In vivo pharmacokinetics of phosphorothioate oligonucleotides containing contiguous guanosines

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 3, 1997, Pages 245-249

  Agrawal, Sudhir ^a   Tan, Weitian ^a   Cai, Quiyin ^b   Xie, Xiaowei ^b   Zhang, Ruiwen ^b  

^a HYBRIDON INC   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG ELIMINATION; DRUG STABILITY; DRUG STRUCTURE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

EID: 0030755036     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.245     Document Type: Conference Paper

References (8)

1. AGRAWAL, S. (1996). Antisense oligonucleotides: Towards clinical trials. Trends Biotechnol. 14, 376-387.
2. AGRAWAL, S., IADAROLA, P.L., TEMSAMANI, J., ZHAO, Q., and SHAW, D.R. (1996a). Effect of G-rich sequences on the synthesis, purification, hybridization, cell uptake, and hemolytic activity of oligonucleotides. Bio. & Med. Chem. Lett. 6, 2219-2224.
3. AGRAWAL, S., JIANG, Z., ZHAO, Q., SHAW, D., CAI, Q., ROSKEY, A., CHANNAVAJJALA, L., SAXINGER, C., and ZHANG, R. (1997). Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: In vitro and in vivo studies. Proc. Natl. Acad. Sci. USA 94, 2620-2625.
4. AGRAWAL, S., TAN, W., JIANG, Z., YU, D., and IYER, R.P. (1996b). Synthetic methods for the radioisotopic labeling of oligonucleotide. In: Antisense Oligonucleotide from Technology to Therapy. K.H. Schlingensiepen, ed. (Blackwell, Berlin), pp. 60-77.
5. AGRAWAL, S., TEMSAMANI, J., GALBRAITH, W., and TANG, J.Y. (1995a). Pharmacokinetics of antisense oligonucleotides. Clin. Pharmacokinetics. 28, 7-16.
6. AGRAWAL, S., TEMSAMANI, J., and TANG, J.Y. (1991). Pharmacokinetics, biodistribution and stability of oligodeoxynucleotide phosphorothioates in mice. Proc. Natl. Acad. Sci. USA 88, 7595-7599.
7. AGRAWAL, S., ZHANG, X., LU, Z., TAMBURIN, J.M., YAN, J., CAI, H., DIASIO, R.B., HABUS, I., IYER, R.P., YU. D., and ZHANG, R. (1995b). Absorption, tissue distribution and in vivo stability in rats of a hybrid antisense oligonucleotide following oral administration. Biochem. Pharmacol. 50, 571-576.
8. ZHANG, R., LU, Z., ZHANG, X., DIASIO, R., LIU, T., JIANG, Z., and AGRAWAL, S. (1995c). In vivo stability and disposition of a self-stabilized oligodeoxynucleotide phosphorothioate in rats. Clin. Chem. 41, 836-843.