Locomotor recovery in the chronic spinal rat: Effects of long-term treatment with a 5-HT2 agonist

European Journal of Neuroscience

Volumn 16, Issue 3, 2002, Pages 467-476

  Antri, M ^a   Orsal, D ^a   Barthe, Jean Yves ^a  

^a SORBONNE UNIVERSITÉ   (France)

Author keywords

EMG; Locomotion; Locomotor recovery; Quipazine; Serotonin; Spinal rat

Indexed keywords

QUIPAZINE; SEROTONIN 2 AGONIST; SEROTONIN 2 RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; CONVALESCENCE; ELECTROMYOGRAPHY; FEMALE; FOOT; LEG MOVEMENT; LOCOMOTION; LONG TERM CARE; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY;

ANIMALS; DRUG ADMINISTRATION SCHEDULE; ELECTROMYOGRAPHY; FEMALE; HINDLIMB; LOCOMOTION; MUSCLE CONTRACTION; MUSCLE, SKELETAL; NERVE NET; NEURONS; PERIODICITY; QUIPAZINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RECOVERY OF FUNCTION; SEROTONIN AGONISTS; SPINAL CORD; SPINAL CORD INJURIES; TREATMENT OUTCOME; VIDEO RECORDING;

EID: 0036460098     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2002.02088.x     Document Type: Conference Paper

References (29)

