Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIα subunit of protein kinase A after oral administration

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 24, 1999, Pages 13989-13994

  Wang, Hui ^a   Cai, Qiuyin ^a   Zeng, Xiaofei ^a   Yu, Dong ^b   Agrawal, Sudhir ^b   Zhang, Ruiwen ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b HYBRIDON INC   (United States)

Author keywords

Antisense therapy; Breast cancer; Colon cancer; Lung cancer; Oral drug delivery

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CISPLATIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR;

ALPHA CHAIN; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER THERAPY; CELL PROLIFERATION; COLON CANCER; ENZYME ACTIVITY; GEL ELECTROPHORESIS; GENE INDUCTION; IMMUNE DEFICIENCY; LEUKEMIA; LUNG CANCER; NUDE MOUSE; PRIORITY JOURNAL; PROGNOSIS; SIGNAL TRANSDUCTION; XENOGRAFT;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL DIVISION; CISPLATIN; COLONIC NEOPLASMS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEMALE; HL-60 CELLS; HUMANS; LUNG NEOPLASMS; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; OLIGONUCLEOTIDES, ANTISENSE; TUMOR CELLS, CULTURED;

MUS MUSCULUS;

EID: 0033598705     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.24.13989     Document Type: Article

References (52)

1. Beebe, S. J. & Corbin, J. D. (1986) in The Enzymes: Control by Phosphorylation, eds. Boyer, P. D. & Kerbes, E. G. (Academic, New York), Vol. 17, Part A, pp. 43-111.
2. Cho-Chung, Y. S. & Clair, T. (1993) Pharmacol. Ther. 60, 265-288.
3. Bradbury, A. W., Miller, W. R. & Carter, D. C. (1991) Br J. Cancer 63, 201-204.
4. Miller, W. R., Watson, D. M. A., Jack, W., Chetty, U. & Elton, R. A. (1993) Breast Cancer Res. Treat. 26, 89-94.
5. Miller, W. R., Hulme, M. J., Bartlett, J. M., MacCallum, J. & Dixon, J. M. (1997) Clin. Cancer Res. 3, 2399-2404.
6. Simpson, J. B. B., Ramage, A. D., Hulme, M. J., Burns, D. J., Katsaros, D., Langdon, S. & Miller, W. R. (1996) Clin. Cancer Res. 2, 201-206.
7. McDaid, H. M., Cairns, M. T., Atkinson, R. J., McAleer, S., Harkin, D. P., Gilmore, P. & Johnston, P. G. (1999) Br. J. Cancer 79, 933-939.
8. Young, M. R. I., Montpetit, M., Lozano, Y., Djordjevic, A., Devata, S., Matthews, J. P., Yedavalli, S. & Chejfec, G. (1995) Int. J. Cancer 61, 104-109.
9. Bradbury, A. W., Carter, D. C., Miller, W. R., Cho-Chung, Y. S. & Clair, T. (1994) Br. J. Cancer 69, 738-742.
10. Bold, R. J., Alpard, S., Ishizuka, J., Townsend, C. M., Jr. & Thompson, R. (1994) Regul. Pept. 53, 61-70.
11. Gordge, P. C., Hulme, M. J., Clegg, R. A. & Miller, W. R. (1996) Eur. J. Cancer 32, 2120-2126.
12. Yang, W. L., Iacono, L., Tang, W. M. & Chin, K. V. (1998) Biochemistry 37, 14175-14180.
13. Abraham, I., Chin, K. V., Gottesman, M. M., Mayo, J. K. & Sampson, K. E. (1990) Exp. Cell Res. 189, 133-141.
14. Rohlff, C. & Glazer, R. T. (1995) Cell. Signalling 7, 431-434.
15. Cvijic, M. E. & Chin, K.-V. (1998) Biochem. Biophys. Res. Commum. 249, 723-727.
16. Barbier, A. J., Poppleton, H. M., Yigzaw, Y., Mullenix, J. B., Wiepz, G. J., Bertics, P. J. & Patel, T. B. (1999) J. Biol. Chem. 274, 14067-14073.
17. Glazer, R. I. & Rohlff, C. (1994) Breast Cancer Res. Treat. 31, 263-271.
18. Yokozaki, H., Budillon, A., Tortora, G., Meissner, S., Beaucage, S. L., Miki, K. & Cho-Chung, Y. S. (1993) Cancer Res. 53, 868-887.
19. Cho-Chung, Y. S., Nesterova, M., Kondrashin, A., Noguchi, K., Srivastava, R. & Pepe, S. (1997) Antisense Nucleic Acid Drug Dev. 7, 217-223.
20. Agrawal, S. & Zhao, Q. (1998) Curr. Opin. Chem. Biol. 2, 519-528.
