메뉴 건너뛰기




Volumn 435, Issue 6, 1999, Pages 596-605

Analysis of p53 and mdm2 proteins in malignant fibrous histiocytoma in absence of gene alteration: Prognostic significance

Author keywords

Malignant fibrous histiocytoma; Mdm2; p53; Prognosis and immunohistochemistry

Indexed keywords

PARAFFIN; PROTEIN MDM2; PROTEIN P53;

EID: 0032731825     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004280050446     Document Type: Article
Times cited : (10)

References (71)
  • 2
    • 0027222956 scopus 로고
    • Mapping of the p53 and mdm2 interaction domains
    • 2. Chen J, Marechal V, Levine AJ (1993) Mapping of the p53 and mdm2 interaction domains. Mol Cell Biol 13:4107-4114
    • (1993) Mol Cell Biol , vol.13 , pp. 4107-4114
    • Chen, J.1    Marechal, V.2    Levine, A.J.3
  • 3
    • 0027983669 scopus 로고
    • Pavietich crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
    • 3. Cho Y, Gorina S, Jeffrey PD (1994) Pavietich crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science 265:346-355
    • (1994) Science , vol.265 , pp. 346-355
    • Cho, Y.1    Gorina, S.2    Jeffrey, P.D.3
  • 9
    • 0023959795 scopus 로고
    • Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered halflife
    • 9. Finlay CA, Hinds PW, Tan TH, Eliyahu D, Oren M, Levine AJ (1988) Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered halflife. Mol Cell Biol 8:531-539
    • (1988) Mol Cell Biol , vol.8 , pp. 531-539
    • Finlay, C.A.1    Hinds, P.W.2    Tan, T.H.3    Eliyahu, D.4    Oren, M.5    Levine, A.J.6
  • 11
    • 0027728787 scopus 로고
    • Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: Some amplica do not include MDM2
    • 11. Forus A, Florenes VA, Maelandsmo GM, Meltzer PS, Fodstad O, Myklebost O (1993) Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: some amplica do not include MDM2. Cell Growth Differ 4:1065-1070
    • (1993) Cell Growth Differ , vol.4 , pp. 1065-1070
    • Forus, A.1    Florenes, V.A.2    Maelandsmo, G.M.3    Meltzer, P.S.4    Fodstad, O.5    Myklebost, O.6
  • 14
    • 0027489384 scopus 로고
    • Clinical implications of the p53 tumor-suppressor gene
    • 14. Harris CC, Hollstein M (1993) Clinical implications of the p53 tumor-suppressor gene. New Engl J Med 329:1318-1327
    • (1993) New Engl J Med , vol.329 , pp. 1318-1327
    • Harris, C.C.1    Hollstein, M.2
  • 15
    • 0030932632 scopus 로고    scopus 로고
    • MDM2 gene amplification and expression in non-small-cell lung cancer: Immunohistochemical expression of its protein is a favourable prognostic marker in patients without p53 protein accumulation
    • 15. Higashiyama M, Doi O, Kodama K, Yokouchi H, Kasugai T, Ishiguro S, Takami K, Nishisho I (1997) MDM2 gene amplification and expression in non-small-cell lung cancer: immunohistochemical expression of its protein is a favourable prognostic marker in patients without p53 protein accumulation. Br J Cancer 75:1302-1308
    • (1997) Br J Cancer , vol.75 , pp. 1302-1308
    • Higashiyama, M.1    Doi, O.2    Kodama, K.3    Yokouchi, H.4    Kasugai, T.5    Ishiguro, S.6    Takami, K.7    Nishisho, I.8
  • 17
    • 0026448672 scopus 로고
    • Regulation of the specific DNA binding function of p53
    • 17. Hupp TR, Meek DW, Midgley CA, Lane DP (1992) Regulation of the specific DNA binding function of p53. Cell 71:875-886
    • (1992) Cell , vol.71 , pp. 875-886
    • Hupp, T.R.1    Meek, D.W.2    Midgley, C.A.3    Lane, D.P.4
  • 18
