3D QSAR models of interactions between β-tubulin and microtubule stabilizing antimitotic agents (MSAA): A survey on taxanes and epothilones

Current Topics in Medicinal Chemistry

Volumn 4, Issue 2, 2004, Pages 203-217

  Manetti, Fabrizio ^a   Maccari, Laura ^a   Corelli, Federico ^a   Botta, Maurizio ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

3D QSAR; Epothilones; Minireceptor model; Taxanes; Tubulin

Indexed keywords

ANTIMITOTIC AGENT; BETA TUBULIN; COLCHICINE; DESOXYEPOTHILONE A; DESOXYEPOTHILONE B; DISCODERMOLIDE; DOCETAXEL; DRUG RECEPTOR; ELEUTHEROBIN DERIVATIVE; EPOTHILONE A; EPOTHILONE B; EPOTHILONE C; EPOTHILONE DERIVATIVE; IXABEPILONE; LAULIMALIDE; LIGAND; PACLITAXEL; POLYISOPRENYL BENZOPHENONE DERIVATIVE; SARCODICTYIN DERIVATIVE; STEROID; TAXANE DERIVATIVE; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE; WS 9885B;

ANTINEOPLASTIC ACTIVITY; BREAST CANCER; CANCER CHEMOTHERAPY; CLINICAL TRIAL; COLORECTAL CANCER; COMPARATIVE STUDY; DATA ANALYSIS; DRUG CLASSIFICATION; DRUG CONFORMATION; DRUG DESIGN; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; EXPERIMENTATION; HEAD AND NECK CANCER; HUMAN; HYDROPHOBICITY; LEUKEMIA; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MICROTUBULE; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OVARY CANCER; PHARMACOPHORE; PROTEIN POLYMERIZATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; SIDE EFFECT; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS; BRIDGED COMPOUNDS; EPOTHILONES; HUMANS; MICROTUBULES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TAXOIDS; TUBULIN;

EID: 1542394399     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568026043451465     Document Type: Review

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