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Volumn 1002, Issue , 2003, Pages 217-235

Chemosensitization and Radiosensitization of Human Cancer by Antisense Anti-MDM2 Oligonucleotides: In Vitro and in Vivo Activities and Mechanisms

Author keywords

5 fluorouracil; Chemotherapy; Human cancer xenograft; Irinotecan; p53; Paclitaxel

Indexed keywords

10 HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; BLEOMYCIN; CISPLATIN; DOXORUBICIN; FLUOROURACIL; IRINOTECAN; PACLITAXEL; PROTEIN MDM2; PROTEIN P53;

EID: 1342332342     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1281.025     Document Type: Conference Paper
Times cited : (43)

References (140)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • HANAHAN, D. & R.A. WEINBERG. 2000. The hallmarks of cancer. Cell 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0022067728 scopus 로고
    • Human P53 cellular tumor antigen: cDNA sequence and expression in COS cells
    • ZAKUT-HOURI, R. et al. 1983. Human P53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J. 4: 1251-1255.
    • (1983) EMBO J. , vol.4 , pp. 1251-1255
    • Zakut-Houri, R.1
  • 3
    • 0032931517 scopus 로고    scopus 로고
    • The p53 pathway
    • PRIVES, C. & P.A. HALL. 1999. The p53 pathway. J. Pathol. 187: 112-126.
    • (1999) J. Pathol. , vol.187 , pp. 112-126
    • Prives, C.1    Hall, P.A.2
  • 4
    • 0032893878 scopus 로고    scopus 로고
    • Regulation of the p53 protein by the MDM2 oncoprotein - Thirty-eighth G.H.A. Clowes Memorial Award lecture
    • FREEDMAN, D.A. & A.J. LEVINE. 1999. Regulation of the p53 protein by the MDM2 oncoprotein - Thirty-eighth G.H.A. Clowes Memorial Award lecture. Cancer Res. 59: 1-7.
    • (1999) Cancer Res. , vol.59 , pp. 1-7
    • Freedman, D.A.1    Levine, A.J.2
  • 5
    • 0034668786 scopus 로고    scopus 로고
    • Strategies for manipulating the p53 pathway in the treatment of human cancer
    • HUPP, T.R. et al. 2000. Strategies for manipulating the p53 pathway in the treatment of human cancer. Biochem. J. 352: 1-17.
    • (2000) Biochem. J. , vol.352 , pp. 1-17
    • Hupp, T.R.1
  • 6
    • 0035835820 scopus 로고    scopus 로고
    • Regulation of p53 function
    • WOODS, D.B. & K.H. VOUSDEN. 2001. Regulation of p53 function. Exp. Cell Res. 264: 56-66.
    • (2001) Exp. Cell Res. , vol.264 , pp. 56-66
    • Woods, D.B.1    Vousden, K.H.2
  • 7
    • 0036219608 scopus 로고    scopus 로고
    • Therapeutic exploitation of the p53 pathway
    • LANE, D.P. & S. LAIN. 2002. Therapeutic exploitation of the p53 pathway. Trends Mol. Med. 8: S38-S42.
    • (2002) Trends Mol. Med. , vol.8
    • Lane, D.P.1    Lain, S.2
  • 8
    • 0036467391 scopus 로고    scopus 로고
    • The p53 and MDM2 families in cancer
    • MICHAEL, D. & M. OREN. 2002. The p53 and MDM2 families in cancer. Curr. Opin. Genet. Dev. 12: 53-59.
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 53-59
    • Michael, D.1    Oren, M.2
  • 9
    • 0025894713 scopus 로고
    • p53 mutations in human cancers
    • HOLLSTEIN, M.D. et al. 1991. p53 mutations in human cancers. Science 253: 49-53.
    • (1991) Science , vol.253 , pp. 49-53
    • Hollstein, M.D.1
  • 10
    • 0030752030 scopus 로고    scopus 로고
    • Database of p53 gene somatic mutations in human tumors and cell lines: Updated compilation and future prospects
    • HAINAUT, P. et al. 1997. Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects. Nucleic Acids Res. 25: 151-157.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 151-157
    • Hainaut, P.1
  • 11
    • 0025804270 scopus 로고
    • Mutation of the p53 gene in human acute myelogenous leukemia
    • SLINGERLAND, J.M. et al. 1991. Mutation of the p53 gene in human acute myelogenous leukemia. Blood 77: 1500-1507.
    • (1991) Blood , vol.77 , pp. 1500-1507
    • Slingerland, J.M.1
  • 12
    • 0025367297 scopus 로고
    • Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines
    • BARTEK, J. et al. 1990. Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines. Oncogene 5: 893-899.
    • (1990) Oncogene , vol.5 , pp. 893-899
    • Bartek, J.1
  • 13
    • 0027935395 scopus 로고
    • P53 gene mutations in breast cancers in midwestern US women: Null as well as missense-type mutations are associated with poor prognosis
    • SAITOH, S. et al. 1994. P53 gene mutations in breast cancers in midwestern US women: null as well as missense-type mutations are associated with poor prognosis. Oncogene 9: 2869-2875.
    • (1994) Oncogene , vol.9 , pp. 2869-2875
    • Saitoh, S.1
  • 14
    • 0026673699 scopus 로고
    • Expression of p53 protein in cutaneous melanoma
    • AKSLEN, L.A. & O. MORKVE. 1992. Expression of p53 protein in cutaneous melanoma. Intl. J. Cancer 52: 13-16.
    • (1992) Intl. J. Cancer , vol.52 , pp. 13-16
    • Akslen, L.A.1    Morkve, O.2
  • 15
    • 0030071853 scopus 로고    scopus 로고
    • Mutation detection by highly sensitive methods indicates that p53 gene mutations in breast cancer can have important prognostic value
    • KOVACH, J.S. et al. 1996. Mutation detection by highly sensitive methods indicates that p53 gene mutations in breast cancer can have important prognostic value. Proc. Natl. Acad. Sci. USA 93: 1093-1096.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 1093-1096
    • Kovach, J.S.1
  • 16
    • 0030460091 scopus 로고    scopus 로고
    • Validation of p53 accumulation as a predictor of distant metastasis at 10 years of follow-up in 1400 node-negative breast cancers
    • SILVESTRINI, R. et al. 1996. Validation of p53 accumulation as a predictor of distant metastasis at 10 years of follow-up in 1400 node-negative breast cancers. Clin. Cancer Res. 2: 2007-2013.
    • (1996) Clin. Cancer Res. , vol.2 , pp. 2007-2013
    • Silvestrini, R.1
  • 17
    • 0035035986 scopus 로고    scopus 로고
    • P53 in bladder cancer: Mechanism of action, prognostic value, and target for therapy
    • SLATON, J.W. et al. 2001. P53 in bladder cancer: mechanism of action, prognostic value, and target for therapy. Urology 57: 852-859.
    • (2001) Urology , vol.57 , pp. 852-859
    • Slaton, J.W.1
  • 18
    • 0031869758 scopus 로고    scopus 로고
    • Predicting response to cancer chemotherapy: The role of p53
    • WELLER, M. 1998. Predicting response to cancer chemotherapy: the role of p53. Cell Tissue Res. 292: 435-445.