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
    • 18. Jones SN, Roe AE, Donehower LA, Bradley A (1995) Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378:206-208
    • (1995) Nature , vol.378 , pp. 206-208
    • Jones, S.N.1    Roe, A.E.2    Donehower, L.A.3    Bradley, A.4
  • 19
    • 0027501841 scopus 로고
    • Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene
    • 19. Juven T, Barak Y, Zauberman A, George DL, Oren M (1993) Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene 8:3411-3416
    • (1993) Oncogene , vol.8 , pp. 3411-3416
    • Juven, T.1    Barak, Y.2    Zauberman, A.3    George, D.L.4    Oren, M.5
  • 21
    • 0029901963 scopus 로고    scopus 로고
    • The MDM2 oncoprotein is overexpressed in rhabdomyosarcoma cell lines and stabilizes wild-type p53 protein
    • 21. Keleti J, Quezado MM, Abaza MM, Raffeld M, Tsokos M (1996) The MDM2 oncoprotein is overexpressed in rhabdomyosarcoma cell lines and stabilizes wild-type p53 protein. Am J Pathol 149:143-151
    • (1996) Am J Pathol , vol.149 , pp. 143-151
    • Keleti, J.1    Quezado, M.M.2    Abaza, M.M.3    Raffeld, M.4    Tsokos, M.5
  • 24
    • 0027281872 scopus 로고
    • Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours
    • 24. Kovar H, Auinger A, Jug G, Aryee D, Zoubek A, Salzer-Kuntschik M, Gadner H (1993) Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours. Oncogene 8:2683-2690
    • (1993) Oncogene , vol.8 , pp. 2683-2690
    • Kovar, H.1    Auinger, A.2    Jug, G.3    Aryee, D.4    Zoubek, A.5    Salzer-Kuntschik, M.6    Gadner, H.7
  • 26
    • 0027956208 scopus 로고
    • Enhanced translation: A novel mechanism of mdm2 oncogene overexpression identified in human tumor cells
    • 26. Landers JE, Haines DS, Strauss JF, George DL (1994) Enhanced translation: a novel mechanism of mdm2 oncogene overexpression identified in human tumor cells. Oncogene 9:2745-2750
    • (1994) Oncogene , vol.9 , pp. 2745-2750
    • Landers, J.E.1    Haines, D.S.2    Strauss, J.F.3    George, D.L.4
  • 27
    • 0018348655 scopus 로고
    • T antigen is bound to a host protein in SV40-transformed cells
    • 27. Lane DP, Crawford LV (1979) T antigen is bound to a host protein in SV40-transformed cells. Nature 278:261-263
    • (1979) Nature , vol.278 , pp. 261-263
    • Lane, D.P.1    Crawford, L.V.2
  • 30
    • 0006611518 scopus 로고    scopus 로고
    • Prognostic factors for patients with localized primary malignant fibrous histiocytoma: A multicenter study of 216 patients with multivariate analysis
    • 30. Le Doussal V, Coindre JM, Leroux A, Hacene K, Terrier P, Bui NB, Bonichon F, Collin F, Mandard AM, Contesso G (1996) Prognostic factors for patients with localized primary malignant fibrous histiocytoma: a multicenter study of 216 patients with multivariate analysis. Cancer 77:1823-1830
    • (1996) Cancer , vol.77 , pp. 1823-1830
    • Le Doussal, V.1    Coindre, J.M.2    Leroux, A.3    Hacene, K.4    Terrier, P.5    Bui, N.B.6    Bonichon, F.7    Collin, F.8    Mandard, A.M.9    Contesso, G.10
  • 32
    • 0025876591 scopus 로고
    • The p53 tumour suppressor gene
    • 32. Levine AJ, Momand J, Finlay CA (1991) The p53 tumour suppressor gene. Nature 351:453-456
    • (1991) Nature , vol.351 , pp. 453-456
    • Levine, A.J.1    Momand, J.2    Finlay, C.A.3
  • 34
    • 84920360115 scopus 로고
    • Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
    • 34. Livingtone LR, White A, Sprouse J, Livanos E, Jacks T, Tisty TD (1979) Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 17:923-935
