Motor proteins of the kinesin family. Structures, variations, and nucleotide binding sites

European Journal of Biochemistry

Volumn 262, Issue 1, 1999, Pages 1-11

  Sack, Stefan ^a   Kull, F Jon ^b   Mandelkow, Eckhard ^a  

^a MAX PLANCK UNIT FOR STRUCTURAL MOLECULAR BIOLOGY   (Germany)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

Kar3; Kinesin crystal structure; Kinesin dimer; Motor protein; Ncd dimer; Nucleotide dependent conformations; P loop

Indexed keywords

KINESIN;

ANIMAL TISSUE; BINDING SITE; CRYSTAL STRUCTURE; INTRACELLULAR TRANSPORT; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; RAT; SHORT SURVEY; X RAY DIFFRACTION;

ANIMALS; BINDING SITES; HUMANS; KINESIN; NUCLEOTIDES; PROTEIN CONFORMATION;

EID: 0033563154     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00341.x     Document Type: Short Survey

References (52)

1. 1. Sheetz, M.P. (1999) Motor and cargo interactions. Eur. J. Biochem. 262, 19-25.
2. 2. Endow, S.A. (1999) Microtubule motors in spindle and chromosome motility. Eur. J. Biochem. 262, 12-18.
3. 3. Vale, R.D. & Fletterick, R.J. (1997) The design plan of kinesin motors. Annu. Rev. Cell Dev. Biol. 13, 745-777.
4. 4. Hirokawa, N. (1998) Kinesin and dynein superfamily proteins and the mechanism of organelle transport. Science 279, 519-526.
5. 5. Kull, F.J., Vale, R.D. & Fletterick, R. (1998) The case for a common ancestor: kinesin and myosin motor proteins and G proteins. J. Muscle Res. Cell Motil. 19, 877-886.
6. 6. Kull, F.J., Sablin, E., Lau, P., Fletterick, R. & Vale, R. (1996) Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Nature 380, 550-554.
7. 7. Sack, S., Müller, J., Marx, A., Thormählen, M., Mandelkow, E.-M., Brady, S.T. & Mandelkow, E. (1997) X-ray structure of motor and neck domains from rat brain kinesin. Biochemistry 36, 16155-16165.
8. 8. Kozielski, F., Sack, S., Marx, A., Thormählen, M., Schönbrunn, E., Biou, V., Thompson, A., Mandelkow, E.-M. & Mandelkow, E. (1997) The crystal structure of dimeric kinesin and implications for microtubule-dependent motility. Cell 91, 985-994.
9. 9. Sablin, E.P., Kull, F.J., Cooke, R., Vale, R.D. & Fletterick, R.J. (1996) Crystal structure of the motor domain of the kinesin-related motor Ncd. Nature 380, 555-559.
10. 10. Sablin, E.P., Case, R.B., Dai, S.C., Hart, C.L., Ruby, A., Vale, R.D. & Fletterick, R.J. (1998) Direction determination in the minus-end-directed kinesin motor ncd. Nature 395, 813-816.
11. 11. Gulick, A., Song, H., Endow, S. & Rayment, I. (1998) X-ray crystal structure of the yeast KAR3 motor domain complexed with MgADP to 2.3 Å resolution. Biochemistry 37, 1769-1776.
12. 12. Yang, J., Laymon, R. & Goldstein, L. (1989) A three-domain structure of kinesin heavy chain revealed by DNA sequence and microtubule binding analyses. Cell 56, 879-889.
13. 13. Woehlke, G., Ruby, A.K., Hart, C.L., Ly, B., Hom-Booher, N. & Vale, R.D. (1997) Microtubule interaction site of the kinesin motor. Cell 90, 207-216.
14. 14. Case, R.B., Pierce, D.W., Hom-Booher, N., Hart, C.L. & Vale, R.D. (1997) The directional preference of kinesin motors is specified by an element outside of the motor catalytic domain. Cell 90, 959-966.
15. 15. Henningsen, U. & Schliwa, M. (1997) Reversal of the direction of movement of a molecular motor. Nature 389, 93-96.
16. 16. Endow, S.A. & Waligora, K.W. (1998) Determinants of kinesin motor polarity. Science 281, 1200-1202.
17. 17. Tripet, B., Vale, R.D. & Hodges, R.S. (1997) Demonstration of coiled-coil interactions within the kinesin neck region using synthetic peptides - implications for motor activity. J. Biol. Chem. 272, 8946-8956.
18. 18. Morii, H., Takenawa, T., Arisaka, F. & Shimizu, T. (1997) Identification of kinesin neck region as a stable alpha-helical coiled coil and its thermodynamic characterization. Biochemistry 36, 1933-1942.
19. 19. Thormählen, M., Marx, A., Sack, S. & Mandelkow, E. (1998) The coiled-coil helix in the neck of kinesin. J. Struct. Biol. 122, 30-41.
20. 20. Marx, A., Thormählen, M., Müller, J., Sack, S., Mandelkow, E.-M. & Mandelkow, E. (1998) Conformations of kinesin: solution vs. crystal structures and interactions with microtubules. Eur. Biophys. J. 27, 455-465.
21. 21. Thormählen, M., Marx, A., Müller, S.A., Song, Y.-H., Mandelkow, E.-M., Aebi, U. & Mandelkow, E. (1998) Interaction of monomeric and dimeric kinesin with microtubules. J. Mol. Biol. 275, 795-809.
22. 22. Hoenger, A., Sack, S., Thormählen, M., Marx, A., Müller, J., Gross, H. & Mandelkow, E. (1998) Image reconstruction of microtubules decorated with monomeric and dimeric kinesins: comparison with X-ray structure and implications for motility. J. Cell Biol. 141, 419-430.
