axonal spike initiation zones in a motor neuron: serotonin activation. J. Neurosci. 12: 2803-2812, 1992.
204. MILLER A. D., S. NONANCKA, S. F. LAKOS, AND L. K. TAN. Diaphragmatic and external intercostal muscle control during vomiting: behavior of inspiratory bulbospinal neurons. J. Neurophysiol. 63: 31-36, 1990.
205. MILLER, J. P. Pyloric mechanisms. In: The Crustacean Stomatogastric System, edited by A. I. Selverston and M. Moulins. Berlin: Springer-Verlag, 1987, p. 109-137.
206. MILLER, J. P., AND A. I. SELVERSTON. Rapid killing of single neurons by an irradiation of intracellularly injected dye. Science Wash. DC 206: 702-704, 1979.
207. MILLER, J. P., AND A. I. SELVERSTON. Mechanisms underlying pattern generation in lobster stomatogastric ganglion as determined by selective inactivation of identified neurons. II. Oscillatory properties of pyloric neurons. J. Neurophysiol. 48: 1378-1391, 1982.
208. MILLER, J. P., AND A. I. SELVERSTON. Mechanisms underlying pattern generation in lobster stomatogastric ganglion as determined by selective inactivation of identified neurons. IV. Network properties of pyloric system. J. Neurophysiol. 48: 1416-1432, 1982.
209. MONTGOMERY, E. B., JR., M. H. CLARE, S. SAHRMANN, S. R. BUCHHOLZ, L. S. HIBBARD, AND W. M. LANDAU. Neuronal multipotentiality: evidence for network representations of physiological function. Brain Res. 580: 49-61, 1992.
210. MORRIS, C., AND H. LECAR. Voltage oscillations in the barnacle giant muscle fiber. Biophys. J. 35: 193-213, 1981.
211. MORTIN, L. I., AND P. S. G. STEIN. Spinal cord segments containing key elements of the central pattern generators for three forms of scratch reflex in the turtle. J. Neurosci. 9: 2285-2296, 1989.
212. MUDGE, A. W., S. E. LEEMAN, AND G. D. FISCHBACH. Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration. Proc. Natl. Acad. Sci. USA 76: 526-530, 1979.
213. MULLONEY, B. Organization of the stomatogastric ganglion of the spiny lobster. V. Coordination of the gastric and pyloric systems. J. Comp. Physiol. 122: 227-236, 1977.
214. MULLONEY, B., D. MURCHISON, AND A. CHRACHRI. Modular organization of pattern-generating circuits in a segmental motor system: the swimmerets of crayfish. Semin. Neurosci. 5: 49-57, 1993.
215. MULLONEY, B., AND A. I. SELVERSTON. Antidromic action potentials fail to demonstrate known interactions between neurons. Science Wash. DC 177: 69-72, 1972.
216. MULLONEY, B., AND A. I. SELVERSTON. Organization of the stomatogastric ganglion in the spiny lobster. I. Neurons driving the lateral teeth. J. Comp. Physiol. 91: 1-32, 1974.
217. MULLONEY, B., AND A. I. SELVERSTON. Organization of the stomatogastric ganglion in the spiny lobster. III. Coordination of the two subsets of the gastric system. J. Comp. Physiol. 91: 53-78, 1974.
218. MURCHISON, D., AND J. L. LARIMER. Dual motor output interneurons in the abdominal ganglia of the crayfish Procambarus clarkii: synaptic activation of motor outputs in both the swimmeret and abdominal positioning systems by single interneurons. J. Exp. Biol. 150: 269-293, 1990.
219. MURCHISON, D., AND J. L. LARIMER. Synaptic interactions among neurons that coordinate swimmeret and abdominal movements in the crayfish. J. Comp. Physiol. A Sens. Neural Behav. Physiol. 170: 739-749, 1992.
220. NADIM, F., Ø. H. OLSEN, E. DE SCHUTTER, AND R. L. CALABRESE. Modeling the leech heartbeat elemental oscillator. I. Interactions of intrinsic and synaptic currents. J. Computat. Neurosci. 2: 215-235, 1995.
