Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones

ChemBioChem

Volumn 2, Issue 1, 2001, Pages 69-75

  Nicolaou, K C ^a,b   Namoto, Kenji ^a,b   Li, Jim ^a,b   Ritzen, Andreas ^b   Ulven, Trond ^a,b   Shoji, Mitsuru ^a,b   Zaharevitz, Dan ^c   Gussio, Rick ^c   Sackett, Dan L ^d   Ward, Rita D ^e   Hensler, Anne ^f   Fojo, Tito ^f   Giannakakou, Paraskevi ^f  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^e NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^f NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Antitumor agents; Epothilones; Natural products; Structure activity relationships; Synthesis design

Indexed keywords

ANTINEOPLASTIC AGENT; C12,13 CYCLOPROPYLEPOTHILONE A; C12,13-CYCLOPROPYLEPOTHILONE A; C12,C13 CYCLOBUTYLEPOTHILONE A; C12,C13-CYCLOBUTYLEPOTHILONE A; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; EPOTHILONE DERIVATIVE; LACTONE; THIAZOLE DERIVATIVE; TUBULIN;

ARTICLE; CELL CULTURE; CHEMICAL STRUCTURE; DRUG RESISTANCE; DRUG SCREENING; ELECTRON MICROSCOPY; HUMAN; METABOLISM; STEREOISOMERISM; SYNTHESIS; ULTRASTRUCTURE;

ANTINEOPLASTIC AGENTS; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; EPOTHILONES; HUMANS; INDICATORS AND REAGENTS; LACTONES; MICROSCOPY, ELECTRON; MODELS, MOLECULAR; STEREOISOMERISM; THIAZOLES; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0035825486     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/1439-7633(20010105)2:1<69::AID-CBIC69>3.0.CO;2-8     Document Type: Article

References (2)

1. For a review see: K. C. Nicolaou, F. Roschangar, D. Vourloumis, Angew. Chem. 1998, 110, 2120-2153;
2. Angew. Chem. Int. Ed. 1998, 372014-2045.