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Journal of Computer-Aided Molecular Design

Volumn 15, Issue 1, 2001, Pages 41-55

Comparative molecular field analysis (CoMFA) study of epothilones-tubulin depolymerization inhibitors: Pharmacophore development using 3D QSAR methods

(2) Lee, K W a Briggs, J M a

a University of Houston (United States)

Author keywords

3D QSAR; Antitumor agent; CoMFA; Epothilone; GFA

Indexed keywords

CELL PROLIFERATION; COMPUTATIONAL CHEMISTRY; MOLECULAR GRAPHICS; MOLECULES; PHARMACODYNAMICS;

3D-QSAR; ANTITUMOUR AGENTS; COMPARATIVE MOLECULAR FIELD ANALYSIS; DESCRIPTORS; EPOTHILONES; GENETIC FUNCTION ALGORITHM; GRID POINTS; PHARMACOPHORES; QSAR MODEL; TRAINING SETS;

LEAST SQUARES APPROXIMATIONS;

EPOTHILONE A; EPOTHILONE B; EPOTHILONE DERIVATIVE; TUBULIN;

ALGORITHM; ANALYTIC METHOD; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DEPOLYMERIZATION; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; MICROTUBULE ASSEMBLY; MOLECULAR MODEL; PHARMACOPHORE; PRIORITY JOURNAL; PROBABILITY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SCORING SYSTEM; THREE DIMENSIONAL IMAGING;

EID: 0035144336 PISSN: 0920654X EISSN: None Source Type: Journal
DOI: 10.1023/A:1011140723828 Document Type: Article

Times cited : (33)

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