    • (1979) Cell , vol.17 , pp. 923-935
    • Livingtone, L.R.1    White, A.2    Sprouse, J.3    Livanos, E.4    Jacks, T.5    Tisty, T.D.6
  • 35
    • 0023696825 scopus 로고
    • Value of nude mice xenografts in the expression of cell heterogeneity of human sarcomas of bone and soft tissue
    • 35. Llombart-Bosch A, Carda C, Boix J, Pellin A, Peydro-Olaya A (1988) Value of nude mice xenografts in the expression of cell heterogeneity of human sarcomas of bone and soft tissue. Pathol Res Pract 183:683-692
    • (1988) Pathol Res Pract , vol.183 , pp. 683-692
    • Llombart-Bosch, A.1    Carda, C.2    Boix, J.3    Pellin, A.4    Peydro-Olaya, A.5
  • 37
    • 0029054396 scopus 로고
    • mdm2 gene amplification and overexpression in non-small cell lung carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations
    • 37. Marchetti A, Buttitta F, Pellegrini S, Merlo G, Chella A, Angeletti CA, Bevilacqua G (1995) mdm2 Gene amplification and overexpression in non-small cell lung carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations. Diagn Mol Pathol 4:93-97
    • (1995) Diagn Mol Pathol , vol.4 , pp. 93-97
    • Marchetti, A.1    Buttitta, F.2    Pellegrini, S.3    Merlo, G.4    Chella, A.5    Angeletti, C.A.6    Bevilacqua, G.7
  • 38
    • 0030443684 scopus 로고    scopus 로고
    • Wild-type p53 protein is unable to activate the mdm-2 gene during F9 cell differentiation
    • 38. Mayo LD, Berberich SJ (1996) Wild-type p53 protein is unable to activate the mdm-2 gene during F9 cell differentiation. Oncogene 13:2315
    • (1996) Oncogene , vol.13 , pp. 2315
    • Mayo, L.D.1    Berberich, S.J.2
  • 39
    • 0030825813 scopus 로고    scopus 로고
    • p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding
    • 39. Midgley CA, Lane DP (1997) p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding. Oncogene 15:1179-1189
    • (1997) Oncogene , vol.15 , pp. 1179-1189
    • Midgley, C.A.1    Lane, D.P.2
  • 42
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • 42. Momand J, Zambetti GP, Olson DC, George D, Levine AJ (1992) The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69:1237-1245
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 44
    • 0028841834 scopus 로고
    • MDM2 gene amplification in bone and soft-tissue tumors: Association with tumor progression in differentiated adipose-tissue tumors
    • 44. Nakayama T, Toguchida J, Wadayama B, Kanoe H, Kotoura Y, Sasaki M (1995) MDM2 gene amplification in bone and soft-tissue tumors: association with tumor progression in differentiated adipose-tissue tumors. Int J Cancer (Pred Oncol) 64:342-346
    • (1995) Int J Cancer (Pred Oncol) , vol.64 , pp. 342-346
    • Nakayama, T.1    Toguchida, J.2    Wadayama, B.3    Kanoe, H.4    Kotoura, Y.5    Sasaki, M.6
  • 45
    • 0026740449 scopus 로고
    • Amplification of a gene encoding a p53-associated protein in human sarcomas
    • 45. Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B (1992) Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358:80-86
    • (1992) Nature , vol.358 , pp. 80-86
    • Oliner, J.D.1    Kinzler, K.W.2    Meltzer, P.S.3    George, D.L.4    Vogelstein, B.5
  • 47
    • 0027179604 scopus 로고
    • Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes
    • 47. Olson DC, Marechal V, Momand J, Chen J, Romocki C, Levine AJ (1993) Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes. Oncogene 8:2353-2360
