Significance of retinoblastoma and mdm2 gene expression as prognostic markers for soft-tissue sarcoma

Langenbeck's Archives of Surgery

Volumn 383, Issue 1, 1998, Pages 99-103

  Würl, Peter ^a   Meye, Axel ^a   Berger, Dieter ^a   Lautenschläger, Christine ^a   Bache, Matthias ^a   Holzhausen, Hans Jürgen ^a   Schmidt, Hannelore ^a   Dralle, Henning ^a   Rath, Friedrich Wilhelm ^a   Taubert, Helge ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Immunohistochemistry; Murine double minute protein; Prognosis; Retinoblastoma protein

Indexed keywords

RETINOBLASTOMA PROTEIN;

ADULT; ARTICLE; CANCER SURVIVAL; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; SOFT TISSUE SARCOMA;

ADULT; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 13; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RETINOBLASTOMA; HUMANS; MALE; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PHENOTYPE; PROGNOSIS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; SARCOMA; SOFT TISSUE NEOPLASMS;

EID: 7144256512     PISSN: 14352443     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004230050099     Document Type: Article

References (48)

1. Yoo GH, Xu H-J, Brennan JA, Westra W, Hruban HR, Koch W, Benedict WF, Sidransky D (1994) Infrequent inactivation of the retinoblastoma gene despite frequent loss of chromosome 13q in head and neck squamous cell carcinoma. Cancer Res 54: 4603-4606
2. Dodson MK, Cliby WA, Xu H-J, DeLacey KA, Hu S-X, Keeney GL, Li J, Podratz KC, Jeakins RB, Benedict WF (1994) Evidence of functional Rb protein in epithelial ovarian carcinomas despite loss of heterozygosity at the Rb locus. Cancer Res 54: 610-613
3. Miller CW, Aslo A, Won A, Tan M, Lampkin B, Koeffler HP (1996) Alterations of the p53, Rb and mdm2 genes in osteosarcorna. J Cancer Res Clin Oncol 122: 559-565
4. Karpeh MS, Brennan MF, Cance WG, Woodruff JM, Pollack D, Casper ES, Dudas ME, Latres E, Drobnjack M, Cordon-Cardo C (1995) Altered patterns of retinoblastoma gene product expression in adult soft tissue sarcomas. Br J Cancer 72: 986-991
5. Dei Tos AP, Maestro R, Doglioni C, Piccinin S, Libera DD, Boiocchi M, Fletcher CDM (1996) Tumor suppressor genes and related molecules in leiomyosarcoma. Am J Pathol 148: 1037-1045
6. Wadayama B, Toguchida J, Shimizu T, Ishizaki K, Sasaki MS, Kotoura Y, Yamamuro T (1994) Mutation spectrum of the retinoblastoma gene in osteosarcomas. Cancer Res 54: 3042-3048
7. Ozaki T, Ikeda S, Kawai A, Inoue H, Oda T (1993) Alterations of retinoblastoma susceptible gene accompanied by c-myc amplification in human bone and soft tissue tumors. Cell Mol Biol 39: 235-242
8. Szekely L, Selivanova G, Magnusson KP, Klein G, Wiman KG (1993) EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins. Proc Natl Acad Sci USA 90: 5455-5459
9. Xiao ZX, Chen J, Levine AJ, Modjtahedi N, Xing J, Sellers WR, Livingston DM (1995) Interaction between the retinoblastoma protein and the oncoprotein mdm2. Nature 375: 694-698
10. Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81:323-330
11. Ludlow JW, Shon J, Pipas JM, Livingston D, DeCaprio JA (1990) The retinoblastoma susceptibility gene product undergoes cell cycle dependent dephosphorylation and binding to and release from SV40 large T. Cell 60: 387-396
12. Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B (1992) Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358: 80-83
13. Fakharzadeh SS, Trusko SP, George DL (1991) Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J 10: 1565-1569
14. Momand J, Zambetti GP, Olson DC, George D, Levine AJ (1992) The mdm2 oncogene product forms a complex with the p53 proteine and inhibits p53 mediated transactivation. Cell 69: 1237-1245
15. Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW, Vogelstein B (1993) Oncoprotein mdm2 conceals the activation domain of tumour suppressor p53. Nature 362: 857-860
16. Olson DC, Marechal V, Momand J, Chen J, Romocki C, Levine AJ (1993) Identification and characterisation of multiple mdm.2 proteins and mdm2-p53 protein complexes. Oncogene 8: 2353-2360
17. Finlay CA (1993) The mdm2 oncogene can overcome wild type p53 suppression of transformed cell growth. Mol Cell Biol 13: 301-306
18. Leach FS, Tokino T, Meltzer P, Burrell M, Oliner JD, Smith S, Hill DE, Sidransky D, Kinzler KW, Vogelstein B (1993) p53 mutation and mdm2 amplification in human soft tissue sarcomas. Cancer Res 53: 2231-2234
19. Barak Y, Juven T, Haffner R, Oren M (1993) mdm2 expression is induced by wild type p53 activity. EMBO J 12: 461-468
20. Landers JE, Haines DS, Straus JF, George DL (1994) Enhanced translation; a novel mechanism of mdm2 oncogene overexpression identified in human tumor cells. Oncogene 9: 2745-2750
21. Meltzer PS, Jankowski SA, Dal Cin P, Sandberg AA, Paz IB, Coccia MA (1991) Identification and cloning of a novel amplified DNA sequence in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors. Cell Growth Differ 2: 495-501
22. Cordon-Cardo C, Latres E, Drobnjak M, Oliva MR, Pollack D, Woodruff JM, Marechal V, Chen J, Brennan MF, Levine JL (1994) Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res 54: 794-799
23. Meddeb M, Valent A, Danglot G, Nguyen VC, Duverger A, Fouquet F, Terrier-Lacombe MJ, Oberlin O, Bernheim A (1996) mdm2 amplification in a primary alveolar rhabdomyosarcoma displaying a t(2;13)(q35:q14). Cytogenet Cell Genet 73: 325-330
24. Shimizu E, Coxon A, Otterson GA, Steinberg SM, Kratzke RA, Kim YW, Fedorko J, Oie H, Johnson BE, Mulshine JL, Minna JD, Gazdar AF, Kaye FJ (1994) Rb protein status and clinical correlation from 171 cell lines representing lung cancer, extrapulmonary small cell carcinoma, and mesothelioma. Oncogene 9: 2441-2448
25. Horowitz JM, Yandell DW, Park S-H, Canning S, Whyte P, Buchkovich K, Harlow E, Weinberg RA, Dryja TP (1989) Point mutational inactivation of the retinoblastoma antioncosene. Science 243: 937-940
26. Cance WG, Brennan MF, Dudas ME, Huang CM, Cordon-Cardo C (1990) Altered expression of the retinoblastoma gene product in human sarcomas. N Engl J Med 323: 1457-1462
27. Reissmann PT, Simon MA, Lee W-H. Slamon DJ (1989) Studies of the retinoblastoma gene in human sarcomas. Oncogene 4: 839-843
28. Wunder JS, Czitrom AA, Kandel R, Andrulis IL (1991) Analysis of alterations in the retinoblastoma gene and tumor grade in bone and soft tissue sarcomas. J Natl Cancer Inst 83: 194-200
29. Li W, Fan J, Hochhauser D, Banerjee D, Zielinski Z, Almasan A, Yin Y, Kelly R, Wahl GM, Bertino JR (1995) Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines. Proc Natl Acad Sci USA 92: 10436-10440