    • (1998) Cell Tissue Res. , vol.292 , pp. 435-445
    • Weller, M.1
  • 19
    • 0026318356 scopus 로고
    • Participation of p53 protein in the cellular response to DNA damage
    • KASTAN, M.B. et al. 1991. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51: 6304-6311.
    • (1991) Cancer Res. , vol.51 , pp. 6304-6311
    • Kastan, M.B.1
  • 20
    • 0027970713 scopus 로고
    • DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
    • DI LEONARDO, A. et al. 1994. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Gene Dev. 8: 2540-2551.
    • (1994) Gene Dev. , vol.8 , pp. 2540-2551
    • Di Leonardo, A.1
  • 21
    • 0031830799 scopus 로고    scopus 로고
    • Enhancement of radiosensitivity of wild-type p53 human glioma cells by adenovirus-mediated delivery of the p53 gene
    • LANG, F.F. et al. 1998. Enhancement of radiosensitivity of wild-type p53 human glioma cells by adenovirus-mediated delivery of the p53 gene. J. Neurosurg. 89: 125-132
    • (1998) J. Neurosurg. , vol.89 , pp. 125-132
    • Lang, F.F.1
  • 22
    • 0032439623 scopus 로고    scopus 로고
    • Radiosensitization and apoptosis
    • MUSCHEL, R.J. et al. 1998. Radiosensitization and apoptosis. Oncogene 17: 3359-3363.
    • (1998) Oncogene , vol.17 , pp. 3359-3363
    • Muschel, R.J.1
  • 23
    • 0033730636 scopus 로고    scopus 로고
    • Prostate cancer radiosensitization in vivo with adenovirus-mediated p53 gene therapy
    • COWEN, D. et al. 2000. Prostate cancer radiosensitization in vivo with adenovirus-mediated p53 gene therapy. Clin. Cancer Res. 6: 4402-4408.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 4402-4408
    • Cowen, D.1
  • 24
    • 0034566035 scopus 로고    scopus 로고
    • Adenoviral-mediated p53 transgene expression sensitizes both wild-type and null p53 prostate cancer cells in vitro to radiation
    • COLLETIER, P.J. et al. 2000. Adenoviral-mediated p53 transgene expression sensitizes both wild-type and null p53 prostate cancer cells in vitro to radiation. Int. J. Radiat. Oncol. Biol. Phys. 48: 1507-1512.
    • (2000) Int. J. Radiat. Oncol. Biol. Phys. , vol.48 , pp. 1507-1512
    • Colletier, P.J.1
  • 25
    • 0026656853 scopus 로고
    • Wild-type p53 is a cell cycle checkpoint determinant following irradiation
    • KUERBITS, S.J. et al. 1992. Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. USA 89: 7491-7495.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7491-7495
    • Kuerbits, S.J.1
  • 26
    • 0027244853 scopus 로고
    • The p53-mdm2 autoregulatory feedback loop
    • Wu, X. et al. 1993. The p53-mdm2 autoregulatory feedback loop. Genes Dev. 7: 1126-1132.
    • (1993) Genes Dev. , vol.7 , pp. 1126-1132
    • Wu, X.1
  • 27
    • 0024436187 scopus 로고
    • Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents
    • FORNACE, A.J., JR. et al. 1989. Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents. Mol. Cell Biol. 9: 4196-4203.
    • (1989) Mol. Cell Biol. , vol.9 , pp. 4196-4203
    • Fornace Jr., A.J.1
  • 28
    • 0028294605 scopus 로고
    • WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis
    • EL-DEIRY, W.S. et al. 1994. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 54: 1169-1174.
    • (1994) Cancer Res. , vol.54 , pp. 1169-1174
    • El-Deiry, W.S.1
  • 29
    • 0030865104 scopus 로고    scopus 로고
    • Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents
    • O'CONNOR, P.M. et al. 1997. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res. 57: 4285-4300.
    • (1997) Cancer Res. , vol.57 , pp. 4285-4300
    • O'Connor, P.M.1
  • 30
    • 0025040233 scopus 로고
    • Suppression of human colorectal carcinoma cell growth by wild-type p53
    • BAKER, S.J. et al. 1990. Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 249: 912-915.
    • (1990) Science , vol.249 , pp. 912-915
    • Baker, S.J.1
  • 31
    • 0031894340 scopus 로고    scopus 로고
    • Sensitization of rat glioblastoma multiforme to cisplatin in vivo following restoration of wild-type p53 function
    • DORIGO, O. et al. 1998. Sensitization of rat glioblastoma multiforme to cisplatin in vivo following restoration of wild-type p53 function. J. Neurosurg. 88: 535-540.
    • (1998) J. Neurosurg. , vol.88 , pp. 535-540
    • Dorigo, O.1
  • 32
    • 0031608678 scopus 로고    scopus 로고
    • P53 tumor suppressor gene therapy for cancer
    • NIELSEN, L.L. & D.C. MANEVAL. 1998. P53 tumor suppressor gene therapy for cancer. Cancer Gene Ther. 5: 52-63.
    • (1998) Cancer Gene Ther. , vol.5 , pp. 52-63
    • Nielsen, L.L.1    Maneval, D.C.2
  • 33
    • 0029856574 scopus 로고    scopus 로고
    • Adenoviral-mediated wild-type p53 gene expression sensitizes colorectal cancer cells to ionizing radiation
    • SPITZ, F.R. et al. 1996. Adenoviral-mediated wild-type p53 gene expression sensitizes colorectal cancer cells to ionizing radiation. Clin. Cancer Res. 2: 1665-1671.
    • (1996) Clin. Cancer Res. , vol.2 , pp. 1665-1671
    • Spitz, F.R.1
  • 34
    • 0031830091 scopus 로고    scopus 로고
    • Gene therapy for primary and metastatic pancreatic cancer with intraperitoneal retroviral vector bearing the wild-type p53 gene
    • HWANG, R.F. et al. 1998. Gene therapy for primary and metastatic pancreatic cancer with intraperitoneal retroviral vector bearing the wild-type p53 gene. Surgery 124: 143-150.
    • (1998) Surgery , vol.124 , pp. 143-150
    • Hwang, R.F.1
  • 35
    • 0031944077 scopus 로고    scopus 로고
    • Adenovirus-mediated p53 gene therapy and paclitaxel have synergistic efficacy in models of human head and neck, ovarian, prostate, and breast cancer
    • NIELSEN, L.L. et al. 1998. Adenovirus-mediated p53 gene therapy and paclitaxel have synergistic efficacy in models of human head and neck, ovarian, prostate, and breast cancer. Clin. Cancer Res. 4: 835-846.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 835-846
    • Nielsen, L.L.1
  • 36
    • 0034489718 scopus 로고    scopus 로고
    • Efficacy with a replication-selective adenovirus plus cisplatin-based chemotherapy: Dependence on sequencing but not p53 functional status or route of administration
    • HEISE, C. et al. 2000. Efficacy with a replication-selective adenovirus plus cisplatin-based chemotherapy: dependence on sequencing but not p53 functional status or route of administration. Clin. Cancer Res. 6: 4908-4914.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 4908-4914
    • Heise, C.1
  • 37
    • 0033944718 scopus 로고    scopus 로고
    • Synergistic chemosensitization and inhibition of tumor growth and metastasis by adenovirus-mediated P53 gene transfer in human bladder cancer model
    • MIYAKE, H. et al. 2000. Synergistic chemosensitization and inhibition of tumor growth and metastasis by adenovirus-mediated P53 gene transfer in human bladder cancer model. Urology 56: 332-336.
