Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms

Science

Volumn 305, Issue 5680, 2004, Pages 61-66

  Skop, Ahna R ^a,b,d   Liu, Hongbin ^c   Yates III, John ^c   Meyer, Barbara J ^a,b   Heald, Rebecca ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENES; LIPIDS; PROTEINS; RNA;

CYTOKINESIS; MORPHOGENETIC EVENTS;

CYTOLOGY;

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; ALPHA TUBULIN; CAENORHABDITIS ELEGANS PROTEIN; CALCYCLIN; CALPHOBINDIN II; CELL CYCLE PROTEIN; CYTOSKELETON PROTEIN; DYNACTIN; DYNAMIN II; DYNEIN ADENOSINE TRIPHOSPHATASE; ENDOPLASMIN; FLOTILIN 1; GLUCOSE REGULATED PROTEIN 78; GLUCOSE TRANSPORTER 1; IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; KINESIN; LIPOCORTIN 2; MIDBODY PROTEIN; NOGGIN; PROTEIN CGI 49; PROTEIN KEAP1; PROTEIN KIF4; PROTEIN RAB GDI; PROTEIN RACK1; PROTEOME; RAB7 PROTEIN; RIBOSOME PROTEIN; TUBULIN; UBIQUITIN PROTEIN LIGASE NEDD4; UNCLASSIFIED DRUG; UNINDEXED DRUG;

BIOLOGY;

ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CELL MEMBRANE TRANSPORT; CELL STRUCTURE; CYTOKINESIS; CYTOSKELETON; LIPID MEMBRANE; LIPID RAFT; MIDBODY; MULTIDIMENSIONAL PROTEIN IDENTIFICATION TECHNOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEOMICS; RNA INTERFERENCE;

ANIMALS; CAENORHABDITIS ELEGANS; CARRIER PROTEINS; CELL CYCLE; CELL DIVISION; CELL FRACTIONATION; CELL MEMBRANE; CHO CELLS; COMPUTATIONAL BIOLOGY; CRICETINAE; CYTOSKELETAL PROTEINS; CYTOSKELETON; GERM CELLS; HELA CELLS; HUMANS; MEMBRANE MICRODOMAINS; MITOTIC SPINDLE APPARATUS; MORPHOGENESIS; ORGANELLES; PROTEIN TRANSPORT; PROTEINS; PROTEOME; PROTEOMICS; SIGNAL TRANSDUCTION;

ANIMALIA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 3042718729     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1097931     Document Type: Article

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67. We thank J. White, M. Mullins, R. Kuriyama, M. Welch, B. Mohler, K. O'Connell, E. Ralston, D. Chu, A. Severson, R. Chan, J. Banks, A. Van Hooser, K. Hagstrom, D. Reiner, and T. Wu for support during midbody isolation, RNAi analysis, and/or for reading the manuscript. We thank M. McNiven for antibodies to Dynamin II and to KHC, T. Hasson for antibody to KEAP1, and A. Caceres for antibody to KIF4. A.R.S. is supported by NIH grant F32 GM64159-01. R.H. is supported by the NIH, The Pew Charitable Trust, and The Cancer Research Coordinating Committee. B.J.M. is an investigator for the Howard Hughes Medical Institute. J.Y. and H.L. are supported by the Yeast Resource Center RR1823 and Office of Naval Research grant N00014-00-0421. This paper is dedicated to K. Van Doren.