221. NAGY, F., AND P. S. DICKINSON. Control of a central pattern generator by an identified modulatory interneurone in crustacea. I. Modulation of the pyloric motor output. J. Exp. Biol. 105: 33-58, 1983.
222. NAGY, F., P. S. DICKINSON, AND M, MOULINS. Control by an identified modulatory neuron of the sequential expression of plateau properties of, and synaptic inputs to, a neuron in a central pattern generator. J. Neurosci. 8: 2875-2886, 1988.
223. NICHOLLS, J. G., AND B. G. WALLACE. Quantal analysis of transmitter release at an inhibitory synapse in the CNS of the leech. J. Physiol. Lond. 281: 171-185, 1978.
224. NICHOLLS, J. G., AND B. G. WALLACE. Modulation of transmission at an inhibitory synapse in the central nervous system of the leech. J. Physiol. Lond. 281: 157-170, 1978.
225. NISSANOV, J., R. C. EATON, AND R. DIDOMENICO. The motor output of the Mauthner cell, a reticulospinal command neuron. Brain Res. 517: 88-98, 1990.
226. NOVICKI, A., AND J. C. WEEKS. Organization of the larval preecdysis motor pattern in the tobacco hornworm, Manduca sexta. J. Comp. Physiol. A Sens. Neural Behav. Physiol. 173: 151-162, 1993.
227. NUSBAUM, M. P. Synaptic basis of swim initiation in the leech. III. Synaptic effects of serotonin-containing interneurons (cell 21 and 61) on swim CPG neurons (cells 18 and 208). J. Exp. Biol. 122: 303-321, 1986.
228. NUSBAUM, M. P., W. O. FRIESEN, W. B. KRISTAN, JR., AND R. A. PEARCE. Neural mechanisms generating the leech swimming rhythm: swim-initiator neurons excite the network of swim oscillator neurons. J. Comp. Physiol. A Sens. Neural Behav. Physiol. 161: 355-366, 1987.
229. NUSBAUM, M. P., AND E. MARDER. A modulatory proctolin-containing neuron (MPN). I. Identification and characterization. J. Neurosci. 9: 1591-1599, 1989.
230. NUSBAUM, M. P., AND E. MARDER. A modulatory proctolin-containing neuron (MPN). II. State-dependent modulation of rhythmic motor activity. J. Neurosci. 9: 1600-1607, 1989.
231. NUSBAUM, M. P., J. M. WEIMANN, J. GOLOWASCH, AND E. MARDER. Presynaptic control of modulatory fibers by their neural network targets. J. Neurosci. 12: 2706-2714, 1992.
232. OHTA, Y., AND S. GRILLNER. Monosynaptic excitatory amino acid transmission from the posterior rhombencephalic reticular nucleus to spinal neurones involved in the control of locomotion in lamprey. J. Neurophysiol. 62: 1079-1089, 1989.
233. OLSEN, Ø. H., F. NADIM, and R. L. CALABRESE. Modeling the leech heartbeat elemental oscillator. II. Exploring the parameter space. J. Computat. Neurosci. 2: 237-257, 1995.
234. OPDYKE, C. A., AND R. L. CALABRESE. A persistent sodium current contributes to oscillatory activity in heart interneurons of the medicinal leech. J. Comp. Physiol. A Sens. Neural Behav. Physiol. 175: 781-789, 1994.
235. PANCHIN, Y. V., R. I. SADREEV, AND Y. I. ARSHAVSKY. Control of locomotion in marine mollusc Clione limadna X. Effects of acetylcholine antagonists. Exp. Brain Res. 106: 135-144, 1995.
236. PASZTOR, V. Modulation of sensitivity in invertebrate sensory receptors. Semin. Neurosci. 1: 5-14, 1989.
237. PEARCE, R. A., AND W. O. FRIESEN. Intersegmental coordination of leech swimming comparison of in situ and isolated nerve cord activity with body wall movement. Brain Res. 299: 363-366, 1984.