    • (2000) Urology , vol.56 , pp. 332-336
    • Miyake, H.1
  • 38
    • 0034814353 scopus 로고    scopus 로고
    • Synergistic inhibition of human lung cancer cell growth by adenovirus-mediated wild-type p53 gene transfer in combination with docetaxel and radiation therapeutics in vitro and in vivo
    • NISHIZAKI, M. et al. 2001. Synergistic inhibition of human lung cancer cell growth by adenovirus-mediated wild-type p53 gene transfer in combination with docetaxel and radiation therapeutics in vitro and in vivo. Clin. Cancer Res. 7: 2887-2897.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 2887-2897
    • Nishizaki, M.1
  • 39
    • 0035138464 scopus 로고    scopus 로고
    • Adenovirus-mediated wild-type p53 gene expression radiosensitizes non-small cell lung cancer cells but not normal lung fibroblasts
    • KAWABE, S. et al. 2001. Adenovirus-mediated wild-type p53 gene expression radiosensitizes non-small cell lung cancer cells but not normal lung fibroblasts. Int. J. Radiat. Biol. 77: 185-194.
    • (2001) Int. J. Radiat. Biol. , vol.77 , pp. 185-194
    • Kawabe, S.1
  • 40
    • 0034905621 scopus 로고    scopus 로고
    • In vitro and in vivo adenovirus-mediated p53 and p16 tumor suppressor therapy in ovarian cancer
    • MODESITT, S.C. et al. 2001. In vitro and in vivo adenovirus-mediated p53 and p16 tumor suppressor therapy in ovarian cancer. Clin. Cancer Res. 7: 1765-1772.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1765-1772
    • Modesitt, S.C.1
  • 41
    • 0036210391 scopus 로고    scopus 로고
    • p53 and PTEN/MMAC1/TEP1 Gene therapy of human prostate pc-3 carcinoma xenograft, using transferrin-facilitated lipofection gene delivery strategy
    • SEKI, M. et al. 2002. p53 and PTEN/MMAC1/TEP1 Gene therapy of human prostate pc-3 carcinoma xenograft, using transferrin-facilitated lipofection gene delivery strategy. Hum. Gene Ther. 13: 761-773.
    • (2002) Hum. Gene Ther. , vol.13 , pp. 761-773
    • Seki, M.1
  • 42
    • 0032145989 scopus 로고    scopus 로고
    • The MDM2 gene amplification database
    • MOMAND, J. et al. 1998. The MDM2 gene amplification database. Nucleic Acids Res. 26: 3453-3459.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 3453-3459
    • Momand, J.1
  • 43
    • 0033959744 scopus 로고    scopus 로고
    • MDM2-master regulator of the p53 tumor suppressor protein
    • MOMAND, J. et al. 2000. MDM2-master regulator of the p53 tumor suppressor protein. Gene 242: 15-29.
    • (2000) Gene , vol.242 , pp. 15-29
    • Momand, J.1
  • 44
    • 0034044571 scopus 로고    scopus 로고
    • MDM2 oncogene as a novel target for human cancer therapy
    • ZHANG, R. & H. WANG. 2000. MDM2 oncogene as a novel target for human cancer therapy. Curr. Pharm. Design 6: 393-416.
    • (2000) Curr. Pharm. Design , vol.6 , pp. 393-416
    • Zhang, R.1    Wang, H.2
  • 45
    • 0025853776 scopus 로고
    • Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line
    • FAKHARZADEH, S.S. et al. 1991. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J. 10: 1565-1569.
    • (1991) EMBO J. , vol.10 , pp. 1565-1569
    • Fakharzadeh, S.S.1
  • 46
    • 14444281159 scopus 로고    scopus 로고
    • Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53
    • LUNDGREN, K. et al. 1997. Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. Genes Dev. 11: 714-725.
    • (1997) Genes Dev. , vol.11 , pp. 714-725
    • Lundgren, K.1
  • 47
    • 0029020147 scopus 로고
    • Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status
    • MCCANN, A.H. et al. 1995. Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status. Br. J. Cancer 71: 981-985.
    • (1995) Br. J. Cancer , vol.71 , pp. 981-985
    • McCann, A.H.1
  • 48
    • 0028983308 scopus 로고
    • mdm2 gene alterations and mdm2 protein expression in breast carcinomas
    • MARCHETTI, A. et al. 1995. mdm2 gene alterations and mdm2 protein expression in breast carcinomas. J. Pathol. 175: 31-38.
    • (1995) J. Pathol. , vol.175 , pp. 31-38
    • Marchetti, A.1
  • 49
    • 0034652452 scopus 로고    scopus 로고
    • Relating genotype and phenotype in breast cancer: An analysis of the prognostic significance of amplification at eight different genes or loci and of p53 mutations
    • CUNY, M. et al. 2000. Relating genotype and phenotype in breast cancer: an analysis of the prognostic significance of amplification at eight different genes or loci and of p53 mutations. Cancer Res. 60: 1077-1083.
    • (2000) Cancer Res. , vol.60 , pp. 1077-1083
    • Cuny, M.1
  • 50
    • 0030667191 scopus 로고    scopus 로고
    • P21/waf1/cip1 and mdm-2 expression in breast carcinoma patients as related to prognosis
    • JIANG, M. et al. 1997. P21/waf1/cip1 and mdm-2 expression in breast carcinoma patients as related to prognosis. Int. J. Cancer. (Pred. Oncol.) 74: 529-534.
    • (1997) Int. J. Cancer. (Pred. Oncol.) , vol.74 , pp. 529-534
    • Jiang, M.1
  • 51
    • 0030877712 scopus 로고    scopus 로고
    • Immunohistochemical expression of p53, bcl-2, mdm2, and waf1/p21 proteins in colorectal adenocarcinomas
    • VALASSIADOU, K.E. et al. 1997. Immunohistochemical expression of p53, bcl-2, mdm2, and waf1/p21 proteins in colorectal adenocarcinomas. Anticancer Res. 17: 2571-2576.
    • (1997) Anticancer Res. , vol.17 , pp. 2571-2576
    • Valassiadou, K.E.1
  • 52
    • 0031470550 scopus 로고    scopus 로고
    • Genetic alterations in patients with esophageal cancer with short- and long-term survival rates after curative esophagectomy
    • SHIMADA, Y. et al. 1997. Genetic alterations in patients with esophageal cancer with short-and long-term survival rates after curative esophagectomy. Ann. Surg. 226: 162-168.
