Effects of the hydrophobicity of taxoids on their interaction with tubulin

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 1, 2000, Pages 145-156

  Guénard, Daniel ^a   Thoret, Sylviane ^a   Dubois, Joelle ^a   Adeline, Marie Thérèse ^a   Wang, Qian ^a   Guéritte, Françoise ^a  

^a CNRS   (France)

Author keywords

Docetaxel; Hydrophobicity; Structure activity relationships; Tubulin

Indexed keywords

ALKYL GROUP; DOCETAXEL; PACLITAXEL; TAXOID; TUBULIN;

ARTICLE; CYTOTOXICITY; DRUG ACTIVITY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ESTERIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; LIPOPHILICITY; MICROTUBULE;

ALKALOIDS; ANIMALS; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG SCREENING ASSAYS, ANTITUMOR; PACLITAXEL; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUMOR CELLS, CULTURED; WATER;

EID: 0343485044     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00279-5     Document Type: Article

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