    • (1993) Oncogene , vol.8 , pp. 2353-2360
    • Olson, D.C.1    Marechal, V.2    Momand, J.3    Chen, J.4    Romocki, C.5    Levine, A.J.6
  • 48
    • 0019830333 scopus 로고
    • Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells
    • 48. Oren M, Maltzman W, Levine AJ (1981) Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells. Mol Cell Biol 1:101-110
    • (1981) Mol Cell Biol , vol.1 , pp. 101-110
    • Oren, M.1    Maltzman, W.2    Levine, A.J.3
  • 52
    • 0030800922 scopus 로고    scopus 로고
    • Mdm2: Keeping p53 under control
    • 52. Piette J, Neel H, Marechal V (1997) Mdm2: keeping p53 under control. Oncogene 15:1001-1010
    • (1997) Oncogene , vol.15 , pp. 1001-1010
    • Piette, J.1    Neel, H.2    Marechal, V.3
  • 53
    • 0001812125 scopus 로고    scopus 로고
    • Enhanced MDM2 oncoprotein expression in soft tissue sarcoma: Several possible regulatory mechanisms
    • 53. Pollock RE, Lang A, El-Naggar AK, Radinsky R, Hung MC (1997) Enhanced MDM2 oncoprotein expression in soft tissue sarcoma: several possible regulatory mechanisms. Sarcoma 1:23-29
    • (1997) Sarcoma , vol.1 , pp. 23-29
    • Pollock, R.E.1    Lang, A.2    El-Naggar, A.K.3    Radinsky, R.4    Hung, M.C.5
  • 54
    • 0027154208 scopus 로고
    • Malignant fibrous histiocytoma of the soft tissue of the trunk and extremities
    • 54. Pritchard DJ, Reiman HM, Turcotte RE, Ilstrup DM (1993) Malignant fibrous histiocytoma of the soft tissue of the trunk and extremities. Clin Orthop 289:58-65
    • (1993) Clin Orthop , vol.289 , pp. 58-65
    • Pritchard, D.J.1    Reiman, H.M.2    Turcotte, R.E.3    Ilstrup, D.M.4
  • 55
    • 0030028076 scopus 로고    scopus 로고
    • DM2 amplification, P53 mutation, and accumulation of the P53 gene product in malignant fibrous histiocytoma
    • 55. Reid AH, Tsai MM, Venzon DJ, Wright CF, Lack EE, O'Leary TJM (1996) DM2 amplification, P53 mutation, and accumulation of the P53 gene product in malignant fibrous histiocytoma. Diagn Mol Pathol 5:65-73
    • (1996) Diagn Mol Pathol , vol.5 , pp. 65-73
    • Reid, A.H.1    Tsai, M.M.2    Venzon, D.J.3    Wright, C.F.4    Lack, E.E.5    O'Leary, T.J.M.6
  • 56
    • 0026089966 scopus 로고
    • Malignant fibrous histiocytoma of soft tissue. A population-based epidemiologic and prognostic study of 137 patients
    • 56. Rooser B, Willen H, Gustafson P, Alvegard TA, Rydholm A (1991) Malignant fibrous histiocytoma of soft tissue. A population-based epidemiologic and prognostic study of 137 patients. Cancer 67:499-505
    • (1991) Cancer , vol.67 , pp. 499-505
    • Rooser, B.1    Willen, H.2    Gustafson, P.3    Alvegard, T.A.4    Rydholm, A.5
  • 58
    • 0020079972 scopus 로고
    • Adenovirus E1b-58Kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 Kd cellular protein in transformed cells
    • 58. Sarnow P, Ho YS, Williams J, Levine AJ (1982) Adenovirus E1b-58Kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 Kd cellular protein in transformed cells. Cell 28:387-394
    • (1982) Cell , vol.28 , pp. 387-394
    • Sarnow, P.1    Ho, Y.S.2    Williams, J.3    Levine, A.J.4
  • 59
  • 60
    • 0028456766 scopus 로고
    • Analysis of prognostic factors and chemotherapy of malignant fibrous histiocytoma of soft tissue: A preliminary report
    • 60. Shinjo K (1994) Analysis of prognostic factors and chemotherapy of malignant fibrous histiocytoma of soft tissue: a preliminary report. Jpn J Clin Oncol 24:154-159