238. PEARCE, R. A., AND W. O. FRIESEN. Intersegmental coordination of the leech swimming rhythm. I. Intrinsic period gradient and coupling strength. J. Neurophysiol. 54: 1444-1459, 1985.
239. PEARCE, R. A., AND W. O. FRIESEN. Intersegmental coordination of the leech swimming rhythm. II. Comparison of long and short chains of ganglia. J. Neurophysiol. 54: 1460-1472, 1985.
240. PEARCE, R. A., AND W. O. FRIESEN. A model for intersegmental coordination in the leech nerve cord. Biol. Cybern. 58: 301-311, 1988.
241. PEARSON, K. G., AND C. R. FOURTNER. Nonspiking interneurons in walking system of the cockroach. J. Neurophysiol. 38: 33-52, 1975.
242. PEARSON, K. G., AND J. M. RAMIREZ. Parallels with other invertebrate and vertebrate motor systems. In: Dynamic Biological Networks: The Stomatogastric Nervous System, edited by R. M. Harris-Warrick, E. Marder, A. I. Selverston, and M. Moulins. Cambridge, MA: MIT Press, 1992, p. 263-281.
243. PENG, Y.-Y., AND J. P. HORN. Continuous repetitive stimuli are more effective than bursts for evoking LHRH release in bullfrog sympathetic ganglia. J. Neurosci. 11: 85-95, 1991.
244. PERKEL, D. H., AND B. MULLONEY. Motor pattern production in reciprocally inhibitory neurons exhibiting postinhibitory rebound. Science Wash. DC 185: 181-183, 1974.
245. PETERSON, E, L. Generation and coordination of heartbeat timing oscillation in the medicinal leech. I. Oscillation in isolated ganglia. J. Neurophysiol. 49: 611-626, 1983.
246. PETERSON, E. L. Generation and coordination of heartbeat timing oscillation in the medicinal leech. II. Intersegmental coordination. J. Neurophysiol. 49: 627-638, 1983.
247. PETERSON, E. L., AND R. L. CALABRESE. Dynamic analysis of rhythmic neural circuit in the leech, Hirudo medicinalis. J. Neurophysiol. 47: 256-271, 1982.
248. PIN, T., M. CREST, E. EHILE, G. JACQUET, AND M. GOLA. Plateau-generating nerve cells in Helix: morphological and electrophysiological characteristics. J. Exp. Biol. 152: 189-209, 1990.
249. PINSKER, H. M. Aplysia bursting neurons as endogenous oscillators. I. Phase-response curves for pulsed inhibitory synaptic input. J. Neurophysiol. 40: 527-543, 1977.
250. PINSKER, H. M. Aplysia bursting neurons as endogenous oscillators. II. Synchronization and entrainment by pulsed inhibitory synaptic input. J. Neurophysiol. 40: 544-556, 1977.
251. POON, M., W. O. FRIESEN, AND G. S. STENT. Neuronal control of swimming in the medicinal leech. V. Connections between oscillatory interneurons and the motor neurones. J. Exp. Biol. 75: 45-63, 1978.
252. PROBST, W. C., E. C. CROPPER, J. HEIERHORST, S. L. HOOPER, H. JAFFE, F. VILIM, S. BEUSHAUSEN, I. KUPFERMANN, AND K. R. WEISS. cAMP-dependent phosphorylation of Aplysia twitching may mediate modulation of muscle contractions by neuropeptide cotransmitters. Proc. Natl. Acad. Sci. USA 91:8487-8491, 1994.
253. RAMIREZ, J. M., AND I. ORCHARD. Octopaminergic modulation of the forewing stretch receptor in the locust, Locusta migratoria. J. Exp. Biol. 149: 255-279, 1990.
254. RAMIREZ, J. M., AND K. G. PEARSON. Octopamine induces bursting and plateau potentials in insect neurones. Brain Res. 549: 332-337, 1991.
