Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: In vitro and in vivo studies

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 6, 1997, Pages 2620-2625

  Agrawal, Sudhir ^a   Jiang, Zhiwei ^a   Zhao, Qiuyan ^a   Shaw, Denise ^b   Cai, Qiuyin ^c   Roskey, Allysen ^a   Channavajjala, Lakshmi ^d   Saxinger, Carl ^d   Zhang, Ruiwen ^c  

^a HYBRIDON INC   (United States)

^b Division of Hematology/Oncology   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

anti HIV agents; coagulation; hemolytic complement; pharmacokinetics

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; DRUG DEGRADATION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ANIMALS; ANTI-HIV AGENTS; BASE SEQUENCE; BLOOD COAGULATION; CELL LINE; CELLS, CULTURED; DRUG DESIGN; HEMOLYSIS; HIV-1; HUMANS; KIDNEY; KINETICS; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MALE; METABOLIC CLEARANCE RATE; MICE; NUCLEIC ACID DENATURATION; OLIGODEOXYRIBONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; OLIGORIBONUCLEOTIDES; RATS; RATS, SPRAGUE-DAWLEY; RIBONUCLEASE H, CALF THYMUS; SPLEEN; THIONUCLEOTIDES; TRIAZINES; VIRUS REPLICATION;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0030909609     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.6.2620     Document Type: Article

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