    • (1997) Ann. Surg. , vol.226 , pp. 162-168
    • Shimada, Y.1
  • 53
    • 0031398767 scopus 로고    scopus 로고
    • Prognostic factors in astrocytomas: Relationship of p53, MDM-2, BCL-2, and PCNA immunohistochemical expression to tumor grade and overall patient survival
    • EHRMANN, J., JR. et al. 1997. Prognostic factors in astrocytomas: relationship of p53, MDM-2, BCL-2, and PCNA immunohistochemical expression to tumor grade and overall patient survival. Neoplasma 44: 299-304.
    • (1997) Neoplasma , vol.44 , pp. 299-304
    • Ehrmann Jr., J.1
  • 54
    • 0030955673 scopus 로고    scopus 로고
    • Alterations affecting the p53 control pathway in bilharzial-related bladder cancer
    • OSMAN, I. et al. 1997. Alterations affecting the p53 control pathway in bilharzial-related bladder cancer. Clin. Cancer Res. 3: 531-536.
    • (1997) Clin. Cancer Res. , vol.3 , pp. 531-536
    • Osman, I.1
  • 55
    • 7144256512 scopus 로고    scopus 로고
    • Significance of retinoblastoma and MDM2 gene expression as prognostic markers for soft-tissue sarcoma
    • WURL, P. et al. 1998. Significance of retinoblastoma and MDM2 gene expression as prognostic markers for soft-tissue sarcoma. Langenbecks Arch. Surg. 383: 99-103.
    • (1998) Langenbecks Arch. Surg. , vol.383 , pp. 99-103
    • Wurl, P.1
  • 56
    • 0032936602 scopus 로고    scopus 로고
    • Clinical significance of mdm2 and p53 expression in bladder cancer. A comparison with cell proliferation and apoptosis
    • SHIINA, H. et al. 1999. Clinical significance of mdm2 and p53 expression in bladder cancer. A comparison with cell proliferation and apoptosis. Oncology 56: 239-247.
    • (1999) Oncology , vol.56 , pp. 239-247
    • Shiina, H.1
  • 57
    • 0032731825 scopus 로고    scopus 로고
    • Analysis of p53 and mdm2 proteins in malignant fibrous histiocytoma in absence of gene alteration: Prognostic significance
    • MOLINA, P. et al. 1999. Analysis of p53 and mdm2 proteins in malignant fibrous histiocytoma in absence of gene alteration: prognostic significance. Virchows Arch. 435: 596-605.
    • (1999) Virchows Arch. , vol.435 , pp. 596-605
    • Molina, P.1
  • 58
    • 0032772364 scopus 로고    scopus 로고
    • Inactivation of the p53 pathway in prostate cancer: Impact on tumor progression
    • OSMAN, I. et al. 1999. Inactivation of the p53 pathway in prostate cancer: impact on tumor progression. Clin. Cancer Res. 5: 2082-2088.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 2082-2088
    • Osman, I.1
  • 59
    • 0033068065 scopus 로고    scopus 로고
    • mdm-2 expression correlates with wild-type p53 status in esophageal adenocarcinoma
    • SOSLOW, R.A. et al. 1999. mdm-2 expression correlates with wild-type p53 status in esophageal adenocarcinoma. Mod. Pathol. 12: 580-586.
    • (1999) Mod. Pathol. , vol.12 , pp. 580-586
    • Soslow, R.A.1
  • 60
    • 0032710435 scopus 로고    scopus 로고
    • Oncoprotein MDM2 overexpression is associated with poor prognosis in distinct non-Hodgkin's lymphoma entities
    • MOLLER, M.B. et al. 1999. Oncoprotein MDM2 overexpression is associated with poor prognosis in distinct non-Hodgkin's lymphoma entities. Mod. Pathol. 12: 1010-1016.
    • (1999) Mod. Pathol. , vol.12 , pp. 1010-1016
    • Moller, M.B.1
  • 61
    • 0342646995 scopus 로고    scopus 로고
    • A multifactorial prognostic model for adult soft tissue sarcoma considering clinical, histopathological and molecular data
    • WURL, P. et al. 2000. A multifactorial prognostic model for adult soft tissue sarcoma considering clinical, histopathological and molecular data. Anticancer Res. 20: 2065-2072.
    • (2000) Anticancer Res. , vol.20 , pp. 2065-2072
    • Wurl, P.1
  • 62
    • 0034129488 scopus 로고    scopus 로고
    • The prognostic value of cyclin D1, p53, and MDM2 protein expression in uveal melanoma
    • COUPLAND, S.E. et al. 2000. The prognostic value of cyclin D1, p53, and MDM2 protein expression in uveal melanoma. J. Pathol. 191: 120-126.
    • (2000) J. Pathol. , vol.191 , pp. 120-126
    • Coupland, S.E.1
  • 63
    • 0034332527 scopus 로고    scopus 로고
    • The prognostic significance of p16(INK4a)/p14(ARF) locus deletion and MDM-2 protein expression in adult acute myelogenous leukemia
    • FADERL, S. et al. 2000. The prognostic significance of p16(INK4a)/p14(ARF) locus deletion and MDM-2 protein expression in adult acute myelogenous leukemia. Cancer 89: 1976-1982.
    • (2000) Cancer , vol.89 , pp. 1976-1982
    • Faderl, S.1
  • 64
    • 0033959324 scopus 로고    scopus 로고
    • Incidence and prognostic significance of MDM2 oncoprotein overexpression in relapsed childhood acute lymphoblastic leukemia
    • ZHOU, M. et al. 2000. Incidence and prognostic significance of MDM2 oncoprotein overexpression in relapsed childhood acute lymphoblastic leukemia. Leukemia 14: 61-67.
    • (2000) Leukemia , vol.14 , pp. 61-67
    • Zhou, M.1
  • 65
    • 0034086242 scopus 로고    scopus 로고
    • Protein expression of MDM2 and its clinicopathological relationships in human hepatocellular carcinoma
    • ENDO, K. et al. 2000. Protein expression of MDM2 and its clinicopathological relationships in human hepatocellular carcinoma. Liver 20: 209-215.
    • (2000) Liver , vol.20 , pp. 209-215
    • Endo, K.1
  • 66
    • 0035105509 scopus 로고    scopus 로고
    • Deregulated expression of cell cycle-associated proteins in solid pseudopapillary tumor of the pancreas
    • MULLER-HOCKER, J. et al. 2001. Deregulated expression of cell cycle-associated proteins in solid pseudopapillary tumor of the pancreas. Mod. Pathol. 14: 47-53.
    • (2001) Mod. Pathol. , vol.14 , pp. 47-53
    • Muller-Hocker, J.1
  • 67
    • 0035022070 scopus 로고    scopus 로고
    • p53, Mdm2, and c-Myc overexpression is associated with a poor prognosis in aggressive non-Hodgkin's lymphomas
    • PAGNANO, K.B. et al. 2001. p53, Mdm2, and c-Myc overexpression is associated with a poor prognosis in aggressive non-Hodgkin's lymphomas. Am. J. Hematol. 67: 84-92.
