Mitotic kinesins: Prospects for antimitotic drug discovery

Current Topics in Medicinal Chemistry

Volumn 5, Issue 2, 2005, Pages 127-145

  Bergnes, Gustave ^a   Brejc, Katjuša ^a   Belmont, Lisa ^a  

^a Cytokinetics Inc   (United States)

Author keywords

Cancer; Eg5; Inhibitor; Kinesin; KSP; Mitosis; Monastrol; Structure

Indexed keywords

ADOCIASULFATE 1; ADOCIASULFATE 10; ADOCIASULFATE 2; ADOCIASULFATE 3; ADOCIASULFATE 4; ADOCIASULFATE 5; ADOCIASULFATE 6; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; CENTROMERE PROTEIN E; CK 0106023; COMPLEMENTARY RNA; HR 22C 16; ISPINESIB; KINESIN; KINESIN INHIBITOR; MONASTROL; MONASTROLINE; PACLITAXEL; PHENOTHIAZINE DERIVATIVE; QUINAZOLINONE DERIVATIVE; RETINOIC ACID; RETINOIC ACID RECEPTOR; SMALL INTERFERING RNA; TAXANE DERIVATIVE; TERPENDOLE C; TERPENDOLE E; TERPENDOLE H; TERPENDOLE I; TRIPHENYLMETHANE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; CANCER; CANCER INHIBITION; CELL DIVISION; CELL PROLIFERATION; CLINICAL TRIAL; CYTOKINESIS; DRUG DESIGN; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME STRUCTURE; HUMAN; MAXIMUM TOLERATED DOSE; MITOSIS SPINDLE; NONHUMAN; OVARY CARCINOMA; PANCREAS CARCINOMA; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SOLID TUMOR; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG DESIGN; HUMANS; KINESIN; MITOSIS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 17144405643     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568026053507697     Document Type: Review

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