30. Cordon-Cardo C, Wartinger D, Patrylak D, Dalbagni G, Fair WR, Fuks Z, Reuter VE (1992) Altered expression of the retinoblastoma gene product' Prognostic indicator in bladder cancer. J Natl Cancer Inst 84: 1251-1256
31. Komblau SM, Chen N, Del Giglio A, O'Brien S, Deisseroth B (1994) Retinoblastoma gene expression is frequently altered in chronic lymphocytic leukemia. Cancer Res 54: 242-246
32. Cordon-Cardo C, Zhang ZF, Dalbagni G, Drobnjak M, Charytonowicz E, Hu SX, Xu HJ, Reuter VE, Benedict WF (1997) Cooperative effects of p53 and pRB alterations in primary superficial bladder tumors. Cancer Res 57: 1217-1221
33. Cordon-Cardo C, Richon VM (1994) Expression of the retinoblastoma protein is regulated in normal human tissue. Am J Pathol 144: 500-510
34. Sanchez-Beato M, Martinez-Montero JC, Doussis-Anagnostopoulou TA, Gatter KC, Garcia J, Garcia JF, Lloret E, Piris MA (1996) Anomalous retinoblastoma protein expression in Sternberg-Reed cells in Hodgkin's disease: a comparative study with p53 and Ki67 expression. Br J Cancer 74: 1056-1062
35. Lin BT-Y, Gruenwald S, Morla AO, Lee WH, Wang JYJ (1991) Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase. EMBO J 10: 857-864
36. Dyson N, Howley PM, Münger K, Harlow E (1989) The human papilloma virus 16E7 oncoprotein is able to bind the retinoblastoma gene product. Science 243: 934-937
37. Mittnacht S, Weinberg RA (1991) G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment. Cell 65: 381-393
38. Templeton DJ (1992) Nuclear binding of purified retinoblastoma gene product is determined by cycle-regulated phosphorylation. Mol Cell Biol 12: 435-443
39. Ladanyi M, Cha C, Lewis R, Jahnwar SC, Huvos AG, Healey JA (1993) mdm2 gene amplification in metastatic osteosarcoma. Cancer Res 53: 16-18
40. Ladanyi M, Lewis R, Jahnwar SC, Gerald W, Huvos AG, Healey JH (1995) mdm2 and CDK4 gene amplification in Ewing's sarcoma. J Pathol 175: 211-217
41. Florenes VA, Maelandsmo GM, Forus A, Andreassen A, Myklebost O, Fodstad O (1994) mdm2 gene amplification and transcript levels in human sarcomas; relationship to tp53 gene status. J Nacl Cancer Inst 86: 1297-1302
42. Waber PG, Chen J, Nisen PD (1993) Infrequency of mdm2 gene amplification in pediatric solid tumors and lack of association with p53 mutations in adult squamous cell carcinomas. Cancer Res 53: 6028-6030
43. Reid AH, Tsai MM, Venzon DJ, Wright CF, Lack EE, O'Leary TJ (1996) mdm amplification, p53 mutation, and accumulation of the p53 gene product in malignant fibrous histiocytoma. Diagn Mol Pathol 5: 65-73
44. Lonardo F, Ueda T, Huvos AG, Healey J, Ladanyi M (1997) p53 and mdm2 alterations in osteosarcomas. Cancer 79: 1541-1547
45. Kondo S, Kondo Y, Hara H, Kaakaji R, Peterson JW, Morimura T, Takeuchi J, Barnett GH (1996) mdm2 gene mediates the expression of mdr1 gene and p-glycoprotein in a human glioblastoma cell line. Br J Cancer 74: 1263-1268
46. Chen J, Wu X, Lin J, Levine AJ (1996) mdm2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol Cell Biol 16: 2445-2452
47. Kussie PH, Gornia S, Marechal V, Elenbaas B, Moreau J, Levine AJ, Pavletich NP (1996) Structure of the mdm2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 274: 948-953
48. Martin K, Trouche D, Hagemeier C, Sorensen TS, La Thangue NB, Kouzarides T (1995) Stimulation of E2F1/DP1 transcriptional activity by mdm2 oncoprotein. Nature 375: 691-694