23. 23. Romberg, L., Pierce, D. & Vale, R. (1998) Role of the kinesin neck region in processive microtubule-based motility. J. Cell Biol. 140, 1407-1416.
24. 24. Hilgenfeld, R. (1995) Regulatory GTPases. Curr. Opin. Struct. Biol. 5, 810-817.
25. 25. Wittinghofer, A. (1996) Deciphering the alphabet of G proteins: The structure of the αβγ-heterotrimer. Structure 4, 357-361.
26. 26. Bohm, A., Gaudet, R. & Sigler, P.B. (1997) Structural aspects of heterotrimeric G-protein signaling. Curr. Opin. Biotech. 8, 480-487.
27. 27. Sprang, S.R. (1997) G-protein mechanisms: insights from structural analysis. Annu. Rev. Biochem. 66, 639-678,.
28. 28. Gulick, A.M. & Rayment, I. (1997) Structural studies on myosin-II: communication between distant protein domains. Bioessays 19, 561-569.
29. 29. Vale, R.D. (1996) Switches, latches, and amplifiers: common themes of G proteins and molecular motors. J. Cell Biol. 135, 291-302.
30. 30. Sosa, H., Dias, D.P., Hoenger, A., Whittaker, M., Wilson-Kubalek, E., Sablin, E., Fletterick, R.J., Vale, R.D. & Milligan, R.A. (1997) A model for the microtubule-Ncd motor protein complex obtained by cryo-electron microscopy and image analysis. Cell 90, 217-224.
31. 31. Mittal, R., Ahmadian, M.R., Goody, R.S. & Wittinghofer, A. (1996) Formation of a transition-state analog of the Ras GTPase reaction by Ras-GDP, tetrafluoroaluminate, and GTPase-activating proteins. Science 273, 115-117.
32. 32. Berchtold, H., Reshetnikova, L., Reiser, C.O., Schirmer, N.K., Sprinzl, M. & Hilgenfeld, R. (1993) Crystal structure of active elongation factor Tu reveals major domain rearrangements. Nature 365, 126-132.
33. 33. Holmes, K.C. (1997) The swinging lever-arm hypothesis of muscle contraction. Current Biol. 7, R112-R118.
34. 34. Dominguez, R., Freyzon, Y., Trybus, K.M. & Cohen, C. (1998) Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: visualization of the pre-power stroke state. Cell 94, 559-571.
35. ++-ADP-vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9 Angstrom resolution. Biochemistry 35, 5404-5417.
36. 4. Biochemistry 34, 8960-8972.
37. 37. Gulick, A.M., Bauer, C.B., Thoden, J.B. & Rayment, I. (1997) X-ray structures of the MgADP, MgATP-gamma-S, and MgAMPPNP complexes of the Dictyostelium discoideum myosin motor domain. Biochemistry 36, 11619-11628.
38. 38. Rayment, I., Rypniewski, W.R., Schmidtbase, K., Smith, R., Tomchick, D.R., Benning, M.M., Winkelmann, D.A., Wesenberg, G. & Holden, H.M. (1993) Three-dimensional structure of myosin subfragment-1 -a molecular motor. Science 261, 50-58.
39. 39. Abel, K., Yoder, M.D., Hilgenfeld, R. & Jurnak, F. (1996) An alpha to beta conformational switch in EF-Tu. Structure 4, 1153-1159.
40. 40. Cope, M., Whisstock, J., Rayment, I. & Kendrick-Jones, J. (1996) Conservation within the myosin motor domain: implications for structure and function. Structure 4, 969-987.
41. 41. Onishi, H., Kojima, S., Katoh, K., Fujiwara, K., Martinez, H. & Morales, M. (1998) Functional transitions in myosin: formation of a critical salt bridge and transmission of the effect to the sensitive tryptophan. Proc. Natl Acad. Sci. USA 95, 6653-6658.
42. 42. Wriggers, W. & Schulten, K. (1998) Nucleotide-dependent movements of the kinesin motor domain predicted by simulated annealing. Biophys. J. 75, 646-661.
43. 43. Song, H. & Endow, S. (1996) Binding sites of microtubules of kinesin motors of the same or opposite polarity. Biochemistry 35, 11203-11209.
44. 44. Hackney, D.D. (1994) Evidence for alternating head catalysis by kinesin during microtubule-stimulated ATP hydrolysis. Proc. Natl Acad. Sci. USA 91, 6865-6869.
45. 45. Ma, Y.Z. & Taylor, E. (1997) Interacting head mechanism of microtubule-kinesin ATPase. J. Biol. Chem. 272, 724-730.
46. 46. Gilbert, S.P., Moyer, M.L. & Johnson, K.A. (1998) Alternating site mechanism of the kinesin ATPase. Biochemistry 37, 792-799.
47. 47. Pai, E., Kabsch, W., Krengel, U., Holmes, K., John, J. & Wittinghofer, A. (1989) Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation. Nature 341, 209-214.
48. 48. Tong, L.A., de Vos, A.M., Milburn, M.V. & Kim, S.H. (1991) Crystal structures at 2.2 Å resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP. J. Mol. Biol. 217, 503-516.
49. 49. Lambright, D.G., Noel, J.P., Hamm, H.E. & Sigler, P.B. (1994) Structural determinants for activation of the alpha-subunit of a heterotrimeric G-protein. Nature 369, 621-628.
50. 50. Noel, J., Hamm, H. & Sigler, P. (1993) The 2.2 Å crystal structure of transducin-alpha complexed with GTP-gamma-S. Nature 366, 654-663.
51. 51. Esnouf, R.M. (1997) Bobscript. J. Mol. Graphics. 15, 132-134.
52. 52. Merritt, E.A. & Bacon, D.J. (1997) Raster3D, version 2: photorealistic molecular graphics. Methods Enzymol. 277, 505-524.