255. RAMIREZ, J. M., AND K. G. PEARSON. Alteration of bursting properties in interneurons during locust flight. J. Neurophysiol. 70: 2148-2160, 1993.
256. REZER, E., AND M. MOULINS. Expression of the crustacean pyloric pattern generator in the intact animal. J. Comp. Physiol. A Sens. Neural Behav. Physiol. 153: 17-28, 1983.
257. RINZEL, J., AND G. B. ERMENTROUT. Analysis of neural excitability and oscillations. In: Methods in Neuronal Modeling, edited by C. Koch and I. Segev. Cambridge, MA: MIT Press, 1989, p. 135-169.
258. RINZEL, J., AND Y. S. LEE. Dissection of a model for neuronal parabolic bursting. J. Math. Biol. 25: 653-675, 1987.
259. ROBERTS, A., M. J. TUNSTALL, AND E. WOLF. Properties of networks controlling locomotion and significance of voltage dependency of NMDA channels: simulation study of rhythm generation sustained by positive feedback. J. Neurophysiol. 73: 485-495, 1995.
260. ROVAINEN, C. M. Synoptic interactions of identified nerve cells in the spinal cord of the sea lamprey. J. Comp. Neurol. 154: 189-206, 1974.
261. ROWAT, P. F., AND A. I. SELVERSTON. Modeling the gastric mill central pattern generator of the lobster with a relaxation-oscillator network. J. Neurophysiol. 70: 1030-1053, 1993.
262. RUSSELL, D. F., AND D. K. HARTLINE. Bursting neural networks: a reexamination. Science Wash. DC 200: 453-456, 1978.
263. SATTERLIE, R. A. Reciprocal inhibition and postinhibitory rebound produce reverberation in locomotor pattern generator. Science Wash. DC 229: 402-404, 1985.
264. SATTERLIE, R. A. Reciprocal inhibition and rhythmicity: swimming in a pteropod mollusc. In: Neuronal and Cellular Oscillators, edited by J. Jacklet. New York: Dekker, 1989, p. 151-171.
265. SATTERLIE, R. A. Neural control of speed changes in an opisto-branch locomotory system. Biol. Bull. 180: 228-233, 1991.
266. SCHMIDT, J., AND R. L. CALABRESE. Evidence that acetylcholine is an inhibitory transmitter of heart interneurons in the leech. J. Exp. Biol. 171: 329-347, 1992.
267. SELVERSTON, A. I. (Editor). Model Neural Networks and Behavior. New York: Plenum, 1985.
268. SELVERSTON, A. I. Lobster gastric mill oscillator. In: Neuronal and Cellular Oscillators, edited by J. Jacklet. New York: Dekker, 1989, p. 339-370.
269. SELVERSTON, A. I., AND J. P. MILLER. Mechanism underlying pattern generation in lobster stomatogastric ganglion as determined by selective inactivation of identified neurons. I. Pyloric system. J. Neurophysiol. 44: 1102-1121, 1980.
270. SELVERSTON, A. I., AND B. MULLONEY. Organization of the stomatogastric ganglion of the spiny lobster. II. Neurons driving the medial tooth. J. Comp. Physiol. 91: 33-51, 1974.
271. SHARP, A. A., L. F. ABBOTT, AND E. MARDER. Artificial electrical synapses in oscillatory neurons. J. Neurophysiol. 67: 1691-1694, 1992.
272. SHARP, A. A., M. B. O'NEIL, L. F. ABBOTT, AND E. MARDER. Dynamic clamp: computer-generated conductances in real neurons. J. Neurophysiol. 69: 992-995, 1993.
273. SHARP, A. A., M. B. O'NEIL, L. F. ABBOTT, AND E. MARDER. The dynamic clamp: artificial conductances in biological neurons. Trends Neurosci. 16: 389-394, 1993.
274. SHARP, A. A., F. K. SKINNER, AND E. MARDER. Dynamic clamp constructed two-cell half-center circuits: mechanisms of oscillation and the interaction and modulation of synaptic and intrinsic conductances. J. Neurophysiol. In press.