    • (2001) Am. J. Hematol. , vol.67 , pp. 84-92
    • Pagnano, K.B.1
  • 68
    • 0035572234 scopus 로고    scopus 로고
    • Malignant peripheral nerve sheath tumours: High Ki67 labelling index is the significant prognostic indicator
    • WATANABE, T. et al. 2001. Malignant peripheral nerve sheath tumours: high Ki67 labelling index is the significant prognostic indicator. Histopathology 39: 187-197.
    • (2001) Histopathology , vol.39 , pp. 187-197
    • Watanabe, T.1
  • 69
    • 0036129145 scopus 로고    scopus 로고
    • Clinical significance of p53, mdm2, and bcl-2 proteins in renal cell carcinoma
    • UCHIDA, T. et al. 2002. Clinical significance of p53, mdm2, and bcl-2 proteins in renal cell carcinoma. Urology 59: 615-620.
    • (2002) Urology , vol.59 , pp. 615-620
    • Uchida, T.1
  • 70
    • 0036157247 scopus 로고    scopus 로고
    • Impact of alterations affecting the p53 pathway in bladder cancer on clinical outcome, assessed by conventional and array-based methods
    • LU, M.L. et al. 2002. Impact of alterations affecting the p53 pathway in bladder cancer on clinical outcome, assessed by conventional and array-based methods. Clin. Cancer Res. 8: 171-179.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 171-179
    • Lu, M.L.1
  • 71
    • 0036154755 scopus 로고    scopus 로고
    • Aberrant p53, MDM2, and proliferation differ in glioblastomas from long-term compared with typical survivors
    • BURTON, E.C. et al. 2002. Aberrant p53, MDM2, and proliferation differ in glioblastomas from long-term compared with typical survivors. Clin. Cancer Res. 8: 180-187.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 180-187
    • Burton, E.C.1
  • 72
    • 0030951971 scopus 로고    scopus 로고
    • Strong correlation of basement membrane degradation with p53 inactivation and/or MDM2 overexpression in superficial urothelial carcinomas
    • OZDEMIR, E. et al. 1997. Strong correlation of basement membrane degradation with p53 inactivation and/or MDM2 overexpression in superficial urothelial carcinomas. J. Urol. 158: 206-211.
    • (1997) J. Urol. , vol.158 , pp. 206-211
    • Ozdemir, E.1
  • 73
    • 7844226611 scopus 로고    scopus 로고
    • Immunohistochemical expression of MDM2 and p21WAF1 in invasive cervical cancer: Correlation with p53 protein and high risk HPV infection
    • TRONCONE, G. et al. 1998. Immunohistochemical expression of MDM2 and p21WAF1 in invasive cervical cancer: correlation with p53 protein and high risk HPV infection. J. Clin. Pathol. 51: 754-760.
    • (1998) J. Clin. Pathol. , vol.51 , pp. 754-760
    • Troncone, G.1
  • 74
    • 0035887146 scopus 로고    scopus 로고
    • HDM2 protein overexpression, but not gene amplification, is related to tumorigenesis of cutaneous melanoma
    • POLSKY, D. et al. 2001. HDM2 protein overexpression, but not gene amplification, is related to tumorigenesis of cutaneous melanoma. Cancer Res. 61: 7642-7646.
    • (2001) Cancer Res. , vol.61 , pp. 7642-7646
    • Polsky, D.1
  • 75
    • 0035034224 scopus 로고    scopus 로고
    • Transition from in situ to invasive testicular germ cell neoplasia is associated with the loss of p21 and gain of MDM2 expression
    • DATTA, M.W. et al. 2001. Transition from in situ to invasive testicular germ cell neoplasia is associated with the loss of p21 and gain of MDM2 expression. Mod. Pathol. 14: 437-42.
    • (2001) Mod. Pathol. , vol.14 , pp. 437-442
    • Datta, M.W.1
  • 76
    • 17144463251 scopus 로고    scopus 로고
    • Abnormal expression of MDM2 in prostate carcinoma
    • LEITE, K.R. et al. 2001. Abnormal expression of MDM2 in prostate carcinoma. Mod. Pathol. 14: 428-436.
    • (2001) Mod. Pathol. , vol.14 , pp. 428-436
    • Leite, K.R.1
  • 77
    • 0035300512 scopus 로고    scopus 로고
    • Alternative and aberrant messenger RNA splicing of the mdm2 oncogene in invasive breast cancer
    • LUKAS, J. et al. 2001. Alternative and aberrant messenger RNA splicing of the mdm2 oncogene in invasive breast cancer. Cancer Res. 61: 3212-3219.
    • (2001) Cancer Res. , vol.61 , pp. 3212-3219
    • Lukas, J.1
  • 78
    • 0031746179 scopus 로고    scopus 로고
    • The expression of the mdm2 gene may be related to the aberration of the p53 gene in human hepatocellular carcinoma
    • QIU, S.J. et al. 1998. The expression of the mdm2 gene may be related to the aberration of the p53 gene in human hepatocellular carcinoma. J. Cancer Res. Clin. Oncol. 124: 253-258.
    • (1998) J. Cancer Res. Clin. Oncol. , vol.124 , pp. 253-258
    • Qiu, S.J.1
  • 79
    • 0033946629 scopus 로고    scopus 로고
    • Overexpression of MDM2 protein in intrahepatic cholangiocarcinoma: Relationship with p53 overexpression, Ki-67 labeling, and clinicopathological features
    • HORIE, S. et al. 2000. Overexpression of MDM2 protein in intrahepatic cholangiocarcinoma: relationship with p53 overexpression, Ki-67 labeling, and clinicopathological features. Virchows Arch. 437: 25-30.
    • (2000) Virchows Arch. , vol.437 , pp. 25-30
    • Horie, S.1
  • 80
    • 0034819270 scopus 로고    scopus 로고
    • Amplification and protein expression of chromosome 12q13-15 genes in osteosarcomas of the jaws
    • LOPES, M.A. et al. 2001. Amplification and protein expression of chromosome 12q13-15 genes in osteosarcomas of the jaws. Oral Oncol. 37: 566-571.
    • (2001) Oral Oncol. , vol.37 , pp. 566-571
    • Lopes, M.A.1
  • 81
    • 0033385056 scopus 로고    scopus 로고
    • Predictive value of cell cycle markers p53, MDM2, p21, and Ki-67 in superficial bladder tumor recurrence
    • PFISTER, C. et al. 1999. Predictive value of cell cycle markers p53, MDM2, p21, and Ki-67 in superficial bladder tumor recurrence. Clin. Cancer Res. 5: 4079-4084.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 4079-4084
    • Pfister, C.1
  • 82
    • 0033979774 scopus 로고    scopus 로고
    • p53 alterations in recurrent squamous cell cancer of the head and neck refractory to radiotherapy
    • GANLY, I. et al. 2000. p53 alterations in recurrent squamous cell cancer of the head and neck refractory to radiotherapy. Br. J. Cancer 82: 392-398.
    • (2000) Br. J. Cancer , vol.82 , pp. 392-398
    • Ganly, I.1
  • 83
    • 0033452513 scopus 로고    scopus 로고
    • mdm-2 expression in human testicular germ-cell tumors and its clinical value
    • EID, H. et al. 1999. mdm-2 expression in human testicular germ-cell tumors and its clinical value. Anticancer Res. 19: 3485-3490.
