Kinesin: Switch I & II and the motor mechanism

Journal of Cell Science

Volumn 115, Issue 1, 2002, Pages 15-23

  Kull, F Jon ^a   Endow, Sharyn A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Conformational changes; Kinesin; Molecular motor; Myosin; Structure function

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; KINESIN; MAGNESIUM ION; MYOSIN; NUCLEOTIDE; WATER;

ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOSKELETON; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; HYDROLYSIS; MICROTUBULE; MOLECULAR INTERACTION; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; RAT; RNA TRANSLATION;

ANIMALIA;

EID: 0036150882     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.115.1.15     Document Type: Article

References (40)

1. Proteolytic mapping of kinesin/ncd-microtubule interface: Nucleotide-dependent conformational changes in the loops L8 and L12
2. Role of the kinesin neck linker and catalytic core in microtubule-based motility
3. The mechanism of muscle contraction
4. Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: Visualization of the pre-power stroke state
5. Determinants of kinesin motor polarity
6. -
7. Role of the salt-bridge between switch-1 and switch-2 of Dictyostelium myosin
8. Structural mechanism of muscle contraction
9. X-ray structures of the MgADP, MgATPgammaS, and MgAMPPNP complexes of the Dictyostelium discoideum myosin motor domain
10. X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg•ADP to 2.3 Å resolution
11. Kinesin ATPase: Rate-limiting ADP release
12. Congruent docking of dimeric kinesin and ncd into three-dimensional electron cryomicroscopy maps of microtubule-motor ADP complexes
13. Atomic structure of scallop myosin subfragment S1 complexed with MgADP: A novel conformation of the myosin head
14. Three conformational states of scallop myosin S1
15. Mechanics of motor proteins and the cytoskeleton
16. 15 Å resolution model of the monomeric kinesin motor, KIF1A
17. Switch-based mechanism of kinesin motors
18. Structure of a genetically engineered molecular motor
19. The crystal structure of dimeric kinesin and implications for microtubule-dependent motility
20. Crystal structure of the kinesin motor domain reveals a structural similarity to myosin
21. A processive single-headed motor: Kinesin superfamily protein KIF1A
22. Functional transitions in myosin: Formation of a critical salt-bridge and transmission of effect to the sensitive tryptophan
23. Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 Å resolution: Implications for the mechanism of GTP hydrolysis
24. Structure of the actin-myosin complex and its implications for muscle contraction
25. Three-dimensional structure of myosin subfragment-1: A molecular motor
26. A structural change in the kinesin motor protein that drives motility
27. Structure-function studies of the myosin motor domain: Importance of the 50-kDa cleft
28. Crystal structure of the motor domain of the kinesin-related motor ncd
29. X-ray structure of motor and neck domains from rat brain kinesin
30. Motor proteins of the kinesin family Structure, variations and nucleotide binding sites
31. Conformational changes during kinesin motility
32. X-ray structure of the magnesium(II)·ADP·vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9 Å resolution
33. Decoupling of nucleotide- And microtubule-binding in a kinesin mutant
34. G protein mechanisms: Insights from structural analysis
35. Drosophila wingless and pair-rule transcripts localize apically by dynein-mediated transport of RNA particles
36. Microtubule interaction site of the kinesin motor
37. A fluorescence temperature-jump study of conformational transitions in myosin subfragment 1
38. The way things move: Looking under the hood of molecular motor proteins
39. Kinesin has three nucleotide-dependent conformations: Implications for strain-dependent release
40. A structural pathway for activation of the kinesin motor ATPase