275. SHERMAN, A., AND J. RINZEL. Rhythmogenic effects of weak electrotonic coupling in neuronal models. Proc. Natl. Acad. Sci. USA 89: 2471-2474, 1992.
276. SIEGLER, M. V. Nonspiking interneurons and motor control in insects. Adv. Insect Physiol. 18: 249-304, 1985.
277. SIGVARDT, K. A. Spinal mechanisms in the control of lamprey swimming. Am. Zool. 29: 19-35, 1989.
278. SIGVARDT, K. A. Intersegmental coordination in the lamprey central pattern generator for locomotion. Semin. Neurosci. 5: 3-15, 1993.
279. SIGVARDT, K. A., S. GRILLNER, P. WALLÉN, AND P. A. M. VAN DONGEN. Activation of NMDA receptors elicits fictive locomotion and bistable membrane properties in the lamprey spinal cord. Brain Res. 336: 390-395, 1985.
280. SILLAR, K. T. Synaptic modulation of cutaneous pathways in the vertebrate spinal cord. Semin. Neurosci. 1: 45-54, 1989.
281. SILLAR, K. T., J. F. S. WEDDERBURN, AND J. A. SIMMERS. The development of swimming rhythmicity in post-embryonic Xenopus laevis. Proc. R. Soc. Lond. Biol. Sci. 246: 147-153, 1991.
282. SIMON, T. W., C. A. OPDYKE, AND R. L. CALABRESE. Modulatory effects of FMRF-NH2 on outward currents and oscillatory activity in heart interneurons of the medicinal leech. J. Neurosci. 12: 525-537, 1992.
283. SIMON, T. W., J. SCHMIDT, AND R. L. CALABRESE. Modulation of high-threshold transmission between heart interneurons of the medicinal leech by FMRF-NH2. J. Neurophysiol. 71: 454-466, 1994.
284. SKINNER, F. K., S. GRAMOLL, R. L. CALABRESE, N. KOPELL, AND E. MARDER. Frequency control in biological half-center oscillators. In: Computation in Neurons and Neural Systems, edited by F. H. Eeckman. Boston: Kluwer, 1994, p. 223-228.
285. SKINNER, F. K., N. KOPELL, AND E. MARDER. Mechanisms for oscillation and frequency control in reciprocal inhibitory model neural networks. J. Computat. Neurosci. 1: 69-87, 1094.
286. SKINNER, F. K., G. G. TURRIGIANO, AND E. MARDER. Frequency and burst duration in oscillating neurons and two-cell networks. Biol. Cybern. 69: 375-383, 1993.
287. SOFFE, S. R. Roles of glycinergic inhibition and N-methyl-D-aspartate receptor-mediated excitation in the locomotor rhythmicity of one half of the Xenopus embryos. Eur. J. Neurosci. 1: 561-571, 1989.
288. SOFFE, S. R. Active and passive membrane properties of spinal cord neurons which are rhythmically active during swimming in Xenopus embryos. Eur. J. Neurosci. 2: 1-10, 1990.
289. SOFFE, S. R. Two distinct rhythmic motor patterns are driven by common premotor and motor neurons in a simple vertebrate spinal cord. J. Neurosci. 13: 4456-4469, 1994.
290. SOLTESZ, I., S. LIGHTOWLER, N. LERESCHE, D. JASSIK-GERSCHENFELD, C. E. POLLARD, AND V. CRUNELLI. Two inward currents and the transformation of low frequency oscillations of rat and cat thalamocortical cells. J. Physiol. Lond. 441: 175-197, 1991.
291. SOMERS, D., AND N. KOPELL. Rapid synchronization through fast threshold modulation. Biol. Cybern. 68: 393-407, 1993.
292. STEIN, P. S. G. Spinal cord circuits for motor pattern selection in the turtle. Ann. NY Acad. Sci. 563: 1-10, 1989.
293. STERIADE, M., D. A. MCCORMICK, AND T. J. SEJNOWSKI. Thalamocortical oscillations in the sleeping and aroused brain. Science Wash. DC 262: 679-685, 1993.