    • (1999) Anticancer Res. , vol.19 , pp. 3485-3490
    • Eid, H.1
  • 84
    • 0033165975 scopus 로고    scopus 로고
    • Expression of p53 and MDM2 mRNA and protein in colorectal carcinomas
    • BROLL, R. et al. 1999. Expression of p53 and MDM2 mRNA and protein in colorectal carcinomas. Eur. J. Cancer 35: 1083-1088.
    • (1999) Eur. J. Cancer , vol.35 , pp. 1083-1088
    • Broll, R.1
  • 85
    • 0033630298 scopus 로고    scopus 로고
    • MDM2/p53 protein expression in the development of colorectal adenocarcinoma
    • ABDEL-FATTAH, G. et al. 2000. MDM2/p53 protein expression in the development of colorectal adenocarcinoma. J. Gastrointest. Surg. 4: 109-114.
    • (2000) J. Gastrointest. Surg. , vol.4 , pp. 109-114
    • Abdel-Fattah, G.1
  • 86
    • 0034026143 scopus 로고    scopus 로고
    • mdm2 expression as a prognostic indicator in clear cell renal cell carcinoma: Comparison with p53 overexpression and clinicopathological parameters
    • HAITEL, A. et al. 2000. mdm2 expression as a prognostic indicator in clear cell renal cell carcinoma: comparison with p53 overexpression and clinicopathological parameters. Clin. Cancer Res. 6: 1840-1844.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 1840-1844
    • Haitel, A.1
  • 87
    • 0035032709 scopus 로고    scopus 로고
    • Dedifferentiation of a well-differentiated liposarcoma to a highly malignant metastatic osteosarcoma: Amplification of 12q14 at all stages and gain of 1q22-q24 associated with metastases
    • FORUS, A. et al. 2001. Dedifferentiation of a well-differentiated liposarcoma to a highly malignant metastatic osteosarcoma: amplification of 12q14 at all stages and gain of 1q22-q24 associated with metastases. Cancer Genet. Cytogenet. 125: 100-111.
    • (2001) Cancer Genet. Cytogenet. , vol.125 , pp. 100-111
    • Forus, A.1
  • 88
    • 0036205872 scopus 로고    scopus 로고
    • Alterations in p53 and pRb pathways and their prognostic significance in oesophageal cancer
    • MATHEW, R. et al. 2002. Alterations in p53 and pRb pathways and their prognostic significance in oesophageal cancer. Eur. J. Cancer 38: 832-841.
    • (2002) Eur. J. Cancer , vol.38 , pp. 832-841
    • Mathew, R.1
  • 89
    • 0027459198 scopus 로고
    • Mdm2 expression is induced by wild type p53 activity
    • BARAK, Y. et al. 1993. Mdm2 expression is induced by wild type p53 activity. EMBO J. 12: 461-468.
    • (1993) EMBO J. , vol.12 , pp. 461-468
    • Barak, Y.1
  • 90
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • MOMAND, J. et al. 1992. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69: 1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1
  • 91
    • 0028221013 scopus 로고
    • Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway
    • CHEN, C.Y. et al. 1994. Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway. Proc. Natl. Acad. Sci. USA 91: 2684-2688.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 2684-2688
    • Chen, C.Y.1
  • 92
    • 0029913730 scopus 로고    scopus 로고
    • MDM2 inhibits the Gl arrest and apoptosis functions of the p53 tumor suppressor protein
    • CHEN, J. et al. 1996. MDM2 inhibits the Gl arrest and apoptosis functions of the p53 tumor suppressor protein. Mol. Cell. Biol. 16: 2445-2452.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2445-2452
    • Chen, J.1
  • 93
    • 0030905284 scopus 로고    scopus 로고
    • MDM2 promotes the rapid degradation of p53
    • HAUPT, Y. et al. 1997. MDM2 promotes the rapid degradation of p53. Nature 387: 296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1
  • 94
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by mdm2
    • KUBBUTAT, M.H.G. et al. 1997. Regulation of p53 stability by mdm2. Nature 387: 299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.G.1
  • 95
    • 0032493350 scopus 로고    scopus 로고
    • Functional and physical interactions of the ARF tumor suppressor with p53 and MDM2
    • KAMIJO, T. et al. 1998. Functional and physical interactions of the ARF tumor suppressor with p53 and MDM2. Proc. Natl. Acad. Sci. USA 95: 8292-8297.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8292-8297
    • Kamijo, T.1
  • 96
    • 0035941033 scopus 로고    scopus 로고
    • Defining the molecular basis of Arf and Hdm2 interactions
    • BOTHNER, B. et al. 2001. Defining the molecular basis of Arf and Hdm2 interactions. J. Mol. Biol. 314: 263-277.
    • (2001) J. Mol. Biol. , vol.314 , pp. 263-277
    • Bothner, B.1
  • 97
    • 0029028354 scopus 로고
    • Interaction between the retinoblastoma protein and the oncoprotein MDM2
    • XIAO, Z. et al. 1995. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 375: 694-698.
    • (1995) Nature , vol.375 , pp. 694-698
    • Xiao, Z.1
  • 98
    • 0029028353 scopus 로고
    • Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein
    • MARTIN, K. et al. 1995. Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. Nature 375: 691-694.
    • (1995) Nature , vol.375 , pp. 691-694
    • Martin, K.1
  • 99
    • 0027999512 scopus 로고
    • The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes
    • MARECHAL, V. et al. 1994. The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes. Mol. Cell. Biol. 14: 7414-7420.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 7414-7420
    • Marechal, V.1
  • 100
    • 0029760621 scopus 로고    scopus 로고
    • The MDM2 oncoprotein binds specifically to RNA through its RING finger domain
    • ELENBAAS, B. et al. 1996. The MDM2 oncoprotein binds specifically to RNA through its RING finger domain. Mol. Med. 2: 439-451.
    • (1996) Mol. Med. , vol.2 , pp. 439-451
    • Elenbaas, B.1
  • 101
    • 0034596987 scopus 로고    scopus 로고
    • MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis
    • GANGULI, G. et al. 2000. MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis. EMBO J. 19: 5135-5147.
    • (2000) EMBO J. , vol.19 , pp. 5135-5147
    • Ganguli, G.1
  • 102
    • 0030921866 scopus 로고    scopus 로고
    • MDM2 protein overexpression promotes proliferation and survival of multiple myeloma cells
    • TEOH, G. et al. 1997. MDM2 protein overexpression promotes proliferation and survival of multiple myeloma cells. Blood 90: 1982-1992.
    • (1997) Blood , vol.90 , pp. 1982-1992
    • Teoh, G.1
  • 103
    • 0032417695 scopus 로고    scopus 로고
    • Overexpression of Mdm2 in mice reveals a p53-independent role for MDM2 in tumorigenesis
    • JONES, S.N. et al. 1998. Overexpression of Mdm2 in mice reveals a p53-independent role for MDM2 in tumorigenesis. Proc. Natl. Acad. Sci. USA 95: 1508-1512.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 1508-1512
    • Jones, S.N.1
  • 104
    • 0035794143 scopus 로고    scopus 로고
    • Stabilization of the MDM2 oncoprotein by mutant p53
    • PENG, Y. et al. 2001. Stabilization of the MDM2 oncoprotein by mutant p53. J. Biol. Chem. 276: 6874-6878.