21. Krieg, A. M., Yi, A. K., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A. & Klinman, D. M. (1995) Nature (London) 374, 546-549.
22. Liang, H., Nishioka, Y., Reich, C. F., Pisetsky, D. S. & Lipsky, P. E. (1996) J. Clin. Invest. 98, 1119-1129.
23. Hartmann, G., Weiner, G. J. & Krieg, A. M. (1999) Proc. Natl. Acad. Sci. USA 96, 9305-9310.
24. Agrawal, S., Jiang, Z., Zhao, Q., Shaw, D., Cai, Q., Roskey, A., Channavajjala, L., Saxinger, C. & Zhang, R. (1997) Proc. Natl. Acad. Sci. USA 94, 2620-2625.
25. Agrawal, S. & Zhao, Q. (1998) Antisense Nucleic Acid Drug Dev. 8, 135-139.
26. Chen, H., Ness, E., Marshell, J., Martin, R., Dvorchik, B., Rizvi, N., Marquis, J., Dahut, W. & Hawkins, M. J. (1999) Proc. Am. Soc. Clin. Oncol. 18, 159a (abstr.).
27. Agrawal, S., Zhang, X., Zhao, H., Lu, Z., Yan, J., Cai, H., Diasio, R. B., Habus, I., Jiang, Z., Iyer, R. P., et al. (1995) Biochem. Pharmacol. 50, 571-576.
28. Agrawal, S. & Zhang, R. (1998) in Antisense Research and Application, ed. Crooke, S. T. (Springer, Berlin), pp. 525-543.
29. Vlassov, V. V., Karamyshev, V. N. & Yakubov, L. A. (1993) FEBS Lett. 327, 271-274.
30. Zhang, R., Lu, Z., Zhao, H., Zhang, X., Diasio, R. B., Habus, I., Jiang, Z., Iyer, R. P., Yu, D. & Agrawal, S. (1995) Biochem. Pharmacol. 50, 545-556.
31. Padmapriya, A. P., Tang, J. Y. & Agrawal, S. (1994) Antisense Res. Dev. 4, 185-199.
32. Agrawal, S., Temsamani, J. & Tang, J.-Y. (1991) Proc. Natl. Acad. Sci. USA 88, 7595-7599.
33. Cai, Q., Lindsey, J. R. & Zhang, R. (1997) Int. J. Oncol. 10, 953-960.
34. Zhang, R., Cai, Q., Lindsey, J. R., Li, Y., Chambless, B. & Naguib, F. N. M. (1997) Int. J. Oncol. 1997, 10, 1147-1156.
35. Liu, W. & Zhang, R. (1998) Int. J. Oncol. 12, 793-804.
36. Zhang, R., Iyer, P., Yu, D., Zhang, X., Lu, Z., Zhao, H. & Agrawal, S. (1996) J. Pharmacol. Exp. Ther. 278, 971-979.
37. Zamecnik, P. C. (1996) in Antisense Therapeutics, ed. Agrawal, S. (Humana, Totowa, NJ), pp. 1-11.
38. Smith, J. B. & Wickstrom, E. (1998) J. Natl. Cancer Inst. 90, 1146-1154.
39. Agrawal, S. (1996) Trends Biotechnol. 14, 376-387.
40. Crooke, S. T. (1998) Antisense Nucleic Acid Drug Dev. 8, vii-viii.
41. Crooke, S. T., Grillone, L. R., Tendolkar, A., Garrett, A., Fratkin, M. J., Leeds, J. & Barr, W. H. (1994) Clin. Pharmacol. Ther. 56, 641-646.
42. Zhang, R., Yan, J., Shahinian, H., Amin, G., Lu, Z., Liu, T., Saag, M. S., Jiang, Z., Temsamani, J., Martin, R. R., et al. (1995) Clin. Pharmacol. Ther. 58, 44-53.
43. Sands, H., Gorey-Feret, L. J., Cocuzza, A. J., Hobbs, F. W., Chidester, D. & Trainor, G. L. (1994) Mol. Pharmacol. 45, 932-943.
44. Temsamani, J., Roskey, A., Chaix, C. & Agrawal, S. (1997) Antisense Nucleic Acid Drug Dev. 7, 159-165.
45. Galbraith, W. M., Hobson, W. C., Giclas, P. C., Schechter, P. & Agrawal, S. (1994) Antisense Res. Dev. 4, 201-206.
46. Agrawal, S., Rustagi, P. K. & Shaw, D. (1996) Toxicol. Lett. 82/83, 431-434.
47. Crooke, S. T. (1998) Antisense Nucleic Acid Drug Dev. 8, 115-122.
48. Crooke, S. T. (1997) Adv. Pharmacol. 40, 1-49.
49. Crooke, S. T., Graham, M. J., Zuckerman, J. E., Brooks, D., Conklin, B. S., Cummins, L. L., Greig, M. J., Guinosso, C. J., Kornbrust, D., Manoharan, M., et al. (1996) J. Pharmacol. Exp. Ther. 277, 923-937.
50. Young, M. R. I., Young, M. E., Lozano, Y. & Bagash, J. M. (1992) Invasion Metastasis 12, 253-263.
51. Srivastava, R. K., Srivastava, A. R., Park, Y. G., Agrawal, S. & Cho-Chung, Y. S. (1998) Breast Cancer Res. Treat. 49, 97-107.
52. Barker, R. H., Jr., Metelev, V., Rapaport, E. & Zamecnik, P. (1996) Proc. Natl. Acad. Sci. USA 93, 514-518.