    • (1994) Jpn J Clin Oncol , vol.24 , pp. 154-159
    • Shinjo, K.1
  • 61
    • 0029824669 scopus 로고    scopus 로고
    • Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: Transforming ability and frequent detection in human cancer
    • 61. Sigalas I, Calvert AH, Anderson JJ, Neal DE, Lunec J (1996) Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer. Nat Med 2:912-991
    • (1996) Nat Med , vol.2 , pp. 912-991
    • Sigalas, I.1    Calvert, A.H.2    Anderson, J.J.3    Neal, D.E.4    Lunec, J.5
  • 62
    • 0026667603 scopus 로고
    • p53 immunohistochemistry in malignant fibrous histiocytoma and other mesenchymal tumours
    • 62. Soini Y, Vahakangas K, Nuorva K, Kamel D, Lane DP, Paakko P (1992) p53 immunohistochemistry in malignant fibrous histiocytoma and other mesenchymal tumours. J Pathol 168:29-33
    • (1992) J Pathol , vol.168 , pp. 29-33
    • Soini, Y.1    Vahakangas, K.2    Nuorva, K.3    Kamel, D.4    Lane, D.P.5    Paakko, P.6
  • 63
    • 0029145778 scopus 로고
    • Molecular and immunohistochemical p53 status in liposarcoma and malignant fibrous histiocytoma: Identification of seven new mutations for soft tissue sarcomas
    • 63. Taubert H, Wurl P, Meye A, Berger D, Thamm B, Neumann K, Hinze R, Schmidt H, Rath FW (1995) Molecular and immunohistochemical p53 status in liposarcoma and malignant fibrous histiocytoma: identification of seven new mutations for soft tissue sarcomas. Cancer 76:1187-1196
    • (1995) Cancer , vol.76 , pp. 1187-1196
    • Taubert, H.1    Wurl, P.2    Meye, A.3    Berger, D.4    Thamm, B.5    Neumann, K.6    Hinze, R.7    Schmidt, H.8    Rath, F.W.9
  • 65
    • 0025711796 scopus 로고
    • Cancer. A deadly inheritance
    • 65. Vogelstein B (1990) Cancer. A deadly inheritance. Nature 348:681-682
    • (1990) Nature , vol.348 , pp. 681-682
    • Vogelstein, B.1
  • 67
    • 0018103050 scopus 로고
    • Malignant fibrous histiocytoma. An analysis of 200 cases
    • 67. Weiss SW, Ezinger FM (1978) Malignant fibrous histiocytoma. An analysis of 200 cases. Cancer 41:2250-2266
    • (1978) Cancer , vol.41 , pp. 2250-2266
    • Weiss, S.W.1    Ezinger, F.M.2
  • 68
    • 0027244853 scopus 로고
    • The p53-mdm-2 autoregulatory feedback loop
    • 68. Wu X, Bayle JH, Olson D, Levine AJ (1993) The p53-mdm-2 autoregulatory feedback loop. Genes Dev 7:1126-1132
    • (1993) Genes Dev , vol.7 , pp. 1126-1132
    • Wu, X.1    Bayle, J.H.2    Olson, D.3    Levine, A.J.4
  • 70
    • 0029090962 scopus 로고
    • Prognostic implication of the p53 protein and Ki-67 antigen immunohistochemistry in malignant fibrous histiocytoma
    • 70. Yang P, Hirose T, Hasegawa T, Seki K, Sano T, Hizawa K (1995) Prognostic implication of the p53 protein and Ki-67 antigen immunohistochemistry in malignant fibrous histiocytoma. Cancer 76:618-625
    • (1995) Cancer , vol.76 , pp. 618-625
    • Yang, P.1    Hirose, T.2    Hasegawa, T.3    Seki, K.4    Sano, T.5    Hizawa, K.6
  • 71
    • 0029928684 scopus 로고    scopus 로고
    • Malignant fibrous histiocytoma: Outcome and prognostic factors following conservation surgery and radiotherapy
    • 71. Zagars GK, Mullen JR, Pollack A (1996) Malignant fibrous histiocytoma: outcome and prognostic factors following conservation surgery and radiotherapy. Int J Radiat Oncol Biol Phys 34:983-994
    • (1996) Int J Radiat Oncol Biol Phys , vol.34 , pp. 983-994
    • Zagars, G.K.1    Mullen, J.R.2    Pollack, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.