    • (2001) J. Biol. Chem. , vol.276 , pp. 6874-6878
    • Peng, Y.1
  • 105
    • 0033135062 scopus 로고    scopus 로고
    • The pathway regulating MDM2 protein degradation can be altered in human leukemic cells
    • PAN, Y. & D.S. HAINES. 1999. The pathway regulating MDM2 protein degradation can be altered in human leukemic cells. Cancer Res. 59: 2064-2067.
    • (1999) Cancer Res. , vol.59 , pp. 2064-2067
    • Pan, Y.1    Haines, D.S.2
  • 106
    • 0029044606 scopus 로고
    • M2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis
    • KONDO, S. et al. 1995. M2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis. Oncogene 10: 2001-2006.
    • (1995) Oncogene , vol.10 , pp. 2001-2006
    • Kondo, S.1
  • 107
    • 0029823094 scopus 로고    scopus 로고
    • MDM2 gene mediates the expression of mdr1 gene and P-glycoprotein in a human glioblastoma cell line
    • KONDO, S. et al. 1996. MDM2 gene mediates the expression of mdr1 gene and P-glycoprotein in a human glioblastoma cell line. Br. J. Cancer 74: 1263-1268.
    • (1996) Br. J. Cancer , vol.74 , pp. 1263-1268
    • Kondo, S.1
  • 108
    • 0031890636 scopus 로고    scopus 로고
    • Role of MDM2 overexpression in doxorubicin resistance of breast carcinoma
    • SUZUKI, A. et al. 1998. Role of MDM2 overexpression in doxorubicin resistance of breast carcinoma. Jpn. J. Cancer Res. 89: 221-227.
    • (1998) Jpn. J. Cancer Res. , vol.89 , pp. 221-227
    • Suzuki, A.1
  • 109
    • 0034641864 scopus 로고    scopus 로고
    • Differences in mutant p53 protein stability and functional activity in teniposide-sensitive and -resistant human leukemic CEM cells
    • MORGAN, S.E. et al. 2000. Differences in mutant p53 protein stability and functional activity in teniposide-sensitive and -resistant human leukemic CEM cells. Oncogene 19: 5010-5019.
    • (2000) Oncogene , vol.19 , pp. 5010-5019
    • Morgan, S.E.1
  • 110
    • 0036565875 scopus 로고    scopus 로고
    • MDM2 induces NF-kappaB/p65 expression transcriptionally through Spl-binding sites: A novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia
    • Gu, L. et al. 2002. MDM2 induces NF-kappaB/p65 expression transcriptionally through Spl-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia. Blood 99: 3367-3375.
    • (2002) Blood , vol.99 , pp. 3367-3375
    • Gu, L.1
  • 111
    • 0035977168 scopus 로고    scopus 로고
    • High levels of the MDM2 oncogene in paediatric rhabdomyosarcoma cell lines may confer multidrug resistance
    • COCKER, H.A. et al. 2001. High levels of the MDM2 oncogene in paediatric rhabdomyosarcoma cell lines may confer multidrug resistance. Br. J. Cancer 85: 1746-1752.
    • (2001) Br. J. Cancer , vol.85 , pp. 1746-1752
    • Cocker, H.A.1
  • 112
    • 0035881581 scopus 로고    scopus 로고
    • Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines
    • KESHELAVA, N. et al. 2001. Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines. Cancer Res. 61: 6185-6193.
    • (2001) Cancer Res. , vol.61 , pp. 6185-6193
    • Keshelava, N.1
  • 113
    • 0034804324 scopus 로고    scopus 로고
    • Prolonged wild-type p53 protein accumulation and cisplatin resistance
    • YAZLOVITSKAYA, E.M. et al. 2001. Prolonged wild-type p53 protein accumulation and cisplatin resistance. Biochem. Biophys. Res. Commun. 283: 732-737.
    • (2001) Biochem. Biophys. Res. Commun. , vol.283 , pp. 732-737
    • Yazlovitskaya, E.M.1
  • 114
    • 0032545222 scopus 로고    scopus 로고
    • p53-independent role of MDM2 in TGF-beta1 resistance
    • SUN, P. et al. 1998. p53-independent role of MDM2 in TGF-beta1 resistance. Science 282: 2270-2272.
    • (1998) Science , vol.282 , pp. 2270-2272
    • Sun, P.1
  • 115
    • 0031939875 scopus 로고    scopus 로고
    • Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage
    • CHEN, L. et al. 1998. Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage. Proc. Natl. Acad. Sci. USA 95: 195-200.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 195-200
    • Chen, L.1
  • 116
    • 0033210893 scopus 로고    scopus 로고
    • MDM2 oncogene as a target for cancer therapy: An antisense approach
    • WANG, H. et al. 1999. MDM2 oncogene as a target for cancer therapy: an antisense approach. Int. J. Oncol. 15: 653-660.
    • (1999) Int. J. Oncol. , vol.15 , pp. 653-660
    • Wang, H.1
  • 117
    • 0032975130 scopus 로고    scopus 로고
    • Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression
    • CHEN, L. et al. 1999. Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression. Mol. Med. 5: 21-34.
    • (1999) Mol. Med. , vol.5 , pp. 21-34
    • Chen, L.1
  • 118
    • 0001864283 scopus 로고    scopus 로고
    • History of antisense oligonucleotides
    • S. Agrawal, Ed.: Humana Press. Totowa, NJ
    • ZAMECNIK, P.C. 1996. History of antisense oligonucleotides. In Antisense Therapeutics. S. Agrawal, Ed.: 1-12. Humana Press. Totowa, NJ.
    • (1996) Antisense Therapeutics , pp. 1-12
    • Zamecnik, P.C.1
  • 119
    • 0030796757 scopus 로고    scopus 로고
    • Pharmacology of therapeutic oligonucleotides antisense nucleic acid
    • DIASIO, R.B. & R. ZHANG. 1997. Pharmacology of therapeutic oligonucleotides antisense nucleic acid. Drug Dev. 7: 239-243.
    • (1997) Drug Dev. , vol.7 , pp. 239-243
    • Diasio, R.B.1    Zhang, R.2
  • 121
    • 0033834587 scopus 로고    scopus 로고
    • Suppression of gene expression by targeted disruption of messenger RNA: Available options and current strategies
    • JEN, K.Y. & A.M. GLWIRTZ. 2000. Suppression of gene expression by targeted disruption of messenger RNA: available options and current strategies. Stem Cells 18: 307-319.
    • (2000) Stem Cells , vol.18 , pp. 307-319
    • Jen, K.Y.1    Glwirtz, A.M.2
  • 124
    • 0035502497 scopus 로고    scopus 로고
    • Antisense anticancer oligonucleotide therapeutics
    • Wang, H. et al. 2001. Antisense anticancer oligonucleotide therapeutics. Curr. Cancer Drug Targets 1: 177-196.