294. STERIADE, M., A. NUÑEZ, AND F. AMZICA. Intracellular analysis of relations between the slow (<1 Hz) neocortical oscillation and other sleep rhythms of the electroencephalogram. J. Neurosci. 13: 3266-3283, 1993.
295. THOMPSON, K. J., AND R. L. CALABRESE. FMRFamide effects on membrane properties of heart cells isolated from the leech, Hirudo medicinalis. J. Neurophysiol. 67: 280-291, 1992.
296. TIERNEY, A. J., AND R. M. HARRIS-WARRICK. Physiological role of the transient potassium current in the pyloric circuit of the lobster stomatogastric ganglion. J. Neurophysiol. 67: 599-609, 1992.
297. TUNSTALL, M. J., AND A. ROBERTS. Longitudinal coordination of motor output during swimming in Xenopus embryos. Proc. R. Soc. Lond. B Biol. Sci. 244: 27-32, 1991.
298. TUNSTALL, M. J., AND A. A. ROBERTS. A longitudinal gradient of synaptic drive in the spinal cord of Xenopus embryos and its role in co-ordination of swimming. J. Physiol. Lond. 474: 393-405, 1994.
299. TUNSTALL, M. J., AND K. T. SILLAR. Physiological and developmental aspects of intersegmental coordination in Xenopus embryos and tadpoles. Semin. Neurosci. 5: 29-40, 1993.
300. TURRIGIANO, G. G., G. LEMASSON, AND E. MARDER. Selective regulation of current densities underlies spontaneous changes in the activity of cultured neurons. J. Neurosci. 15: 3640-3652, 1995.
301. VAN VREESWIJK, C., L. F. ABBOTT, AND G. B. ERMENTROUT. When inhibition not excitation synchronizes neural firing. J. Computat. Neurosci. 1: 313-321, 1994.
302. WALL, M. J., AND N. DALE. A role for potassium currents in the generation of the swimming motor pattern of Xenopus embryos. J. Neurophysiol. 72: 337-348, 1994.
303. WALLÉN, P., O. EKEBERG, A. LANSNER, L. BRODIN, H. TRAVÉN, AND S. GRILLNER. A computer-based model for realistic simulations of neuronal networks. II. The segmental network generating locomotor rhythmicity in the lamprey. J. Neurophysiol. 68: 1939-1950, 1992.
304. WALLÉN, P., AND S. GRILLNER. N-methyl-D-aspartate receptor-induced inherent activity in neurons active during fictive locomotion in the lamprey. J. Neurosci. 7: 2745-2755, 1987.
305. WALLÉN, P., AND T. L. WILLIAMS. Fictive locomotion in the lamprey spinal cord in vitro compared with swimming in the intact and spinal animal. J. Physiol. Lond. 347: 225-239, 1984.
306. WANG, X.-J., AND J. RINZEL. Alternating and synchronous rhythms in reciprocally inhibitory model neurons. Neural Comp. 4: 84-97, 1992.
307. WEEKS, J. C. Neuronal basis of leech swimming: separation of swim initiation, pattern generation and intersegmental coordination by selective lesions. J. Neurophysiol. 45: 698-723, 1981.
308. WEEKS, J. C. Synaptic basis of swim initiation in the leech. I. Connections of a swim-initiation neuron (cell 204) with motor neurons and pattern-generating "oscillator" neurons. J. Comp. Physiol. A Sens. Neural Behav. Physiol. 148: 253-263, 1982.
309. WEEKS, J. C. Synaptic basis of swim initiation in the leech. II. A pattern-generating neuron (cell 208) which mediates motor effects of swim-initiating neurons. J. Comp. Physiol. A Sens. Neural Behav. Physiol. 148: 265-279, 1982.
