Synthesis and biological activity of novel epothilone aziridines

Organic Letters

Volumn 3, Issue 17, 2001, Pages 2693-2696

  Regueiro Ren, Alicia ^a   Borzilleri, Robert M ^a   Zheng, Xiaoping ^a   Kim, Soong Hoon ^a   Johnson, James A ^a   Fairchild, Craig R ^a   Lee, Francis Y F ^a   Long, Byron H ^a   Vite, Gregory D ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; AZIRIDINE DERIVATIVE; EPOXIDE;

ARTICLE; CHEMISTRY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; AZIRIDINES; EPOXY COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035940099     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol016273w     Document Type: Article

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30. +.
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35. 0.01 values are expressed as the mean with standard deviation obtained from three different concentrations, (b) Cytoxicity was assessed in HCT-116 human colon carcinoma cells by MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-car-boxymethoxyphenyl)-2-(4-sulphenyl)-2H- tetrazolium, inner salt) assay as reported in Riss, T. L.; Moravec, R. A. Mol. Biol. Cell 1992, 3(Suppl), 184a (abstract 1067).
36. 0.01 values are expressed as the mean with standard deviation obtained from three different concentrations, (b) Cytoxicity was assessed in HCT-116 human colon carcinoma cells by MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-car-boxymethoxyphenyl)-2-(4-sulphenyl)-2H- tetrazolium, inner salt) assay as reported in Riss, T. L.; Moravec, R. A. Mol. Biol. Cell 1992, 3(Suppl), 184a (abstract 1067).