    • (2001) Curr. Cancer Drug Targets , vol.1 , pp. 177-196
    • Wang, H.1
  • 125
    • 0035502598 scopus 로고    scopus 로고
    • Antisense and/or immunostimulatory oligonucleotide therapeutics
    • AGRAWAL, S. & E.R. KANDIMALLA. 2001. Antisense and/or immunostimulatory oligonucleotide therapeutics. Cancer Drug Targets 1: 197-209.
    • (2001) Cancer Drug Targets , vol.1 , pp. 197-209
    • Agrawal, S.1    Kandimalla, E.R.2
  • 126
    • 0037082474 scopus 로고    scopus 로고
    • Oligodeoxynucleotide-mediated inhibition of c-myb gene expression in autografted bone marrow: A pilot study
    • LUGER, S.M. et al. 2002. Oligodeoxynucleotide-mediated inhibition of c-myb gene expression in autografted bone marrow: a pilot study. Blood 99: 1150-1158.
    • (2002) Blood , vol.99 , pp. 1150-1158
    • Luger, S.M.1
  • 127
    • 0030909609 scopus 로고    scopus 로고
    • Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: In vitro and in vivo studies
    • AGRAWAL, S. et al. 1997. Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: in vitro and in vivo studies. Proc. Natl. Acad. Sci. USA 94: 2620-2625.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2620-2625
    • Agrawal, S.1
  • 128
    • 0030755036 scopus 로고    scopus 로고
    • In vivo pharmacokinetics of phosphorothioate oligonucleotides containing contiguous guanosines
    • AGRAWAL, S. et al. 1997. In vivo pharmacokinetics of phosphorothioate oligonucleotides containing contiguous guanosines. Antisense Nucleic Acid Drug Dev. 7: 245-249.
    • (1997) Antisense Nucleic Acid Drug Dev. , vol.7 , pp. 245-249
    • Agrawal, S.1
  • 130
    • 0031300863 scopus 로고    scopus 로고
    • Pharmacokinetics of oligonucleotides
    • Oligonucleotides as Therapeutic agents. Wiley. Chichester, UK
    • AGRAWAL, S. & R. ZHANG. 1997. Pharmacokinetics of oligonucleotides. In Oligonucleotides as Therapeutic agents. Ciba Found. Symp. 209: 60-78. Wiley. Chichester, UK.
    • (1997) Ciba Found. Symp. , vol.209 , pp. 60-78
    • Agrawal, S.1    Zhang, R.2
  • 131
    • 0000397940 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavailability of oligonucleotides following oral and colorectal administrations in experimental animals
    • S. Crooke, Ed.: Springer-Verlag. Heidelberg
    • AGRAWAL, S. & R. ZHANG. 1997. Pharmacokinetics and bioavailability of oligonucleotides following oral and colorectal administrations in experimental animals. In Antisense Research and Applications. S. Crooke, Ed.: 25-543. Springer-Verlag. Heidelberg.
    • (1997) Antisense Research and Applications , pp. 25-543
    • Agrawal, S.1    Zhang, R.2
  • 132
    • 0033598705 scopus 로고    scopus 로고
    • Anti-tumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to RIα subunit of protein kinase A after oral administration
    • WANG, H. et al. 1999. Anti-tumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to RIα subunit of protein kinase A after oral administration. Proc. Natl. Acad. Sci. USA 96: 13989-13994.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 13989-13994
    • Wang, H.1
  • 133
    • 0035186743 scopus 로고    scopus 로고
    • Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: In vitro and in vivo activities and mechanisms
    • WANG, H. et al. 2001. Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: in vitro and in vivo activities and mechanisms. Clin. Cancer Res. 7: 3613-3624.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3613-3624
    • Wang, H.1
  • 134
    • 0036548741 scopus 로고    scopus 로고
    • Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: In vivo activity and mechanisms
    • WANG, H. et al. 2002. Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: in vivo activity and mechanisms. Intl. J. Oncol. 20: 745-752.
    • (2002) Intl. J. Oncol. , vol.20 , pp. 745-752
    • Wang, H.1
  • 135
    • 0036248845 scopus 로고    scopus 로고
    • Antisense anti-MDM2 oligonucleotides as a novel spproach to the treatment of glioblastoma multiforme
    • PRASAD, G. et al. 2002. Antisense anti-MDM2 oligonucleotides as a novel spproach to the treatment of glioblastoma multiforme. Anticancer Res. 22: 107-116.
    • (2002) Anticancer Res. , vol.22 , pp. 107-116
    • Prasad, G.1
  • 136
    • 1342304702 scopus 로고    scopus 로고
    • Modulation of gene expression by antisense olingonucleotides
    • S.W. Kim & R.I. Mahato, Eds.: Harwood Academic Publishers
    • ZHANG, R. & H. WANG. 2002. Modulation of gene expression by antisense olingonucleotides. In Pharmaceutical Pespectives of Nucleic Acid-based Therapeutics. S.W. Kim & R.I. Mahato, Eds.: 33-53. Harwood Academic Publishers.
    • (2002) Pharmaceutical Pespectives of Nucleic Acid-based Therapeutics , pp. 33-53
    • Zhang, R.1    Wang, H.2
  • 137
    • 0036042573 scopus 로고    scopus 로고
    • Anti-tumor efficacy of a novel antisense anti-MDM2 mixed-backbone oligonucleotide in human colon cancer models: p53-Dependent and p53-independent mechanisms
    • WANG, H. et al. 2002. Anti-tumor efficacy of a novel antisense anti-MDM2 mixed-backbone oligonucleotide in human colon cancer models: p53-Dependent and p53-independent mechanisms. Mol. Med. 8: 184-198.
    • (2002) Mol. Med. , vol.8 , pp. 184-198
    • Wang, H.1
  • 138
    • 0037441417 scopus 로고    scopus 로고
    • Experimental therapy of human prostate cancer by inhibiting mdm2 expression with novel mixed-backbone antisense oligonucleotides: In vitro and in vivo activities and mechanisms
    • WANG, H. et al. 2003. Experimental therapy of human prostate cancer by inhibiting mdm2 expression with novel mixed-backbone antisense oligonucleotides: in vitro and in vivo activities and mechanisms. Prostate 54: 194-205.
    • (2003) Prostate , vol.54 , pp. 194-205
    • Wang, H.1
  • 139
    • 0037942897 scopus 로고    scopus 로고
    • Antisense oligonucleotide inhibitors of MDM2 oncogene expression
    • ZHANG, R. & H. WANG. 2003. Antisense oligonucleotide inhibitors of MDM2 oncogene expression. Methods Mol. Med. 85: 205-222.
    • (2003) Methods Mol. Med. , vol.85 , pp. 205-222
    • Zhang, R.1    Wang, H.2
  • 140
    • 1342304701 scopus 로고    scopus 로고
    • Radiosensitization of human cancers by inhibiting MDM2 expression: In vitro and in vivo models and mechanisms
    • th Annual Meeting AACR 44: 1021.
    • (2003) th Annual Meeting AACR , vol.44 , pp. 1021
    • Zhang, Z.1


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