310. WEEKS, J. C., AND W. B. KRISTAN, JR. Initiation, maintenance and modulation of swimming in the medicinal leech by the activity of a single neuron. J. Exp. Biol. 77: 71-88, 1978.
311. WEIMANN, J. M., AND E. MARDER. Switching neurons are integral members of multiple oscillatory networks. Curr. Biol. 4: 896-902, 1994.
312. WEIMANN, J. M., E. MARDER, B. EVANS, AND R. L. CALABRESE. The effects of SDRNFLRFamide and TNRNFLRFamide on the motor patterns of the stomatogastric ganglion of the crab Cancer borealis. J. Exp. Biol. 181: 1-26, 1993.
313. WEIMANN, J. M., P. MEYRAND, AND E. MARDER. Neurons that form multiple pattern generators: identification and multiple activity patterns of gastric/pyloric neurons in the crab stomatogastric system. J. Neurophysiol. 65: 111-122, 1991.
314. WEISS, K. R., J. L. COHEN, AND I. KUPFERMANN. Modulatory control of buccal musculature by a serotonergic neuron (metacerebral cell) in Aplysia. J. Neurophysiol. 41: 181-203, 1978.
315. WEISS, K. R., D. E. MANDELBAUM, M. SCHONBERG, AND I. KUPFERMANN. Modulation of buccal muscle contractility by serotonergic metacerebral cells in Aplysia: evidence for a role of cyclic adenosine monophosphate. J. Neurophysiol. 42: 791-803, 1979.
316. WHIM, M. D., AND P. E. LLOYD. Frequency-dependent release of peptide cotransmitters from identified cholinergic motor neurons in Aplysia. Proc. Natl. Acad. Sci. USA 86: 9034-9038, 1989.
317. WHIM, M. D., AND P. E. LLOYD. Neuropeptide cotransmitters released from an identified cholinergic motor neuron modulate neuromuscular efficacy in Aplysia. J. Neurosci. 10: 3313-3322, 1990.
318. WIERSMA, C. A. G., AND K. IKEDA. Interneurons commanding swimmeret movements in the crayfish, Procambarus clarkii (Girard). Comp. Biochem. Physiol. 12: 509-525, 1964.
319. WILLIAMS, T. L. Phase coupling by synaptic spread in chains of coupled neuronal oscillators. Science Wash. DC 258: 662-665, 1992.
320. WILLIAMS, T. L. Phase coupling in simulated chains of coupled oscillators representing the lamprey spinal cord. Neural Comp. 4: 54-558, 1992.
321. WILLIAMS, T. L., S. GRILLNER, V. V. SMOLJANINOV, P. WALLÉN, S. KASHIN, AND S. ROSSIGNOL. Locomotion in lamprey and trout: the relative timing of activation and movement. J. Exp. Biol. 143: 559-566, 1989.
322. WILLIAMS, T. L., AND K. A. SIGVARDT. Intersegmental phase lags in the lamprey spinal cord: experimental confirmation of the existence of a boundary region. J. Computat. Neurosci. 1: 61-67, 1994.
323. WILLIAMS, T. L., K. A. SIGVARDT, N. KOPELL, G. B. ERMENTROUT, AND M. P. REMLER. Forcing of coupled nonlinear oscillators: studies of intersegmental coordination in the lamprey locomotor central pattern generator. J. Neurophysiol. 64: 862-871, 1990.
324. WILSON, D. The central nervous control of locust flight. J. Exp. Biol. 38: 471-490, 1961.
325. WOLF, H., AND K. G. PEARSON. Comparison of motor patterns in the intact and deafferented flight system of the locust. J. Comp. Physiol. A Sens. Neural Behav. Physiol. 160: 269-279, 1987.
326. WU, J., L. B. COHEN, AND C. X. FALK. Neuronal activity during different behaviors in Aplysia: a distributed organization. Science Wash. DC 263: 820-822, 1994.
327. ZIEGLGÄNSBERGER, W., AND T. R. TÖLLE. The pharmacology of pain signaling. Curr. Biol. 3: 611-618, 1993.