1. Barthe, J.Y. & Clarac, F. (1997) Modulation of the spinal network for locomotion by substance P in the neonatal rat. Exp. Brain Res., 115, 485-492.
2. Basso, D.M., Beattie, M.S. & Bresnahan, J.C. (1995) A sensitive and reliable locomotor rating scale for open field testing in rats. J. Neurotrauma, 12, 1-21.
3. Bayliss, D.A., Viana, F., Talley, E.M. & Berger, A.J. (1997) Neuromodulation of hypoglossal motoneurons: Cellular and developmental mechanisms. Respir. Physiol., 110, 139-150.
4. Björklund, A. & Dunnett, S.B. (1992) Neural transplantation in adult rats. In Dunnett, S.B. & Björklund, A. (eds), Neural Transplantation: A Practical Approach. Oxford University Press, Oxford, pp. 57-78.
5. Carlin, K.P., Jiang, Z. & Brownstone, R.M. (2000a) Characterization of calcium currents in functionally mature mouse spinal motoneurons. Eur. J. Neurosci., 12, 1624-1634.
6. Carlin, K.P., Jones, K.E., Jiang, Z., Jordan, L.M. & Brownstone, R.M. (2000b) Dendritic 1-type calcium currents in mouse spinal motoneurons: Implications for bistability. Eur. J. Neurosci., 12, 1635-1646.
7. Cazalets, J.R., Grillner, P., Menard, I., Cremieux, J. & Clarac, F. (1990) Two types of motor rhythm induced by NMDA and amines in an in vitro spinal cord preparation of neonatal rat. Neurosci. Lett., 111, 116-121.
8. Cazalets, J.R., Sqalli-Houssaini, Y. & Clarac, F. (1992) Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat. J. Physiol. (Lond.), 455, 187-204.
9. Clarke, K.A. & Kirby, K. (1994) Stimulation of locomotion in neonate rats by TRH analogue CG3703. Neuropeptides, 26, 71-75.
10. Feraboli-Lohnherr, D., Barthe, J.Y. & Orsal, D. (1999) Serotonin-induced activation of the network for locomotion in adult spinal rats. J. Neurosci. Res., 55, 87-98.
11. Feraboli-Lohnherr, D., Orsal, D., Yakovleff, A., Ribotta, M. & Privat, A. (1997) Recovery of locomotor activity in the adult chronic spinal rat after sublesional transplantation of embryonic nervous cells: Specific role of serotonergic neurons. Exp. Brain Res., 113, 443-454.
12. Goudard, I., Orsal, D. & Cabelguen, J.-M. (1992) An electromyographic study of the hindlimb locomotor movements in the acute thalamic rat. Eur. J. Neurosci., 4, 1130-1139.
13. Hochman, S., Garraway, S.M., Machacek, D.W. & Shay, B.L. (2001) 5-HT receptors and the neuromodulatory control of spinal cord Function. In Cope, T.C. (ed.), Motor Neurobiology of the Spinal Cord. CRC Press, London, pp. 47-87.
14. Hochman, S. & McCrea, D.A. (1994) Effects of chronic spinalization on ankle extensor motoneurons. II. Motoneuron electrical properties. J. Neurophysiol., 71, 1468-1479.
15. Jiang, Z., Rempel, J., Li, J., Sawchuk, M.A., Carlin, K.P. & Brownstone, R.M. (1999) Development of 1-type calcium channels and a nifedipine-sensitive motor activity in the postnatal mouse spinal cord. Eur. J. Neurosci., 11, 3481-3487.
16. Kim, D., Adipudi, V., Shibayama, M., Giszter, S., Tessler, A., Murray, M. & Simansky, K.J. (1999) Direct agonists for serotonin receptors enhance locomotor function in rats that received neural transplants after neonatal spinal transection. J. Neurosci., 19, 6213-6224.
17. Kim, D., Murray, M. & Simansky, K.J. (2001) The serotonergic 5-HT (2C) agonist m-chlorophenylpiperazine increases weight-supported locomotion without development of tolerance in rats with spinal transections. Exp. Neurol., 169, 496-500.
18. Kow, L.M. & Pfaff, D.W. (1996) Thyrotropin-releasing hormone (TRH) has independent excitatory and modulatory actions on lamina IX neurons of lumbosacral spinal cord slices from adult rats. Peptides, 17, 131-138.
19. Lee, R.H. & Heckman, C.J. (1998a) Bistability in spinal motoneurons in vivo: Systematic variations in rhythmic firing patterns. J. Neurophysiol., 80, 572-582.
20. Lee, R.H. & Heckman, C.J. (1998b) Bistability in spinal motoneurons in vivo: Systematic variations in persistent inward currents. J. Neurophysiol., 80, 583-593.
21. Ribotta, M. & Privat, A. (1998) Biological interventions for spinal cord injury. Curr. Opin. Neurol., 11, 647-654.
22. Ribotta, M.G., Provencher, J., Feraboli-Lohnherr, D., Rossignol, S., Privat, A. & Orsal, D. (2000) Activation of locomotion in adult chronic spinal rats is achieved by transplantation of embryonic raphe cells reinnervating a precise lumbar level. J. Neurosci., 20, 5144-5152.
23. Rossignol, S., Bélanger, M., Chau, C., Giroux, N., Brustein, E., Bouyer, L., Grenier, T., Drew, T., Barbeau, H. & Reader, T.A. (2000) The spinal cat. In Kalb, R.G. & Strittmatter, S.M. (eds), Neurobiology of Spinal Cord Injury. Humana Press, Totowa, pp. 57-87.
24. Russo, R.E., Nagy, F. & Hounsgaard, J. (1997) Modulation of plateau properties in dorsal horn neurones in a slice preparation of the turtle spinal cord. J. Physiol. (Lond.), 499, 459-474.
25. Schmidt, B.J. & Jordan, L.M. (2000) The role of serotonin in reflex modulation and locomotor rhythm production in the mammalian spinal cord. Brain Res. Bull., 53, 689-710.
26. Slawinska, U., Majczynski, H. & Djavadian, R. (2000) Recovery of hindlimb motor functions after spinal cord transection is enhanced by grafts of the embryonic raphe nuclei. Exp. Brain Res., 132, 27-38.
27. Svensson, E., Grillner, S. & Parker, D. (2001) Gating and braking of short- and long-term modulatory effects by interactions between colocalized neuromodulators. J. Neurosci., 21, 5984-5992.
28. Yakovleff, A.K., Cabelguen, J.M., Orsal, D., Ribotta, M.G.y., Rajaofetra, N., Drian, M.J., Bussel, B., & Prival, A. (1995) Fictive motor activities in adult spinal rats transplanted with embryonic brainstem neurons. Exp. Brain Res., 106, 69-78.
29. Yi, D.K., Adipudi, V., Shibayama, M., Anderson, K.N., Simansky, K.J. & Murray, M. (1998) Transplant-mediated locomotion is improved by selective serotonergic agonists. Ann. NY Acad. Sci., 860, 524-527.