Chemical synthesis and biological properties of pyridine epothilones

Chemistry and Biology

Volumn 7, Issue 8, 2000, Pages 593-599

  Nicolaou, Kc ^a,b   Scarpelli, R ^a,b   Bollbuck, B ^a,b   Werschkun, B ^a,b   Pereira, Mma ^a,b   Wartmann, M ^c   Altmann, K H ^c   Zaharevitz, D ^d   Gussio, R ^d   Giannakakou, P ^e  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

^d NATIONAL CANCER INSTITUTE   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Antitumor activity; Chemical synthesis; Epothilones; Molecular modeling; Pyridine epothilones

Indexed keywords

ANTINEOPLASTIC AGENT; EPOTHILONE A; EPOTHILONE B; EPOTHILONE DERIVATIVE; EPOXIDE; MACROLIDE; PYRIDINE DERIVATIVE; THIAZOLE DERIVATIVE; TUBULIN;

ARTICLE; CELL CULTURE; CELL DIVISION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; DRUG RESISTANCE; DRUG SCREENING; HUMAN; IC 50; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CELL DIVISION; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, NEOPLASM; EPOTHILONES; EPOXY COMPOUNDS; HUMANS; INHIBITORY CONCENTRATION 50; MACROLIDES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0033826818     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00006-5     Document Type: Article

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